Friedreich's Ataxia (DBCOND0037758)

Identifiers

Synonyms
Friedreich Ataxia / Friedreich's ataxia / Friedreich ataxia (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Omaveloxolone
A semisynthetic triterpenoid used to treat Friedreich’s ataxia in adults and adolescents 16 years and older.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT02179333
Preliminary Study of the Scale To Assess Ataxia and Neurologic Dysfunction (STAND)No drug interventionsNot AvailableNot Availablecompleted
NCT01303406
Patient Reported Outcomes in Friedreich's Ataxia Patients After Withdrawal From Treatment With Idebenone (PROTI)treatment3completed
NCT02497534
Biomarkers in Friedreich's AtaxiaNo drug interventionsNot AvailableNot Availablerecruiting
NCT01962363
EPI-743 in Friedreich's Ataxia Point Mutationstreatment2completed
NCT01016366
Safety Study of Carbamylated Erythropoietin to Treat Patients With the Neurodegenerative Disorder Friedreich's AtaxiaNo drug interventionstreatment2completed
NCT00697073
Study to Assess the Safety and Tolerability of Idebenone in the Treatment of Friedreich's Ataxia Patientstreatment3completed
NCT02415127
Safety, Tolerability and Efficacy of ACTIMMUNE® Dose Escalation in Friedreich's Ataxiatreatment3completed
NCT00993967
Long-Term Safety and Tolerability of Idebenone in Friedreich's Ataxia Patients (MICONOS Extension)treatment3completed
NCT01921868
An Open-label Study of the Effects of Acetyl-L-Carnitine on Cardiovascular Outcomes in Friedreich's AtaxiatreatmentNot Availableunknown_status
NCT00803868
Pilot Study of Varenicline (Chantix®) in the Treatment of Friedreich's Ataxiatreatment2 / 3terminated
NCT02840669
A Study to Characterize the Cardiac Phenotype of Individuals With Friedreich's Ataxia (CARFA Study)No drug interventionsdiagnosticNot Availablecompleted
NCT02660112
(+) Epicatechin to Treat Friedreich's Ataxiatreatment2completed
NCT00811681
Effect of Pioglitazone Administered to Patients With Friedreich's Ataxia: Proof of Concepttreatment3completed
NCT02316314
Characterization of the Cardiac Phenotype of Friedreich's Ataxia (FRDA)No drug interventionsNot AvailableNot Availablerecruiting
NCT01728064
Safety and Efficacy of EPI-743 in Patients With Friedreich's Ataxiatreatment2completed
NCT00897221
A Study Investigating the Long-term Safety and Efficacy of Deferiprone in Patients With Friedreich's Ataxiatreatment2completed
NCT00631202
Efficacy of Epoetin Alfa in Patients With Friedreich's Ataxiatreatment2completed
NCT01898884
Safety and Pharmacology Study of VP 20629 in Adults With Friedreich's Ataxiatreatment1completed
NCT01035671
Safety and Efficacy Study of A0001 in Subjects With Friedreich's Ataxiatreatment2completed
NCT02069509
Patient Registry of the European Friedreich's Ataxia Consortium for Translational Studies (EFACTS)No drug interventionsNot AvailableNot Availablerecruiting
NCT02593773
Safety, Tolerability and Efficacy of ACTIMMUNE® Dose Escalation in Friedreich's Ataxia Studytreatment3completed
NCT00530127
A Study Investigating the Safety and Tolerability of Deferiprone in Patients With Friedreich's Ataxiatreatment1 / 2completed
NCT02445794
A First in Human Study of RT001 in Patients With Friedreich's AtaxiaNo drug interventionstreatment1 / 2completed
NCT02797080
Long-Term Safety Extension Study of ACTIMMUNE® (Interferon γ-1b) in Children and Young Adults With Friedreich's Ataxiatreatment3completed
NCT00537680
Study to Assess the Efficacy, Safety and Tolerability of Idebenone in the Treatment of Friedreich's Ataxiatreatment3completed
NCT04102501
A Study to Assess Efficacy, Long Term Safety and Tolerability of RT001 in Subjects With Friedreich's AtaxiaNo drug interventionstreatment3completed
