Lower Respiratory Tract Infection (LRTI) (DBCOND0035453)

Identifiers

Synonyms

Lower respiratory tract infection NOS / Lower Tract Respiratory Infection / LRTI / Lower Respiratory Tract Infections / Lower Respiratory Tract Infection / Chest infection / Lower respiratory tract infection (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Amoxicillin	A penicillin derivative used for the treatment of infections caused by gram-positive bacteria, in particular streptococcal bacteria causing upper respiratory tract infections.	Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Solute carrier family 22 member 6transporter Cytochrome P450 2C8enzyme Albumincarrier Beta-lactamase 2enzyme Penicillin binding proteintarget
Aztreonam	A beta-lactam antibiotic used to treat select aztreonam sensitive gram negative bacteria.	Penicillin-binding protein 3target Beta-lactamasetarget Beta-lactamase Toho-1target Peptidoglycan synthase FtsItarget
Bacampicillin	An ampicillin prodrug used to treat various susceptible bacterial infections in the body, such as respiratory infections and skin and subcutaneous tissue infections.	Penicillin-binding proteintarget
Cefoperazone	A broad-spectrum cephalosporin antibiotic used for the treatment of bacterial infections in various locations, including the respiratory tract, abdomen, skin, and female genital tracts.	Albumincarrier Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Solute carrier family 22 member 11transporter Solute carrier family 22 member 7transporter Peptidoglycan synthase FtsItarget Penicillin-binding protein 1Btarget Penicillin-binding protein 2target Penicillin-binding protein 1Atarget D-alanyl-D-alanine carboxypeptidase DacCtarget D-alanyl-D-alanine carboxypeptidase DacAtarget D-alanyl-D-alanine carboxypeptidase DacBtarget Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget
Cefpodoxime	A third-generation cephalosporin antibiotic used in the treatment of various bacterial infections, including gonorrhea, community acquired pneumonia, and sinusitis.	Peptidoglycan synthase FtsItarget
Ceftazidime	An injected broad-spectrum third-generation cephalosporin beta-lactam antibiotic used to treat or prevent a variety of bacterial infections, including pneumonia, gynecological infections, bone and joint infections, and septicemia, among others.	Solute carrier family 22 member 6transporter Peptidoglycan synthase FtsItarget Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Penicillin-binding protein 2target Albumincarrier Beta-lactamase Toho-1target
Ceftibuten	A third-generation cephalosporin antibiotic commonly used in the treatment of acute bacterial exacerbations of chronic bronchitis (ABECB), acute bacterial otitis media, pharyngitis, and tonsillitis.	Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Peptidoglycan synthase FtsItarget Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Penicillin-binding protein 2target Solute carrier family 22 member 6transporter Organic anion transporter 3transporter
Cefuroxime	A cephalosporin indicated for the treatment of a variety of infections including acute bacterial otitis media, several upper respiratory tract infections, skin infections, urinary tract infections, gonorrhea, early Lyme disease, and impetigo.	Penicillin-binding protein 1Atarget Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter
Clavulanic acid	A beta lactamase inhibitor used to enhance the effectiveness of beta lactam antibiotics.	Bacterial beta-lactamase enzymestarget Sodium/glucose cotransporter 1transporter Beta-lactamasetarget
Dirithromycin	An antibiotic used to treat a variety of respiratory, skin, and other infections.	23S ribosomal RNAtarget Cytochrome P450 3A4enzyme
