Name
Furans
Accession Number
DBCAT000766
Description

Compounds with a 5-membered ring of four carbons and an oxygen. They are aromatic heterocycles. The reduced form is tetrahydrofuran.

Drugs
DrugDrug Description
NitrofuralA topical antibacterial for the prevention and treatment of bacterial infections of the skin.
FurazolidoneA drug for the treatment of infectious diarrhea.
NitrofurantoinAn antibiotic used to treat urinary tract infections.
RanitidineA histamine H2 antagonist used to treat duodenal ulcers, Zollinger-Ellison syndrome, gastric ulcers, GERD, and erosive esophagitis.
DarunavirA HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies.
Homoserine LactoneNot Available
gamma-ButyrolactoneOne of the furans with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used...
FirocoxibUsed for the treatment of pain inflammation and fever in horses and dogs.
LasalocidLasalocid is an agent that presents antibacterial and coccidiostat activities. It is produced by strains of Streptomyces lasaliensis.
MonensinMonensin is a polyether isolated from Streptomyces cinnamonensis that presents antibiotic properties. It is widely used in ruminant animal feeds.
NifurpirinolNot Annotated
SemduramicinNot Annotated
NifurtimoxAn antiparasitic drug used for the treatment of Chagas disease (Trypanosoma cruzi infection).
NifurzideNot Annotated
FurazidinNot Annotated
NaftidrofurylA peripheral vasodilator indicated in the treatment of chronic venous ulcers.
NifuratelA nitrofuran derivative indicated in the treatment of leucorrhea, vulvovaginal infections, and urinary tract infections.
NifurtoinolNot Annotated
NifuroxazideAn antibiotic indicated in the treatment of susceptible gastrointestinal infections.
NigericinA polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus. (From Merck Index, 11th ed)
FuraltadoneIndicated in combination with other drugs for the treatment of otitis media and externa.
Drugs & Drug Targets
DrugTargetType
NitrofuralGlutathione reductasetarget
NitrofuralXanthine dehydrogenase/oxidaseenzyme
FurazolidoneDNAtarget
FurazolidoneAmine oxidase [flavin-containing] Benzyme
FurazolidoneAmine oxidase [flavin-containing] Aenzyme
Nitrofurantoin30S ribosomal protein S10target
NitrofurantoinOxygen-insensitive NADPH nitroreductasetarget
NitrofurantoinProbable pyruvate-flavodoxin oxidoreductasetarget
NitrofurantoinATP-binding cassette sub-family G member 2transporter
NitrofurantoinNADPH--cytochrome P450 reductaseenzyme
NitrofurantoinBile salt export pumptransporter
NitrofurantoinP-glycoprotein 1transporter
NitrofurantoinCanalicular multispecific organic anion transporter 1transporter
RanitidineHistamine H2 receptortarget
RanitidineCytochrome P450 1A2enzyme
RanitidineCytochrome P450 2D6enzyme
RanitidineSolute carrier family 22 member 1transporter
RanitidineP-glycoprotein 1transporter
RanitidineSolute carrier family 22 member 8transporter
RanitidineCytochrome P450 3A4enzyme
RanitidineAcetylcholinesterasetarget
RanitidineSolute carrier family 22 member 2transporter
RanitidineAcetylcholinesteraseenzyme
DarunavirHuman immunodeficiency virus type 1 proteasetarget
DarunavirCytochrome P450 3A4enzyme
DarunavirSolute carrier organic anion transporter family member 1B1transporter
DarunavirP-glycoprotein 1transporter
DarunavirSerum albumincarrier
DarunavirAlpha-1-acid glycoprotein 1carrier
DarunavirCytochrome P450 2D6enzyme
Homoserine LactoneSodium/hydrogen exchanger 1target
gamma-ButyrolactoneO-GlcNAcase NagJtarget
FirocoxibProstaglandin G/H synthase 2target
MonensinP-glycoprotein 1transporter
NifurtimoxATP-binding cassette sub-family G member 2transporter
NifurtimoxNitroreductasestarget
NifurtimoxNitroreductasesenzyme
NifurtimoxSerum albumincarrier
NifurtimoxGlyceraldehyde-3-phosphate dehydrogenase, glycosomaltarget