Hypoactive Sexual Desire Disorder (HSDD) (DBCOND0035717)

Identifiers

Synonyms

Hypoactive Sexual Desire Disorder(HSDD) / Hypoactive Sexual Desire Disorder / Lack or loss of sexual desire (disorder) / Does not enjoy having sex (finding) / Decreased libido / Sexual desire decreased / Sexual arousal decreased / Sexual feeling decreased / Libido decreased / Reduced libido (finding)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Bremelanotide	Bremelanotide is indicated to treat premenopausal women with hypoactive sexual desire disorder that is not due to a medical or psychiatric condition, problems with the relationship, or the effects of...	Melanocyte-stimulating hormone receptortarget Melanocortin receptor 4target Melanocortin receptor 3target Melanocortin receptor 5target Adrenocorticotropic hormone receptortarget
Flibanserin	A 5-HT receptor modulator used for the treatment of selected premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD).	5-hydroxytryptamine receptor 1Atarget 5-hydroxytryptamine receptor 2Atarget D(4) dopamine receptortarget Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT03080298	Study of the Efficacy and Safety of BP101 in Female Patients With Decrease or Loss of Sexual Desire	No drug interventions	treatment	2	completed
NCT03619005	Prasterone (DHEA) for the Treatment of Hypoactive Sexual Desire Disorder (HSDD) - Second Study	Prasterone	treatment	3	withdrawn
NCT00349791	Study to Assess the Efficacy/Safety of Transdermal Testosterone Patches in Naturally Menopausal Women With Low Libido	Testosterone	treatment	3	completed
NCT03102489	Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of BP101 in Healthy Volunteers	No drug interventions	treatment	1	completed
NCT02070029	Acupuncture for Sexual Dysfunction	No drug interventions	treatment	Not Available	completed
NCT01702818	Stress Hormones, Mood and Women's Sexual Desire (MODEST)	No drug interventions	Not Available	Not Available	completed
NCT02101203	Lybridos in Pre-and Postmenopausal Women With Hypoactive Sexual Desire Disorder	Buspirone Olive oil Testosterone	treatment	2	completed
NCT01803802	Effects of Early Abuse on Adult Intimate Relationships	No drug interventions	treatment	Not Available	completed
NCT00613002	Safety and Efficacy of LibiGel® for the Treatment of Hypoactive Sexual Desire Disorder in Surgically Menopausal Women	Testosterone	treatment	3	completed
NCT03780751	Waitlist Controlled Comparison of Cognitive-behavioral vs. Mindfulness-based Online-treatments for Women With Low Sexual Desire	No drug interventions	treatment	Not Available	completed
NCT02333071	1. Study to Evaluate the Efficacy/Safety of Bremelanotide in Premenopausal Women With Hypoactive Sexual Desire Disorder	Bremelanotide	treatment	3	completed
NCT03463707	BP101 for Adults With Female Sexual Dysfunction	No drug interventions	treatment	3	completed
NCT00551785	Surveillance Study of Women Taking Intrinsa®	No drug interventions	Not Available	Not Available	terminated
NCT00612742	Safety and Efficacy of LibiGel® for Treatment of Hypoactive Sexual Desire Disorder in Postmenopausal Women	Testosterone	treatment	3	completed
NCT00569413	A Combined Psycho-pharmacological and Brain Imaging Study of Human Sexuality	No drug interventions	Not Available	Not Available	suspended
NCT01382719	Bremelanotide in Premenopausal Women With Female Sexual Arousal Disorder and/or Hypoactive Sexual Desire Disorder	Bremelanotide	treatment	2	completed
NCT04336891	Effect of Testosterone Treatment on Clitoral Arteries' Hemodynamic Parameters.	Avobenzone Estradiol Homosalate Octisalate Octocrylene Oxybenzone Testosterone	Not Available	Not Available	completed
NCT01096329	A Pharmacokinetic (PK) Study to Compare the Absorption of Two Formulations of Transdermal Testosterone Spray and Intrinsa®	Testosterone	prevention	1	terminated
NCT03232801	A Mindfulness-based Intervention for Older Women With Low Sexual Desire	No drug interventions	other	Not Available	completed
