Non-valvular Atrial Fibrillation (DBCOND0063787)

Identifiers

Synonyms

Non Valvular Atrial Fibrillation (nv AF) / Non Valvular Atrial Fibrillation / Non-valvular Atrial Fibrillation (NVAF) / Nonvalvular Atrial Fibrillation

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Apixaban	An anticoagulant used for the prophylaxis of stroke and systemic embolism in nonvalvular atrial fibrillation, and deep vein thrombosis(DVT) leading to pulmonary embolism(PE), including in patients after a hip or knee replacement surgery.	Coagulation factor Xtarget Cytochrome P450 3A4enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2J2enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 3A5enzyme
Dabigatran etexilate	An anticoagulant used for the prevention of venous thromboembolic events or stroke in patients with recent elective hip or knee replacement surgery and atrial fibrillation.	Prothrombintarget ATP-dependent translocase ABCB1transporter Liver carboxylesterase 1enzyme Cocaine esteraseenzyme UDP-glucuronosyltransferase 1A9enzyme UDP-glucuronosyltransferase 2B7enzyme UDP-glucuronosyltransferase 2B15enzyme Ribosyldihydronicotinamide dehydrogenase [quinone]enzyme Albumincarrier
Edoxaban	A novel oral anticoagulant used for reducing the risk of stroke and systemic embolism (SE) in patients with nonvalvular atrial fibrillation (NVAF).	Coagulation factor Xtarget ATP-dependent translocase ABCB1transporter
Rivaroxaban	A factor Xa inhibitor used to treat deep vein thrombosis (DVT) and pulmonary embolism (PE). May also be used as thrombosis prophylaxis in specific situations.	Coagulation factor Xtarget Cytochrome P450 3A4enzyme Cytochrome P450 2J2enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 3A5enzyme Broad substrate specificity ATP-binding cassette transporter ABCG2transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06168942	Laminar LAAX Pivotal IDE Study	No drug interventions	treatment	Not Available	enrolling_by_invitation
NCT02488421	Real Evidence of Anticoagulation Treatment in Non-valvular Atrial Fibrillation in Germany, UK and France: REACT-AF2	No drug interventions	Not Available	Not Available	completed
NCT02422602	Better Adherence With New Oral Anticoagulant in Atrial Fibrillation : Effectiveness of a Personalized Education Program	Rivaroxaban	supportive_care	Not Available	completed
NCT04722679	A Study to Collect Information on the Characteristics of Elderly Belgian Patients With NVAF That Are Treated With a NOAC for This Indication With a Special Focus on Their Fear of Bleeding While Using a NOAC vs the Clinical Benefit of a NOAC of Thrombosis/Stroke Prevention.	No drug interventions	Not Available	Not Available	completed
NCT05471505	Safety and Effectiveness of Apixaban Compared to Warfarin in Patients With Non-valvular Atrial Fibrillation (a Type of Irregular Heart Rhythm) at Higher Chance of Bleeding	No drug interventions	Not Available	Not Available	completed
NCT03616028	The CONFORMAL Early Feasibility Study	No drug interventions	device_feasibility	Not Available	active_not_recruiting
NCT05438888	Safety and Effectiveness of Apixaban in Very Elderly Patients With Non-valvular Atrial Fibrillation (NVAF) Compared to Warfarin Using Administrative Claims Data	Apixaban Warfarin	Not Available	Not Available	completed
NCT02654470	Watchman FLX Left Atrial Appendage Closure Device Post Approval Study ( Europe Only)	No drug interventions	Not Available	Not Available	completed
NCT05565599	An Early Feasibility Study Evaluating the Safety and Efficacy of the Laminar Left Atrial Appendage Closure System in Subjects With Non-Valvular Atrial Fibrillation	No drug interventions	treatment	Not Available	active_not_recruiting
