Cytochrome P-450 CYP2A6 Substrates

Name
Cytochrome P-450 CYP2A6 Substrates
Accession Number
DBCAT002613
Description
Not Available
Drugs
DrugDrug Description
NifedipineA dihydropyridine calcium channel blocker indicated for the management of several subtypes of angina pectoris, and hypertension.
VortioxetineAn atypical antipsychotic and antidepressant indicated for the treatment of major depressive disorder (MDD).
CinnarizineFor the treatment of vertigo/meniere's disease, nausea and vomiting, motion sickness and also useful for vestibular symptoms of other origins.
PropacetamolPropacetamol is a paracetamol prodrug of intravenous administration used to control fever and pain of perioperative period in multimodal analgesia therapy.
NicotineA stimulatory alkaloid found in tobacco products that is often used for the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
FormoterolAn inhaled long-acting beta2-adrenergic receptor agonist used as a bronchodilator in the management of asthma and COPD.
LetrozoleAn aromatase inhibitor used to treat breast cancer in postmenopausal women.
ChlorzoxazoneA drug with muscle relaxant properties that is used as an adjunct to physical therapy and analgesics to treat stiffness and pain caused by a variety of musculoskeletal conditions.
HalothaneA general inhalation anesthetic used for the induction and maintenance of general anesthesia.
SelegilineA monoamine oxidase inhibitor used to treat major depressive disorder and Parkinson's.
IfosfamideAn alkylating and immunosuppressive agent used in chemotherapy for the treatment of cancers, including testicular cancer, ovarian cancer, cervical cancer, osteocarcinoma, bladder cancer, small cell lung cancer, and non-Hodgkin's lymphoma.
Valproic acidAn anticonvulsant used to control complex partial seizures and both simple and complex absence seizures.
NevirapineA non-nucleoside reverse transcriptase inhibitor used as part of a management regimen for HIV-1 virus infection.
FlunarizineA selective calcium-entry blocker used as migraine prophylaxis in patients with severe and frequent episodes who have not responded adequately to more common treatments.
MontelukastA leukotriene receptor antagonist used as part of an asthma therapy regimen, to prevent exercise induced bronchoconstriction, and to treat seasonal allergic rhinitis.
CisaprideA medication used to treat heartburn associated with GERD.
ClomethiazoleInvestigated for use/treatment in strokes.
ClozapineAn antipsychotic drug used in treatment resistant schizophrenia and to decrease suicide risk in schizophrenic patients.
CyclophosphamideA nitrogen mustard used to treat lymphomas, myelomas, leukemia, mycosis fungoides, neuroblastoma, ovarian adenocarcinoma, retinoblastoma, and breast carcinoma.
FlunitrazepamFor short-term treatment of severe insomnias, that are not responsive to other hypnotics.
FluorouracilA pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment.
LidocaineA local anesthetic used in a wide variety of superficial and invasive procedures.
MethoxyfluraneFor use in the induction and maintenance of general anesthesia
AcetaminophenAn analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent.
PhenacetinUsed principally as an analgesic.
AntipyrineAn antipyretic agent used for the symptomatic treatment of acute otitis media, most commonly in combination with benzocaine.
SevofluraneA inhalation anaesthetic agent used for induction and maintenance of general anesthesia during surgical procedures.
TamoxifenA selective estrogen receptor modulator used to treat estrogen receptor positive breast cancer, reduce the risk of invasive breast cancer following surgery, or reduce the risk of breast cancer in high risk women.
ZidovudineA dideoxynucleoside used in the treatment of HIV infection.
FlurazepamA long-acting benzodiazepine with a rapid onset of action that is commonly used to treat insomnia.
TretinoinA vitamin A derivative used to treat acne vulgaris, certain types of promyelocytic leukemia, and fine wrinkles.
ArformoterolA beta-2 adrenergic agonist and bronchodilator used for long term, symptomatic treatment of reversible bronchoconstriction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema.
LorcaserinA serotonin 2C receptor agonist used in conjunction with physical activity and calorie restriction for weight loss in obese patients with a body mass index (BMI) of 30 and above, and in overweight patients with weight-related comorbidities.
DapagliflozinA sodium-glucose cotransporter 2 inhibitor used in the management of type 2 diabetes mellitus.
TegafurAn antineoplastic agent used in combination with other anticancer medications to treat advanced gastric and colorectal cancers.
Tegafur-uracilTegafur-uracil is indicated for the first line treatment of metastatic colorectal cancer with concomitant administration of calcium folinate. Colorectal cancer is the third most diagnosed cancer and 30% of the...
AsunaprevirAsunaprevir is indicated in combination with other agents for the treatment of chronic hepatitis C in adult patients with hepatitis C virus genotypes 1 or 4 and compensated liver cirrhosis....
ArtesunateArtesunate is an artemesinin derivative indicated for the initial treatment of severe malaria.
MetronidazoleA nitroimidazole used to treat trichomoniasis, amebiasis, inflammatory lesions of rosacea, and bacterial infections, as well as prevent postoperative infections.
ApremilastA non-steroidal medication used for the treatment of inflammatory conditions such as psoriasis and psoriatic arthritis.
AzelastineA histamine H1-receptor antagonist used intranasally to treat allergic and vasomotor rhinitis and in an ophthalmic solution to treat allergic conjunctivitis.
PlitidepsinIntended for the treatment of various forms of cancer.
NorethisteroneA synthetic second-generation progestin used for contraception, prevention of endometrial hyperplasia in hormone replacement therapy, and in the treatment of other hormone-mediated illnesses such as endometriosis.
CenobamateA small molecule drug indicated to treat partial onset seizures in adults.
PhenytoinAn anticonvulsant drug used in the prophylaxis and control of various types of seizures.
