Neuroendocrine Carcinomas (NEC) (DBCOND0132635)

Identifiers

Synonyms
Neuroendocrine; Carcinoma / Neuroendocrine Carcinoma / Neuroendocrine Carcinomas / Neuroendocrine carcinoma (disorder) / Neuroendocrine tumor (morphologic abnormality) / Carcinoma, Neuroendocrine / Other benign neuroendocrine tumors / Neuroendocrine tumor (disorder) / Neuroendocrine tumour / Neuroendocrine Tumors / Neuroendocrine tumor / Neuroendocrine neoplasm (morphologic abnormality)

Associated Data

Indicated Drugs and Targets
Not Available
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT06406465
A UGT1A1 Genotype-Directed Study of Belinostat Pharmacokinetics and Toxicitytreatment2not_yet_recruiting
NCT04525638
A Clinical Study to Assess the Combination of Two Drugs (177Lu-DOTATATE and Nivolumab) in Neuroendocrine Tumourstreatment2recruiting
NCT03110978
Stereotactic Body Radiation Therapy with or Without Nivolumab in Treating Patients with Stage I-IIA or Recurrent Non-small Cell Lung Cancertreatment2active_not_recruiting
NCT03728361
Nivolumab and Temozolomide in Treating Patients with Recurrent or Refractory Small-Cell Lung Cancer or Advanced Neuroendocrine Cancertreatment2active_not_recruiting
NCT03074513
Atezolizumab and Bevacizumab in Treating Patients with Rare Solid Tumorstreatment2active_not_recruiting
NCT04701307
Niraparib and Dostarlimab for the Treatment of Small Cell Lung Cancer and Other High-Grade Neuroendocrine Carcinomastreatment2active_not_recruiting
NCT02236910
An Open Label Registry Study of Lutetium-177 (DOTA0, TYR3) Octreotate (Lu-DOTA-TATE) Treatment in Patients with Somatostatin Receptor Positive TumoursNo drug interventionstreatment2active_not_recruiting
NCT03591731
Nivolumab +/- Ipilimumab in Patients with Advanced, Refractory Pulmonary or Gastroenteropancreatic Poorly Differentiated Neuroendocrine Tumors (NECs)treatment2active_not_recruiting
NCT04471727
A Study in Participants With Advanced Cancers Associated With Expression of DLL3 (MK-6070-001/HPN328-4001)treatment1 / 2recruiting
NCT05619744
A Study to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Anti-tumor Activity of RO7616789 in Advanced Small Cell Lung Cancer and Other Neuroendocrine Carcinomastreatment1recruiting
NCT04069299
Use of 68Ga-dotatate PET Scan in Neuroendocrine Carcinoma of the GI TractNot AvailableNot Availablerecruiting
NCT05237934
Tissue Procurement and Natural History Study of Neuroendocrine Neoplasms (NENs) Including Adrenocortical Carcinoma (ACC)No drug interventionsNot AvailableNot Availablerecruiting
NCT06041516
Antibody Drug Conjugate ADCT-701 in Neuroendocrine Tumors and CarcinomasNo drug interventionstreatment1recruiting
NCT06333314
Dostarlimab for Locally Advanced or Metastatic Cancer (non-colorectal/non-endometrial) with Tumor DMMR/MSItreatment2recruiting
NCT05978284
Study of ZG006 in Participants With Small Cell Lung Cancer or Neuroendocrine CarcinomaNo drug interventionstreatment1 / 2recruiting
NCT00363051
Safety/Efficacy of Everolimus in Adults With Advanced Pancreatic Neuroendocrine Cancer Not Responsive to Chemotherapytreatment2completed
NCT01642251
Cisplatin and Etoposide With or Without Veliparib in Treating Patients With Extensive Stage Small Cell Lung Cancertreatment1 / 2completed
NCT03837977
Second-line Therapy for Patients With Progressive Poorly Differentiated Extra-pulmonary Neuroendocrine Carcinomatreatment2active_not_recruiting
NCT03278405
Avelumab in G3 NECtreatment1 / 2completed
NCT02754297
Personalized PRRT of Neuroendocrine Tumorstreatment2active_not_recruiting
