Oral Contraceptives (DBCOND0046978)

Identifiers

Synonyms

Contraceptive, Oral, Hormonal / Oral Contraceptive Use / Oral Contraceptive / Oral Contraception / Contraceptives, Oral, Hormonal / OC / The pill / Birth control pill / Uses oral contraception (finding) / Contraceptives, Oral

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Chlormadinone	A progestin indicated in combination with an estrogen for oral combined hormonal contraceptive therapy.	Cytochrome P450 3A4enzyme
Dienogest	An oral progestin used for the treatment of endometriosis as monotherapy or contraception in combination with ethinylestradiol.	Cytochrome P450 3A4enzyme Progesterone receptortarget Androgen receptortarget
Estetrol	An estrogen used in combination with drospirenone for oral contraception.	Albumincarrier Cytochrome P450 3A4enzyme UDP-glucuronosyltransferase 2B7enzyme Estrogen receptortarget Estrogen receptor betatarget Alpha-1-acid glycoprotein 1carrier
Estradiol valerate	An estradiol prodrug used to treat some effects of menopause, hypoestrogenism, androgen dependant carcinoma of the prostate, and in combination products for endometriosis and contraception.	Estrogen receptortarget Nuclear receptor subfamily 1 group I member 2target Sex hormone-binding globulincarrier Estrogen receptor betatarget Cytochrome P450 1A2enzyme UDP-glucuronosyltransferase 1A1enzyme Albumincarrier Fatty acid-binding protein, intestinalcarrier Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter Solute carrier family 22 member 3transporter Solute carrier organic anion transporter family member 2B1transporter Solute carrier organic anion transporter family member 1A2transporter ATP-binding cassette sub-family C member 10transporter Solute carrier family 22 member 11transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter ATP-dependent translocase ABCB1transporter Cytochrome P450 1A1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Organic anion transporter 3transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier organic anion transporter family member 1C1transporter Solute carrier organic anion transporter family member 4A1transporter Neuronal acetylcholine receptor subunit alpha-4target Nuclear receptor coactivator 2target G-protein coupled estrogen receptor 1target ATP synthase subunit atarget Beclin-1target 17-beta-hydroxysteroid dehydrogenase type 2target Estrogen-related receptor gammatarget
Ethynodiol diacetate	An oral contraceptive used to prevent pregnancy.	Estrogen receptortarget Progesterone receptortarget Cytochrome P450 3A4enzyme
Ferrous fumarate	A medication used to treat iron-deficiency anemia.	Transferrin receptor protein 1target Egl nine homolog 1target Histone deacetylase 8target Alpha-hemoglobin-stabilizing proteintarget Hemoglobin subunit alphatarget Frataxin, mitochondrialtarget Ferritin heavy chaintarget Flap endonuclease 1target Endonuclease 8-like 1target Endonuclease 8-like 2target DNA polymerase betatarget Ceruloplasmintarget Serotransferrintarget
Gestodene	Gestodene is a progestogen hormonal contraceptive. Products containing gestoden include Meliane, which contains 20 mcg of ethinylestradiol and 75 mcg of gestodene; and Gynera, which contains 30 mcg of ethinylestradiol...	Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Progesterone receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 2C19enzyme
Lynestrenol	A progestin used for contraception and in the treatment of menstrual disorders.	Cytochrome P450 3A4enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme
Mestranol	A synthetic estradiol found in oral contraceptive pills for contraception and the treatment of other conditions in the female reproductive system, such as dysmenorrhea and dysfunctional uterine bleeding.	Estrogen receptortarget Cytochrome P450 2C9enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme
Nomegestrol acetate	Nomegestrol acetate, also known as NOMAC, is a progestin used in oral contraceptives, menopausal hormone therapy, and for the treatment of gynecological disorders.	Cytochrome P450 3A4enzyme Estrogen receptortarget
Norethisterone	A synthetic second-generation progestin used for contraception, prevention of endometrial hyperplasia in hormone replacement therapy, and in the treatment of other hormone-mediated illnesses such as endometriosis.	Progesterone receptortarget ATP-dependent translocase ABCB1transporter Cytochrome P450 2C19enzyme Albumincarrier Sex hormone-binding globulincarrier Aldo-keto reductase family 1 member C4enzyme 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme 3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme Aldo-keto reductase family 1 member D1enzyme Cytochrome P450 3A4enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2A6enzyme Glucocorticoid receptortarget Androgen receptortarget
Norgestimate	A progesterone used as a contraceptive and to treat acne vulgaris.	Progesterone receptortarget Estrogen receptortarget ATP-binding cassette sub-family C member 2transporter Cytochrome P450 3A4enzyme Androgen receptortarget Cytochrome P450 2B6enzyme Cytochrome P450 2C9enzyme UDP-glucuronosyltransferase 1A1enzyme Albumincarrier Sex hormone-binding globulincarrier ATP-dependent translocase ABCB1transporter
