NCT04195503
Liver Transplant for Stable, Advanced Intrahepatic Cholangiocarcinoma No drug interventions treatment Not Available enrolling_by_invitation NCT03377179
A Study of ABC294640 (Yeliva ®) Alone and in Combination With Hydroxychloroquine Sulfate in Treatment of Patients With Advanced Cholangiocarcinoma treatment 2 completed NCT04527679
Cisplatin and Gemcitabine Chemotherapy and Lenvatinib for Patients With Unresectable Intrahepatic Cholangiocarcinoma treatment 2 unknown_status NCT03951597
Combined Therapy Using Oxaliplatin and Gemcitabine Chemotherapy, Lenvatinib and PD1 Antibody (JS001) for Patients With Advanced and Unresectable Intrahepatic Cholangiocarcinoma treatment 2 unknown_status NCT04077983
Nab-Paclitaxel Combined With Gemcitabine Adjuvant Chemotherapy After Radical Resection of Intrahepatic Cholangiocarcinoma prevention 2 unknown_status NCT04361331
Two-cohort Study of Toripalimab(PD1)+Lenvatnib, or Gemox+Lenvatinib in Advanced Intrahepatic Cholangiocarcinoma treatment 2 unknown_status NCT03414489
Expanded Access for the Treatment of Advanced Cholangiocarcinoma With ABC294640 (Yeliva ®) Not Available Not Available available NCT04782804
Adjuvant PD-1 Antibody in Combination With Capecitabine for Patients With ICC at High-Risk of Postoperative Recurrence prevention 1 / 2 unknown_status NCT05124002
Recombinant Human Adenovirus Type 5 Plus HAIC of FOLFOX for Intrahepatic Cholangiocarcinoma No drug interventions treatment 4 recruiting NCT03405909
Standardized CEUS Algorithms for Diagnosis of HCC - Prospective German Multicenter Study No drug interventions Not Available Not Available completed NCT06140134
Liver Transplantation in Intrahepatic Cholangiocarcinoma No drug interventions Not Available Not Available recruiting NCT04634058
PD-L1 Antibody Combined With CTLA-4 Antibody for Patients With Advanced Intrahepatic Cholangiocarcinoma Who Progressed After Standard Treatment No drug interventions treatment 2 recruiting NCT05210322
Percutaneous Cholangiopancreatoscopy Registry No drug interventions Not Available Not Available recruiting NCT03316222
Study of GNS561 in Patients With Liver Cancer treatment 1 / 2 terminated NCT06381648
Detecting Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma (LyMIC) No drug interventions Not Available Not Available recruiting NCT04264260
Evaluation the Palliative Effects of Colchicine on Primary Hepatic Malignant Tumors Unable to Receive Curative Treatment treatment 2 recruiting NCT03267940
Study of PEGPH20 With Cisplatin (CIS) and Gemcitabine (GEM); PEGPH20 With Atezolizumab (ATEZO), CIS, and GEM; and CIS and GEM Alone in Participants With Previously Untreated, Unresectable, Locally Advanced, or Metastatic Intrahepatic and Extrahepatic Cholangiocarcinoma and Gallbladder Adenocarcinoma treatment 1 terminated NCT04506281
PD1 Antibody (Toripalimab), GEMOX and Lenvatinib Neoadjuvant Treatment for Resectable Intrahepatic Cholangiocarcinoma With High-risk Recurrence Factors No drug interventions treatment 2 unknown_status NCT04072250
Surgery for Recurrent Intrahepatic Cholangiocarcinoma No drug interventions Not Available Not Available completed NCT03044587
Nal-IRI With 5-fluorouracil (5-FU) and Leucovorin or Gemcitabine Plus Cisplatin in Advanced Biliary-tract Cancer treatment 2 active_not_recruiting NCT04684862
Infusion System for Hepatic Cancer No drug interventions treatment Not Available recruiting NCT05712356
A Study of LSTA1 When Added to Standard of Care Versus Standard of Care Alone in Patients with Advanced Solid Tumors treatment 2 recruiting NCT06648525