BelinostatA histone deacetylase (HDAC) inhibitor used for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma (PTCL).
Drugs & Drug Targets
DrugTargetType
NifedipineCytochrome P450 3A4enzyme
NifedipineCytochrome P450 2E1enzyme
NifedipineCytochrome P450 2D6enzyme
NifedipineCalmodulintarget
NifedipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
NifedipineVoltage-dependent L-type calcium channel subunit alpha-1Starget
NifedipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
NifedipineVoltage-dependent L-type calcium channel subunit beta-2target
NifedipinePotassium voltage-gated channel subfamily D member 3target
NifedipineVoltage-dependent T-type calcium channeltarget
NifedipineCytochrome P450 1A2enzyme
NifedipineCytochrome P450 2A6enzyme
NifedipineCytochrome P450 2C8enzyme
NifedipineCanalicular multispecific organic anion transporter 2transporter
NifedipineP-glycoprotein 1transporter
NifedipineCanalicular multispecific organic anion transporter 1transporter
NifedipineCytochrome P450 1A1enzyme
NifedipineCytochrome P450 2B6enzyme
NifedipineNuclear receptor subfamily 1 group I member 2target
NifedipineSolute carrier organic anion transporter family member 1B1transporter
NifedipineBile salt export pumptransporter
NifedipineCytochrome P450 2C9enzyme
NifedipineSerum albumincarrier
Nifedipinealpha1-acid glycoproteincarrier
NifedipineCytochrome P450 3A5enzyme
VortioxetineSodium-dependent serotonin transportertarget
Vortioxetine5-hydroxytryptamine receptor 3Atarget
Vortioxetine5-hydroxytryptamine receptor 7target
Vortioxetine5-hydroxytryptamine receptor 1Btarget
Vortioxetine5-hydroxytryptamine receptor 1Atarget
VortioxetineBeta-1 adrenergic receptortarget
VortioxetineSodium-dependent noradrenaline transportertarget
VortioxetineCytochrome P450 2D6enzyme
VortioxetineCytochrome P450 3A4enzyme
VortioxetineCytochrome P450 3A5enzyme
VortioxetineCytochrome P450 2C19enzyme
VortioxetineCytochrome P450 2C9enzyme
VortioxetineCytochrome P450 2A6enzyme
VortioxetineCytochrome P450 2C8enzyme
VortioxetineCytochrome P450 2B6enzyme
CinnarizineHistamine H1 receptortarget
CinnarizineDopamine D2 receptortarget
CinnarizineVoltage-dependent T-type calcium channel subunit alpha-1Htarget
CinnarizineCytochrome P450 2D6enzyme
CinnarizineCytochrome P450 2B6enzyme
CinnarizineCytochrome P450 2C9enzyme
CinnarizineCytochrome P450 1A1enzyme
CinnarizineCytochrome P450 1A2enzyme
CinnarizineCytochrome P450 2A6enzyme
CinnarizineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
CinnarizineVoltage-dependent L-type calcium channel subunit alpha-1Starget
CinnarizineVoltage-dependent L-type calcium channel subunit alpha-1Ftarget
CinnarizineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
CinnarizineVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
CinnarizineVoltage-dependent T-type calcium channel subunit alpha-1Itarget
CinnarizineD(1) dopamine receptortarget
CinnarizineMuscarinic acetylcholine receptortarget
CinnarizineCytochrome P450 3A4enzyme
PropacetamolCholinesteraseenzyme
PropacetamolProstaglandin G/H synthase 1target
PropacetamolProstaglandin G/H synthase 2target
PropacetamolTransient receptor potential cation channel subfamily V member 1target
PropacetamolCannabinoid receptor 1target
PropacetamolCytochrome P450 2E1enzyme
PropacetamolCytochrome P450 1A2enzyme
PropacetamolCytochrome P450 2D6enzyme
PropacetamolUDP-glucuronosyltransferase 1-1enzyme
PropacetamolUDP-glucuronosyltransferase 1-6enzyme
PropacetamolUDP-glucuronosyltransferase 1-9enzyme
PropacetamolUDP-glucuronosyltransferase 2B15enzyme
PropacetamolUDP-glucuronosyltransferase 1-10enzyme
PropacetamolSulfotransferase 1A1enzyme
PropacetamolSulfotransferase 1A3/1A4enzyme
PropacetamolEstrogen sulfotransferaseenzyme
PropacetamolBile salt sulfotransferaseenzyme
PropacetamolArylamine N-acetyltransferase 2enzyme
PropacetamolCytochrome P450 2C9enzyme
PropacetamolCytochrome P450 3A4enzyme
NicotineNeuronal acetylcholine receptor subunit alpha-2target
NicotineNeuronal acetylcholine receptor subunit beta-2target
NicotineNeuronal acetylcholine receptor subunit alpha-7target
NicotineNeuronal acetylcholine receptor subunit alpha-4target
NicotineNeuronal acetylcholine receptor subunit alpha-10target
NicotineNeuronal acetylcholine receptor subunit alpha-9target
NicotineCytochrome P450 2A6enzyme
NicotineCytochrome P450 2E1enzyme
NicotineCytochrome P450 2A13enzyme
NicotineCytochrome P450 2B6enzyme
NicotineNeuronal acetylcholine receptor subunit beta-4target
NicotineNeuronal acetylcholine receptor subunit alpha-3target
