Dihydropteroate synthase

BE0000803ProteinEscherichia coli (strain K12)folP

Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives. It is acted on by 35 drugs in DrugBank.

Gene name
folP
UniProtKB entry
P0AC13Swiss-Prot
Residues / weight
282 residues · 30,615 Da
Also known as
2.5.1.15 · dhpS · Dihydropteroate pyrophosphorylase

Resolves to

Protein
UniProtP0AC13UniProt nameDHPS_ECOLI
Gene
NCBI Gene947691GenBank41273
Pharmacology
KEGGecj:JW3144
Structure
PDB1AJ0PDB1AJ2PDB1AJZ
Drugs

What you can answer from here — as of September 07, 2019

35DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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90+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dihydropteroate synthase, how selective are they, and which programs against it are still in active trials?

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