Norgestrel	A progestin used in combination with ethinyl estradiol for oral contraception and prevention of pregnancy in women.	Progesterone receptortarget 3-oxo-5-alpha-steroid 4-dehydrogenase 1target Androgen receptortarget Cytochrome P450 3A4enzyme Aromataseenzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00653614	Cycle Control and Safety of E2-DRSP	No drug interventions	prevention	2	completed
NCT05802277	Characterization of the Mechanical Properties of the Hamstring Muscle Group in Female.	No drug interventions	basic_science	Not Available	recruiting
NCT04564300	The Influence of Oral Contraceptive Use on Muscle Recovery	No drug interventions	basic_science	Not Available	completed
NCT02398903	Evaluation of Hormonal Contraceptive Treatments in Obese Women	No drug interventions	Not Available	Not Available	unknown_status
NCT02021097	Study Evaluating Levonorgestrel and Ethinyl Estradiol for Oral Contraception	Ethinylestradiol Levonorgestrel	treatment	3	unknown_status
NCT00248963	Study Evaluating Levonorgestrel and Ethinyl Estradiol in Oral Contraception	No drug interventions	educational_counseling_training	3	completed
NCT00739622	TMC278-TiDP6-C136: Effect of TMC278 on Ethinylestradiol and Norethindrone in Healthy Women.	No drug interventions	treatment	1	completed
NCT00471991	Valette (Combined Oral Contraceptive SH T04769G and SH D00659AF) Low Ovulation Inhibition	No drug interventions	treatment	2	completed
NCT01318005	Oral Contraceptive (OC) Estrogen Dose and Breast Proliferation	No drug interventions	basic_science	Not Available	unknown_status
NCT00778609	Effect of a New Oral Contraceptive Pill on Hormone Related Symptoms Such as Pelvic Pain and Headache	No drug interventions	prevention	3	completed
NCT06426459	Social Media Usage in Adolescent Girls	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT01252186	A Multicenter Study to Evaluate the Effects of a 91-Day Extended Cycle Oral Contraceptive on Hemostatic Parameters in Healthy Women	No drug interventions	basic_science	2	completed
NCT00972439	Oral Contraceptive (OC) Progestin Dose and Breast Proliferation	No drug interventions	basic_science	Not Available	completed
NCT00302666	Bleeding Pattern Study	No drug interventions	prevention	3	completed
NCT01076582	Comparative Trial in Hormone Withdrawal Associated Symptoms	No drug interventions	treatment	3	completed
NCT01388491	A Multinational Study to Evaluate the Effects of a 28-Day Oral Contraceptive on Hemostatic Parameters in Healthy Women	No drug interventions	basic_science	2	completed
NCT01291004	A Study to Evaluate Ovarian Follicular Activity and Hormone Levels for DR-102 Compared to Two 28-Day Oral Contraceptives	No drug interventions	basic_science	1	completed
NCT00567164	Efficacy and Safety of Two Flexible Extended Regimens of BAY86-5300 (SH T00186D) in Comparison With the Conventional Regimen of YAZ	No drug interventions	prevention	3	completed
NCT05683119	The Effect of Menstrual Cycle and Oral Contraceptive Pill Phase on Aspects of Exercise Physiology	No drug interventions	screening	Not Available	recruiting
NCT01200186	Non-interventional Study on Oral Contraception Not Containing Ethinylestradiol (EE) to Assess Continuation Rates and Satisfaction	No drug interventions	Not Available	Not Available	completed
NCT01110525	A Drug-drug Interaction Study to Investigate the Effects of AZD1981 on the Metabolism and Pharmacodynamics of Oral Contraceptives	No drug interventions	basic_science	1	completed
NCT06124274	Oral Contraceptive vs Menstrual Cycle Ex Vivo Model	No drug interventions	other	Not Available	recruiting
NCT00677703	Txt Now 2 Decrease Pregnancies L8r: A Study to Evaluate the Effect of Daily Text Message Reminders on Pill Continuation	No drug interventions	Not Available	Not Available	completed
NCT02785809	Ovarian Function and Reserve Parameters After Discontinuation of Long-term Use of Oral Contraception	No drug interventions	Not Available	Not Available	unknown_status
NCT00480532	A Study of Continuous Oral Contraceptives and Doxycycline	No drug interventions	treatment	Not Available	completed
NCT00673686	Study to Investigate the Effect of Missed Pills on Follicular Development in Two Application Regimens of SH T 00186 D	No drug interventions	treatment	2	completed
NCT06275048	The Influence of Oral Contraceptives During Disuse	No drug interventions	basic_science	Not Available	recruiting
NCT00709644	Bioequivalence Study of the Oral Contraceptive (OC) Tablet Containing Norgestimate (NGM)/Ethinyl Estradiol (EE) With or Without Folic Acid in Healthy Women.	No drug interventions	prevention	1	completed
NCT00468481	Efficacy and Safety Study for an Oral Contraceptive Containing Folate	No drug interventions	prevention	3	completed
NCT04901377	A Study to Gather Information About User Satisfaction in Women in Russia Who Take Estradiol Valerate/Dienogest	No drug interventions	Not Available	Not Available	completed
NCT00677742	The Impact of Pack Supply on Birth Control Pill Continuation	No drug interventions	prevention	Not Available	completed