Erythromycin	A macrolide antibiotic used to treat and prevent a variety of bacterial infections.	23S ribosomal RNAtarget Cytochrome P450 3A4enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1B1transporter Motilin receptortarget Voltage-gated inwardly rectifying potassium channel KCNH2target Cytochrome P450 3A5enzyme Solute carrier organic anion transporter family member 1B3transporter Bile salt export pumptransporter ATP-binding cassette sub-family C member 2transporter Solute carrier organic anion transporter family member 1A2transporter
Phenoxymethylpenicillin	A penicillin antibiotic used to prevent and treat mild to moderately severe infections in the respiratory tract, skin, and soft tissues.	Penicillin-binding protein 1Atarget MecA PBP2' (penicillin binding protein 2')target D-alanyl-D-alanine carboxypeptidase DacBtarget Penicillin acylasetarget Solute carrier family 15 member 1target
Piperacillin	A penicillin antibiotic combined with tazobactam to treat piperacillin-resistant, piperacillin/tazobactam­ susceptible, β-lactamase generating strains of several bacteria.	Solute carrier family 22 member 6transporter Penicillin-binding protein 3target Penicillin-binding protein 2Btarget Penicillin-binding protein 2atarget Penicillin-binding protein 1btarget Organic anion transporter 3transporter
Respiratory syncytial virus vaccine, adjuvanted	An adjuvanted respiratory syncytial virus vaccine in older adults.	No drug targets

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02240134	Wood Stove Interventions and Child Respiratory Health	No drug interventions	prevention	Not Available	completed
NCT00353951	An Observational Study of Cough / Lower Respiratory Tract Infection (LRTI) in Primary Care	No drug interventions	Not Available	Not Available	completed
NCT02130986	Procalcitonin Antibiotic Consensus Trial (ProACT)	No drug interventions	treatment	Not Available	completed
NCT05921526	Effectiveness of Point-of-care Lung Ultrasound for the Management of Childhood Lower Respiratory Infections	No drug interventions	treatment	Not Available	not_yet_recruiting
NCT01917461	Observational, Prospective Clinical Study to Evaluate Biomarkers as Indicators of Acute Bacterial or Viral Infections	No drug interventions	Not Available	Not Available	completed
NCT02025699	Prospective Study to Characterize Host-pathogen Related Factors in Hospitalized and ED Patients With LRTI and/or Sepsis	No drug interventions	Not Available	Not Available	completed
NCT03109106	Procalcitonin for Stewardship in Respiratory Infections A Stewardship Project	No drug interventions	diagnostic	Not Available	completed
NCT05063149	Protecting Preterm Infants From Respiratory Tract Infections and Wheeze by Using Bacterial Lysates.	OM85	prevention	3	recruiting
NCT02388516	Maternal Vitamin D for Acute Respiratory Infections in Infancy	No drug interventions	prevention	3	completed
NCT05937126	Rapid Diagnostic Supporting Antimicrobial Stewardship in Patients With Pneumonia	No drug interventions	Not Available	Not Available	completed
NCT01431326	Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care	Alfentanil Amikacin Aminocaproic acid Bosentan Cefepime Cidofovir Ciprofloxacin Clozapine Fosfomycin Haloperidol Labetalol Lurasidone Methylprednisolone Molindone Nafcillin Nifedipine Oxycodone Pentobarbital Piperacillin Rocuronium Sevelamer Spironolactone Tazobactam Tobramycin Tranexamic acid Vancomycin Vecuronium Warfarin Ziprasidone Zolpidem	Not Available	Not Available	completed
NCT02926612	Pathogen Identification in Pediatric Hematopoietic Stem Cell Transplant Patients With Suspected Lower Respiratory Tract Infection	No drug interventions	Not Available	Not Available	unknown_status
NCT01861184	Pneumococcal Carriage in Patients With Lower Respiratory Tract Infection (LRTI)	No drug interventions	Not Available	Not Available	completed
NCT02053870	Lung Sounds as Indicators of Severity and Recovery of Lung Disease	No drug interventions	diagnostic	Not Available	completed
