Menopausal Symptoms (DBCOND0028731)

Identifiers

Synonyms

Menopausal Symptom / Menopausal symptoms / Recurrence of menopausal symptoms / Menopausal symptom (finding)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Belladonna	No therapeutic indications.	No drug targets
Black cohosh	A herbal product indicated in the symptomatic treatment of menopause.	Cytochrome P450 3A4enzyme Cytochrome P450 3A2enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2D6enzyme
Estradiol valerate	An estradiol prodrug used to treat some effects of menopause, hypoestrogenism, androgen dependant carcinoma of the prostate, and in combination products for endometriosis and contraception.	Estrogen receptortarget Nuclear receptor subfamily 1 group I member 2target Sex hormone-binding globulincarrier Estrogen receptor betatarget Cytochrome P450 1A2enzyme UDP-glucuronosyltransferase 1A1enzyme Albumincarrier Fatty acid-binding protein, intestinalcarrier Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter Solute carrier family 22 member 3transporter Solute carrier organic anion transporter family member 2B1transporter Solute carrier organic anion transporter family member 1A2transporter ATP-binding cassette sub-family C member 10transporter Solute carrier family 22 member 11transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter ATP-dependent translocase ABCB1transporter Cytochrome P450 1A1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Organic anion transporter 3transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier organic anion transporter family member 1C1transporter Solute carrier organic anion transporter family member 4A1transporter Neuronal acetylcholine receptor subunit alpha-4target Nuclear receptor coactivator 2target G-protein coupled estrogen receptor 1target ATP synthase subunit atarget Beclin-1target 17-beta-hydroxysteroid dehydrogenase type 2target Estrogen-related receptor gammatarget
Nomegestrol acetate	Nomegestrol acetate, also known as NOMAC, is a progestin used in oral contraceptives, menopausal hormone therapy, and for the treatment of gynecological disorders.	Cytochrome P450 3A4enzyme Estrogen receptortarget
Phenobarbital	A long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures.	Gamma-aminobutyric acid receptor subunit alpha-1target Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 1A2enzyme Cytochrome P450 3A4enzyme ATP-binding cassette sub-family C member 3transporter Bile salt export pumptransporter ATP-dependent translocase ABCB1transporter Multidrug resistance-associated protein 1transporter Solute carrier organic anion transporter family member 2A1transporter ATP-binding cassette sub-family C member 2transporter Neuronal acetylcholine receptor subunit alpha-4target Neuronal acetylcholine receptor subunit alpha-7target Glutamate receptor 2target Glutamate receptor ionotropic, kainate 2target Cytochrome P450 2A6enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A5enzyme Cytochrome P450 1A1enzyme Cytochrome P450 2C18enzyme Cytochrome P450 3A7enzyme Cytochrome P450 4B1enzyme NMDA receptortarget Nuclear receptor subfamily 1 group I member 2target UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 2B7enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04837729	The Effect of Acupressure Applied to Menopausal Women on Menopausal Symptoms and Quality of Life	No drug interventions	supportive_care	Not Available	completed
NCT05342610	Effect of Reiki Application on Menopausal Symptoms	No drug interventions	supportive_care	Not Available	completed
NCT04209543	Estetrol for the Treatment of Moderate to Severe Vasomotor Symptoms in Postmenopausal Women (E4Comfort Study I)	No drug interventions	treatment	3	active_not_recruiting
NCT00214903	European Active Surveillance Study of Women Taking Hormone Replacement Therapy (HRT)	No drug interventions	Not Available	Not Available	completed
NCT00427245	Goserelin in Preventing Early Menopause in Premenopausal Women Undergoing Chemotherapy for Stage I, Stage II, or Stage III Breast Cancer	No drug interventions	supportive_care	3	completed
NCT06151028	An Observational Study of Menopausal Symptom in Patients With Gynecological Malignancy After Oophorectomy	No drug interventions	Not Available	Not Available	recruiting
NCT00031811	Raloxifene With or Without Exercise Compared With Exercise Alone in Women Who Have Been Previously Treated for Breast Cancer	Raloxifene	supportive_care	Not Available	completed
NCT00179556	Effects of Soy Isoflavones on Menopausal Hot Flashes	Isoflavone	treatment	2 / 3	completed
NCT00454441	Sleep Quality in CHIMES (MF101)	No drug interventions	treatment	2	completed
NCT00026286	Hormone Replacement Therapy for Hot Flashes and/or Vaginal Symptoms in Postmenopausal Women Receiving Tamoxifen for Breast Cancer	Conjugated estrogens Medroxyprogesterone acetate	supportive_care	3	completed
NCT02269891	A Clinical Trial on the Efficacy of a Combination Herbal Product, Biotropics' Nu Femme, on Menopausal Symptoms and Quality of Life in Women	No drug interventions	other	2	completed
NCT00892268	Acupuncture or Medication in Reducing Pain in Postmenopausal Women With Breast Cancer and Joint Pain	No drug interventions	supportive_care	2	terminated
NCT05414812	Intervening on Women's Health for Rural Young Breast Cancer Survivors	No drug interventions	supportive_care	Not Available	recruiting
NCT04731402	The Effect of Acupressure, Laughter Yoga and Mindfulness on Menopausal Symptoms and Quality of Life	No drug interventions	supportive_care	Not Available	unknown_status
NCT00003771	Hormone Replacement Therapy and the Risk of Breast Cancer Recurrence in Women With Previous Early Stage Breast Cancer	Estradiol Norethisterone	supportive_care	3	completed
NCT00956813	Flaxseed in Treating Postmenopausal Women With Hot Flashes Who Have a History of Breast Cancer or Other Cancer or Who Do Not Wish to Take Estrogen Therapy	No drug interventions	supportive_care	3	completed
NCT05586724	Micronized Progesterone Versus Norethisterone Acetate in Combination With Estrogen as Menopausal Hormone Therapy	No drug interventions	treatment	3	recruiting
NCT00764322	Studying Blood Samples From Women With Breast Cancer or Ductal Carcinoma In Situ Who Are Receiving Tamoxifen	No drug interventions	treatment	2	completed
NCT00079248	Hormone Replacement Therapy in Relieving Menopausal Symptoms in Postmenopausal Women With Previous Stage I or Stage II Breast Cancer	Conjugated estrogens Progesterone	supportive_care	Not Available	unknown_status
NCT04090957	Estetrol for the Treatment of Moderate to Severe Vasomotor Symptoms in Postmenopausal Women	No drug interventions	treatment	3	completed
NCT05977426	The Effects of Reiki on Menopausal Symptoms and Depression Levels	No drug interventions	supportive_care	Not Available	completed
NCT00068601	S0230 Goserelin in Preventing Ovarian Failure in Women Receiving Chemotherapy for Breast Cancer	Cyclophosphamide Goserelin	supportive_care	3	completed