Accession Number

Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS.

DrugDrug Description
TrospiumAn antimuscarinic agent used to treat the symptoms of overactive bladder (OAB).
OxyphenoniumFor the treatment of visceral spasms
HyoscyamineAn anticholinergic indicated to treat functional gastrointestinal disorders, biliary and renal colic, and acute rhinitis.
AtropineA muscarinic antagonist used to treat poisoning by muscarinic agents, including organophosphates and other drugs.
ClidiniumA synthetic anticholinergic used to treat peptic ulcer disease, colicky abdominal pain, diverticulitis, and IBS.
DicyclomineAn antimuscarinic agent used to treat IBS.
BiperidenA muscarinic receptor antagonist used to treat parkinsonism and control extrapyramidal side effects of neuroleptic drugs.
CyclopentolateAn anticholinergic used to cause mydriasis and cycloplegia for diagnostic testing.
OxybutyninAn antimuscarinic agent that reduces detrusor muscle activity, relaxing the bladder and preventing the urge to void.
FlavoxateA muscarinic antagonist and spasmolytic used for the symptomatic relief of conditions associated with lack of muscle control in the bladder, such as dysuria, urgency, and nocturia.
OrphenadrineA muscarinic antagonist used as an adjunct for the symptomatic relief of musculoskeletal pain and discomfort.
TiotropiumA long-acting bronchodilator used in the management of chronic obstructive pulmonary disease (COPD).
AlverineUsed to relieve cramps or spasms of the stomach and intestines. It is also useful in treating irritable bowel syndrome (IBS) and similar conditions. It can also be used to...
AlrestatinNot Available
DrotaverineA phosphodiesterase-4 inhibitor used to alleviate gastrointestinal and genitourinary smooth muscle spasms.
EperisoneEperisone is an antispasmodic drug which relaxes both skeletal muscles and vascular smooth muscles, and demonstrates a variety of effects such as reduction of myotonia, improvement of circulation, and suppression...
DexetimideA muscarinic antagonist that has been used to treat neuroleptic-induced parkinsonism. Benzetimide is the (-)-enantimorph of dexetimide.
BenactyzineBenactyzine is an anticholinergic drug used as an antidepressant in the treatment of depression and associated anxiety. Benactyzine is no longer widely used in medicine, although it is still a...
TrimebutineA spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and treatment of postoperative paralytic ileus following abdominal surgery.
PinaveriumA spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and functional disorders of the biliary tract.
CimetropiumCimetropium is a semi-synthetic belladonna alkaloid and derivative of scopolamine. It is a potent antimuscarinic and an effective antispasmodic drug. It is also endowed of a direct myolitic action which...
ButylscopolamineAn antispasmodic and anticholinergic agent used for the symptomatic treatment of abdominal cramping and pain.
HomatropineAn anticholinergic agent used to dilate the pupil, treat inflammation of the uveal tract, and suppress a cough.
Peppermint oilAn ingredient used in a variety of natural health products and is not an approved medication.
MethscopolamineMethscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The...
AnisodamineAnisodamine has been investigated for the treatment of Intestinal Diseases.
OxitropiumOxitropium has been investigated for the treatment of Pulmonary Disease, Chronic Obstructive.
MoxaverineMoxaverine has been investigated for the treatment of Retina, Ocular Physiology, and Regional Blood Flow.
PropiverineAn antimuscarinic agent used to treat urinary incontinence or increased urinary frequency or urgency.
MebeverineMebeverine has been investigated for the treatment of Irritable Bowel Syndrome and Post-cholecystectomy Gastrointestinal Spasms.
FenoverineFenoverine has been used in trials studying the treatment of Irritable Bowel Syndrome.
TiropramideTiropramide is under investigation in clinical trial NCT01629212 (Comparison of the Efficacy and Safety of Tiropramide and Octylonium in the Treatment of Irritable Bowel Syndrome).
OtiloniumNot Annotated
EmeproniumNot Annotated
RociverineNot Annotated
HydroquinineNot Annotated
TerodilineNot Annotated
CamylofinNot Annotated
MethylatropineNot Annotated
DiphemanilUsed in the treatment of peptic ulcer, gastric hyperacidity, and hypermotility in gastritis and pylorospasm, and in the treatment of hyperhidrosis (excessive perspiration).
HydroquinidineHydroquinidine is under investigation in clinical trial NCT00927732 (Hydroquinidine Versus Placebo in Patients With Brugada Syndrome).
