Acute Decompensated Heart Failure (ADHF)

Also known as: Decompensated cardiac failure / Decompensated Heart Failure / ADHF / Acute Decompensated Heart Failure / Decompensated cardiac failure (disorder) / Heart failure / Heart failure (disorder) / Failure heart / Heart failure (NOS) / Heart failures / Cardiac failure / Heart: [weak] or [failure NOS] / Heart failure NOS (disorder) / Heart failure NOS / (Congestive cardiac failure) or (dropsy) or (cardiac insufficiency) or (right heart failure) or (right ventricular failure) / Heart failure, unspecified / Cardiac failure NOS / Cardiac failure (NOS) / Cardiac insufficiency / Insufficiency cardiac / Cardiac function failure / Cardiac function failed / Heart insufficiency / Acute cardiac insufficiency / Cardiac failure acute / Acute heart failure (disorder) / Acute heart failure

Drug	Drug Name	Drug Description
DB00922	Levosimendan	A calcium sensitizer indicated to treat acutely decompensated severe chronic heart failure.
DB00235	Milrinone	A PDE-III inhibitor with inotropic, lusitropic, and vasodilatory properties used for the short-term treatment of acute decompensated heart failure.
DB04899	Nesiritide	A recombinant natriuretic peptide used for the treatment of patients with acutely decompensated congestive heart failure who have dyspnea at rest or with minimal activity.

Drug	Drug Name	Target	Type
DB00922	Levosimendan	Troponin C, slow skeletal and cardiac muscles	target
DB00922	Levosimendan	ATP-sensitive inward rectifier potassium channel 11	target
DB00922	Levosimendan	ATP-sensitive inward rectifier potassium channel 8	target
DB00922	Levosimendan	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	target
DB00235	Milrinone	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	target
DB04899	Nesiritide	Atrial natriuretic peptide receptor 1	target
DB04899	Nesiritide	Atrial natriuretic peptide receptor 2	target
DB04899	Nesiritide	Atrial natriuretic peptide receptor 3	target

Drug	Drug Name	Phase	Status	Count
DB11777	Cenderitide	1	Completed	1
DB00695	Furosemide	1 / 2	Withdrawn	1
DB11777	Cenderitide	2	Completed	2
DB09038	Empagliflozin	2	Completed	1
DB05259	Glatiramer	2	Completed	1
DB06157	Istaroxime	2	Completed	1
DB00524	Metolazone	2	Withdrawn	1
DB12199	TRV-120027	2	Completed	1
DB09026	Aliskiren	3	Completed	1
DB00126	Ascorbic acid	3	Recruiting	1
DB00121	Biotin	3	Recruiting	1
DB00169	Cholecalciferol	3	Recruiting	1
DB01987	Cocarboxylase	3	Recruiting	1
DB00872	Conivaptan	3	Terminated	1
DB00115	Cyanocobalamin	3	Recruiting	1
DB06292	Dapagliflozin	3	Recruiting	1
DB09357	Dexpanthenol	3	Recruiting	1
DB09038	Empagliflozin	3	Recruiting	1
DB03247	Flavin mononucleotide	3	Recruiting	1
DB00158	Folic acid	3	Recruiting	1
DB00922	Levosimendan	3	Recruiting	2
DB00524	Metolazone	3	Terminated	1
DB02701	Nicotinamide	3	Recruiting	1
DB00165	Pyridoxine	3	Recruiting	1
DB05034	Ularitide	3	Completed	1
DB00162	Vitamin A	3	Recruiting	1
DB00163	Vitamin E	3	Recruiting	1
DB00819	Acetazolamide	4	Completed	1
DB00880	Chlorothiazide	4	Withdrawn	1
DB00988	Dopamine	4	Terminated	2
DB00695	Furosemide	4	Completed	1
DB00695	Furosemide	4	Terminated	3
DB00695	Furosemide	4	Withdrawn	1
DB00524	Metolazone	4	Terminated	1
DB04899	Nesiritide	4	Completed	1
DB00727	Nitroglycerin	4	Completed	1
DB00806	Pentoxifylline	4	Not Yet Recruiting	1
DB06212	Tolvaptan	4	Completed	1
DB00819	Acetazolamide	Not Available	Not Yet Recruiting	1
DB00887	Bumetanide	Not Available	Not Yet Recruiting	1
DB00887	Bumetanide	Not Available	Terminated	1
DB01914	D-glucose	Not Available	Recruiting	1
DB00695	Furosemide	Not Available	Not Yet Recruiting	1
DB00695	Furosemide	Not Available	Terminated	2
DB00999	Hydrochlorothiazide	Not Available	Not Yet Recruiting	1
DB09263	Patiromer	Not Available	Completed	1
DB00421	Spironolactone	Not Available	Completed	1
DB00214	Torasemide	Not Available	Not Yet Recruiting	1
DB00214	Torasemide	Not Available	Terminated	1