NCT00657501	Safety and Efficacy of LibiGel® for Treatment of Hypoactive Sexual Desire Disorder in Surgically Menopausal Women	Testosterone	treatment	3	completed
NCT02770768	Effects of Flibanserin on the Pre- and Post-menopausal Female Brain	Flibanserin	basic_science	Not Available	terminated
NCT00331123	Study of Transdermal Testosterone Patches in Surgically Menopausal Women With Low Libido	Testosterone	treatment	3	completed
NCT01208038	Testosterone Patch's Effects on the Cardiovascular System and Libido	Testosterone	supportive_care	4	completed
NCT00034021	Ginkgo Biloba: Antidepressant-Induced Sexual Dysfunction	Ginkgo biloba	treatment	2	completed
NCT02430987	Low Sexual Desire and Metabolic Syndrome	No drug interventions	basic_science	Not Available	completed
NCT01235754	Extension Study to Assess Persistence of Benefit of LibiGel for the Treatment of Hypoactive Sexual Desire Disorder (HSDD)	Testosterone	treatment	3	completed
NCT00140153	Testosterone in Female Hypoactive Sexual Desire Disorder	Testosterone	treatment	3	completed
NCT02419209	The Effect of Individualised Homeopathic Treatment on Low Sexual Desire in Perimenopause	No drug interventions	treatment	2	completed
NCT02859285	A Study Evaluating the Effects of Topical Clitoral Estradiol Cream in Post Menopausal Women	No drug interventions	other	Not Available	completed
NCT03287232	Prasterone (DHEA) for the Treatment of Hypoactive Sexual Desire Disorder (HSDD)	Prasterone	treatment	3	completed
NCT00467259	Endometrial Safety Study of Transdermal Testosterone (300 Mcg/Day) in Naturally Postmenopausal Women	Testosterone	treatment	3	completed
NCT02968342	Role of Progesterone in Hypoactive Sexual Desire Disorder in Menopausal Women	No drug interventions	treatment	4	unknown_status
NCT02714049	Flibanserin (Addyi®) vs. Flibanserin and Sex Therapy	Flibanserin	treatment	4	terminated
NCT06082817	An Open-Label Study of 50 mg Oral Testosterone Undecanoate (Kyztrex) in Menopausal Women With Low Testosterone and HSDD	Testosterone undecanoate	treatment	2	not_yet_recruiting
NCT04179734	Role of the Melanocortin-4 Receptor in Hypoactive Sexual Desire Disorder	Bremelanotide	treatment	4	completed
NCT02593396	Bupropion in Sexual Dysfunction Among Methadone Maintenance Treatment Men	Bupropion	treatment	2	completed
NCT00916396	Dehydroepiandrosterone (DHEA) Treatment in Women and Men Experiencing Hypoactive Sexual Desire Disorder	Prasterone	treatment	Not Available	unknown_status
NCT01743235	Lybridos in Pre- and Postmenopausal Women With Hypoactive Sexual Desire Disorder Due to Maladaptive Activation of Sexual Inhibitory Systems	Buspirone Testosterone	treatment	2	completed
NCT01432665	Lybrido for Female Sexual Dysfunction	Sildenafil Testosterone	treatment	2	completed
NCT04824820	Improving Female Sexual Wellness	No drug interventions	treatment	Not Available	completed
NCT02338960	2. Study to Evaluate the Efficacy/Safety of Bremelanotide in Premenopausal Women With Hypoactive Sexual Desire Disorder	Bremelanotide	treatment	3	completed
NCT00281372	Sexual Dysfunction and Dental Care	No drug interventions	Not Available	Not Available	completed
NCT04943068	A Phase 3, Bridging, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Trial to Evaluate the Efficacy and Safety of Subcutaneously Administered Bremelanotide in Premenopausal Women With Hypoactive Sexual Desire Disorder (With or Without Decreased Arousal)	Bremelanotide	treatment	3	unknown_status
NCT00384046	Testosterone Therapy in Naturally Menopausal Women With Low Sexual Desire Receiving Transdermal Estrogen	Testosterone	treatment	3	completed
NCT00338312	Study of Transdermal Testosterone Patches in Naturally Menopausal Women With Low Libido	Testosterone	treatment	3	completed
NCT00131495	Study of Transdermal Testosterone Patches in Menopausal Women With Low Libido	Testosterone	treatment	3	completed
NCT00331214	Study of Transdermal Testosterone Patches in Surgically Menopausal Women With Low Libido	Testosterone	treatment	3	completed