Search
Aldosterone from Steroidogenesis
smpdb.ca/view/SMP0121126PhysiologicalAngiotensin II from the circulation binds to receptors on the zona glomerulosa cell membrane, activating the G protein and triggering a signaling cascade. … From there, cholesterol undergoes a series of reactions in both the mitochondrion and the smooth endoplasmic reticulum (steroidogenesis) where it finally becomes aldosterone.
Glutaminolysis and Cancer
smpdb.ca/view/SMP0002298DiseaseGlutamine not only provides a major substrate for respiration but also for the synthesis of other macromolecules, such as nucleotides, proteins and hexosamines. … The transportation of glutamine in and out regulates mTOR activation to coordinate cell growth and proliferation.
Drugs: Pyridoxal phosphate · Pyruvic acid · Biotin · Aspartic acid · L-Glutamine · Succinic acid +9 moreNicotinate and Nicotinamide Metabolism
smpdb.ca/view/SMP0000048Metabolicand plants. … The specifics of the de novo pathway varies between organisms, but most begin by forming quinolinic acid (QA) from tryptophan (Trp) in animals, or aspartic acid in some bacteria (intestinal microflora)
Fructose and Mannose Degradation
smpdb.ca/view/SMP0000064MetabolicFructose causes less of an insulin response compared to glucose and thus may be a preferred sugar for diabetics. … Fructose and mannose are monosaccharides that can be found in many foods. Fructose can join with glucose to form sucrose. Mannose can be converted to glucose. Both may be used as food sweeteners.
Androgen and Estrogen Metabolism
smpdb.ca/view/SMP0000068MetabolicThis pathway describes the inactivation and catabolism of male (androgen) and female (estrogen) hormones. … Many steroid hormones are transformed by sulfatases, dehydrogenases and glucuronide transferases to enhance their solubility and to facilitate their elimination.
NAD+ Signalling and Aging
smpdb.ca/view/SMP0084271SignalingAn interesting link has emerged between NAD+ metabolism, SIRT1, SIRT3, and mitochondrial function. … NR and PARP inhibitors increased life span in worms via activation of the mitochondrial unfolded protein response UPRmt by sir2.1.
Glycine and Serine Metabolism
smpdb.ca/view/SMP0000004MetabolicAll of these compounds share common intermediates and almost all can be biosynthesized from one another. Serine and glycine are not essential amino acids and can be synthesized from several routes. … Cystathionine beta-lyase then converts this double amino acid to cysteine, ammonia, and alpha-ketoglutarate. Glycine is biosynthesized in the body from the amino acid serine.
Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 moreTaurine and Hypotaurine Metabolism
smpdb.ca/view/SMP0000021MetabolicTo put this process in context, its occurrence is often seen in vivo, in hepatocytes, and is fundamental in the cyclical process of recovering bile acids from the intenstine, turning them back into salts … and returning them to the bile.
Pantothenate and CoA Biosynthesis
smpdb.ca/view/SMP0000027MetabolicThe nutrient gets its name from the greek word “pantothen” which means “from everywhere.” The reason it is called this is because pantothenic acid is found in almost every food. … Pantothenic acid, pantetheine 4’-phosphate and pantetheine are all found in red blood cells.
Starch and Sucrose Metabolism
smpdb.ca/view/SMP0000058MetabolicOnce released from starch or once ingested, sucrose can be degraded into beta-D-fructose and alpha-D-glucose via lysosomal alpha-glucosidase or sucrose-isomaltase. … The products of starch digestion are but not limited to maltotriose, maltose, limit dextrin, and glucose.
Drugs: Pyridoxal phosphate · NADH · ATP · Calcium · Magnesium cation · Uridine diphosphate glucose +4 more