NicotineNeuronal acetylcholine receptor subunit alpha-5target
NicotineNeuronal acetylcholine receptor subunit alpha-6target
NicotineNeuronal acetylcholine receptor subunit beta-3target
NicotineSolute carrier family 22 member 2transporter
NicotineSolute carrier family 22 member 1transporter
NicotineSolute carrier family 22 member 3transporter
NicotineSolute carrier family 22 member 5transporter
NicotineSolute carrier family 22 member 4transporter
NicotineCytochrome P450 1A1enzyme
NicotineCytochrome P450 1A2enzyme
NicotineCytochrome P450 2C19enzyme
NicotineCytochrome P450 2C8enzyme
NicotineCytochrome P450 2C9enzyme
NicotineCytochrome P450 2D6enzyme
NicotineCytochrome P450 3A4enzyme
NicotineAmine oxidase [flavin-containing] Aenzyme
NicotineAmine oxidase [flavin-containing] Benzyme
NicotineCytochrome P450 19A1target
NicotineCholine O-acetyltransferasetarget
FormoterolBeta-2 adrenergic receptortarget
FormoterolBeta-1 adrenergic receptortarget
FormoterolBeta-3 adrenergic receptortarget
FormoterolCytochrome P450 2D6enzyme
FormoterolCytochrome P450 2C19enzyme
FormoterolCytochrome P450 2C9enzyme
FormoterolCytochrome P450 2A6enzyme
FormoterolUDP-glucuronosyltransferase 1A1enzyme
FormoterolUDP-glucuronosyltransferase 1-8enzyme
FormoterolUDP-glucuronosyltransferase 1-9enzyme
FormoterolUDP-glucuronosyltransferase 2B7enzyme
FormoterolUDP-glucuronosyltransferase 2B15enzyme
FormoterolSolute carrier family 22 member 1transporter
FormoterolSolute carrier family 22 member 4transporter
FormoterolSolute carrier family 22 member 5transporter
FormoterolSolute carrier family 22 member 3transporter
FormoterolSerum albumincarrier
LetrozoleCytochrome P450 19A1target
LetrozoleCytochrome P450 3A4enzyme
LetrozoleCytochrome P450 2A6enzyme
LetrozoleCytochrome P450 19A1enzyme
LetrozoleCytochrome P450 2C19enzyme
LetrozoleUDP-glucuronosyltransferase 2B7enzyme
LetrozoleSerum albumincarrier
LetrozoleP-glycoprotein 1transporter
ChlorzoxazoneCalcium-activated potassium channel subunit alpha-1target
ChlorzoxazoneCytochrome P450 2E1enzyme
ChlorzoxazoneCytochrome P450 1A2enzyme
ChlorzoxazoneCytochrome P450 2A6enzyme
ChlorzoxazoneCytochrome P450 1A1enzyme
ChlorzoxazoneCytochrome P450 2D6enzyme
ChlorzoxazoneCytochrome P450 3A4enzyme
HalothaneGamma-aminobutyric acid receptor subunit alpha-1target
HalothaneGlycine receptor subunit alpha-1target
HalothaneCalcium-activated potassium channel subunit alpha-1target
HalothaneNADH-ubiquinone oxidoreductase chain 1target
HalothaneIntermediate conductance calcium-activated potassium channel protein 4target
HalothaneRhodopsintarget
HalothaneG protein-activated inward rectifier potassium channel 2target
HalothaneG protein-activated inward rectifier potassium channel 1target
HalothaneGuanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2target
HalothaneNeuropeptide S receptortarget
HalothaneCytochrome P450 2E1enzyme
HalothaneCytochrome P450 2A6enzyme
HalothaneCytochrome P450 3A4enzyme
HalothaneGlutamate receptor ionotropic, NMDA 3Atarget
HalothaneGlutamate receptor ionotropic, NMDA 3Btarget
HalothaneGlutamate receptor ionotropic, NMDA 2Atarget
HalothanePotassium channel subfamily K member 3target
HalothanePotassium channel subfamily K member 9target
HalothaneSerum albumincarrier
HalothaneCytochrome P450 2B6enzyme
HalothaneCytochrome P450 2C9enzyme
HalothaneGABA(A) Receptortarget
HalothanePlasma membrane calcium-transporting ATPasetarget
SelegilineAmine oxidase [flavin-containing] Btarget
SelegilineCytochrome P450 2B6enzyme
SelegilineAmine oxidase [flavin-containing] Atarget
SelegilineCytochrome P450 2A6enzyme
SelegilineCytochrome P450 3A4enzyme
SelegilineP-glycoprotein 1transporter
SelegilineCytochrome P450 1A2enzyme
SelegilineCytochrome P450 2C19enzyme
SelegilineCytochrome P450 2C8enzyme
SelegilineCytochrome P450 2C9enzyme
SelegilineCytochrome P450 2D6enzyme
SelegilineCytochrome P450 2E1enzyme
IfosfamideCytochrome P450 2B6enzyme
IfosfamideDNAtarget
IfosfamideCytochrome P450 3A4enzyme
IfosfamideCytochrome P450 3A5enzyme
IfosfamideCytochrome P450 2C9enzyme
IfosfamideCytochrome P450 2C8enzyme
IfosfamideCytochrome P450 2A6enzyme
IfosfamideCytochrome P450 2C19enzyme
IfosfamideCytochrome P450 2C18enzyme
IfosfamideProstaglandin G/H synthase 1enzyme
IfosfamideNuclear receptor subfamily 1 group I member 2target
Valproic acidHistone deacetylase 9target
Valproic acidShort/branched chain specific acyl-CoA dehydrogenase, mitochondrialtarget
Valproic acidCytochrome P450 2A6enzyme
Valproic acidCytochrome P450 2B6enzyme
Valproic acidCytochrome P450 2C9enzyme