Adebrelimab Combined with Irinotecan Liposomes, 5-FU, CF ± Lenvatinib As First-line Treatment for Advanced ICC No drug interventions treatment 2 not_yet_recruiting NCT06643208
D-TACE-HAIC Combined With Envafolimab and Lenvatinib in the Treatment of Unresectable Intrahepatic Cholangiocarcinoma: a Prospective, Single-arm, Phase II Clinical Study No drug interventions Not Available Not Available recruiting NCT02834013
Nivolumab and Ipilimumab in Treating Patients With Rare Tumors treatment 2 active_not_recruiting NCT05286814
M9241 in Combination With Hepatic Artery Infusion Pump (HAIP) and Systemic Therapy for Subjects With Metastatic Colorectal Cancer or Intrahepatic Cholangiocarcinoma treatment 2 recruiting NCT06160752
Safety and Anti-Tumor Activity of TYRA-200 in Advanced Cholangiocarcinoma With Activating FGFR2 Gene Alterations No drug interventions treatment 1 recruiting NCT04526106
REFOCUS: a First-in-Human Study of Highly Selective FGFR2 Inhibitor, RLY-4008, in Patients with ICC and Other Advanced Solid Tumors treatment 1 / 2 active_not_recruiting NCT04561453
Feasibility Study of Multi-Platform Profiling of Resected Biliary Tract Cancer No drug interventions Not Available Not Available active_not_recruiting NCT06313203
HAI-Floxuridine, or SIRT, Combined With Gemox For Patients With Intra-Hepatic Cholangiocarcinoma Not Amenable to Resection (TOMCAT) treatment 2 recruiting NCT03345303
Bortezomib in Intrahepatic Cholangiocellular Carcinoma treatment 3 unknown_status NCT05400902
HAIC Combined With Sintilimab and Bevacizumab for Unresectable Intrahepatic Cholangiocarcinoma treatment 2 recruiting NCT06098547
LIver Transplantation for Non-Resectable Intrahepatic CholAngiocarcinoma (LIRICA) No drug interventions treatment Not Available recruiting NCT05913661
Pemigatinib Combined With PD-1 Inhibitor in Unresectable or Metastatic Intrahepatic Cholangiocarcinoma treatment 2 recruiting NCT04546828
A Single-arm Study of Gemcitabine, Cisplatin, and Nab-Paclitaxel as Neoadjuvant Therapy for Resectable Oncologically High-Risk IHCC in Korea treatment 2 withdrawn NCT06583993
A Clinical Trial Evaluating the Safety and Efficacy of Intravenous HNF4α srRNA in Treating Advanced ICC Patients No drug interventions treatment 0 not_yet_recruiting NCT04961788
Anti-PD1 Antibody Toripalimab Combined With Gemox as First-line Therapy in Late-stage Intrahepatic Cholangiocarcinoma No drug interventions treatment 2 unknown_status NCT04238637
Immunotherapy Combined With Y-90 SIRT Therapy in Advanced Stage Intrahepatic Biliary Tract Cancer (BTC) treatment 2 recruiting NCT06239532
HAIC Sequential TAE Combined With Tislelizumab and Surufatinib in Unresectable Intrahepatic Cholangiocarcinoma treatment 2 recruiting NCT04961970
HAIC With FOLFOX Versus Systemic Chemotherapy With GP for Unresectable ICC treatment 3 recruiting NCT06375642
A Single Arm, Single Centered Phase II Trial on the Combination of Adebrelimab, Surufatinib and Irinotecan Liposome-based HAIC in Advanced iCC treatment 2 not_yet_recruiting NCT05236699
A Clinical Study of DEB-TACE Combined With Surufatinib and Camrelizumab in the Treatment of Inoperable or Metastatic ICC treatment 2 recruiting NCT05678218
Preoperative Evaluation of Lymph Nodes of Cholangiocarcinoma No drug interventions Not Available Not Available recruiting NCT05930119
HMPL-453 Food Effect and PPI Study in Healthy Volunteer Study treatment 1 completed NCT03521219
A Study of Second-line Treatment With Apatinib for Advanced Intrahepatic Cholangiocarcinoma treatment 2 unknown_status NCT04295317
PD-1 Antibody (SHR-1210) Plus Capecitabine in Patients With Intrahepatic Cholangiocarcinoma After Surgery treatment 2 unknown_status NCT03781934
