Acute Exacerbation of Chronic Bronchitis (AECB) (DBCOND0037906)

Identifiers

Synonyms

Acute Exacerbations of Chronic Bronchitis / Acute Exacerbation of Chronic Bronchitis / Acute episodes of chronic bronchitis / Acute exacerbation of chronic bronchitis NOS / Acute exacerbation of chronic bronchitis (disorder) / Acute on chronic bronchitis / Chronic obstructive pulmonary disease with (acute) exacerbation / Acute exacerbation of chronic obstructive airways disease (disorder) / Bronchitis NOS / Bronchitis / Bronchitis (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Aminophylline	A bronchodilator consisting of theophylline that is used for the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis.	cGMP-inhibited 3',5'-cyclic phosphodiesterase 3Atarget Adenosine receptor A3target Adenosine receptor A1target Cytochrome P450 1A2enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A4enzyme Histone deacetylase 2target
Amoxicillin	A penicillin derivative used for the treatment of infections caused by gram-positive bacteria, in particular streptococcal bacteria causing upper respiratory tract infections.	Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Solute carrier family 22 member 6transporter Cytochrome P450 2C8enzyme Albumincarrier Beta-lactamase 2enzyme Penicillin binding proteintarget
Cefdinir	A third generation cephalosporin used to treat susceptible Gram negative and Gram positive bacterial infections.	Myeloperoxidasetarget Penicillin-binding protein 2target PBP3target Organic cation/carnitine transporter 2transporter Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Peptidoglycan transpeptidasetarget
Dirithromycin	An antibiotic used to treat a variety of respiratory, skin, and other infections.	23S ribosomal RNAtarget Cytochrome P450 3A4enzyme
Etafedrine	A beta-2 adrenoceptor agonist used to treat a cough associated with inflamed mucosa.	Beta-2 adrenergic receptortarget
Moxifloxacin	A fluoroquinolone antibiotic used to treat various bacterial infections.	DNA gyrase subunit Atarget DNA topoisomerase 4 subunit Atarget DNA topoisomerase 2-alphatarget Cytochrome P450 1A2enzyme Serum paraoxonase/arylesterase 1target DNA gyrase subunit Atarget DNA gyrase subunit Btarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00546676	Ketek in CAP / AECB in Ambulatory Adult Patients	Telithromycin	treatment	4	completed
NCT02157571	A Multi-center, Randomized, Double-blind, Double-dummy Clinical Study to Evaluate the Safety and Efficacy of Prulifloxacin Film-coated Tablet for the Treatment of Acute Exacerbations of Chronic Bronchitis With Levofloxacin Hydrochloride Tablet as Active Control	Levofloxacin Prulifloxacin	treatment	3	unknown_status
NCT02250027	A Multicenter, Randomized, Double-blind, Parallel Group Study to Determine the Optimal Dose of HL301 After 7 Days Oral Administration in Acute Bronchitis or Acute Exacerbations of Chronic Bronchitis Patients (HL301: Mixed Extract of Rehmannia Glutinosa, Schisandra and so on)	Microcrystalline cellulose	treatment	2	completed
NCT01979926	Comparative Evaluate the Efficacy to Acute and Chronic Bronchitis	No drug interventions	treatment	2	completed
NCT03400735	Comparison of Cefdinir and Cefdinir/Clavulanic Acid Combination in Adults	Cefdinir	treatment	4	unknown_status
NCT03132610	A Study of Andrographolide Sulfonate in Patients With Acute Exacerbation of Chronic Bronchitis	Andrographolide	treatment	4	unknown_status