Valproic acidSolute carrier family 22 member 5transporter
Valproic acidSolute carrier family 22 member 6transporter
Valproic acidSolute carrier family 22 member 8transporter
Valproic acidMonocarboxylate transporter 1transporter
Valproic acidSolute carrier family 22 member 7transporter
Valproic acidCytochrome P450 3A5enzyme
Valproic acidUDP-glucuronosyltransferase 1-9enzyme
Valproic acidProstaglandin G/H synthase 1enzyme
Valproic acidCytochrome P450 1A2enzyme
Valproic acidCytochrome P450 2C19enzyme
Valproic acidCytochrome P450 3A4enzyme
Valproic acidUDP-glucuronosyltransferase 1-4enzyme
Valproic acidUDP-glucuronosyltransferase 1-8enzyme
Valproic acidUDP-glucuronosyltransferase 1-10enzyme
Valproic acidUDP-glucuronosyltransferase 1-6enzyme
Valproic acidUDP-glucuronosyltransferase 1-3enzyme
Valproic acidUDP-glucuronosyltransferase 2B7enzyme
Valproic acidUDP-glucuronosyltransferase 2B15enzyme
Valproic acid2-oxoglutarate dehydrogenase, mitochondrialtarget
Valproic acidSuccinate-semialdehyde dehydrogenase, mitochondrialtarget
Valproic acidSodium channel proteintarget
Valproic acidHistone deacetylase 2target
Valproic acidPeroxisome proliferator-activated receptor alphatarget
Valproic acidPeroxisome proliferator-activated receptor deltatarget
Valproic acidPeroxisome proliferator-activated receptor gammatarget
Valproic acidSerum albumincarrier
Valproic acidUDP-glucuronosyltransferase 1-1enzyme
Valproic acidSolute carrier organic anion transporter family member 2B1transporter
NevirapineCytochrome P450 3A4enzyme
NevirapineCytochrome P450 2B6enzyme
NevirapineCytochrome P450 3A5enzyme
NevirapineCytochrome P450 2C9enzyme
NevirapineCytochrome P450 2A6enzyme
NevirapineCytochrome P450 2D6enzyme
NevirapineReverse transcriptase/RNaseHtarget
NevirapineSerum albumincarrier
NevirapineCytochrome P450 1A2enzyme
NevirapineSolute carrier family 22 member 1transporter
NevirapineCytochrome P450 3A7enzyme
FlunarizineHistamine H1 receptortarget
FlunarizineVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
FlunarizineVoltage-dependent T-type calcium channel subunit alpha-1Htarget
FlunarizineVoltage-dependent T-type calcium channel subunit alpha-1Itarget
FlunarizineCalmodulintarget
FlunarizineCytochrome P450 2D6enzyme
FlunarizineCytochrome P450 2C9enzyme
FlunarizineCytochrome P450 1A1enzyme
FlunarizineCytochrome P450 1A2enzyme
FlunarizineCytochrome P450 2A6enzyme
FlunarizineCytochrome P450 3A4enzyme
MontelukastCysteinyl leukotriene receptor 1target
MontelukastArachidonate 5-lipoxygenasetarget
MontelukastCytochrome P450 3A4enzyme
MontelukastCytochrome P450 2C9enzyme
MontelukastCytochrome P450 2C8enzyme
MontelukastSolute carrier organic anion transporter family member 2B1transporter
MontelukastProstaglandin G/H synthase 1enzyme
MontelukastCytochrome P450 2A6enzyme
Cisapride5-hydroxytryptamine receptor 4target
Cisapride5-hydroxytryptamine receptor 3Atarget
CisapridePotassium voltage-gated channel subfamily H member 2target
Cisapride5-hydroxytryptamine receptor 2Atarget
CisaprideCytochrome P450 3A4enzyme
CisaprideCytochrome P450 3A5enzyme
CisaprideCytochrome P450 3A7enzyme
CisaprideCytochrome P450 2A6enzyme
CisaprideCytochrome P450 2B6enzyme
CisaprideCytochrome P450 2C19enzyme
CisaprideCytochrome P450 2C8enzyme
CisaprideCytochrome P450 2C9enzyme
CisaprideCytochrome P450 2D6enzyme
ClomethiazoleGamma-aminobutyric acid receptor subunit alpha-1target
ClomethiazoleCytochrome P450 2A6enzyme
ClomethiazoleCytochrome P450 2B6enzyme
ClomethiazoleCytochrome P450 2C19enzyme
ClomethiazoleCytochrome P450 3A4enzyme
ClozapineDopamine D4 receptortarget
ClozapineHistamine H1 receptortarget
ClozapineDopamine D2 receptortarget
ClozapineNeuron-specific vesicular protein calcyontarget
ClozapineHistamine H4 receptortarget
Clozapine5-hydroxytryptamine receptor 2Atarget
Clozapine5-hydroxytryptamine receptor 1Atarget
Clozapine5-hydroxytryptamine receptor 2Ctarget
ClozapineDopamine D1 receptortarget
ClozapineCytochrome P450 1A2enzyme
ClozapineCytochrome P450 2D6enzyme
ClozapineDopamine D3 receptortarget
ClozapineMuscarinic acetylcholine receptor M1target
ClozapineMuscarinic acetylcholine receptor M2target
ClozapineMuscarinic acetylcholine receptor M3target
ClozapineMuscarinic acetylcholine receptor M4target
ClozapineMuscarinic acetylcholine receptor M5target
Clozapine5-hydroxytryptamine receptor 1Btarget
Clozapine5-hydroxytryptamine receptor 1Dtarget
Clozapine5-hydroxytryptamine receptor 1Etarget
Clozapine5-hydroxytryptamine receptor 3Atarget
Clozapine5-hydroxytryptamine receptor 6target
Clozapine5-hydroxytryptamine receptor 7target
