Cardiovascular Events

Also known as: Event, Cardiac / Cardio-vascular Events / Cardiac Event / Cardiac Events / Cardiovascular Event / Cardiac vascular event / Cardiovascular event (event)

DrugDrug NameDrug Description
DB00945Acetylsalicylic acidA salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events.
DB00381AmlodipineA calcium channel blocker used to treat hypertension and angina.
DB00612BisoprololA beta-1 adrenergic blocking agent used to prevent myocardial infarction and heart failure and to treat mild to moderate hypertension.
DB00758ClopidogrelAn antiplatelet agent used to prevent blood clots in peripheral vascular disease, coronary artery disease, and cerebrovascular disease.
DB06779DalteparinA low molecular weight heparin used for the prophylaxis of thrombotic events in certain patients and prevent acute cardiac ischemic events in patients with unstable angina and non-Q-wave myocardial infarction.
DB08887Icosapent ethylAn ethyl ester of eicosapentaenoic acid (EPA) that reduces synthesis and enhances clearance of triglycerides that is used to treat patients with severe hypertriglyceridemia.
DB00722LisinoprilAn ACE inhibitor used to treat hypertension, heart failure, and acute myocardial infarction.
DB00790PerindoprilAn ACE inhibitor prodrug used to treat hypertension, mild to moderate congestive heart failure, and to reduce cardiovascular risk in patients with hypertension or post-myocardial infarction.
DB06209PrasugrelA P2Y12 platelet inhibitor used to reduce risk of thrombotic cardiovascular events in unstable angina or non-ST-elevation myocardial infarction (NSTEMI), and in patients with STEMI when managed with either primary or delayed PCI.
DB00178RamiprilAn ACE inhibitor used for the management of hypertension and the reduction of cardiovascular mortality following myocardial infarction in hemodynamically stable patients with clinical signs of congestive heart failure.
DB01098RosuvastatinAn HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.
DB13928SemaglutideA glucagon-like peptide 1 receptor agonist used to improve glycemic control in type 2 diabetes mellitus.
DB00641SimvastatinAn HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular events including myocardial infarction and stroke.
DB00966TelmisartanAn ARB used to treat hypertension, diabetic nephropathy, and congestive heart failure.
DB00775TirofibanA platelet aggregation inhibitor used to prevent thrombotic events in non-ST elevated acute coronary syndrome.
DB09030VorapaxarA platelet aggregation inhibitor used to reduce thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or peripheral arterial disease (PAD).
DrugDrug NameTargetType
DB00945Acetylsalicylic acidProstaglandin G/H synthase 1target
DB00945Acetylsalicylic acidProstaglandin G/H synthase 2target
DB00945Acetylsalicylic acidAldo-keto reductase family 1 member C1target
DB00945Acetylsalicylic acidSolute carrier family 22 member 6transporter
DB00945Acetylsalicylic acidP-glycoprotein 1transporter
DB00945Acetylsalicylic acidCytochrome P450 2C19enzyme
DB00945Acetylsalicylic acidCytochrome P450 2C9enzyme
DB00945Acetylsalicylic acid5'-AMP-activated protein kinasetarget
DB00945Acetylsalicylic acidEndothelin-1 receptortarget
DB00945Acetylsalicylic acidCellular tumor antigen p53target