NCT01876771
A Trial to Assess the Safety and Effectiveness of Lutetium-177 Octreotate Therapy in Neuroendocrine Tumourstreatment2recruiting
NCT03168607
Study to Evaluate the Efficiency of FOLFIRI as Seconde-line Chemotherapy in Neuroendocrine Carcinomatreatment2unknown_status
NCT05262556
NP-101 (TQ Formula) With Nivolumab and Ipilimumab in Advanced or Metastatic Extra-pulmonary Neuroendocrine Carcinomastreatment1active_not_recruiting
NCT05420636
Iadademstat in Combination With Paclitaxel in Relapsed/Refractory SCLC and Extrapulmonary High Grade NETtreatment2recruiting
NCT05396118
Simultaneous Hyperpolarized [1-13C]Pyruvate and 18F-FDG PET/MRS in Cancer Patientsdiagnostic2enrolling_by_invitation
NCT04705519
Nab-paclitaxel Combined With Bevacizumab in the Treatment of Metastatic Neuroendocrine Carcinomatreatment2unknown_status
NCT02687958
Study of Everolimus as Maintenance Therapy for Metastatic NEC With Pulmonary or Gastroenteropancreatic Origintreatment2active_not_recruiting
NCT00019786
Isolated Hepatic Perfusion With Melphalan in Treating Patients With Primary Unresectable Liver Cancer or Liver Metastasestreatment2completed
NCT02970786
Phase I Trial: 68Ga-NODAGA-E(c[RGDyK])2 Positron Emission Tomography for Imaging Angiogenesis in Primary and Metastatic Tumor Lesions in HumansNo drug interventionsdiagnostic1unknown_status
NCT04464122
Rediscovering Biomarkers for the Diagnosis and Early Treatment Response in NEN (REBORN)Not AvailableNot Availablerecruiting
NCT04325425
Chemotherapy For Metastatic Grade 3 Poorly Differentiated NEuroendocrine Carcinoma Of GastroEnteroPancreatic And Unknown Primarytreatment2recruiting
NCT05461430
Mass Response of Tumor Cells as a Biomarker for Rapid Therapy Guidance (TraveraRTGx)No drug interventionsNot AvailableNot Availablerecruiting
NCT04985357
Defining the Clinical Potential of Mass Response as a Biomarker for Patient Tumor Sensitivity to DrugsNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT03012620
Secured Access to Pembrolizumab for Patients With Selected Rare Cancer Typestreatment2completed
NCT01396382
68Ga-DOTATATE PET Scan in Neuroendocrine CancerNo drug interventionsdiagnostic2completed
NCT05627427
Multi-cohort Study of Surufatinib Plus Sintilimab in Metastatic NEN and Pancreatic Carcinoma Who Failed Standard Chemotherapytreatment2recruiting
NCT00113360
RAD001 Plus Octreotide Depot in Metastatic or Unresectable Low Grade Neuroendocrine Carcinomatreatment2completed
NCT02688894
The Molecular Screening Study for the Umbrella Trial (SUKSES) in Relapsed Small Cell Lung Cancer Patients [SUKSES-S]No drug interventionsNot AvailableNot Availablerecruiting
NCT03168594
Study to Compare Irinotecan Combined With Cisplatin (IP) Versus Etoposide Combined With Cisplatin (EP) in Advanced and Metastatic Gastrointestinal Pancreatic and Esophageal Neuroendocrine Carcinomatreatment2terminated
NCT00511862
TheraSphere for the Treatment of Liver MetastasesNo drug interventionstreatment2completed
NCT05747729
A Single-arm, Open-label, Clinical Trial of Surufatinib/Serplulimab/Platinum/Etoposide in Neuroendocrine Carcinoma.treatment1 / 2not_yet_recruiting
NCT00663429
Extension Study of the Safety and Efficacy of Atiprimod Treatment in Neuroendocrine Carcinomatreatment2completed
NCT00926640
A Phase I Study of Belinostat in Combination With Cisplatin and Etoposide in Adults With Small Cell Lung Carcinoma and Other Advanced Cancerstreatment1completed
NCT03079440
TEMCAP in Grade 3 and Low Ki-67 Gastroenteropancreatic Neuroendocrine Tumorstreatment2completed