ClozapineAlpha-1A adrenergic receptortarget
ClozapineAlpha-1B adrenergic receptortarget
ClozapineAlpha-2A adrenergic receptortarget
ClozapineAlpha-2B adrenergic receptortarget
ClozapineAlpha-2C adrenergic receptortarget
ClozapineCytochrome P450 2C9enzyme
ClozapineP-glycoprotein 1transporter
ClozapineCytochrome P450 3A4enzyme
ClozapineCytochrome P450 2C19enzyme
ClozapineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
ClozapineUDP-glucuronosyltransferase 1-4enzyme
ClozapineCytochrome P450 1A1enzyme
ClozapineCytochrome P450 2A6enzyme
ClozapineCytochrome P450 2C8enzyme
ClozapineGlutathione S-transferase Ptarget
CyclophosphamideDNAtarget
CyclophosphamideCytochrome P450 2B6enzyme
CyclophosphamideCytochrome P450 2C9enzyme
CyclophosphamideCytochrome P450 3A4enzyme
CyclophosphamideCytochrome P450 2C19enzyme
CyclophosphamideCytochrome P450 2A6enzyme
CyclophosphamideCytochrome P450 2C18enzyme
CyclophosphamideCytochrome P450 2C8enzyme
CyclophosphamideCytochrome P450 3A5enzyme
CyclophosphamideNuclear receptor subfamily 1 group I member 2target
FlunitrazepamCytochrome P450 2C19enzyme
FlunitrazepamUDP-glucuronosyltransferase 2B7enzyme
FlunitrazepamCytochrome P450 2A6enzyme
FlunitrazepamCytochrome P450 2B6enzyme
FlunitrazepamCytochrome P450 2C9enzyme
FlunitrazepamCytochrome P450 3A4enzyme
FlunitrazepamCytochrome P450 2E1enzyme
FlunitrazepamUDP-glucuronosyltransferase 1-1enzyme
FlunitrazepamUDP-glucuronosyltransferase 1-3enzyme
FlunitrazepamGABA(A) Receptortarget
FlunitrazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
FluorouracilThymidylate synthasetarget
FluorouracilCytochrome P450 1A2enzyme
FluorouracilThymidine phosphorylaseenzyme
FluorouracilSerum albumincarrier
FluorouracilCytochrome P450 2C9enzyme
FluorouracilDihydropyrimidine dehydrogenase [NADP(+)]enzyme
FluorouracilUridine phosphorylase 1enzyme
FluorouracilUridine phosphorylase 2enzyme
FluorouracilDNAtarget
FluorouracilRNAtarget
FluorouracilCytochrome P450 2A6enzyme
FluorouracilCytochrome P450 2C8enzyme
FluorouracilMethylenetetrahydrofolate reductaseenzyme
FluorouracilThymidylate synthaseenzyme
FluorouracilUridine 5'-monophosphate synthaseenzyme
FluorouracilAmidophosphoribosyltransferaseenzyme
FluorouracilSolute carrier family 22 member 7transporter
FluorouracilEquilibrative nucleoside transporter 1transporter
FluorouracilATP-binding cassette sub-family G member 2transporter
FluorouracilCanalicular multispecific organic anion transporter 2transporter
FluorouracilMultidrug resistance-associated protein 4transporter
FluorouracilMultidrug resistance-associated protein 5transporter
FluorouracilThyroxine-binding globulincarrier
LidocaineSodium channel protein type 5 subunit alphatarget
LidocaineSodium channel protein type 10 subunit alphatarget
LidocaineEpidermal growth factor receptortarget
LidocaineSodium channel protein type 9 subunit alphatarget
LidocaineCytochrome P450 1A2enzyme
LidocaineCytochrome P450 2D6enzyme
LidocaineCytochrome P450 3A4enzyme
LidocaineCytochrome P450 3A5enzyme
LidocaineCytochrome P450 3A7enzyme
LidocaineSolute carrier family 22 member 5transporter
LidocaineP-glycoprotein 1transporter
LidocaineCytochrome P450 2A6enzyme
LidocaineCytochrome P450 2B6enzyme
LidocaineCytochrome P450 2C8enzyme
LidocaineCytochrome P450 2C9enzyme
LidocaineSodium channel protein type 4 subunit alphatarget
LidocaineAlpha-1-acid glycoprotein 1target
LidocaineAlpha-1-acid glycoprotein 2target
MethoxyfluraneCalcium-transporting ATPase type 2C member 1target
MethoxyfluraneNADH-ubiquinone oxidoreductase chain 1target
MethoxyfluraneGamma-aminobutyric acid receptor subunit alpha-1target
MethoxyfluranePotassium voltage-gated channel subfamily A member 1target
MethoxyfluraneGlutamate receptor 1target
MethoxyfluraneGlycine receptor subunit alpha-1target
MethoxyfluraneCytochrome P450 2E1enzyme
MethoxyfluraneCytochrome P450 1A2enzyme
MethoxyfluraneCytochrome P450 2A6enzyme
MethoxyfluraneCytochrome P450 2B6enzyme
MethoxyfluraneCytochrome P450 2C9enzyme
MethoxyfluraneCytochrome P450 2D6enzyme
MethoxyfluraneCytochrome P450 3A4enzyme
MethoxyfluraneGABA(A) Receptortarget
AcetaminophenProstaglandin G/H synthase 1target
AcetaminophenProstaglandin G/H synthase 2target
AcetaminophenCytochrome P450 1A2enzyme
AcetaminophenCytochrome P450 2E1enzyme
AcetaminophenP-glycoprotein 1transporter
AcetaminophenCytochrome P450 2D6enzyme
AcetaminophenCytochrome P450 2A6enzyme
AcetaminophenCytochrome P450 3A4enzyme
AcetaminophenUDP-glucuronosyltransferase 1-1enzyme
AcetaminophenUDP-glucuronosyltransferase 1-6enzyme
