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Displaying results 41 - 50 of 138749 in total
  1. Pathway

    Fructose and Mannose Degradation

    smpdb.ca/view/SMP0000064
    Metabolic

    Fructose causes less of an insulin response compared to glucose and thus may be a preferred sugar for diabetics. … Fructose and mannose are monosaccharides that can be found in many foods. Fructose can join with glucose to form sucrose. Mannose can be converted to glucose. Both may be used as food sweeteners.

    Drugs: NADH · ATP · Magnesium cation · Zinc · Sorbitol · D-glyceraldehyde 3-phosphate +5 more
  2. Pathway

    Androgen and Estrogen Metabolism

    smpdb.ca/view/SMP0000068
    Metabolic

    This pathway describes the inactivation and catabolism of male (androgen) and female (estrogen) hormones. … Many steroid hormones are transformed by sulfatases, dehydrogenases and glucuronide transferases to enhance their solubility and to facilitate their elimination.

    Drugs: NADH · Testosterone · Estrone · Estradiol · Calcium · Androstenedione +6 more
  3. Pathway

    NAD+ Signalling and Aging

    smpdb.ca/view/SMP0084271
    Signaling

    An interesting link has emerged between NAD+ metabolism, SIRT1, SIRT3, and mitochondrial function. … NR and PARP inhibitors increased life span in worms via activation of the mitochondrial unfolded protein response UPRmt by sir2.1.

    Drugs: 5-O-phosphono-alpha-D-ribofuranosyl diphosphate · Nicotinamide · Flavin adenine dinucleotide
  4. Pathway

    Glycine and Serine Metabolism

    smpdb.ca/view/SMP0000004
    Metabolic

    Cystathionine beta-lyase then converts this double amino acid to cysteine, ammonia, and alpha-ketoglutarate. Glycine is biosynthesized in the body from the amino acid serine. … This pathway describes the synthesis and breakdown of several small amino acids, including glycine, serine, and cysteine.

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 more
  5. Pathway

    Taurine and Hypotaurine Metabolism

    smpdb.ca/view/SMP0000021
    Metabolic

    This includes acids such as chenodeoxycholic acid and cholic acid, and in turn the formation of bile salts occurs. … Moreover, this entire process can be catalyzed via bile acid and a special amino acid N-acetyltransferase.

    Drugs: Pyridoxal phosphate · Cysteine · Cysteamine · Iron · Taurine
    Enzymes: Cysteine sulfinic acid decarboxylase
  6. Pathway

    Pantothenate and CoA Biosynthesis

    smpdb.ca/view/SMP0000027
    Metabolic

    Most of pantothenic acid is found in food as phosphopentetheine or coenzyme A. Pantothenic acid, pantetheine 4’-phosphate and pantetheine are all found in red blood cells. … It is a precursor of coenzyme A, which is an essential part of many reactions in the body, specifically important in the production of compounds like cholesterol and different fatty acids.

    Drugs: Adenosine phosphate · Cysteine · ATP · Cysteamine · Calcium · Pantothenic acid +3 more
  7. Pathway

    Starch and Sucrose Metabolism

    smpdb.ca/view/SMP0000058
    Metabolic

    The action of enterocytes of the small intestine microvilli further break down limit dextrins and disaccharides into monosaccharides: glucose, galactose, and fructose. … Amylase enzymes secreted in saliva by the parotid gland and in the small intestine play an important role in initiating starch digestion.

    Drugs: Pyridoxal phosphate · NADH · ATP · Calcium · Magnesium cation · Uridine diphosphate glucose +4 more
  8. Pathway

    Spermidine and Spermine Biosynthesis

    smpdb.ca/view/SMP0000445
    Metabolic

    Spermidine and spermine are produced in many tissues, as they are involved in the regulation of genetic processes from DNA synthesis to cell migration, proliferation, differentiation and apoptosis. … The Spermidine and Spermine Biosynthesis pathway highlights the creation of these cruicial polyamines.

    Drugs: Pyridoxal phosphate · Ademetionine · Spermine · Ornithine · Methionine · ATP +6 more
  9. Pathway

    Ethacrynic Acid Action Pathway

    smpdb.ca/view/SMP0000097
    Drug action

    Etacrynic acid (also known as ethacrynic acid and Edecrin) is a loop diuretic that can inhibit water reabsorption by binding and inhibiting solute carrier family 12 member 1 (also known as sodium-potassium-chloride … Binding of the transporter can prevent import of sodium from lumen from loop of Henle to basolateral interstitium, which lead to more hypertonic environment in lumen than interstitium, and result in prevention

    Drugs: Cysteine · Etacrynic acid · Potassium cation · Urea
    Enzymes: Neutral and basic amino acid transport protein rBAT, Sodium- and chloride-dependent transporter XTRP3
  10. Pathway

    Mefenamic Acid Action Pathway

    smpdb.ca/view/SMP0000109
    Drug action

    Mefenamic acid can block prostaglandin synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2. … Prostaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway.

    Drugs: Glutamic acid · Glutathione · Mefenamic acid · Dinoprostone · Calcium · Magnesium cation +5 more