Porphyrins

Name
Porphyrins
Accession Number
DBCAT001084
Description

A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin.

Drugs
DrugDrug Description
Porfimer sodiumA hematoporphyrin derivative used to treat esophageal cancer, endobronchial cancer, and high grade dysplasia in Barrett's Esophagus.
Bacteriochlorophyll AA specific bacteriochlorophyll that is similar in structure to CHLOROPHYLL A.
N-MethylmesoporphyrinN-methylmesoporphyrin is a solid. This compound belongs to the porphyrins. These are compounds containing a fundamental skeleton of four pyrrole nuclei united through the alpha-positions by four methine groups to...
Chlorophyll ANot Available
ProtoporphyrinNot Available
Hydrogenobyrinic acidNot Available
MesohemeThe color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.
SirohemeNot Available
Ferroheme CNot Available
HeminAn iron-containing porphyrin injection used for the relief of recurrent attacks of acute intermittent porphyria (AIP) associated with the menstrual cycle when carbohydrate therapy is not effective.
DiacetyldeuterohemeNot Available
Heme DNot Available
Coproporphyrin INot Available
Coproporphyrinogen IIINot Available
Chlorophyll BA light, silvery, metallic element. It has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. Its salts are essential in nutrition, being required for the activity of...
VerdohemeNot Available
StannsoporfinInvestigated for use/treatment in liver disease, metabolic disease, and pediatric indications.
Motexafin lutetiumInvestigated for use/treatment in brain cancer, breast cancer, cervical dysplasia/cancer, prostate cancer, cancer/tumors (unspecified), coronary artery disease, macular degeneration, and peripheral vascular disease.
Motexafin gadoliniumInvestigated for use/treatment in brain cancer, cancer/tumors (unspecified), lung cancer, and lymphoma (non-hodgkin's).
AEOL-10150Investigated for use/treatment in amyotrophic lateral sclerosis (ALS).
TemoporfinA photosensitizer used to treat squamous cell carcinomas of the head and neck.
HematinNot Annotated
2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide-a2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide-a is under investigation in clinical trial NCT01668823 (Photodynamic Therapy in Treating Patients With Lung Cancer).
Dihematoporphyrin etherDihematoporphyrin ether is under investigation in clinical trial NCT00118222 (High Light and Low Light Dose PDT in Glioma).
VerteporfinA benzoporphyrin derivative used to treat pathological myopia, ocular histoplasmosis, and choroidal neovascularization in macular degeneration.
PadeliporfinNot Annotated
Zinc protoporphyrinNot Available
HemoporfinA porphyrin derivative combined with vitamin B12 for the treatment of asthenia.
Tin protoporphyrin IXNot Available
Sodium copper chlorophyllinSodium copper chlorophyllin (SCC) is a water-soluble and bright green mixture derived from natural chlorophyll that has potential antimutagenic and antioxidant properties . This compound is used as a food...
Drugs & Drug Targets
DrugTargetType
Porfimer sodiumLow-density lipoprotein receptortarget
Porfimer sodiumHigh affinity immunoglobulin gamma Fc receptor Itarget
Bacteriochlorophyll ABacteriochlorophyll a proteintarget
Bacteriochlorophyll ABacteriochlorophyll a proteintarget
N-MethylmesoporphyrinFerrochelatasetarget
Chlorophyll ABeta-lactamase 2target
ProtoporphyrinFerritin light chaintarget
Hydrogenobyrinic acidPrecorrin-8X methylmutasetarget
SirohemeSulfite reductase [NADPH] hemoprotein beta-componenttarget
Ferroheme CNitrite reductasetarget
Ferroheme CHigh-molecular-weight cytochrome ctarget
Ferroheme CCytochrome c''target
Ferroheme CQuinohemoprotein ethanol dehydrogenase type-1target
Ferroheme CNitrite reductasetarget
Ferroheme CCytochrome c4target
Ferroheme CCytochrome ctarget
Ferroheme CCytochrome c-552target
Ferroheme CCytochrome c2target
Ferroheme CCytochrome c-550target
Ferroheme CCytochrome c-552target
Ferroheme CCytochrome c-551target
Ferroheme CCytochrome c3target
Ferroheme CSplit-Soret cytochrome ctarget
Ferroheme CGroup 1 truncated hemoglobin GlbNtarget
Ferroheme CCytochrome c-553target
Ferroheme CCytochrome P450 2C9target
Ferroheme CNine-heme cytochrome ctarget
Ferroheme CCytochrome c3, 13 kDatarget
Ferroheme CCytochrome c551 peroxidasetarget
Ferroheme CCytochrome c3target
Ferroheme CCytochrome c'target
Ferroheme CCytochrome c3target
Heme DNitrite reductasetarget
Heme DNitrite reductasetarget
Coproporphyrin IUroporphyrinogen decarboxylasetarget
Coproporphyrinogen IIIUroporphyrinogen decarboxylasetarget
VerdohemeHeme oxygenase 1target
StannsoporfinHeme oxygenase 1target
StannsoporfinHeme oxygenase 2target
Motexafin gadoliniumThioredoxin reductase 1, cytoplasmictarget
Motexafin gadoliniumThioredoxin reductase 2, mitochondrialtarget
Motexafin gadoliniumRibonucleoside-diphosphate reductase subunit M2target
Zinc protoporphyrinCytochrome ctarget