AcetaminophenUDP-glucuronosyltransferase 1-9enzyme
AcetaminophenUDP-glucuronosyltransferase 2B15enzyme
AcetaminophenSulfotransferase 1A1enzyme
AcetaminophenSulfotransferase 1A3/1A4enzyme
AcetaminophenArylamine N-acetyltransferase 2enzyme
AcetaminophenProstaglandin E synthase 3target
AcetaminophenTransient receptor potential cation channel subfamily V member 1target
AcetaminophenSerum albumincarrier
AcetaminophenFatty-acid amide hydrolase 1enzyme
AcetaminophenGlutathione S-transferase Penzyme
AcetaminophenGlutathione S-transferase Mu 1enzyme
PhenacetinProstaglandin G/H synthase 1target
PhenacetinCytochrome P450 1A2enzyme
PhenacetinCytochrome P450 2D6enzyme
PhenacetinSolute carrier family 22 member 6transporter
PhenacetinCytochrome P450 1A1enzyme
PhenacetinCytochrome P450 2A13enzyme
PhenacetinCytochrome P450 2A6enzyme
PhenacetinCytochrome P450 2C19enzyme
PhenacetinCytochrome P450 2C9enzyme
PhenacetinCytochrome P450 2E1enzyme
PhenacetinCytochrome P450 3A4enzyme
AntipyrineCytochrome P450 2C8enzyme
AntipyrineCytochrome P450 2C9enzyme
AntipyrineCytochrome P450 1A2enzyme
AntipyrineCytochrome P450 2C19enzyme
AntipyrineCytochrome P450 3A4enzyme
AntipyrineSolute carrier family 22 member 6transporter
AntipyrineCytochrome P450 2A6enzyme
AntipyrineCytochrome P450 2B6enzyme
AntipyrineCytochrome P450 2C18enzyme
AntipyrineCytochrome P450 2D6enzyme
AntipyrineCytochrome P450 2E1enzyme
AntipyrineProstaglandin G/H synthase 2target
AntipyrineProstaglandin G/H synthase 1target
SevofluraneCalcium-transporting ATPase type 2C member 1target
SevofluraneNADH-ubiquinone oxidoreductase chain 1target
SevofluraneGlycine receptor subunit alpha-1target
SevofluraneGlutamate receptor 1target
SevofluraneGamma-aminobutyric acid receptor subunit alpha-1target
SevofluraneCytochrome P450 2E1enzyme
SevofluraneSerum albumincarrier
SevofluraneCytochrome P450 2A6enzyme
SevofluraneCytochrome P450 2B6enzyme
SevofluraneCytochrome P450 3A4enzyme
SevofluraneGABA(A) Receptortarget
SevofluraneMitochondrial potassium channeltarget
TamoxifenEstrogen receptor alphatarget
TamoxifenEstrogen receptor betatarget
TamoxifenCytochrome P450 2C9enzyme
TamoxifenCytochrome P450 3A4enzyme
TamoxifenCytochrome P450 2D6enzyme
TamoxifenCytochrome P450 2C8enzyme
TamoxifenCytochrome P450 2B6enzyme
TamoxifenLiver carboxylesterase 1enzyme
TamoxifenCytochrome P450 3A5enzyme
TamoxifenCytochrome P450 1A1enzyme
TamoxifenCytochrome P450 1B1enzyme
TamoxifenCytochrome P450 2C19enzyme
TamoxifenDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
TamoxifenDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
TamoxifenCytochrome P450 3A7enzyme
TamoxifenP-glycoprotein 1transporter
TamoxifenATP-binding cassette sub-family G member 2transporter
TamoxifenCytochrome P450 19A1enzyme
TamoxifenCytochrome P450 2A6enzyme
TamoxifenCytochrome P450 2E1enzyme
TamoxifenUDP-glucuronosyltransferase 1-10enzyme
TamoxifenSulfotransferase 1A1enzyme
TamoxifenCanalicular multispecific organic anion transporter 1transporter
Tamoxifen3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerasetarget
TamoxifenProtein kinase Ctarget
TamoxifenAndrogen receptortarget
TamoxifenPotassium voltage-gated channel subfamily H member 2target
TamoxifenNuclear receptor subfamily 1 group I member 2target
TamoxifenEstrogen-related receptor gammatarget
TamoxifenSex hormone-binding globulintarget
TamoxifenBile salt export pumptransporter
TamoxifenThyroxine-binding globulincarrier
TamoxifenBile salt sulfotransferaseenzyme
TamoxifenCytochrome P450 1A2enzyme
TamoxifenUDP-glucuronosyltransferase 2B7enzyme
TamoxifenUDP-glucuronosyltransferase 2B17enzyme
TamoxifenEstrogen sulfotransferaseenzyme
TamoxifenATP-binding cassette sub-family A member 1transporter
TamoxifenMitogen-activated protein kinase 8target
TamoxifenSerum albumincarrier
ZidovudineSerum albumincarrier
ZidovudineCytochrome P450 2A6enzyme
ZidovudineCytochrome P450 2C9enzyme
ZidovudineCytochrome P450 3A4enzyme
ZidovudineReverse transcriptase/RNaseHtarget
ZidovudineSolute carrier family 22 member 2transporter
ZidovudineSolute carrier family 22 member 6transporter
ZidovudineSolute carrier family 22 member 7transporter
ZidovudineSolute carrier family 22 member 8transporter
ZidovudineSolute carrier family 22 member 11transporter
ZidovudineSodium/nucleoside cotransporter 1transporter
ZidovudineEquilibrative nucleoside transporter 2transporter
ZidovudineP-glycoprotein 1transporter
ZidovudineMultidrug resistance-associated protein 4transporter
ZidovudineMultidrug resistance-associated protein 5transporter