1,3,5-TrimethoxybenzeneNot Annotated
Drugs & Drug Targets
TrospiumMuscarinic acetylcholine receptor M1target
TrospiumCytochrome P450 2D6enzyme
TrospiumMuscarinic acetylcholine receptor M3target
OxyphenoniumMuscarinic acetylcholine receptor M1target
HyoscyamineMuscarinic acetylcholine receptor M1target
HyoscyamineMuscarinic acetylcholine receptor M2target
HyoscyamineMuscarinic acetylcholine receptor M3target
HyoscyamineMuscarinic acetylcholine receptor M4target
HyoscyamineAdenylate cyclase type 1target
AtropineMuscarinic acetylcholine receptor M2target
AtropineMuscarinic acetylcholine receptor M1target
AtropineMuscarinic acetylcholine receptor M4target
AtropineMuscarinic acetylcholine receptor M5target
AtropineMuscarinic acetylcholine receptor M3target
AtropineGlycine receptor subunit alpha-1target
AtropineNeuronal acetylcholine receptor subunit alpha-4target
AtropineNeuronal acetylcholine receptor subunit beta-2target
AtropineBile salt export pumptransporter
ClidiniumMuscarinic acetylcholine receptor M1target
DicyclomineMuscarinic acetylcholine receptor M1target
DicyclomineMuscarinic acetylcholine receptor M2target
BiperidenMuscarinic acetylcholine receptor M1target
BiperidenCytochrome P450 2D6enzyme
CyclopentolateMuscarinic acetylcholine receptor M1target
OxybutyninMuscarinic acetylcholine receptor M1target
OxybutyninMuscarinic acetylcholine receptor M2target
OxybutyninMuscarinic acetylcholine receptor M3target
OxybutyninCytochrome P450 3A4enzyme
OxybutyninCytochrome P450 2C8enzyme
OxybutyninCytochrome P450 2D6enzyme
OxybutyninCytochrome P450 3A5enzyme
OxybutyninAlpha-1-acid glycoprotein 1carrier
OxybutyninSerum albumincarrier
FlavoxateMuscarinic acetylcholine receptor M1target
FlavoxateMuscarinic acetylcholine receptor M2target
OrphenadrineGlutamate receptor ionotropic, NMDA 1target
OrphenadrineGlutamate receptor ionotropic, NMDA 2Dtarget
OrphenadrineGlutamate receptor ionotropic, NMDA 3Btarget
OrphenadrineGlutamate receptor ionotropic, NMDA 3Atarget
OrphenadrineHistamine H1 receptortarget
OrphenadrineCytochrome P450 2B6enzyme
OrphenadrineCytochrome P450 2E1enzyme
OrphenadrineCytochrome P450 3A4enzyme
OrphenadrineSodium-dependent noradrenaline transportertarget
OrphenadrineSodium channel protein type 10 subunit alphatarget
OrphenadrineCytochrome P450 1A2enzyme
OrphenadrineCytochrome P450 2D6enzyme
TiotropiumMuscarinic acetylcholine receptor M3target
TiotropiumCytochrome P450 2D6enzyme
TiotropiumCytochrome P450 3A4enzyme
TiotropiumMuscarinic acetylcholine receptor M1target
TiotropiumMuscarinic acetylcholine receptor M2target
TiotropiumSolute carrier family 22 member 5transporter
TiotropiumSolute carrier family 22 member 4transporter
TiotropiumMuscarinic acetylcholine receptor M4target
TiotropiumMuscarinic acetylcholine receptor M5target
Alverine5-hydroxytryptamine receptor 1Atarget
AlrestatinAldose reductasetarget
DrotaverinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DrotaverineVoltage-dependent L-type calcium channeltarget
EperisoneCytochrome P450 3A4enzyme
TrimebutineMu-type opioid receptortarget
TrimebutineVoltage-dependent L-type calcium channeltarget
TrimebutineCalcium-activated potassium channeltarget
TrimebutineVoltage-dependent T-type calcium channeltarget
TrimebutineMuscarinic acetylcholine receptor M1target
TrimebutineMuscarinic acetylcholine receptor M2target
TrimebutineMuscarinic acetylcholine receptor M3target
TrimebutineMuscarinic acetylcholine receptor M4target
TrimebutineCytochrome P450 3A4enzyme
PinaveriumVoltage-dependent L-type calcium channel subunit alpha-1Starget
PinaveriumCytochrome P450 3A4enzyme
ButylscopolamineMuscarinic acetylcholine receptor M3target
ButylscopolamineMuscarinic acetylcholine receptor M2target
HomatropineLiver carboxylesterase 1enzyme
HomatropineMuscarinic acetylcholine receptor M1target
HomatropineMuscarinic acetylcholine receptor M2target
HomatropineMuscarinic acetylcholine receptor M3target
HomatropineMuscarinic acetylcholine receptor M4target
HomatropineMuscarinic acetylcholine receptor M5target
Peppermint oilCytochrome P450 1A2enzyme
Peppermint oilCytochrome P450 3A4enzyme
AnisodamineCytochrome P450 2D6enzyme
PropiverineMuscarinic acetylcholine receptor M1target
PropiverineMuscarinic acetylcholine receptor M2target
PropiverineMuscarinic acetylcholine receptor M3target
PropiverineMuscarinic acetylcholine receptor M4target
PropiverineMuscarinic acetylcholine receptor M5target
PropiverineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
PropiverineAlpha-1A adrenergic receptortarget
PropiverineCytochrome P450 3A4enzyme
PropiverineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
PropiverineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
OtiloniumCytochrome P450 3A4enzyme
RociverineMuscarinic acetylcholine receptor M1target
RociverineMuscarinic acetylcholine receptor M2target
RociverineMuscarinic acetylcholine receptor M3target
RociverineMuscarinic acetylcholine receptor M4target
RociverineMuscarinic acetylcholine receptor M5target
TerodilineCytochrome P450 3A4enzyme
DiphemanilMuscarinic acetylcholine receptor M3target