Fluid replacement therapy (DBCOND0025735)

Identifiers

Synonyms

Replacement Fluid / Fluid replacement / Fluid replenishment therapy / Volume replacement / Fluid replacement NOS / Body fluid replacement (procedure)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
D-glucose	A most commonly occurring isomer of glucose used as a carbohydrate supplementation in case of nutrient deprivation and metabolic disorders, such as hypoglycemia.	Hexokinase-1enzyme Hexokinase-4enzyme Solute carrier family 2, facilitated glucose transporter member 1transporter Solute carrier family 2, facilitated glucose transporter member 2transporter Solute carrier family 2, facilitated glucose transporter member 3transporter Solute carrier family 2, facilitated glucose transporter member 4transporter Solute carrier family 2, facilitated glucose transporter member 5transporter Solute carrier family 2, facilitated glucose transporter member 6transporter Solute carrier family 2, facilitated glucose transporter member 7transporter Solute carrier family 2, facilitated glucose transporter member 8transporter Solute carrier family 2, facilitated glucose transporter member 9transporter Solute carrier family 2, facilitated glucose transporter member 10transporter Solute carrier family 2, facilitated glucose transporter member 11transporter Solute carrier family 2, facilitated glucose transporter member 12transporter Sodium/glucose cotransporter 1transporter Sodium/glucose cotransporter 2transporter Albumincarrier
Dipotassium phosphate	An ionic compound used for electrolyte replenishment and total parenteral nutrition (TPN) therapy.	No drug targets
Gluconic Acid	An electrolyte supplement used in total parenteral nutrition.	No drug targets
Gluconic Acid	An electrolyte supplement used in total parenteral nutrition.	No drug targets
Lactic acid	An emollient and keratolytic used agent in various cosmetic products and used as an additive in various pharmaceutical products for its antibacterial properties.	Bifunctional protein PutAtarget NimA-related proteintarget Monocarboxylate transporter 2transporter Solute carrier organic anion transporter family member 2B1transporter Monocarboxylate transporter 1transporter Monocarboxylate transporter 10transporter Solute carrier organic anion transporter family member 2A1transporter Monocarboxylate transporter 4transporter
Magnesium acetate tetrahydrate	An ionic compound used for electrolyte replenishment and total parenteral nutrition (TPN) therapy.	Glutamate (NMDA) receptortarget
Magnesium chloride	An ionic compound and source of magnesium used for electrolyte replenishment and conditions associated with magnesium deficiencies.	No drug targets
Monopotassium phosphate	An ionic compound used for electrolyte replenishment and total parenteral nutrition (TPN) therapy.	No drug targets
Potassium chloride	A potassium salt used to treat hypokalemia.	Solute carrier family 12 member 2target Solute carrier family 12 member 1target Solute carrier family 12 member 5target Solute carrier family 12 member 6target Solute carrier family 12 member 7target Solute carrier family 12 member 4target Solute carrier family 12 member 2transporter Solute carrier family 12 member 1transporter Solute carrier family 12 member 5transporter Solute carrier family 12 member 6transporter Solute carrier family 12 member 7transporter Solute carrier family 12 member 4transporter
Sodium acetate	A compound used for electrolyte replenishment and total parenteral nutrition (TPN) therapy.	Acetyl-coenzyme A synthetase, cytoplasmicenzyme
Sodium chloride	An ingredient found in a variety of nutritional products as a source of electrolytes and water.	No drug targets
Sodium phosphate, monobasic	A source of phosphorus used prevent or correct hypophosphatemia in patients with restricted or no oral intake.	Sodium-dependent phosphate transporter 1transporter Sodium-dependent phosphate transporter 2transporter Sodium-dependent phosphate transport protein 2Atransporter Sodium-dependent phosphate transport protein 2Btransporter Sodium-dependent phosphate transport protein 2Ctransporter
Sulfamethoxazole	An oral sulfonamide antibiotic, given in combination with trimethoprim, used to treat a variety of infections of the urinary tract, respiratory system, and gastrointestinal tract.	Cytochrome P450 2C9enzyme Albumincarrier Arylamine N-acetyltransferase 1enzyme Arylamine N-acetyltransferase 2enzyme Dihydropteroate synthasetarget Cytochrome P450 3A4enzyme Bile salt export pumptransporter
Trimethoprim	An antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract.	Dihydrofolate reductasetarget Cytochrome P450 2C8enzyme Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2C9enzyme Cytochrome P450 1A2enzyme Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter Dihydrofolate reductasetarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04071171	Comparison of Biphozyl® and Phoxilium® as a Replacement Fluid During CVVH for AKI in Adults and Their Effects on pH-, Bicarbonate-levels and Respiratory Situation	Calcium chloride Magnesium chloride Potassium chloride Sodium bicarbonate Sodium chloride Sodium phosphate, dibasic	treatment	2	completed