A Study to Evaluate MIV-818 in Patients With Liver Cancer Manifestations treatment 1 / 2 active_not_recruiting NCT06406816
Neoantigen Vaccine Plus Capecitabine as Adjuvant Therapy for Intrahepatic Cholangiocarcinoma After Radical Resection prevention 0 not_yet_recruiting NCT04669496
Phase II-III Clinical Trial of PD1 Antibody (Toripalimab), Lenvatinib and GEMOX Neoadjuvant Treatment for Resectable Intrahepatic Cholangiocarcinoma With High-risk Recurrence Factors No drug interventions treatment 2 / 3 recruiting NCT05247996
TACE Combined With "Target Immune" Therapy for First-line Treatment in the Treatment of Intrahepatic Cholangiocarcinoma No drug interventions treatment Not Available unknown_status NCT06296563
Perioperative Treatment of Resectable Intrahepatic Cholangiocarcinoma With the Combination of Adebrelimab and Apatinib and HAIC treatment 2 recruiting NCT03081039
A Study of Cisplatin or Carboplatin With Gemcitabine Versus Gemcitabine Alone as Adjuvant Therapy in Patients With Resected or Ablation Intra-Hepatic Cholangiocarcinoma treatment 3 withdrawn NCT06290739
A Machine-learning Model to Predict Lymph Node Metastasis of Intrahepatic Cholangiocarcinoma No drug interventions Not Available Not Available recruiting NCT05242822
A Study to Evaluate KIN-3248 in Participants With Advanced Tumors Harboring FGFR2 and//or FGFR3 Gene Alterations treatment 1 active_not_recruiting NCT04834674
DEB-TACE Combined With Apatinib and PD-1 for the Treatment of Intrahepatic Cholangiocarcinoma treatment 2 recruiting NCT04087876
Expanded Access Use of Derazantinib for Advanced Intrahepatic Cholangiocarcinoma (iCCA) With FGFR Genomic Alterations Not Available Not Available available NCT05342194
Toripalimab Plus Lenvatinib and Gemcitabine-based Chemotherapy in 1L Treatment of Advanced ICC: a Phase III Study treatment 3 not_yet_recruiting NCT06208462
Neoadjuvant Therapy of HAIC（GEMOX） Combined With Adebrelimab and Lenvatinib for Resectable Intrahepatic Cholangiocarcinoma With High-risk Recurrence Factors treatment 2 recruiting NCT05251662
Sintilimab Combined With GEMOX ± IBI305 (Bevacizumab Biosimilar) Versus GEMOX in Advanced Intrahepatic Cholangiocarcinoma treatment 2 recruiting NCT01938729
Hepatic Arterial Infusion With Floxuridine and Dexamethasone in Combination With Gemcitabine as Adjuvant Treatment After Resection of Intrahepatic Cholangiocarcinoma treatment 1 completed NCT05328167
Contrast-Enhanced Ultrasound for the Prediction of Bile Duct Cancer Response to Radioembolization Treatment diagnostic 2 recruiting NCT04479904
A Trial of Famitinib in Patients With Failure of First-Line Treatment For Intrahepatic Cholangiocarcinoma treatment 2 withdrawn NCT06298968
Combined Therapy Using Gemcitabine and Cisplatin Chemotherapy, Lenvatinib and Adebrelimab for Patients With Advanced and Unresectable Intrahepatic Cholangiocarcinoma treatment 2 recruiting NCT05010668
Cryoablation Combined With Sintilimab Plus Lenvatinib in Patients With Advanced Intrahepatic Cholangiocarcinoma treatment 2 recruiting NCT05239169
Immunotherapy With Durva and Treme With or Without Capecitabine in Adjuvant Treatment for Biliary Tract Cancer treatment 2 active_not_recruiting NCT05010681
Lenvatinib Plus Sintilimab in Patients With Immune Checkpoint Inhibitor Previously Treated Advanced Liver Cancer treatment 2 recruiting NCT02807181
SIRT Followed by CIS-GEM Chemotherapy Versus CIS-GEM Chemotherapy Alone as 1st Line Treatment of Patients With Unresectable Intrahepatic Cholangiocarcinoma treatment 2 / 3 completed NCT04299581