ZidovudineATP-binding cassette sub-family G member 2transporter
ZidovudineTelomerase reverse transcriptasetarget
ZidovudineThymidine kinase, cytosolicenzyme
ZidovudineUDP-glucuronosyltransferase 2B7enzyme
ZidovudineUDP-glucuronosyltransferase 1-1enzyme
FlurazepamCytochrome P450 3A4enzyme
FlurazepamP-glycoprotein 1transporter
FlurazepamCytochrome P450 2E1enzyme
FlurazepamCytochrome P450 2A6enzyme
FlurazepamSolute carrier family 22 member 2transporter
FlurazepamGABA(A) Receptortarget
FlurazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
TretinoinRetinoic acid receptor gammatarget
TretinoinRetinoic acid receptor RXR-betatarget
TretinoinRetinal dehydrogenase 1target
TretinoinRetinoic acid-induced protein 3target
TretinoinRetinoic acid receptor RXR-gammatarget
TretinoinRetinal dehydrogenase 2target
TretinoinRetinoic acid receptor responder protein 1target
TretinoinCytochrome P450 2C8enzyme
TretinoinCellular retinoic acid-binding protein 1transporter
TretinoinCellular retinoic acid-binding protein 2transporter
TretinoinCytochrome P450 2B6enzyme
TretinoinCytochrome P450 3A4enzyme
TretinoinCytochrome P450 3A5enzyme
TretinoinCytochrome P450 2A6enzyme
TretinoinCytochrome P450 3A7enzyme
TretinoinCytochrome P450 2C18enzyme
TretinoinCytochrome P450 2C9enzyme
TretinoinCytochrome P450 4A11enzyme
TretinoinCytochrome P450 1A1enzyme
TretinoinRetinoic acid receptor alphatarget
TretinoinRetinoic acid receptor betatarget
TretinoinLipocalin-1target
TretinoinOdorant-binding protein 2atarget
TretinoinRetinol-binding protein 4target
TretinoinSerum albumincarrier
Tretinoin[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrialtarget
TretinoinRetinoic acid receptor RXR-alphatarget
TretinoinCytochrome P450 26A1target
TretinoinCytochrome P450 26B1target
TretinoinCytochrome P450 26C1target
TretinoinHematopoietic prostaglandin D synthasetarget
ArformoterolBeta-2 adrenergic receptortarget
ArformoterolCytochrome P450 2D6enzyme
ArformoterolCytochrome P450 2C19enzyme
ArformoterolCytochrome P450 2A6enzyme
ArformoterolCytochrome P450 2C9enzyme
Lorcaserin5-hydroxytryptamine receptor 2Ctarget
LorcaserinCytochrome P450 1A2enzyme
LorcaserinCytochrome P450 2A6enzyme
LorcaserinCytochrome P450 2B6enzyme
LorcaserinCytochrome P450 2C19enzyme
LorcaserinCytochrome P450 2D6enzyme
LorcaserinCytochrome P450 3A4enzyme
LorcaserinDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
LorcaserinCytochrome P450 1A1enzyme
DapagliflozinSodium/glucose cotransporter 2target
DapagliflozinCytochrome P450 1A1enzyme
DapagliflozinCytochrome P450 1A2enzyme
DapagliflozinCytochrome P450 2A6enzyme
DapagliflozinCytochrome P450 2C9enzyme
DapagliflozinCytochrome P450 2D6enzyme
DapagliflozinCytochrome P450 3A4enzyme
DapagliflozinUDP-glucuronosyltransferase 1-9enzyme
DapagliflozinUDP-glucuronosyltransferase 2B4enzyme
DapagliflozinUDP-glucuronosyltransferase 2B7enzyme
DapagliflozinP-glycoprotein 1transporter
TegafurCytochrome P450 2A6enzyme
TegafurThymidylate synthasetarget
TegafurCytochrome P450 1A2enzyme
TegafurCytochrome P450 2C8enzyme
TegafurCytochrome P450 2E1enzyme
TegafurCytochrome P450 3A5enzyme
TegafurThyroxine-binding globulincarrier
Tegafur-uracilCytochrome P450 2A6enzyme
Tegafur-uracilDihydropyrimidine dehydrogenase [NADP(+)]enzyme
Tegafur-uracilDihydropyrimidine dehydrogenase [NADP(+)]target
Tegafur-uracilThymidylate synthasetarget
Tegafur-uracilRNAtarget
Tegafur-uracilDNAtarget
Tegafur-uracilSolute carrier family 22 member 7transporter
Tegafur-uracilEquilibrative nucleoside transporter 1transporter
Tegafur-uracilEquilibrative nucleoside transporter 2transporter
Tegafur-uracilSodium/nucleoside cotransporter 1transporter
Tegafur-uracilSodium/nucleoside cotransporter 2transporter
Tegafur-uracilSolute carrier family 28 member 3transporter
AsunaprevirGenome polyproteintarget
AsunaprevirCytochrome P450 3A4enzyme
AsunaprevirCytochrome P450 3A5enzyme
AsunaprevirCytochrome P450 2A6enzyme
AsunaprevirCytochrome P450 2B6enzyme
AsunaprevirCytochrome P450 2C9enzyme
AsunaprevirCytochrome P450 2C19enzyme
AsunaprevirCytochrome P450 2D6enzyme
AsunaprevirSolute carrier organic anion transporter family member 1B1transporter
AsunaprevirSolute carrier organic anion transporter family member 1B3transporter
AsunaprevirSolute carrier organic anion transporter family member 2B1transporter
AsunaprevirP-glycoprotein 1transporter
ArtesunateMalaria protein EXP-1target
ArtesunateCytochrome P450 2A6enzyme
ArtesunateUDP-glucuronosyltransferase 2B7enzyme
ArtesunateUDP-glucuronosyltransferase 1-9enzyme
ArtesunateATP-binding cassette sub-family G member 2transporter