NCT06369181
Neuroendocrine Transformation in RB1/TP53 Inactivated NSCLCNo drug interventionsNot AvailableNot Availablerecruiting
NCT02487095
Trial of Topotecan With VX-970 (M6620), an ATR Kinase Inhibitor, in Small Cell Cancers and Extrapulmonary Small Cell Cancerstreatment1 / 2active_not_recruiting
NCT00003514
Antineoplaston Therapy in Treating Patients With Neuroendocrine Tumor That Is Metastatic or Unlikely to Respond to Surgery or Radiation Therapytreatment2withdrawn
NCT05113355
Chidamide Plus Sintilimab for Chemotherapy-refractory Advanced High-grade Neuroendocrine Neoplasmtreatment2recruiting
NCT02936323
PEN-221 in Somatostatin Receptor 2 Expressing Advanced Cancers Including Neuroendocrine and Small Cell Lung Cancerstreatment1 / 2completed
NCT02038738
68Ga-DOTATATE PET Scan Imaging in Patients With Neuroendocrine Tumorsdiagnostic1 / 2unknown_status
NCT04268121
Efficacy of Neoadjuvant Chemotherapy in Terms of DFS in Patients With Localized Digestive Neuroendocrine Carcinomastreatment2recruiting
NCT03290079
Phase II Study of Pembrolizumab and Lenvatinib in Advanced Well-differentiated Neuroendocrine Tumorstreatment2completed
NCT01886287
P:II Above-Label Octreotide-LAR With Insufficiently Controlled Carcinoid Syndrometreatment2terminated
NCT06577987
Safety/Efficacy Study of CID-078 in Patients With Advanced Solid Tumor MalignanciesNo drug interventionstreatment1recruiting
NCT03600233
Study of CVM-1118 for Patients With Advanced Neuroendocrine Tumorstreatment2active_not_recruiting
NCT06400654
PrognostIc and Predictive Factors in Unresectable Locally Advanced NEC and MANECNo drug interventionsNot AvailableNot Availablerecruiting
NCT04583605
The Aim of This Study is to Demonstrat That Vacuum-assisted Closure Versus Conventional Wound Closure Enables to Diminish Local Complications After Lymph Node Dissection in Patients With Metastatic Skin TumorsNo drug interventionsNot AvailableNot Availableunknown_status
NCT05709171
Dual 64Cu-DOTATATE and 18F-FDG PET/CT Imaging of Patients With Neuroendocrine Neoplasmsdiagnostic2enrolling_by_invitation
NCT03901378
Pembrolizumab With Chemotherapy in Metastatic or Unresectable High Grade Gastroenteropancreatic or Lung Neuroendocrine Carcinomatreatment2withdrawn
NCT03517488
A Study of XmAb®20717 in Subjects With Selected Advanced Solid Tumorstreatment1completed
NCT02250885
KPT-330 to Treat Poorly Differentiated Lung and Gastroenteropancreatic Tumorstreatment2completed
NCT03037385
Phase 1/2 Study of the Highly-selective RET Inhibitor, Pralsetinib (BLU-667), in Participants With Thyroid Cancer, Non-Small Cell Lung Cancer, and Other Advanced Solid Tumorstreatment1 / 2completed
NCT02205515
An Open Label, Single-Centre, Pilot Study of Everolimus With EBRT for the Treatment of mNET Liver Metastasistreatment1 / 2completed
NCT00353015
Irinotecan and Cisplatin for High Grade Neuroendocrine Carcinoma of the Gastrointestinal Tracttreatment2completed
NCT00607113
Avastin (Bevacizumab) and RAD001 (Everolimus) in Advanced Low or Intermediate Grade Neuroendocrine Carcinomatreatment2completed
NCT06242119
Clinical Application of the J-PET Scanner PrototypeNo drug interventionsNot AvailableNot Availablerecruiting
NCT00388063
Safety and Efficacy of Atiprimod Treatment for Patients With Low to Intermediate Grade Neuroendocrine Carcinomatreatment2completed
NCT04488263
Natural History Study of Children and Adults With Neuroendocrine Neoplasms (NEN)sNo drug interventionsNot AvailableNot Availableterminated