NCT03133806	Canadian Left Atrial Appendage Closure Study	No drug interventions	treatment	Not Available	unknown_status
NCT04747496	Real-world Study on Edoxaban Treatment for Patients With Non-valvular Atrial Fibrillation in China	Edoxaban	Not Available	Not Available	active_not_recruiting
NCT03508258	Study to Describe Risk of Bleeding in Patients Depending on the Different Anticoagulant Therapy They Are on for Atrial Fibrillation (AF)	No drug interventions	Not Available	Not Available	withdrawn
NCT04096963	Observe the Safety and Effectiveness of the WATCHMAN FLX™ for Subjects in Hong Kong	No drug interventions	Not Available	Not Available	completed
NCT02937025	Study of Safety and Efficacy of a Left Atrial Appendage Occulder	No drug interventions	treatment	1 / 2	unknown_status
NCT04193826	The Conformal Prague Study	No drug interventions	treatment	Not Available	completed
NCT06189365	Amplatzer Amulet China Post Market Study (PMS)	No drug interventions	Not Available	Not Available	recruiting
NCT04829929	Evaluation od Safety and Performance of the Omega™ LAA (Left Atrial Appendage) Occluder and Omega™ Delivery System in Patients With Non-Valvular Atrial Fibrillation and High Bleeding Risk	No drug interventions	treatment	Not Available	recruiting
NCT04519944	Edoxaban in Patients With Non-valvular Atrial Fibrillation Undergoing Percutaneous Coronary Intervention	Edoxaban	Not Available	Not Available	completed
NCT02147444	Evaluation of Effectiveness and Safety of Xa Inhibitor for the Prevention of Stroke And Systemic Embolism in a Nationwide Cohort of Japanese Patients Diagnosed as Non-valvular Atrial Fibrillation	No drug interventions	Not Available	Not Available	unknown_status
NCT03002740	Bleeding Events and Oral Anticoagulant Treatment in Non-Valvular Atrial Fibrillation	No drug interventions	Not Available	Not Available	withdrawn
NCT05321810	Safety and Effectiveness of Apixaban Compared to Warfarin in Secondary Prevention in Patients With Atrial Fibrillation	Apixaban Warfarin	Not Available	Not Available	completed
NCT02756481	Local Adaptation of Cost Effectiveness Model for Apixaban Atrial Fibrillation Indication - Venezuela	No drug interventions	Not Available	Not Available	completed
NCT03315650	Rivaroxaban in Patients With Atrial Fibrillation Undergoing PCI	No drug interventions	Not Available	Not Available	completed
NCT01884350	Assessment of an Education and Guidance Programme for Eliquis Adherence in Non-Valvular Atrial Fibrillation (AEGEAN)	Apixaban	other	4	completed
NCT02222090	Therapy With New Oral Anticoagulants	No drug interventions	Not Available	Not Available	unknown_status
NCT03087487	Clinical and Economic Outcomes of Oral Anticoagulants in Non-valvular Atrial Fibrillation	No drug interventions	Not Available	Not Available	completed
NCT03570047	Safety and Effectiveness of Oral Anticoagulants in Patients With Non-valvular Atrial Fibrillation	No drug interventions	Not Available	Not Available	completed
NCT03515083	Better Outcomes for Anticoagulation Treatment Through Observation of Atrial Rhythm	No drug interventions	supportive_care	Not Available	completed
NCT04174859	Study Aims to Collect Information in Routine Clinical Practice in Italy About the Number of Patients Suffering From Irregularly Heart Beats Which Are Not Caused by a Heart Valve Problem (Non-valvular Atrial Fibrillation, NVAF) Who Stopped or Changed Rivaroxaban Treatment	Rivaroxaban	Not Available	Not Available	completed
