refractory, metastatic Non small cell lung cancer (DBCOND0025490)

Identifiers

Synonyms

Refractory, metastatic non small-cell lung cancer / Refractory, metastatic Non-small cell lung cancer / Refractory, metastatic Non Small Cell Lung Cancer

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Alectinib	A kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer.	ALK tyrosine kinase receptortarget Broad substrate specificity ATP-binding cassette transporter ABCG2transporter ATP-dependent translocase ABCB1transporter
Ceritinib	An antineoplastic kinase inhibitor used to treat anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) in patients with inadequate clinical response or intolerance to crizotinib.	ALK tyrosine kinase receptortarget ATP-dependent translocase ABCB1transporter Cytochrome P450 2C9enzyme Cytochrome P450 3A4enzyme
Docetaxel	A taxoid antineoplastic agent used in the treatment of various cancers, such as locally advanced or metastatic breast cancer, metastatic prostate cancer, gastric adenocarcinoma, and head and neck cancer.	Apoptosis regulator Bcl-2target Tubulin beta-1 chaintarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 10transporter Cytochrome P450 1B1enzyme Microtubule-associated protein 2target Microtubule-associated protein 4target Microtubule-associated protein tautarget Solute carrier organic anion transporter family member 1B3transporter Solute carrier family 22 member 7transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter ATP-binding cassette sub-family C member 2transporter Multidrug resistance-associated protein 1transporter Nuclear receptor subfamily 1 group I member 2target

Clinical Trials

Not Available