NCT03647163
Ph I/II Trial of Systemic VSV-IFNβ-NIS in Combination With Checkpoint Inhibitor Therapy in Patients With Select Solid Tumorstreatment1 / 2recruiting
NCT05076786
Chidamide Plus Etoposide and Cisplatin/Carboplatin as First-line Treatment for Extrapulmonary Neuroendocrine Carcinomatreatment2recruiting
NCT01121939
Combination of Bevacizumab, Pertuzumab, and Sandostatin for Adv. Neuroendocrine Cancerstreatment2completed
NCT00004922
Irinotecan in Treating Patients With Advanced Neuroendocrine Tumorstreatment2completed
NCT02315625
Study of Mutation-Targeted Therapy With Sunitinib or Everolimus in People With Advanced Low- or Intermediate-Grade Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas With or Without Cytoreductive Surgerytreatment2terminated
NCT06440057
Dose Escalation Study of ZG006 in Participants With Advanced Small Cell Lung Cancer or Neuroendocrine Carcinoma, Followed by Dose Expansion Study in Participants With Neuroendocrine Carcinoma.No drug interventionstreatment1 / 2not_yet_recruiting
NCT01879657
68-Ga-DOTATATE PET-CT Scan for Diagnosis of Primary and Metastatic Somatostatin Receptor-positive Neuroendocrine Tumors (NETs)No drug interventionsdiagnosticNot Availablecompleted
NCT06372626
Study of ZG005 in Combination With Etoposide and Cisplatin in Participants With Advanced Neuroendocrine Carcinoma.treatment1 / 2recruiting
NCT00193531
Paclitaxel, Carboplatin, and Oral Etoposide Followed by Weekly Paclitaxel in High Grade Neuroendocrine Carcinomatreatment2completed
NCT03387592
CAPTEM or FOLFIRI as SEcond-line Therapy in NEuroendocrine CArcinomastreatment2unknown_status
NCT02270567
RegisterNET - A Registry for Neuroendocrine Tumors in the USANo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT03834701
Endoscopic Ultrasound-guided RadioFrequency Ablation for the Treatment Pancreatic NeuroEndocrine NeoplasmsNo drug interventionstreatmentNot Availablecompleted
NCT02248012
Everolimus and Temozolomide in Advanced Gastroenteropancreatic Neuroendocrine Carcinoma (G3)treatment2completed
NCT03279614
Study to Evaluate the Efficiency of SOX as Seconde-line Chemotherapy in Neuroendocrine CarcinomaNo drug interventionstreatment2unknown_status
NCT03858855
Inhaled Essential Oil Effect on Common QOL Concerns During Cancer TreatmentNo drug interventionssupportive_careNot Availablecompleted
NCT05064150
Neuroendocrine Tumors - Patient Reported OutcomesNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT04524208
A Trial of Cabozantinib in Patients With Advanced, Low Proliferative NEN G3treatment2active_not_recruiting
NCT02695459
Cisplatinum and Everolimus in Patients With Metastatic or Unresectable NEC of Extrapulmonary Origintreatment2unknown_status
NCT02457273
Phase II Study to Evaluate the Efficacy and Safety of TLC388 for Differentiated Neuroendocrine Carcinomas Patientstreatment2completed
NCT04122911
Temozolomide for Second-Line Treatment of Neuroendocrine Carcinomastreatment2completed
NCT01203306
Bevacizumab Plus Somatostatin Analogue and Metronomic Capecitabine in Patients With Advanced Neuroendocrine Tumorstreatment2unknown_status
NCT05337735
A Phase II Clinical Trial to Evaluate Safety and Efficacy of XmAb20717 in Advanced Rare Cancerstreatment2suspended
NCT02820857
Assessment of the Efficacy of Bevacizumab in Combination With Folfiri as Second-line Treatment in Patients Suffering From an Advanced Inoperable Poorly Differentiated Neuroendocrine Carcinoma of an Unknown or Gastroentero-pancreatic Primary Cancertreatment2active_not_recruiting