NCT02362659	Antithrombotic Strategy Variability In ATrial Fibrillation and Obstructive Coronary Disease Revascularized With PCI - The AVIATOR 2 Registry	No drug interventions	Not Available	Not Available	completed
NCT04701749	Study of the Effects of Anticoagulant Interruption Covered by Percutaneous Left Atrial Occlusion in Patients With Chronic Atrial Fibrillation and Radiation Cystitis at Risk of Bleeding	No drug interventions	Not Available	Not Available	recruiting
NCT02502396	Rivaroxaban Utilization for Treatment and Prevention of Thromboembolism in Cancer Patients: Experience at a Comprehensive Cancer Center	No drug interventions	Not Available	Not Available	completed
NCT03917563	Registry to Evaluate Chinese Real-World Clinical Outcomes in Patients With AF Using the WATCHMAN Left Atrial Appendage Closure Technology	No drug interventions	treatment	Not Available	unknown_status
NCT01857622	Safety and Pharmacokinetics Study of DU-176b Administered to Non-valvular Atrial Fibrillation With Severe Renal Impairment	Edoxaban	prevention	3	completed
NCT03715725	A Nationwide Observational Study Looking at Effectiveness and Bleeding Complications of NOACs vs. VKA in Non-valvular Atrial Fibrillation Patients.	Apixaban Dabigatran Rivaroxaban Warfarin	Not Available	Not Available	terminated
NCT05320627	Population Pharmacokinetics of Edoxaban in Chinese Patients With Non-Valvular Atrial Fibrillation	Edoxaban	other	4	recruiting
NCT05761704	Exploratory Observation of Two Short-term Regimens After LAA Occlusion by LAMax LAAC® Device for Subjects With Non-valvular Atrial Fibrillation	No drug interventions	prevention	Not Available	recruiting
NCT03088072	A Pilot Study of Edoxaban in Patients With Non-Valvular Atrial Fibrillation and Left Atrial Appendage Closure	Acetylsalicylic acid Clopidogrel Edoxaban Warfarin	treatment	4	unknown_status
NCT04297072	Study to Gather Information on the Kidney Function of Patients With Non-valvular Atrial Fibrillation (Irregularly Heart Beats Which is Not Caused by a Heart Valve Problem) Treated With Rivaroxaban or Vitamin K Antagonists	Rivaroxaban	Not Available	Not Available	completed
NCT04429646	LAMax Vs. Watchman LAAC Device for Subjects With Non-valvular AF to Reduce the Risk of Stroke	No drug interventions	prevention	Not Available	completed
NCT03204695	WAVECREST Post Market Clinical Follow-Up (PMCF) Study	Clopidogrel	prevention	Not Available	terminated
NCT04559243	Left Atrial Appendage Closure as Secondary Prevention of Atrial Fibrillation-related Embolic Events	No drug interventions	Not Available	Not Available	recruiting
NCT03136510	Evolution of Coagulation Activity in Non Valvular Atrial Fibrillation Patients Under Apixaban	Apixaban	screening	Not Available	terminated
NCT06606275	The Safety and Effectiveness of Warfarin Vs Apixaban in Patients with NVAF/ VTE and ESKD on Dialysis	Apixaban Warfarin	Not Available	Not Available	active_not_recruiting
NCT01598051	Xarelto [SPAF-QOL] Post-marketing Surveillance in Japan	Rivaroxaban	Not Available	Not Available	completed
NCT05027061	A Study of Participants With Non-Valvular Atrial Fibrillation (NVAF) Treated or Untreated With Oral Anticoagulant in the National Cerebral and Cardiovascular Center (NCVC) in Japan	No drug interventions	Not Available	Not Available	completed
NCT02153424	Early Post-marketing Study of Eliquis (Apixaban)	Apixaban	Not Available	Not Available	withdrawn
NCT02663076	Factor XA - Inhibition in RENal Patients With Non-valvular Atrial Fibrillation - Observational Registry	No drug interventions	Not Available	Not Available	completed