NCT00905268
A Study of Efficacy, Safety and Tolerability of Idebenone in the Treatment of Friedreich's Ataxia (FRDA) Patientstreatment3completed
NCT05485987
A Study of Vatiquinone for the Treatment of Participants With Friedreich Ataxiatreatment2active_not_recruiting
NCT06496451
Frataxin mRNA in BiofluidsNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT04268147
Instrumented Data Exchange for Ataxia StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT03761511
Study of the Efficacy and Safety of Nicotinamide in Patients With Friedreich Ataxiatreatment2withdrawn
NCT06054893
A Study of Omaveloxolone in Children With Friedreich's Ataxiatreatment1recruiting
NCT03214588
Efficacy, Tolerability, and Pharmacokinetics of Multiple Doses of Oral TAK-831 in Adults With Friedreich Ataxiatreatment2completed
NCT05874388
Characterisation of the Cognitive Profile of Patients Suffering From Friedreich's AtaxiaNo drug interventionshealth_services_researchNot Availablenot_yet_recruiting
NCT00229632
Idebenone to Treat Friedreich's Ataxiatreatment2completed
NCT04577352
A Study to Assess the Efficacy and Safety of Vatiquinone for the Treatment of Participants With Friedreich Ataxiatreatment2 / 3completed
NCT05515536
A Study to Assess the Safety and Efficacy of Vatiquinone in Participants With Friedreich Ataxiatreatment3enrolling_by_invitation
NCT03120013
Rehabilitative Trial With Cerebello-Spinal tDCS in Neurodegenerative AtaxiaNo drug interventionstreatmentNot Availablecompleted
NCT02594917
Genetic and Environmental Determinants That Control Metabolism in Pulmonary HypertensionNo drug interventionsNot AvailableNot Availablecompleted
NCT02424435
Methylprednisolone Treatment of Friedreich Ataxiatreatment0completed
NCT00056186
Transitional Life Events in Patients With Friedreich's Ataxia: Implications for Genetic CounselingNo drug interventionsNot AvailableNot Availablecompleted
NCT04649866
Coronary Artery Disease in Patients With Friedreich's AtaxiaNo drug interventionsdiagnosticNot Availablecompleted
NCT04273165
Safety and Efficacy of Etravirine in Friedreich Ataxia Patientstreatment2completed
NCT02035020
A Phase IIa Trial to Test Safety and Efficacy Interferon Gamma Treatment in Elevating Frataxin Levels in FRDA PatientsNo drug interventionstreatment2completed
NCT04176991
Single Ascending Dose Study of CTI-1601 Versus Placebo in Subjects With Friedreich's Ataxiatreatment1completed
NCT05285540
Study to Evaluate DT-216 in Adult Patients With Friedreich AtaxiaNo drug interventionstreatment1completed
NCT04519567
Multiple Ascending Dose Study of CTI-1601 Versus Placebo in Subjects With Friedreich's Ataxiatreatment1completed
NCT06016946
Friedreich Ataxia Global Clinical Consortium UNIFIED Natural History StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT00078481
Phase 1 Trial of Idebenone to Treat Patients With Friedreich's Ataxiatreatment1completed
NCT05445323
Gene Therapy for Cardiomyopathy Associated With Friedreich's AtaxiaNo drug interventionstreatment1 / 2recruiting
NCT00015808
Safety Study of Idebenone to Treat Friedreich's Ataxiatreatment1completed
NCT04801303
Evaluation of the Effects of Calcitriol's in the Neurological Symptoms of Friedreich's Ataxia Patientstreatment4completed
NCT05028764
Determine Range of Tissue Frataxin Concentrations and Other Potential BiomarkersNo drug interventionsNot AvailableNot Availablecompleted
NCT01776164
Early and Longitudinal Assessment of Neurodegeneration in the Brain and Spinal Cord in Friedreich's AtaxiaNo drug interventionsNot AvailableNot Availablecompleted
NCT03888664
Open Trail of γIFN for Friedreich AtaxiaNo drug interventionstreatment2completed
