Myoclonus (DBCOND0017788)

Identifiers

Synonyms

Myoclonia / Myoclonus (finding) / Myoclonic jerks / Drug-induced myoclonus (disorder) / Myoclonus, Palatal / Palatal myoclonus (disorder) / Palatal myoclonus / Clonus / Clonus (finding)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Fluoxetine	A selective serotonin reuptake inhibitor used to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I.	Sodium-dependent serotonin transportertarget Cytochrome P450 2C9enzyme Cytochrome P450 2D6enzyme CYP2B proteinenzyme Cytochrome P450 1A2enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2C19enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2B6enzyme Cytochrome P450 3A5enzyme Albumincarrier Alpha-1-acid glycoprotein 1carrier Voltage-gated inwardly rectifying potassium channel KCNH2target 5-hydroxytryptamine receptor 2Ctarget Cyclin-dependent kinases regulatory subunit 1target Neuronal acetylcholine receptor subunit alpha-2target Neuronal acetylcholine receptor subunit alpha-3target Neuronal acetylcholine receptor subunit beta-4target
Piracetam	A nootropic cyclic GABA derivative used in myoclonus, sickle cell disease, alcohol dependence, and as a general cognitive enhancer.	No drug targets

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00029965	Natural History of Glycosphingolipid Storage Disorders and Glycoprotein Disorders	No drug interventions	Not Available	Not Available	recruiting
NCT06585605	A Retrospective Survey-based Multicenter Study to Delineate the Molecular and Phenotypic Spectrum of Epilepsy-dyskinesia Syndromes	No drug interventions	Not Available	Not Available	recruiting
NCT05317390	Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia	No drug interventions	diagnostic	Not Available	recruiting
NCT04235452	Electrophysiological Characteristics and Anatomical Differentiation of Epileptic and Non-epileptic Myoclonus.	No drug interventions	Not Available	Not Available	completed
NCT00001663	Treatment of Cortical Myoclonus With Repetitive Transcranial Magnetic Stimulation	No drug interventions	treatment	1	completed
NCT00506012	Pilot Efficacy Study of T2000 in Myoclonus Dystonia	T-2000	treatment	2	terminated
NCT00244361	Effectiveness of Rituximab in Pediatric OMS Patients.	Rituximab	treatment	1 / 2	completed
NCT05754762	Median Effective Dose of Remifentanil for the Prevention of Myoclonus Induced by Etomidate Injection	Remifentanil	prevention	Not Available	not_yet_recruiting
NCT02518789	Effects and Mechanism of Pretreatment With Dexmedetomidine to Etomidate Induce Myoclonus	Atracurium Cisatracurium Dexmedetomidine Etomidate Fentanyl Midazolam Propofol Remifentanil Rocuronium Sodium chloride	treatment	4	unknown_status
NCT00001667	Genotype/Phenotype Correlation of Movement Disorders and Other Neurological Diseases	No drug interventions	Not Available	Not Available	completed