Cryoablation Combined With Anti-PD-1 Antibody in Patients With Advanced Intrahepatic Cholangiocarcinoma treatment 2 recruiting NCT02588755
TACE Plus Tegafur Versus TACE for Intrahepatic Cholangiocarcinoma After Curative Resection No drug interventions treatment Not Available unknown_status NCT05174650
Treatment of Atezolizumab and Derazantinib in Patients With Advanced iCCA With FGFR2 Fusions/Rearrangements treatment 2 active_not_recruiting NCT05644743
Clinical Transformation of Organoid Model to Predict the Efficacy of GC in the Treatment of Intrahepatic Cholangiocarcinoma No drug interventions Not Available Not Available not_yet_recruiting NCT05292443
Therapeutic ResistAnce and Clonal Evolution Assessed With Liquid Biopsy in ICIs Treated Primary Liver Cancer No drug interventions Not Available Not Available withdrawn NCT03251443
A Study of Second-line Treatment With Apatinib in Patients With Advanced Intrahepatic Cholangiocarcinoma treatment 2 completed NCT05422690
The Purpose of This Research Study is to See if Combining Gemcitabine, Cisplatin and Durvalumab Chemotherapy Treatments With a Direct Tumor Therapy Yittrium-90 (Y-90) Will Work Better Together to Shrink Tumors and Control Cancer No drug interventions treatment 2 recruiting NCT02762721
Analysis of Oncogenes in Intrahepatic Cholangiocarcinoma or Mixed Hepatocellular-Cholangiocarcinoma in Tumor Tissue Samples No drug interventions Not Available Not Available completed NCT01715402
Optimization of Health Expenditure in Liver Surgery No drug interventions Not Available Not Available unknown_status NCT01347333
Stereotactic Body Radiotherapy for Liver Tumors No drug interventions treatment Not Available completed NCT02881554
Sulfur Colloid SPECT/CT in Measuring Liver Function in Patients With Primary or Metastatic Liver Cancer Undergoing Radiation Therapy or Surgery diagnostic Not Available recruiting NCT06313554
Surufatinib Combined With Toripalimab and HAIC in the Treatment of Inoperable or Metastatic Intrahepatic Cholangiocarcinoma treatment Not Available not_yet_recruiting NCT05009953
Study of Irinotecan Liposome Injection in Patients With Advanced Biliary Tract Cancer treatment 2 terminated NCT05019677
GP Chemotherapy in Combination With Tislelizumab and Ociperlimab as First-line Treatment in Advanced BTC No drug interventions treatment 2 withdrawn NCT06101277
Locally ablatIVe thErapy for oLigo-progressive gastrOintestiNal maliGnancies (LIVELONG) No drug interventions treatment Not Available recruiting NCT05535647
Second Line Therapy for Advanced Intrahepatic Cholangiocarcinoma treatment 2 not_yet_recruiting NCT01954745
Cabozantinib (XL-184) Monotherapy for Advanced Cholangiocarcinoma treatment 2 completed NCT04454905
Camrelizumab in Combination With Apatinib in Advanced ICC: A Single-arm Phase II Study treatment 2 recruiting NCT03086993
Percutaneous Hepatic Perfusion vs. Cisplatin/Gemcitabine in Patients With Intrahepatic Cholangiocarcinoma treatment 2 / 3 unknown_status NCT04511793
Hepatic Artery Infusion (HAI) Program at Duke University No drug interventions treatment Not Available withdrawn NCT06134193
Combination Therapy of HAIC, Surufatinib and Tislelizumab for Unresectable or Metastatic Biliary Tract Cancer treatment 2 not_yet_recruiting NCT02526771
Conventional or Unconventional Lymph Node Dissection During Resection of Intrahepatic Cholangiocarcinoma No drug interventions treatment Not Available unknown_status NCT02184871
Next Generation Sequencing in Intrahepatic Cholangiocarcinoma No drug interventions Not Available Not Available unknown_status NCT05557578