NCT01716221
An Objective Double-blind Evaluation of Bupropion and Citalopram in an Individual With Friedreich Ataxiasupportive_care4completed
NCT06483802
A Study of ASP2016 in Adults Who Have Heart Disease Associated With Friedreich Ataxiatreatment1not_yet_recruiting
NCT05943002
Patient-reported, Health Economic and Psychosocial Outcomes in Friedreich AtaxiaNo drug interventionsNot AvailableNot Availablerecruiting
NCT01339884
A Study of Resveratrol as Treatment for Friedreich Ataxiatreatment1 / 2completed
NCT02705547
Rosuvastatin (Crestor) in Friedreich Ataxiatreatment0completed
NCT05573698
Study to Evaluate Multiple Ascending Dose and Multi-Dose of DT-216 in Adult Patients With Friedreich AtaxiaNo drug interventionstreatment1completed
NCT06539598
Respiratory Training in Friedreich's AtaxiaNo drug interventionsotherNot Availablenot_yet_recruiting
NCT04817111
NAD+ Precursor Supplementation in Friedreich's AtaxiaNo drug interventionsother2completed
NCT05302271
Phase IA Study of AAVrh.10hFXN Gene Therapy for the Cardiomyopathy of Friedreich's Ataxiatreatment1recruiting
NCT04631224
Longitudinal Analysis of Oral Communication in Friedreich's AtaxiaNo drug interventionsNot AvailableNot Availablecompleted
NCT02255435
RTA 408 Capsules in Patients With Friedreich's Ataxia - MOXIetreatment2active_not_recruiting
NCT03933163
Micronised Resveratrol as a Treatment for Friedreich Ataxiatreatment2completed
NCT03122925
TCA Cycle in the Dentate in Friedreich's AtaxiaNo drug interventionsNot AvailableNot Availablecompleted
NCT03917225
A Clinical Study to Evaluate the Effect of MIN-102 on the Progression of Friedreich's Ataxia in Male and Female Patientstreatment2completed
NCT06447025
An Open Label Extension Study of CTI-1601 in Subjects With Friedreich's Ataxiatreatment2enrolling_by_invitation
NCT04921930
Evaluation of the Effect of Artesunate in Friedreich Ataxia (FA)treatment1 / 2completed
NCT05168774
FRDA Investigator Initiated Study (IIS) With Elamipretidetreatment1 / 2completed
NCT01493973
Efficacy Study of Epoetin Alfa in Friedreich Ataxiatreatment2completed
NCT01965327
Interferon Gamma-1b in Friedreich Ataxia (FRDA)treatment2completed
NCT05579691
A Double-Blind, Placebo-Controlled, Dose Exploration Study of CTI-1601 in Adult Subjects With Friedreich's Ataxiatreatment2completed
NCT04255680
A Study to Assess Variation in Potential Biomarkers in Friedreich AtaxiaNo drug interventionsNot AvailableNot Availablecompleted
NCT03090789
FA Clinical Outcome MeasuresNo drug interventionsNot AvailableNot Availablerecruiting
NCT03418740
Neurology Measures in FA ChildrenNo drug interventionsNot AvailableNot Availablecompleted
NCT00224640
Iron-Chelating Therapy and Friedreich Ataxiatreatment1 / 2completed
NCT01793168
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at SanfordNo drug interventionsNot AvailableNot Availablerecruiting
NCT06560346
Understanding the Natural History Early in the Course or Presentation of Friedreich AtaxiaNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT00824512
Efficacy of EGb761 in Patients Suffering From Friedreich Ataxiasupportive_care2completed
NCT04564495
Home Based Tele-exercise for People With Chronic Neurological ImpairmentsNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT04349514
A Natural History Study to TRACK Brain and Spinal Cord Changes in Individuals With Friedreich Ataxia (TRACK-FA)No drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04346238
Characterization of the Interruptions of the GAA Expansion and Study of Their Influence on the Severity of Friedreich's AtaxiaNo drug interventionsNot AvailableNot Availableunknown_status