Tinea Cruris (DBCOND0041588)
Identifiers
- Synonyms
- Jock Itch / Tinea cruris / Ringworm of scrotum / Tinea cruris (disorder) / Groin tinea / Ringworm of groin
Associated Data
- Indicated Drugs and Targets
Drug Description Targets Amorolfine A morpholine derivative commonly applied as a lacquer for onychomycosis but is also used for superficial dermatomycosis.No drug targets Butenafine A topical antifungal used to treat tinea versicolor, tinea pedis, tinea cruris, and tinea corporis.- Squalene monooxygenasetarget
- Squalene monooxygenasetarget
Ciclopirox A broad-spectrum topical antifungal agent used to treat mild to moderate onychomycosis of fingernails and toenails in immunocompetent patients.Clioquinol An antifungal cream used to treat a variety of fungal infections.Clotrimazole A topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis.- Intermediate conductance calcium-activated potassium channel protein 4target
- Cytochrome P450 2D6enzyme
- Cytochrome P450 2C8enzyme
- Cytochrome P450 3A4enzyme
- Cytochrome P450 2B6enzyme
- ATP-dependent translocase ABCB1transporter
- Cytochrome P450 2A6enzyme
- Cytochrome P450 2C9enzyme
- Cytochrome P450 2E1enzyme
- Cytochrome P450 3A7enzyme
- Lanosterol 14-alpha demethylasetarget
- Nuclear receptor subfamily 1 group I member 2target
- Hydroxycarboxylic acid receptor 2target
- Bile salt export pumptransporter
- Solute carrier organic anion transporter family member 1B1transporter
- Solute carrier organic anion transporter family member 1B3transporter
- Ergosteroltarget
- C-X-C chemokine receptor type 2target
Econazole A topical antifungal used to treat tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis and tinea versicolor.Fenticonazole An imidazole antifungal used to treat a variety of topical fungal infections.No drug targets Flutrimazole A topical antifungal used to treat pityriasis capitis and seborrheic dermatitis.No drug targets Griseofulvin An antifungal agent used to treat a variety of superficial tinea infections and fungal infections of the fingernails and toes.- Keratin, type I cytoskeletal 12target
- Cytochrome P450 1A2enzyme
- Cytochrome P450 3A4enzyme
- Tubulin beta chaintarget
Miconazole An azole antifungal with broad-spectrum activity used to treat fungal infections affecting the vagina, mouth and skin, including candidiasis.- Cytochrome P450 2C9enzyme
- Cytochrome P450 2D6enzyme
- Cytochrome P450 3A4enzyme
- ATP-dependent translocase ABCB1transporter
- Lanosterol 14-alpha demethylasetarget
- Nitric oxide synthase 3target
- Nitric oxide synthase, inducibletarget
- Cytochrome P450 11B1, mitochondrialenzyme
- Cytochrome P450 2A6enzyme
- Cytochrome P450 2B6enzyme
- Cytochrome P450 2C19enzyme
- Cytochrome P450 2E1enzyme
- Nuclear receptor subfamily 1 group I member 2target
- Lanosterol 14-alpha demethylaseenzyme
- Aromataseenzyme
- Calcium-activated potassium channeltarget
- Voltage-gated Potassium Channelstarget
- Inward rectifier potassium channeltarget
- Voltage gated L-type calcium channeltarget
- Albumincarrier
- Cytochrome P450 2C8enzyme
Naftifine An antifungal agent used to treat infections of the Tinea, Trichophyton, and Epidermophyton species.- Squalene monooxygenasetarget
Oxiconazole A topical antifungal used to treat a variety of dermatophyte infections.Sulconazole A topical antifungal agent used for the treatment of tinea cruris, tinea corporis, and tinea versicolor caused by susceptible fungal strains.- Cytochrome P450 1A2enzyme
- Cytochrome P450 2C9enzyme
- Cytochrome P450 2D6enzyme
- Lanosterol 14-alpha demethylasetarget
Terbinafine An allylamine antifungal used to treat dermatophyte infections of toenails and fingernails as well as other fungal skin infections.- Squalene monooxygenasetarget
- Cytochrome P450 2D6enzyme
- Cytochrome P450 2C9enzyme
- Cytochrome P450 1A2enzyme
- Cytochrome P450 3A4enzyme
- Cytochrome P450 2C8enzyme
- Cytochrome P450 2C19enzyme
- Prostaglandin G/H synthase 1enzyme
- Albumincarrier
- alpha1-acid glycoproteincarrier
- ABC multidrug transporter MDR2transporter
- Squalene monooxygenasetarget
Tolnaftate An antifungal agent used to treat various skin infections caused by fungi.- Squalene monooxygenasetarget
- Squalene monooxygenasetarget
- Clinical Trials
Identifier Title Drug(s) Purpose Phase Status NCT01885156 Evaluation of Efficacy and Safety of Naftin 1% Cream in Adolescent Subjects With Tinea Cruris treatment 3 completed NCT00750152 Multicenter Study of the Safety and Efficacy of NAFT-500 in Tinea Cruris No drug interventions treatment 3 completed NCT01349998 Safety of a Topical Antifungal Treatment for Tinea Cruris, Tinea Pedis and Tinea Corporis No drug interventions Not Available 3 completed NCT01105013 Evaluate the Efficacy and Safety of Tolnaftate Cream in the Treatment of Patients With Fungal Infections treatment 3 unknown_status NCT05881980 Efficacy and Safety of Terbinafine and Itraconazole treatment 2 / 3 not_yet_recruiting NCT02767271 Maximal Use of Luliconazole Cream 1% in Pediatric Participants With Moderate to Severe Tinea Pedis or Tinea Cruris treatment 4 completed NCT01342315 Topical Antifungal Treatment for Tinea Cruris No drug interventions treatment 3 completed NCT03359070 Clinical Trial Comparing Dapaconazole Versus Miconazole in Patients With Tinea Cruris treatment 2 completed NCT05363449 Safety, Tolerability, and Pharmacokinetics of UHE-103 Cream in Subjects With Tinea Cruris and/or Tinea Pedis treatment 1 completed NCT01712360 Pharmacokinetic Study of Pediatric Subjects With Tinea Cruris and Tinea Pedis treatment 4 completed NCT02394340 Study Evaluating the Drug Interaction Potential of Luliconazole Cream 1% in Participants With Tinea Pedis and Tinea Cruris treatment 4 completed