NCT03887780	A Study to Evaluate the Safety and Effectiveness of Rivaroxaban (Xarelto) for Prevention of Stroke and Systemic Embolism in Indian Patients With Non-valvular Atrial Fibrillation (NVAF)	Rivaroxaban	Not Available	Not Available	active_not_recruiting
NCT03234114	Optimal Antithrombotic Therapy for ACS Patients Concomitant With AF and Implanted With New-generation DES (OPTIMA-3, 4)	No drug interventions	treatment	4	recruiting
NCT02954237	AMPLATZER™ Cardiac Plug Observational Post-Approval Study	No drug interventions	Not Available	Not Available	completed
NCT05022758	A Study to Learn Whether There Are Differences in the Kidney's Ability to Work Properly in Korean Patients With Non-valvular Atrial Fibrillation (Irregular and Often Rapid Heartbeat Not Caused by a Heart Valve Problem) Treated With Rivaroxaban as Compared to Those Treated With Warfarin	Rivaroxaban Warfarin	Not Available	Not Available	completed
NCT02906527	Benefit/Risk in Real Life of New Oral Anticoagulants and Vitamin K Antagonists in Patients Aged 75 Years and Over Suffering From Non Valvular Atrial Fibrillation (nv AF)	No drug interventions	Not Available	Not Available	unknown_status
NCT04356989	Study to Gain Information on the Drug Xarelto for the Prevention of Brain Attack and Blockage of an Artery in the Non-central Nervous System Due to Irregular Heartbeat in Taiwanese Patients Suffering From Decreased Renal Function	Rivaroxaban	Not Available	Not Available	completed
NCT03746301	Xarelto on Prevention of Stroke and Non-Central Nervous Systemic Embolism in Renally Impaired Korean Patients With Non-valvular Atrial Fibrillation	Rivaroxaban	Not Available	Not Available	completed
NCT05232643	A Study Evaluating the Associations Between Clinical Characteristics and Use of Oral Anticoagulants in Italian Elderly Participants With Non-Valvular Atrial Fibrillation	No drug interventions	Not Available	Not Available	recruiting
NCT04494347	Watchman for Patients With Atrial Fibrillation Undergoing Transcatheter Mitral Valve Repair (WATCH-TMVR)	No drug interventions	treatment	Not Available	recruiting
NCT01885598	Eliquis Regulatory Post Marketing Surveillance	Apixaban	Not Available	Not Available	completed
NCT00684307	Prevention of Stroke and Systemic Embolic Events in Patients With Atrial Fibrillation	Atecegatran metoxil Phylloquinone Warfarin	prevention	2	completed
NCT04073316	AntiCoagulants and COGnition	Rivaroxaban Warfarin	supportive_care	4	unknown_status
NCT05715658	Pharmacokinetic Study to Evaluate Dabigatran Etexilate in Elderly Subjects	Dabigatran etexilate	basic_science	Not Available	recruiting
NCT05731882	First in Man Study of Left Atrial Appendage Pulsed Field Ablation Occluder	No drug interventions	treatment	Not Available	recruiting
NCT04586972	Safety and Efficacy of Apixaban in Very Old Geriatric Subjects (> 80 Years) With Atrial FIbrillation in a Prospective reAl World Study;	No drug interventions	Not Available	Not Available	recruiting
NCT02007655	Eliquis Safety Surveillance in Japanese Patients With NonValvular Atrial Fibrillation	Apixaban	Not Available	Not Available	completed
NCT02919982	Benchmarking an Oral Anticoagulant Treatment Rate in Patients With Nonvalvular Atrial Fibrillation	No drug interventions	Not Available	Not Available	completed
NCT04942873	The Adherence to Oral Anticoagulant in Chinese Patients With NVAF	No drug interventions	Not Available	Not Available	unknown_status
NCT02674594	Evaluation of Hospital Readmissions Among Hospitalized Non-valvular Atrial Fibrillation (NVAF) Patients in the US	No drug interventions	Not Available	Not Available	completed
NCT03374540	Rivaroxaban vs Warfarin for SPAF in Multi-morbid Patients	Phylloquinone Rivaroxaban	Not Available	Not Available	completed