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Displaying results 91 - 100 of 220 in total
  1. Pathway

    Lidocaine (Local Anaesthetic) Metabolism Pathway

    smpdb.ca/view/SMP0000620
    Drug metabolism

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Lidocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Lidocaine diffuses across the neuronal plasma membrane in its uncharged base form.

    Drugs: NADH · Lidocaine · Mesoheme · Formaldehyde
    Enzymes: Sodium channel subunit beta-1, Sodium channel protein type 10 subunit alpha
  2. Pathway

    Alvimopan Action Pathway

    smpdb.ca/view/SMP0000685
    Drug action

    Alvimopan is prescribed to treat patient opioid-induced constipation, a common side effect of opioid therapy. This side effect results in delayed discharge for hospitalized patients following surgery. Alvimopan helps to increase gastroin...

    Drugs: ATP · Norepinephrine · Dopamine · Potassium cation · Calcium · Alvimopan
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  3. Pathway

    Morphine Action Pathway

    smpdb.ca/view/SMP0000406
    Drug action

    G(i) also activates potassium channels and inactivates calcium channels causing the neuron to hyperpolarize. … The end result is decreased nerve conduction and reduced neurotransmitter release, which blocks the perception of pain signals.

    Drugs: ATP · Morphine · Norepinephrine · Dopamine · Potassium cation · Calcium +1 more
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  4. Pathway

    Methamphetamine Dopamine Reuptake Inhibitor Action Pathway

    smpdb.ca/view/SMP0125231
    Drug action

    Methamphetamine activates trace amine receptor 1 which internalizes sodium dependent dopamine transporters as well as reversing of the transporter. … Methamphetamine enters the neuron through sodium-dependent dopamine transporters where it also is a negative modulator for the transporter, preventing dopamine from re-entering the neuron.

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin +9 more
    Enzymes: Sodium-dependent dopamine transporter, Sodium-dependent serotonin transporter
  5. Pathway

    Lidocaine (Antiarrhythmic) Action Pathway

    smpdb.ca/view/SMP0000328
    Drug action

    Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium … The extra sodium and calcium ions that entered the cell during the action potential are extruded via sodium-potassium ATPases and NCX and intra- and extracellular ion concentrations are restored.

    Drugs: NADH · ATP · Lidocaine · Potassium cation · Calcium · Mesoheme +1 more
    Enzymes: Sodium/calcium exchanger 1, Sodium channel protein type 5 subunit alpha
  6. Indication

    Arrhythmia

    go.drugbank.com/conditions/DBCOND0007740
    Drugs: Dextrose, unspecified form · Dopamine · Lidocaine · Magnesium aspartate
  7. Indication

    End-stage Chronic Kidney Failure

    go.drugbank.com/conditions/DBCOND0085008
    Drugs: Calcium chloride · D-glucose
  8. Indication

    Gingival Bleeding

    go.drugbank.com/conditions/DBCOND0073368
    Drugs: Chlorhexidine · Sodium bicarbonate
  9. Indication

    Upper GI Bleeding

    go.drugbank.com/conditions/DBCOND0054684
    Drugs: Omeprazole · Sodium bicarbonate
  10. Pathway

    Dopamine Action Pathway

    smpdb.ca/view/SMP0125137
    Drug action

    In the synapse, dopamine prevents the re-uptake of norepinephrine by inhibiting Sodium-dependent noradrenaline transporter. … Dopamine enters the sympathetic neuron through a sodium-dependent dopamine transporter.. In the neuron, it is catalyzed by Dopamine beta-hydroxylase to synthesize norepinephrine.

    Drugs: Ascorbic acid · ATP · Norepinephrine · Dopamine · Calcium · Pyrroloquinoline Quinone
    Enzymes: Sodium/calcium exchanger 1, Sodium-dependent dopamine transporter