GOT Applied as Neoadjuvant Regimen for Patients of Resectable ICC With High-risk Factors of Recurrence treatment 2 recruiting NCT05327907
Establishment of Scoring Model for Early and Differential Diagnosis of Intrahepatic Cholangiocarcinoma No drug interventions Not Available Not Available unknown_status NCT05896956
The Construction of Clinical Database and Multiomics Biobank Based on a Multicentral Prospective Cohort of Benign and Malignant Biliary Tract Diseases No drug interventions Not Available Not Available not_yet_recruiting NCT06375915
Precision Medicine in Patients With Unresectable CholAngiocarcinoma: RadioEmbolization and Combined Biological Therapy treatment 2 recruiting NCT01862315
Hepatic Arterial Infusion (HAI) With Floxuridine (FUDR) and Dexamethasone (Dex) Combined With Systemic Gemcitabine and Oxaliplatin in Patients With Unresectable Intrahepatic Cholangiocarcinoma (ICC) treatment 2 active_not_recruiting NCT05672537
Durvalumab Combined With GemCis Neoadjuvant Therapy of Resectable Intrahepatic Cholangiocarcinoma With High Recurrence Risk treatment 2 recruiting NCT03779100
Lenvatinib Plus PD-1 Antibody for Unresectable ICC treatment 2 suspended NCT06567600
Low-dose Gemcitabine and Cisplatin and PD-1/PD-L1 Antibody Therapy in Intrahepatic Cholangiocarcinoma treatment 2 not_yet_recruiting NCT05678270
A Study of ICP-192 in Patients With FGFR2-Rearranged Unresectable or Metastatic Intrahepatic Cholangiocarcinoma No drug interventions treatment 2 recruiting NCT01917370
VEGF Signaling Promotes Cell Growth and Metastasis in Intrahepatic Cholangiocarcinoma in a VEGF Receptor Mediated Pathway No drug interventions Not Available Not Available unknown_status NCT03801499
Lenvatinib for Unresectable Intrahepatic Cholangiocarcinoma treatment 2 withdrawn NCT06417606
Lenvatinib and Adebrelimab Combined With GEMOX in the Perioperative Treatment of Potentially Resectable Intrahepatic Cholangiocarcinoma treatment 4 not_yet_recruiting NCT05681949
Therapeutic Assistance and Decision-making Algorithms in Hepatobiliary Tumor Boards No drug interventions health_services_research Not Available not_yet_recruiting NCT02415036
Melphalan for Use With the Hepatic Delivery System Treatment in Patients With Unresectable Hepatocellular Carcinoma or Intra Hepatic Cholangiocarcinoma treatment 2 terminated NCT02238613
Radioactive Stents for Treatment of Unresectable Biliary Tract Cancer No drug interventions treatment Not Available unknown_status NCT03230318
Derazantinib in Subjects With FGFR2 Gene Fusion-, Mutation- or Amplification- Positive Inoperable or Advanced Intrahepatic Cholangiocarcinoma treatment 2 completed NCT03796819
Routine Lymphadenectomy for Intrahepatic Cholangiocarcinoma No drug interventions treatment Not Available completed NCT01668134
Stereotactic Body Radiotherapy for Hepatocellular Carcinoma, and Intrahepatic Cholangiocarcinoma No drug interventions treatment 1 completed NCT05223816
An Open-Label, Multiple-Center, Phase IIa/IIb Clinical Trial to Evaluate the Efficacy, Safety and Tolerability of VG161 as Monotherapy and in Combination With Nivolumab for Treatment of Patients With Hepatocellular Carcinoma or Intrahepatic Cholangiocarcinoma treatment 2 recruiting NCT05290116
HAIC Combined With Tislelizumab and Apatinib for Unresectable Intrahepatic Cholangiocarcinoma treatment 2 unknown_status NCT05285358
Pressurized Intraperitoneal Aerosolized Nab-Paclitaxel in Combination With Gemcitabine and Cisplatin for the Treatment of Biliary Tract Cancer Patients With Peritoneal Metastases treatment 1 recruiting NCT05781958