NCT02852070	Study Bronchoalveolar Lavage Fluid Driven Pathogenic Diagnosis of Lower Respiratory Tract Infections	No drug interventions	diagnostic	Not Available	unknown_status
NCT01315418	Effect of the Consumption of a Fermented Milk on Common Infections in Adults Submitted to Multi-stressor Situation	No drug interventions	basic_science	Not Available	terminated
NCT01920165	Smoking Ban and Paediatric Hospital Admissions for Respiratory Tract Infections in England	No drug interventions	Not Available	Not Available	completed
NCT01971112	Nutritional Intervention and Respiratory Infections in Older Subjects	No drug interventions	prevention	Not Available	unknown_status
NCT05762302	The Impact of MeMed BV® on Management of Patients with Suspected Lower Respiratory Tract Infections (LRTI) in the Emergency Department (ED) and Urgent Care Center (UCC) ("JUPITER" TRIAL)	No drug interventions	diagnostic	Not Available	recruiting
NCT01154803	Effectiveness of Nutritional Supplementation in Preventing Malnutrition in Children With Infection	No drug interventions	prevention	Not Available	completed
NCT01735084	Using Pneumococcal Vaccines in Combination for Maximum Protection From Ear and Lung Infections in First 3 Years of Life	Streptococcus pneumoniae type 1 capsular polysaccharide antigen Streptococcus pneumoniae type 14 capsular polysaccharide antigen Streptococcus pneumoniae type 18c capsular polysaccharide antigen Streptococcus pneumoniae type 19f capsular polysaccharide antigen Streptococcus pneumoniae type 23f capsular polysaccharide antigen Streptococcus pneumoniae type 4 capsular polysaccharide antigen Streptococcus pneumoniae type 5 capsular polysaccharide antigen Streptococcus pneumoniae type 6b capsular polysaccharide antigen Streptococcus pneumoniae type 7f capsular polysaccharide antigen Streptococcus pneumoniae type 9v capsular polysaccharide antigen	prevention	4	completed
NCT01931254	Assess a Diagnostic Tool to Distinguish Between Bacterial and Viral Infection	No drug interventions	Not Available	Not Available	completed
NCT02093247	Characterize Novel Pathogen- and Host- Related Factors in Hospitalized Patients and Patients on the Emergency Department Presenting With Lower Respiratory Tract Infections and/or Sepsis	No drug interventions	Not Available	Not Available	unknown_status
NCT05110261	Evaluate the Safety and Efficacy of Nirsevimab in Healthy Preterm and Term Infants in China	Nirsevimab	prevention	3	recruiting
NCT05463406	Procalcitonin and Lung Ultrasonography Guided Antibiotherapy in Emergency Departments	No drug interventions	diagnostic	Not Available	recruiting
NCT03915236	Approach for Optimizing Meropenem Therapy in Intubated and Mechanically-Ventilated, Adult Patients With Severe Gram-Negative Lower Respiratory Tract Infection	No drug interventions	treatment	Not Available	terminated
NCT00707941	Oseltamivir Randomised Controlled Efficacy Trial	Oseltamivir	treatment	3	completed
NCT01076166	Recovery Time in Children With Lower Respiratory Tract Infections Treated With Klacid® Granules for Oral Suspension.	Clarithromycin	Not Available	Not Available	completed
NCT04311320	A Low-Resource Oxygen Blender Prototype for Use in Modified Bubble CPAP Circuits	No drug interventions	device_feasibility	Not Available	completed
NCT06210282	The Effect of Focused Lung Ultrasonography on Antibiotic Prescribing in General Practice	No drug interventions	diagnostic	Not Available	active_not_recruiting
NCT03391076	The Clinical Value of FA in AHLRI Patients	No drug interventions	diagnostic	Not Available	unknown_status
NCT06016244	Safe, Effective and Cost-Effective Oxygen Saturation Targets for Children and Adolescents With Respiratory Distress: a Randomized Controlled Trial	No drug interventions	treatment	Not Available	recruiting
NCT03846401	Bronchoscopy in Lower Respiratory Tract Infection in Respiratory Intensive Care Unit	No drug interventions	Not Available	Not Available	unknown_status
