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Salicylic Acid COX Action Pathway
smpdb.ca/view/SMP0124590Drug actionSalicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. … Salicylic acid inhibits the action of COX-1 and COX-2 on the endoplasmic reticulum membrane. This reduces the formation of prostaglandin H2 and therefore, prostaglandin E2 (PGE2).
Valine, Leucine, and Isoleucine Degradation
smpdb.ca/view/SMP0000032MetabolicValine, isoleuciine, and leucine are essential amino acids and are identified as the branched-chain amino acids (BCAAs). … The catabolism of all three amino acids starts in muscle and yields NADH and FADH2 which can be utilized for ATP generation.
Enzymes: Branched-chain-amino-acid aminotransferase, cytosolic, Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial3-Hydroxyisobutyric Acid Dehydrogenase Deficiency
smpdb.ca/view/SMP0000521DiseaseThis enzyme converts 2-methyl-3-oxopropanoate, CoA and water into propanoyl-CoA, using NAD+ as an oxidizing agent, and producing a hydrogen ion and hydrogencarbonate as byproducts. … acid.
Enzymes: Branched-chain-amino-acid aminotransferase, cytosolic, Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrialVitamin Deficiencies
go.drugbank.com/conditions/DBCOND0106956Drugs: Ascorbic acid · Biotin · Cholecalciferol · Cobaltous sulfate · Cyanocobalamin · DL-alpha tocopheryl acetate +12 moreSynonyms: Vitamin Deficiency, Vitamin DeficienciesDeficiency, Vitamin C
go.drugbank.com/conditions/DBCOND0154004Synonyms: Ascorbic acid (vitamin C) deficiency, (Ascorbic acid (vitamin C) deficiency) or (scurvy)Metabolism and Physiological Effects of Dimethylglycine
smpdb.ca/view/SMP0124873MetabolicDimethylglycine (DMG) is an amino acid derivative found in the cells of all plants and animals and can be obtained in the diet in small amounts from grains and meat. … Dimethylglycine enters the bloodstream and can cause toxic effects on the cardiovascular system.
Drugs: Choline · Methionine · NADH · Zinc · N,N-dimethylglycine · Flavin adenine dinucleotide +1 moreCongenital Bile Acid Synthesis Defect Type III
smpdb.ca/view/SMP0125690DiseaseCBASIII is characterized by accumulation of bile acids in the urine. Symptoms include severe cholestasis, cirrhosis, and liver failure. … The synthesis of primary bile acids from cholesterol occurs via two pathways: the classic neutral pathway involving cholesterol 7-alpha-hydroxylase (CYP7A1), and the acidic pathway involving a distinct
Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
smpdb.ca/view/SMP0000354SignalingProstacyclin binding to its receptor increases vasodilation and decreases platelet aggregation. … The receptor is a G-protein coupled receptor, upon its binding it activates G proteins causing the activation of adenylyl cyclase and production of cAMP messenger molecules. cAMP activates PKA (protein
Calcium
go.drugbank.com/drugs/DB01373ApprovedInvestigationalNutraceuticalCalcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. … Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast.
Mixtures: Prenatal Vitamin No 53 Iron Fum Folic Acid Docusate CA DHA, Hvp Chelated Cal/mag With Zinc and Vitamins C and DCategories: ascorbic acid (vit C) and calcium, etidronic acid and calcium, sequentialMetabolsim and Physiological Effects of 4-Ethylphenylsulfate
smpdb.ca/view/SMP0125541Metabolicacid. … This is metabolized into phenylpyruvic acid Phenylacetic acid which is then metabolized into 3-(3-Hydroxyphenyl)propanoic acid.
Drugs: Pyridoxal phosphate · Phenylalanine · Tyrosine · Iron · Oxogluric acid · Propanoic acid +3 moreEnzymes: Aromatic-amino-acid aminotransferase