Cadonilimab Combined With Gem/Cis as First Line Therapy in Patients With Advanced ICC treatment 2 active_not_recruiting NCT06370663
First-line Treatment for Unresectable Locally Advanced Distal Cholangiocarcinoma Combining Radiotherapy and HAIC No drug interventions treatment 2 recruiting NCT06505486
GEMOX-HAIC Plus GEM-SYS in Combination With Lenvatinib and PD-1 Inhibitor for Large Unresectable ICC Not Available Not Available recruiting NCT02273739
Study of Orally Administered Enasidenib (AG-221) in Adults With Advanced Solid Tumors, Including Glioma, or Angioimmunoblastic T-cell Lymphoma, With an IDH2 Mutation treatment 1 / 2 completed NCT05220722
Pressure Enabled Delivery of SD-101 With Checkpoint Blockade for Primary Liver Tumors treatment 1 / 2 active_not_recruiting NCT04078230
Regional or Extend LymphAdenectomy During Resection of Intrahepatic Cholangiocarcinoma No drug interventions treatment Not Available recruiting NCT03633773
Safety and Efficacy Evaluation of MUC-1 CART in the Treatment of Intrahepatic Cholangiocarcinoma No drug interventions treatment 1 / 2 recruiting NCT02878473
Liver Transplantation for Early Intrahepatic Cholangiocarcinoma No drug interventions treatment 2 recruiting NCT06335927
HAIC Combined With Cadonilimab and Regorafenib as 2nd-line Treatment for ICC treatment 2 recruiting NCT01862276
Role of Bile Duct Resection in Major Hepatectomy Due to Intrahepatic Cholangiocarcinoma No drug interventions Not Available Not Available completed NCT05565794
Pemigatinib After Curative Local Therapy in Advanced iCCA With FGFR2 Fusion/Rearrangements treatment 2 recruiting NCT01775280
Response of Hepatic Tumors to Radioembolization No drug interventions treatment 2 withdrawn NCT03320980
RALPPS in Patients With Hilar and Intrahepatic Cholangiocarcinoma No drug interventions Not Available Not Available completed NCT06572189
The Safety and Efficacy of CD-801 in Patients With Advanced Intrahepatic Cholangiocarcinoma No drug interventions treatment 0 not_yet_recruiting NCT01914289
Prognosis of Resection and Radiotherapy in the Treatment of Intrahepatic Cholangiocarcinoma Patients No drug interventions treatment Not Available unknown_status NCT04891289
Gemcitabine and Oxaliplatin Chemotherapy With or Without a Floxuridine and Dexamethasone Pump in People With Cholangiocarcinoma That Cannot Be Removed With Surgery treatment 2 recruiting NCT02512692
Gemcitabine-Cisplatin-90Y TARE for Unresectable Intrahepatic Cholangiocarcinoma device_feasibility Not Available terminated NCT05489692
HAIC Plus Targeted Therapy and/or PD-1 Inhibitors for Unresectable Intrahepatic Cholangiocarcinoma No drug interventions Not Available Not Available completed NCT05240040
Treat Primary and Metastatic Liver Tumors No drug interventions Not Available Not Available unknown_status NCT03849469
A Study of XmAb®22841 Monotherapy & in Combination w/ Pembrolizumab in Subjects w/ Selected Advanced Solid Tumors treatment 1 completed NCT03771846
HAIC Versus Systemic Chemotherapy for Unresectable ICC treatment 3 unknown_status NCT04954781
TACE Combined With Tislelizumab in Patients With Advanced Intrahepatic Cholangiocarcinoma treatment 2 recruiting NCT02254681
Low-Dose Radiation Therapy to the Whole Liver With Gemcitabine and Cisplatin in IHC treatment 2 terminated NCT06342414
An Exosome-Based Liquid Biopsy for the Differential Diagnosis of Primary Liver Cancer No drug interventions Not Available Not Available recruiting NCT04556214
Liver Transplantation for Non-Resectable Intrahepatic Cholangiocarcinoma: a Prospective Exploratory Trial (TESLA Trial) No drug interventions supportive_care Not Available recruiting