- Accession Number
Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)
Drug Drug Description LErafAON Intended for the treatment of various forms of cancer. AGRO100 Investigated for use/treatment in cancer/tumors (unspecified), kidney cancer, leukemia (myeloid), and pancreatic cancer. Egaptivon pegol Platelet aggregation, thrombosis and acute coronary syndromes Mipomersen An oligonucleotide drug used for the treatment of homozygous familial hypercholesterolemia. CPG 10101 Investigated for use/treatment in hepatitis (viral, C) and viral infection. Trabedersen Investigated for use/treatment in brain cancer, colorectal cancer, melanoma, and pancreatic cancer. Alicaforsen Investigated for use/treatment in crohn's disease and ulcerative colitis. Pegnivacogin Investigated for use/treatment in thrombosis, coronary artery disease, and vascular diseases. Aprinocarsen Investigated for use/treatment in lung cancer. Fomivirsen Indicated for the local treatment of cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS), when other therapy has been ineffective or is considered unsuitable [FDA Label, L1428]. Pegaptanib A selective vascular endothelial growth factor (VEGF) antagonist used for the treatment of neovascular (wet) age-related macular degeneration. ISS-1018 Investigated for use/treatment in colorectal cancer, hepatitis (viral, B), and lymphoma (non-hodgkin's). ISS 1018 is currently being investigated in combination with HBsAg vaccine as a prophylactic treatment for to prevent... NF-kappaB Decoy Investigated for use/treatment in atopic dermatitis, inflammatory disorders (unspecified), and skin infections/disorders. GTI-2040 GTI-2040 is under investigation in clinical trial NCT00084643 (GTI-2040, Oxaliplatin, and Capecitabine in Treating Patients With Locally Advanced or Metastatic Colorectal Cancer or Other Solid Tumors). ARC-19499 ARC-19499 is under investigation in clinical trial NCT01191372 (First-in-Human and Proof-of-Mechanism Study of ARC19499 Administered to Hemophilia Patients). Eteplirsen An antisense oligonucleotide used to treat Duchenne muscular dystrophy (DMD) only in patients who are confirmed to have a specific type of mutation. Lexaptepid pegol Lexaptepid pegol has been used in trials studying the treatment of Anemia, Inflammation, Chronic Diseases, End Stage Renal Disease, and Anemia of Chronic Disease. Oblimersen Not Annotated Inotersen An antisense oligonucleotide used to treat polyneuropathy of hereditary transthyretin-mediated amyloidosis. Radavirsen Radavirsen is under investigation in clinical trial NCT01375985 (Safety Study of Single Administration Intravenous Treatment for Influenza). Adenylyl-(3'-5')-uridine 3'-monophosphate Not Available Givosiran A 5-aminolevulinic acid synthase-directed small interfering RNA (siRNA) used in the prophylaxis of acute hepatic porphyria. Viltolarsen An antisense phosphorodiamidate morpholino oligonucleotide specific for exon 53 of the human DMD gene that is capable of inducing exon 53 skipping to produce a functional truncated dystrophin protein in Duchenne muscular dystrophy patients with specific underlying mutations. ISIS 2503 ISIS 2503 is under investigation in clinical trial NCT00004193 (ISIS 2503 in Treating Patients With Metastatic And/or Locally Recurrent Colorectal Cancer). ISIS 104838 ISIS 104838 is under investigation in clinical trial NCT00048321 (ISIS 104838, an Inhibitor of Tumor Necrosis Factor, for Active Rheumatoid Arthritis). Casimersen An antisense phosphorodiamidate morpholino oligonucleotide used to treat Duchenne muscular dystrophy patients with mutations amenable to exon 45 skipping.
- Drugs & Drug Targets