Progressive Multiple Sclerosis (PMS) (DBCOND0110090)

Identifiers

Synonyms

Multiple Sclerosis, Progressive / Progressive Multiple Sclerosis / Progressive multiple sclerosis (disorder) / Multiple Sclerosis, Chronic Progressive

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Ozanimod	A sphingosine 1-phosphate receptor modulator being studied to treat Multiple Sclerosis (MS) and inflammatory bowel disease (IBD).	Sphingosine 1-phosphate receptor 1target Sphingosine 1-phosphate receptor 5target Amine oxidase [flavin-containing] Btransporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter ATP-dependent translocase ABCB1transporter Aldehyde dehydrogenase family 3 member A2enzyme Alcohol dehydrogenase class-3enzyme Arylamine N-acetyltransferase 2enzyme Cytochrome P450 2C8enzyme Amine oxidase [flavin-containing] Benzyme Aldo-keto reductase family 1 member C1enzyme Aldo-keto reductase family 1 member C2enzyme Cytochrome P450 3A4enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT03523858	A Study to Evaluate Ocrelizumab Treatment in Participants With Progressive Multiple Sclerosis	Ocrelizumab	treatment	3	active_not_recruiting
NCT02301247	Treating New Learning and Memory Deficits in Progressive Multiple Sclerosis (MS)	No drug interventions	treatment	Not Available	completed
NCT02950454	The Effect of High Intensity Interval Training on Cardiovascular Fitness in People With Progressive Multiple Sclerosis.	No drug interventions	treatment	Not Available	completed
NCT05811013	Effects of Transcranial Static Magnetic Field Stimulation (tSMS) in Progressive Multiple Sclerosis	No drug interventions	treatment	Not Available	recruiting
NCT06566261	ABA-101 in Participants with Progressive Multiple Sclerosis	No drug interventions	treatment	1	recruiting
NCT03423121	A Trial of Bile Acid Supplementation in Patients With Multiple Sclerosis	Tauroursodeoxycholic acid	treatment	1 / 2	completed
NCT05937802	Osmotin Plant Protein for Progressive Multiple Sclerosis	No drug interventions	treatment	Not Available	recruiting
NCT04856384	Effect of Variance on Error Correction During Coupling	No drug interventions	other	Not Available	recruiting
NCT03980145	G-EO Gait Rehabilitation Training in Progressive Multiple Sclerosis	No drug interventions	treatment	Not Available	completed
NCT04289909	Identification of Retinal Perivascular Inflammation in Patients With Multiple Sclerosis Using Adaptive Optics (RETIMUS)	No drug interventions	other	Not Available	unknown_status
NCT01305837	Cyclic Oral Methylprednisolone Trial in Multiple Sclerosis	Methylprednisolone	treatment	2	completed
NCT06451159	A Study of KYV-101, a CD19 CAR T Cell Therapy, in Participants With Treatment Refractory Progressive Multiple Sclerosis	Cyclophosphamide Fludarabine	treatment	1	recruiting
NCT01719159	Intrathecal Therapy With Monoclonal Antibodies in Progressive Multiple Sclerosis	Rituximab	treatment	2	completed
NCT04201470	Serum Neurofilaments and GFAP in Atypical Multiple Sclerosis	No drug interventions	other	Not Available	completed
NCT03493841	Comparing Tolerability and Absorption of Racemic and R-lipoic Acid in Progressive Multiple Sclerosis	Lipoic acid	treatment	1	completed
NCT05740722	Nicotinamide Riboside Supplementation In Progressive Multiple Sclerosis	No drug interventions	treatment	2	recruiting
NCT02559765	Access, Use and Opinions of Physiotherapy and Rehabilitation Services of People With Progressive MS in the UK.	No drug interventions	Not Available	Not Available	completed
NCT05706220	Visual Processing Speed and Objective Analysis of Ocular Movements in Multiple Sclerosis	No drug interventions	Not Available	Not Available	enrolling_by_invitation
NCT02804594	A Study of Oxidative Pathways in MS Fatigue	Cysteine	treatment	2	completed
NCT02583594	A Study to Characterize Subcutaneous or Intravenous Alemtuzumab in Patients With Progressive Multiple Sclerosis	Acetaminophen Acyclovir Alemtuzumab Dexchlorpheniramine Loratadine Methylprednisolone	treatment	1	completed
NCT04749667	Study of Mesenchymal Autologous Stem Cells as Regenerative Treatment for Multiple Sclerosis	No drug interventions	treatment	1 / 2	active_not_recruiting
NCT01364246	Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Therapy for Patients With Progressive Multiple Sclerosis and Neuromyelitis Optica	Human Umbilical Cord Mesenchymal Stem Cells	treatment	1 / 2	unknown_status
NCT05685784	Multiple Sclerosis Prediction and Monitoring of Progression Study	No drug interventions	diagnostic	Not Available	recruiting
NCT02977533	A Single Ascending Dose Study of GZ402668 in Patients With Progressive Multiple Sclerosis	Acyclovir	treatment	1	completed
NCT06261528	Study of Circadian Focused Light Therapy in Progressive Multiple Sclerosis	No drug interventions	treatment	1	recruiting
NCT03552211	Evaluation of the Incidence of Relapses in Patients With Biotin-treated Progressive Multiple Sclerosis	Biotin	Not Available	Not Available	unknown_status
NCT03269071	Neural Stem Cell Transplantation in Multiple Sclerosis Patients	No drug interventions	treatment	1	completed
NCT05441488	Masitinib in the Treatment of Patients With Primary Progressive or Non-active Secondary Progressive Multiple Sclerosis	Masitinib	treatment	3	recruiting
NCT02313285	A Long-term Follow-up Study Of Multiple Sclerosis Patients Who Participated In Genzyme-sponsored Studies of GZ402668	No drug interventions	Not Available	Not Available	completed
NCT06485115	Telerehabilitation in Progressive Multiple Sclerosis	No drug interventions	treatment	Not Available	not_yet_recruiting
NCT01815632	Assessment of Bone Marrow-derived Cellular Therapy in Progressive Multiple Sclerosis (ACTiMuS)	No drug interventions	treatment	2	unknown_status
NCT04120675	Efficacy of Early Harvest Olive Oil in Cognition of Primary (PPMS) or Secondary (SPMS) Progressive Multiple Sclerosis	No drug interventions	treatment	Not Available	completed
NCT03302806	Study to Assess Effect and Safety of High Dose of Biotin (Qizenday®) in Progressive Multiple Sclerosis	No drug interventions	Not Available	Not Available	completed
NCT02282826	A First-in-human, Single Ascending Dose Study of GZ402668 in Patients With Progressive Multiple Sclerosis	Acyclovir	treatment	1	completed
NCT04695080	ChariotMS - Cladribine to Halt Deterioration in People With Advanced Multiple Sclerosis	Cladribine	treatment	2 / 3	recruiting
NCT02580669	Study by Magnetic Resonance Imaging in the Progressive Forms of Multiple Sclerosis	No drug interventions	diagnostic	Not Available	terminated