NCT04233268	RASCALS: Rapid Assay for Sick Children With Acute Lung Infection Study	No drug interventions	Not Available	Not Available	recruiting
NCT00157612	A Clinical Pathway for Nursing Home Acquired Pneumonia	No drug interventions	treatment	Not Available	completed
NCT02454114	HOME FIRST Pilot: a Study of Early Supported Discharge in Patients With Lower Respiratory Tract Infections	No drug interventions	supportive_care	Not Available	completed
NCT00350987	Procalcitonin Guided Antibiotic Therapy and Hospitalisation in Patients With Lower Respiratory Tract Infections: The "ProHOSP" Study	No drug interventions	diagnostic	Not Available	completed
NCT03011515	Evaluating a Host-response Based Diagnostic for Distinguishing Between Bacterial and Viral Etiology in Patients With Lower Respiratory Tract Infection (LRTI)	No drug interventions	Not Available	Not Available	completed
NCT05374070	Antiviral Activity of Oral Probiotics	No drug interventions	basic_science	Not Available	unknown_status
NCT01779570	Anti-inflammatory Effects of Macrolide Treatment in Influenza Lower Respiratory Tract Infections	No drug interventions	treatment	4	completed
NCT01952470	Preliminary Study of Dornase Alfa to Treat Chest Infections Post Lung Transplant.	Dornase alfa	treatment	2	completed
NCT06294899	CRP and Lung Ultrasound in Respiratory Evaluation	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT06156436	A Study Evaluating the Use of ResAppDx v2.0 as an Aid to Diagnose Respiratory Disease in Paediatric Patients in an Emergency Department	No drug interventions	Not Available	Not Available	completed
NCT01944319	Meropenem Dosage Strategy Based on PPK Model	Meropenem	treatment	4	completed
NCT06583317	Recurrent Pneumonia in Children	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT03446534	The Norwegian Antibiotics for Pneumonia in Children Study	Amoxicillin	treatment	4	unknown_status
NCT00632463	RI-001 in Immunosuppressed Respiratory Syncytial Virus (RSV) Infected Patients at Risk of Lower Tract RSV Illness	No drug interventions	treatment	2	completed
NCT03808922	Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study	DAS-181	treatment	3	recruiting
NCT00420966	Utilization and Compliance of Respiratory Syncytial Virus Monoclonal Antibody Therapy	No drug interventions	Not Available	Not Available	completed
NCT01985620	The Impact of a Short Intervention During RSV Prophylaxis on Influenza Vaccination Rate.	No drug interventions	prevention	Not Available	unknown_status
NCT02973282	Diagnosing Respiratory Disease in Children Using Cough Sounds	No drug interventions	Not Available	Not Available	completed
NCT03341273	Placebo-Controlled Trial of Antibiotic Therapy in Adults With Suspect Lower Respiratory Tract Infection (LRTI) and a Procalcitonin Level	Azithromycin	diagnostic	Not Available	terminated
NCT01048073	Non-influenza Etiologies of Acute Respiratory Illness in Southeast Asia	No drug interventions	Not Available	Not Available	completed
NCT00975780	A Trial to Reduce Pneumonia in Nursing Home Residents	No drug interventions	prevention	3	completed
NCT03694392	Flublok v. Standard Dose Vaccine Effectiveness Among Kaiser Permanente Northern California Adults 18-64 Years	Influenza A virus A/California/7/2009 (H1N1) recombinant hemagglutinin antigen Influenza A virus A/Hong Kong/4801/2014 (H3N2) recombinant hemagglutinin antigen Influenza A virus A/Michigan/45/2015 (H1N1) recombinant hemagglutinin antigen Influenza A virus A/Victoria/361/2011 (H3N2) recombinant hemagglutinin antigen Influenza B virus B/Brisbane/60/2008 recombinant hemagglutinin antigen Influenza B virus B/Phuket/3073/2013 recombinant hemagglutinin antigen Influenza B virus B/Wisconsin/1/2010 recombinant hemagglutinin antigen	Not Available	Not Available	completed
NCT02929680	Clinical Evaluation of FilmArray LRTI Panel	No drug interventions	Not Available	Not Available	recruiting