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Chlorphenamine H1-Antihistamine Action
smpdb.ca/view/SMP0056661Drug actionChlorphenamine (chlorpheniramine) is a first-generation alkylamine H1-antihistamine. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to t...
Metabolism and Physiological Effects of Phenyl sulfate
smpdb.ca/view/SMP0123213MetabolicPhenyl sulphate is a phenolic compound that is formed through gut microbial metabolism from dietary tyrosine and a sulfation reaction in liver hepatic cells. After being transported into gut microbes, tyrosine undergoes a reaction with t...
Carbimazole Action Pathway
smpdb.ca/view/SMP0124888Drug actionCarbimazole an imidazole antithyroid agent used for the treatment of hyperthyroidism and thyrotoxicosis. It is also used to prepare patients for thyroidectomy. Carbimazole is a prodrug, which is converted to methimazole in the gastrointe...
Lorazepam Action Pathway
smpdb.ca/view/SMP0125053Drug actionSome off-label indications of lorazepam include rapid tranquilization of an agitated patient, alcohol withdrawal delirium, alcohol withdrawal syndrome, muscle spasms, insomnia, panic disorder, delirium
Dextromethorphan metabolism
smpdb.ca/view/SMP0125172MetabolicDextromethorphan is an antitussive drug used as a cough suppressant in most over-the-counter cough medication such as cough syrup or drugs such as dayquil. Dextromethorphan is taken orally and digested then from the intestine it is trans...
Immunometabolism Pathway (Viral Activation)
smpdb.ca/view/SMP0125488DiseaseThe normal response to a virus infection involves viral coat proteins activating the Toll-like receptors TLR4 and TLR2 on the membranes of macrophages, T-cells and dendritic cells. In addition to this protein activation, the viral DNA (o...
Bacterial Sepsis
smpdb.ca/view/SMP0125493DiseaseBacterial sepsis begins when bacteria activate the Toll-like receptor TLR4 on the membranes of macrophages, T-cells and dendritic cells. TLR4 activates the production of interferon regulatory factor 3 (IRF3), TIR-domain-containing adapte...
Aromatic L-Aminoacid Decarboxylase Deficiency
smpdb.ca/view/SMP0125610DiseaseAromatic L-Aminoacid Decarboxylase Deficiency (DOPA decarboxylase; DDC) is an autosomal recessive disease caused by a mutation in the DDC gene which codes for aromatic-L-aminoacid decarboxylase. A deficiency in this enzyme results in acc...
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Tyrosine · Norepinephrine · Epinephrine +4 moreLeigh Syndrome
smpdb.ca/view/SMP0125770DiseaseLeigh Syndrome, also called Leigh Disease or infantile subacute necrotizing encephalopathy, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder that is caused by a mutation of any one of 75 different genes. Disrup...
Primary Hyperoxaluria II, PH2
smpdb.ca/view/SMP0125773DiseasePrimary hyperolaria type 2 (PH2) is a rare condition resulting from glyoxylate reductase/hydroxypyruvate reductase (GR/HPR) enzyme deficiency. PH2 results in calcium oxalate (also known as oxalic acid) deposits and end-stage renal diseas...