Immunomodulatory Agents

Name
Immunomodulatory Agents
Accession Number
DBCAT003615
Description

Not Available

Drugs
DrugDrug Description
Interferon beta-1aA form of recombinant human interferon used to slow disease progression and reduce the frequency of clinical symptoms in patients who have relapsing multiple sclerosis.
NatalizumabA monoclonal anti-integrin antibody which binds to the alpha 4 subunit of integrins to prevent migration of immune cells, and is used to treat Crohn's disease or multiple sclerosis.
DaclizumabA monoclonal anti-CD25 antibody that blocks the interleukin-2 receptor which is used to treat relapsing forms of multiple sclerosis.
ThalidomideA medication used to treat cancers, particularly newly diagnosed multiple myeloma, and erythema nodosum leprosum.
GlatiramerAn immunomodulator used to reduce the frequency of relapses in Multiple Sclerosis (MS).
TeriflunomideA pyrimidine synthesis inhibitor with anti-inflammatory and immunomodulatory properties used to treat patients with the relapsing-remitting form of multiple sclerosis.
OcrelizumabA CD20 specific monoclonal antibody used to treat relapsing remitting multiple sclerosis.
UstekinumabA targeted antibody therapy used to manage inflammatory conditions such as plaque psoriasis, psoriatic arthritis, Crohn's Disease, and ulcerative colitis.
FingolimodA sphingosine 1-phosphate receptor modulator used to treat patients with the relapsing-remitting form of multiple sclerosis (MS) and studied to manage lung complications of COVID-19.
SiponimodA medication used to treat relapsing multiple sclerosis.
OzanimodA sphingosine 1-phosphate receptor modulator being studied to treat Multiple Sclerosis (MS) and inflammatory bowel disease (IBD).
Dimethyl fumarateA medication used to treat patients with the relapsing-remitting form of multiple sclerosis.
PonesimodA sphingosine 1-phosphate receptor modulator indicated to treat relapsing multiple sclerosis.
DarvadstrocelA mesenchymal stem cell advanced therapy used to treat complex perianal fistulas in adults with non-active or mildly active luminal Crohn’s disease after an inadequate response to at least one standard treatments.
Drugs & Drug Targets
DrugTargetType
Interferon beta-1aInterferon alpha/beta receptor 1target
Interferon beta-1aInterferon alpha/beta receptor 2target
Interferon beta-1aCytochrome P450 1A2enzyme
NatalizumabIntegrin alpha-4target
NatalizumabLow affinity immunoglobulin gamma Fc region receptor III-Btarget
NatalizumabHigh affinity immunoglobulin gamma Fc receptor Itarget
NatalizumabIntercellular adhesion molecule 1target
DaclizumabInterleukin-2 receptor subunit alphatarget
DaclizumabLow affinity immunoglobulin gamma Fc region receptor III-Btarget
DaclizumabComplement C1r subcomponenttarget
DaclizumabComplement C1q subcomponent subunit Atarget
DaclizumabComplement C1q subcomponent subunit Btarget
DaclizumabComplement C1q subcomponent subunit Ctarget
DaclizumabLow affinity immunoglobulin gamma Fc region receptor III-Atarget
DaclizumabHigh affinity immunoglobulin gamma Fc receptor Itarget
DaclizumabLow affinity immunoglobulin gamma Fc region receptor II-atarget
DaclizumabInterleukin-2 receptor subunit betatarget
DaclizumabLow affinity immunoglobulin gamma Fc region receptor II-btarget
DaclizumabLow affinity immunoglobulin gamma Fc region receptor II-ctarget
ThalidomideCytochrome P450 2C19enzyme
ThalidomideCytochrome P450 2C9enzyme
ThalidomideProstaglandin G/H synthase 1enzyme
ThalidomideProstaglandin G/H synthase 2enzyme
ThalidomideCytochrome P450 3A5enzyme
ThalidomideDNAtarget
ThalidomideProtein cereblontarget
Thalidomidealpha1-acid glycoproteintarget
ThalidomideCytochrome P450 3A4enzyme
ThalidomideCytochrome P450 1A1enzyme
ThalidomideCytochrome P450 2B6enzyme
GlatiramerHLA class II histocompatibility antigen, DRB1-1 beta chaintarget
GlatiramerHLA class II histocompatibility antigen, DRB1-15 beta chaintarget
GlatiramerHLA class II histocompatibility antigen, DRB1-4 beta chaintarget
TeriflunomideATP-binding cassette sub-family G member 2transporter
TeriflunomideDihydroorotate dehydrogenase (quinone), mitochondrialtarget
TeriflunomideCytochrome P450 2C8enzyme
TeriflunomideSolute carrier organic anion transporter family member 1B1transporter
TeriflunomideCytochrome P450 1A2enzyme
OcrelizumabB-lymphocyte antigen CD20target
UstekinumabInterleukin-12 subunit betatarget
UstekinumabInterleukin-23target
FingolimodSphingosine 1-phosphate receptor 5target
FingolimodSphingosine kinase 1enzyme
FingolimodCytochrome P450 2E1enzyme
FingolimodLeukotriene-B(4) omega-hydroxylase 1enzyme
FingolimodHistone deacetylase 1target
FingolimodExcitatory amino acid transporter 2transporter
FingolimodExcitatory amino acid transporter 1transporter
FingolimodP-glycoprotein 1transporter
FingolimodMultidrug resistance-associated protein 1transporter
FingolimodSphingosine 1-phosphate receptor 1target
FingolimodSphingosine 1-phosphate receptor 4target
FingolimodSphingosine 1-phosphate receptor 3target
SiponimodSphingosine 1-phosphate receptor 5target
SiponimodSphingosine 1-phosphate receptor 1target
SiponimodCytochrome P450 3A4enzyme
SiponimodCytochrome P450 2C9enzyme
OzanimodSphingosine 1-phosphate receptor 1target
OzanimodSphingosine 1-phosphate receptor 5target
OzanimodAmine oxidase [flavin-containing] Btransporter
OzanimodATP-binding cassette sub-family G member 2transporter
OzanimodP-glycoprotein 1transporter
OzanimodFatty aldehyde dehydrogenaseenzyme
OzanimodAlcohol dehydrogenase class-3enzyme
OzanimodArylamine N-acetyltransferase 2enzyme
OzanimodCytochrome P450 2C8enzyme
OzanimodAmine oxidase [flavin-containing] Benzyme
OzanimodAldo-keto reductase family 1 member C1enzyme
OzanimodAldo-keto reductase family 1 member C2enzyme
OzanimodCytochrome P450 3A4enzyme
Dimethyl fumarateKelch-like ECH-associated protein 1target
Dimethyl fumarateTranscription factor p65target
PonesimodSphingosine 1-phosphate receptor 1target
PonesimodCytochrome P450 2J2enzyme
PonesimodCytochrome P450 3A4enzyme
PonesimodCytochrome P450 3A5enzyme
PonesimodCytochrome P450 4F3enzyme
PonesimodCytochrome P450 4F12enzyme
PonesimodUDP-glucuronosyltransferase 1-1enzyme
PonesimodUDP-glucuronosyltransferase 2B7enzyme