DB00945Acetylsalicylic acid78 kDa glucose-regulated proteintarget
DB00945Acetylsalicylic acidRibosomal protein S6 kinase alpha-3target
DB00945Acetylsalicylic acidNF-kappa-B inhibitor alphatarget
DB00945Acetylsalicylic acidTumor necrosis factor-inducible gene 6 proteintarget
DB00945Acetylsalicylic acidCaspase-1target
DB00945Acetylsalicylic acidCaspase-3target
DB00945Acetylsalicylic acidInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB00945Acetylsalicylic acidExtracellular signal-regulated kinase (ERK)target
DB00945Acetylsalicylic acidG1/S-specific cyclin-D1target
DB00945Acetylsalicylic acidMyc proto-oncogene proteintarget
DB00945Acetylsalicylic acidProliferating cell nuclear antigentarget
DB00945Acetylsalicylic acidCyclin Atarget
DB00945Acetylsalicylic acidUDP-glucuronosyltransferase 1-6enzyme
DB00945Acetylsalicylic acidArylamine N-acetyltransferase 2enzyme
DB00945Acetylsalicylic acidSolute carrier family 22 member 8transporter
DB00945Acetylsalicylic acidSialidase-1target
DB00381AmlodipineCarbonic anhydrase 1target
DB00381AmlodipineCytochrome P450 3A4enzyme
DB00381AmlodipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00381AmlodipineCytochrome P450 1A1enzyme
DB00381AmlodipineCytochrome P450 2B6enzyme
DB00381AmlodipineVoltage-dependent N-type calcium channel subunit alpha-1Btarget
DB00381AmlodipineVoltage-dependent L-type calcium channel subunit beta-1target
DB00381AmlodipineVoltage-dependent calcium channel subunit alpha-2/delta-3target
DB00381AmlodipineCytochrome P450 3A5enzyme
DB00381AmlodipineP-glycoprotein 1transporter
DB00381AmlodipineCytochrome P450 2C8enzyme
DB00381AmlodipineCytochrome P450 2D6enzyme
DB00381AmlodipineSphingomyelin phosphodiesterasetarget
DB00381AmlodipineVoltage-dependent T-type calcium channel subunit alpha-1Itarget
DB00381AmlodipineVoltage-dependent N-type calcium channeltarget
DB00381AmlodipineCytochrome P450 2C19enzyme
DB00381AmlodipineCytochrome P450 2C9enzyme
DB00612BisoprololBeta-1 adrenergic receptortarget
DB00612BisoprololBeta-2 adrenergic receptortarget
DB00612BisoprololCytochrome P450 3A4enzyme
DB00612BisoprololP-glycoprotein 1transporter
DB00758ClopidogrelP2Y purinoceptor 12target
DB00758ClopidogrelCytochrome P450 3A4enzyme
DB00758ClopidogrelCytochrome P450 2B6enzyme
DB00758ClopidogrelCytochrome P450 3A5enzyme
DB00758ClopidogrelCytochrome P450 2C19enzyme
DB00758ClopidogrelCytochrome P450 2C9enzyme
DB00758ClopidogrelCytochrome P450 1A2enzyme
DB00758ClopidogrelCytochrome P450 2C8enzyme
DB00758ClopidogrelLiver carboxylesterase 1enzyme
DB00758ClopidogrelP-glycoprotein 1transporter
DB00758ClopidogrelSolute carrier family 22 member 1transporter
DB00758ClopidogrelSolute carrier family 22 member 2transporter
DB00758ClopidogrelSerum albumincarrier
DB06779DalteparinVascular endothelial growth factor Atarget
DB06779DalteparinHeparanaseenzyme
DB06779DalteparinAntithrombin-IIItarget
DB06779DalteparinP-selectintarget
DB00722LisinoprilAngiotensin-converting enzymetarget
DB00722LisinoprilSolute carrier family 15 member 1transporter
DB00722LisinoprilSolute carrier family 15 member 2transporter
DB00722LisinoprilRenintarget
DB00790PerindoprilAngiotensin-converting enzymetarget
DB00790PerindoprilSolute carrier family 15 member 1transporter
DB00790PerindoprilSolute carrier family 15 member 2transporter