ArtesunateP-glycoprotein 1transporter
ArtesunateSolute carrier organic anion transporter family member 1B1transporter
ArtesunateSolute carrier family 22 member 8transporter
ArtesunateSerum albumincarrier
MetronidazoleOxygen-insensitive NADPH nitroreductasetarget
MetronidazoleCytochrome P450 2C9enzyme
MetronidazoleCytochrome P450 3A4enzyme
MetronidazoleCytochrome P450 2C8enzyme
MetronidazoleUDP-glucuronosyltransferase 1-1enzyme
MetronidazoleAnaerobic bacterial DNAtarget
MetronidazoleProtozoal DNAtarget
MetronidazoleP-glycoprotein 1transporter
MetronidazoleCytochrome P450 2A6enzyme
MetronidazoleCytochrome P450 3A5enzyme
MetronidazoleCytochrome P450 3A7enzyme
ApremilastPhosphodiesterase isozyme 4target
ApremilastCytochrome P450 3A4enzyme
ApremilastCytochrome P450 2A6enzyme
ApremilastCytochrome P450 1A2enzyme
ApremilastP-glycoprotein 1transporter
AzelastineHistamine H1 receptortarget
AzelastineCytochrome P450 1A2enzyme
AzelastineCytochrome P450 2D6enzyme
AzelastineCytochrome P450 3A4enzyme
AzelastineCytochrome P450 2C19enzyme
AzelastineCytochrome P450 1A1enzyme
AzelastineCytochrome P450 3A5enzyme
AzelastineCytochrome P450 2C9enzyme
AzelastineCytochrome P450 2C8enzyme
AzelastineP-glycoprotein 1transporter
AzelastineCytochrome P450 2A6enzyme
AzelastineCytochrome P450 2E1enzyme
AzelastineHistamine H2 receptortarget
AzelastinePhospholipase A2target
AzelastineLeukotriene C4 synthasetarget
AzelastineCytochrome P450 2B6enzyme
PlitidepsinCytochrome P450 3A4enzyme
PlitidepsinCytochrome P450 2A6enzyme
PlitidepsinCytochrome P450 2E1enzyme
PlitidepsinCytochrome P450 4A11enzyme
NorethisteroneProgesterone receptortarget
NorethisteroneP-glycoprotein 1transporter
NorethisteroneCytochrome P450 2C19enzyme
NorethisteroneSerum albumincarrier
NorethisteroneSex hormone-binding globulincarrier
NorethisteroneAldo-keto reductase family 1 member C4enzyme
Norethisterone3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme
Norethisterone3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme
Norethisterone3-oxo-5-beta-steroid 4-dehydrogenaseenzyme
NorethisteroneCytochrome P450 3A4enzyme
NorethisteroneCytochrome P450 1A2enzyme
NorethisteroneCytochrome P450 2A6enzyme
NorethisteroneGlucocorticoid receptortarget
NorethisteroneAndrogen receptortarget
CenobamateUDP-glucuronosyltransferase 2B7enzyme
CenobamateUDP-glucuronosyltransferase 2B4enzyme
CenobamateCytochrome P450 2E1enzyme
CenobamateCytochrome P450 2A6enzyme
CenobamateCytochrome P450 2B6enzyme
CenobamateCytochrome P450 2C19enzyme
CenobamateCytochrome P450 3A4enzyme
CenobamateCytochrome P450 3A5enzyme
CenobamateSerum albumincarrier
CenobamateCytochrome P450 2C8enzyme
PhenytoinSodium channel protein type 5 subunit alphatarget
PhenytoinSodium channel protein type 1 subunit alphatarget
PhenytoinCytochrome P450 2C8enzyme
PhenytoinCytochrome P450 2C19enzyme
PhenytoinCytochrome P450 2C9enzyme
PhenytoinCytochrome P450 2B6enzyme
PhenytoinCytochrome P450 3A5enzyme
PhenytoinSerum albumincarrier
PhenytoinCytochrome P450 3A4enzyme
PhenytoinSolute carrier organic anion transporter family member 1C1transporter
PhenytoinP-glycoprotein 1transporter
PhenytoinCanalicular multispecific organic anion transporter 1transporter
PhenytoinCytochrome P450 11B1, mitochondrialenzyme
PhenytoinCytochrome P450 3A7enzyme
PhenytoinNuclear receptor subfamily 1 group I member 2target
PhenytoinSodium channel subunit beta-1target
PhenytoinSodium channel protein type 3 subunit alphatarget
PhenytoinUDP-glucuronosyltransferase 1-1enzyme
PhenytoinUDP-glucuronosyltransferase 1-6enzyme
PhenytoinUDP-glucuronosyltransferase 1-9enzyme
PhenytoinThyroxine-binding globulincarrier
PhenytoinPotassium voltage-gated channel subfamily H member 2target
PhenytoinVoltage-dependent L-type calcium channeltarget
PhenytoinSodium channel protein type 2 subunit alphatarget
PhenytoinSodium channel protein type 8 subunit alphatarget
PhenytoinGABA(A) Receptortarget
PhenytoinCytochrome P450 1A2enzyme
PhenytoinCytochrome P450 2A6enzyme
PhenytoinCytochrome P450 2D6enzyme
PhenytoinCytochrome P450 2E1enzyme
PhenytoinEpoxide hydrolase 1enzyme
PhenytoinUDP-glucuronosyltransferase 1-4enzyme
PhenytoinCatechol O-methyltransferaseenzyme
PhenytoinNAD(P)H dehydrogenase [quinone] 1enzyme
PhenytoinCytochrome P450 2C18enzyme
BelinostatHistone deacetylasetarget
BelinostatCytochrome P450 1A2enzyme
BelinostatUDP-glucuronosyltransferase 1-4enzyme
BelinostatCytochrome P450 2C8enzyme
BelinostatCytochrome P450 2C9enzyme
BelinostatP-glycoprotein 1transporter
BelinostatCytochrome P450 3A4enzyme