DB00790PerindoprilCholinesteraseenzyme
DB00790PerindoprilSecreted frizzled-related protein 4target
DB06209PrasugrelP2Y purinoceptor 12target
DB06209PrasugrelCocaine esteraseenzyme
DB06209PrasugrelCytochrome P450 3A4enzyme
DB06209PrasugrelCytochrome P450 2B6enzyme
DB06209PrasugrelCytochrome P450 2C9enzyme
DB06209PrasugrelCytochrome P450 2C19enzyme
DB06209PrasugrelSerum albumincarrier
DB00178RamiprilAngiotensin-converting enzymetarget
DB00178RamiprilSolute carrier family 15 member 1transporter
DB00178RamiprilSolute carrier family 15 member 2transporter
DB00178RamiprilCholinesteraseenzyme
DB00178RamiprilB1 bradykinin receptortarget
DB01098Rosuvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB01098RosuvastatinCytochrome P450 2C9enzyme
DB01098RosuvastatinMultidrug resistance-associated protein 4transporter
DB01098RosuvastatinSolute carrier organic anion transporter family member 1A2transporter
DB01098RosuvastatinSolute carrier organic anion transporter family member 1B3transporter
DB01098RosuvastatinSolute carrier organic anion transporter family member 2B1transporter
DB01098RosuvastatinCystine/glutamate transportertransporter
DB01098RosuvastatinSolute carrier organic anion transporter family member 1B1transporter
DB01098RosuvastatinBile salt export pumptransporter
DB01098RosuvastatinATP-binding cassette sub-family G member 2transporter
DB01098RosuvastatinSerum albumincarrier
DB01098RosuvastatinCanalicular multispecific organic anion transporter 1transporter
DB01098RosuvastatinSolute carrier family 22 member 8transporter
DB01098RosuvastatinSodium/bile acid cotransportertransporter
DB01098RosuvastatinIntegrin alpha-Ltarget
DB13928SemaglutideSerum albumincarrier
DB13928SemaglutideDipeptidyl peptidase 4enzyme
DB13928SemaglutideNeprilysinenzyme
DB13928SemaglutideGlucagon-like peptide 1 receptortarget
DB13928SemaglutideLipoprotein lipaseenzyme
DB13928SemaglutideAlpha-amylase 1enzyme
DB00641Simvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB00641SimvastatinCytochrome P450 3A4enzyme
DB00641SimvastatinCytochrome P450 2C8enzyme
DB00641SimvastatinCytochrome P450 2C9enzyme
DB00641SimvastatinCytochrome P450 3A5enzyme
DB00641SimvastatinP-glycoprotein 1transporter
DB00641SimvastatinSolute carrier organic anion transporter family member 1A2transporter
DB00641SimvastatinSolute carrier organic anion transporter family member 1B1transporter
DB00641SimvastatinCytochrome P450 2B6enzyme
DB00641SimvastatinCytochrome P450 2D6enzyme
DB00641SimvastatinUDP-glucuronosyltransferase 1-1enzyme
DB00641SimvastatinUDP-glucuronosyltransferase 1-3enzyme
DB00641SimvastatinUDP-glucuronosyltransferase 2B7enzyme
DB00641SimvastatinCanalicular multispecific organic anion transporter 1transporter
DB00641SimvastatinIntegrin alpha-Ltarget
DB00641SimvastatinBile salt export pumptransporter
DB00641SimvastatinCytochrome P450 2C19enzyme
DB00641SimvastatinSolute carrier organic anion transporter family member 2B1transporter
DB00641SimvastatinSolute carrier organic anion transporter family member 1B3transporter
DB00641SimvastatinHistone deacetylase 2target
DB00641SimvastatinCocaine esteraseenzyme
DB00641SimvastatinLiver carboxylesterase 1enzyme
DB00966TelmisartanType-1 angiotensin II receptortarget
DB00966TelmisartanPeroxisome proliferator-activated receptor gammatarget
DB00966TelmisartanP-glycoprotein 1transporter
DB00966TelmisartanCanalicular multispecific organic anion transporter 1transporter
DB00966TelmisartanATP-binding cassette sub-family G member 2transporter
DB00966TelmisartanCytochrome P450 2C19enzyme
DB00966TelmisartanBile salt export pumptransporter
DB00966TelmisartanUDP-glucuronosyltransferase 1-3enzyme
DB00775TirofibanIntegrin alpha-IIbtarget
DB00775TirofibanIntegrin beta-3target
DB09030VorapaxarProteinase-activated receptor 1target
DB09030VorapaxarCytochrome P450 3A4enzyme
DB09030VorapaxarCytochrome P450 2J2enzyme
DB09030VorapaxarP-glycoprotein 1transporter
DrugDrug NamePhaseStatusCount
DB06699Degarelix2Not Yet Recruiting1
DB00644Gonadorelin2Not Yet Recruiting1
DB16498Vasomera2Terminated1
DB13453Xenon2Not Yet Recruiting1
DB09026Aliskiren3Terminated1
DB00381Amlodipine3Terminated1
DB00999Hydrochlorothiazide3Terminated1
DB01373Calcium4Completed1
DB00258Calcium acetate4Completed1
DB06724Calcium carbonate4Completed1
DB01184Domperidone4Withdrawn1
DB00030Insulin human4Completed1
DB00448Lansoprazole4Withdrawn1
DB00922Levosimendan4Recruiting1
DB00658Sevelamer4Completed1
DB09043AlbiglutideNot AvailableActive Not Recruiting1
DB06203AlogliptinNot AvailableActive Not Recruiting1
DB11842Angiotensin IINot AvailableNot Yet Recruiting1
DB08907CanagliflozinNot AvailableActive Not Recruiting1
DB01112CefuroximeNot AvailableWithdrawn1
DB00215CitalopramNot AvailableCompleted1
DB06292DapagliflozinNot AvailableActive Not Recruiting1
DB09045DulaglutideNot AvailableActive Not Recruiting1
DB09038EmpagliflozinNot AvailableActive Not Recruiting1
DB11827ErtugliflozinNot AvailableActive Not Recruiting1
DB01276ExenatideNot AvailableActive Not Recruiting1
DB00222GlimepirideNot AvailableActive Not Recruiting1
DB01067GlipizideNot AvailableActive Not Recruiting1
DB01016GlyburideNot AvailableActive Not Recruiting1
DB10791Influenza A virus A/California/7/2009 X-179A (H1N1) antigen (formaldehyde inactivated)Not AvailableRecruiting1
DB14455Influenza A virus A/California/7/2009 X-181 (H1N1) antigen (formaldehyde inactivated)Not AvailableRecruiting1
DB10792Influenza A virus A/Switzerland/9715293/2013 NIB-88 (H3N2) antigen (formaldehyde inactivated)Not AvailableRecruiting1
DB14445Influenza A virus A/Victoria/210/2009 X-187 (H3N2) antigen (formaldehyde inactivated)Not AvailableRecruiting1
DB10794Influenza B virus B/Brisbane/60/2008 antigen (formaldehyde inactivated)Not AvailableRecruiting1
DB14456Influenza B virus B/Brisbane/9/2014 antigen (formaldehyde inactivated)Not AvailableRecruiting1
DB09564Insulin degludecNot AvailableActive Not Recruiting1
DB00047Insulin glargineNot AvailableActive Not Recruiting1
DB01235LevodopaNot AvailableCompleted1
DB08882LinagliptinNot AvailableActive Not Recruiting1
DB06655LiraglutideNot AvailableActive Not Recruiting1
DB09265LixisenatideNot AvailableActive Not Recruiting1
DB00331MetforminNot AvailableActive Not Recruiting1
DB01132PioglitazoneNot AvailableActive Not Recruiting1
DB00412RosiglitazoneNot AvailableActive Not Recruiting1
DB06335SaxagliptinNot AvailableActive Not Recruiting1
DB13928SemaglutideNot AvailableActive Not Recruiting1
DB00641SimvastatinNot AvailableActive Not Recruiting1
DB01261SitagliptinNot AvailableActive Not Recruiting1