Accession Number

Compounds with a 5-membered ring of four carbons and an oxygen. They are aromatic heterocycles. The reduced form is tetrahydrofuran.

DrugDrug Description
NitrofuralA topical antibacterial for the prevention and treatment of bacterial infections of the skin.
NitrofurantoinAn antibiotic used to treat urinary tract infections.
RanitidineA histamine H2 antagonist used to treat duodenal ulcers, Zollinger-Ellison syndrome, gastric ulcers, GERD, and erosive esophagitis.
DarunavirA HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies.
LasalocidLasalocid is an agent that presents antibacterial and coccidiostat activities. It is produced by strains of Streptomyces lasaliensis.
MonensinMonensin is a polyether isolated from Streptomyces cinnamonensis that presents antibiotic properties. It is widely used in ruminant animal feeds.
NifurtimoxAn antiparasitic drug used for the treatment of Chagas disease (Trypanosoma cruzi infection).
NaftidrofurylA peripheral vasodilator indicated in the treatment of chronic venous ulcers.
NigericinA polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus. (From Merck Index, 11th ed)
gamma-ButyrolactoneOne of the furans with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used...
FurazolidoneA drug for the treatment of infectious diarrhea.
Homoserine LactoneNot Available
FirocoxibUsed for the treatment of pain inflammation and fever in horses and dogs.
NifurpirinolNot Annotated
SemduramicinNot Annotated
NifurzideNot Annotated
FurazidinNot Annotated
NifuratelA nitrofuran derivative indicated in the treatment of leucorrhea, vulvovaginal infections, and urinary tract infections.
NifurtoinolNot Annotated
NifuroxazideAn antibiotic indicated in the treatment of susceptible gastrointestinal infections.
FuraltadoneIndicated in combination with other drugs for the treatment of otitis media and externa.
FurfuralNot Annotated
5-HydroxymethylfurfuralAes-103 has been used in trials studying the treatment and prevention of Hypoxia, Anemia, Sickle Cell, and Sickle Cell Disease.
Drugs & Drug Targets
NitrofuralGlutathione reductasetarget
NitrofuralXanthine dehydrogenase/oxidaseenzyme
Nitrofurantoin30S ribosomal protein S10target
NitrofurantoinOxygen-insensitive NADPH nitroreductasetarget
NitrofurantoinProbable pyruvate-flavodoxin oxidoreductasetarget
NitrofurantoinATP-binding cassette sub-family G member 2transporter
NitrofurantoinNADPH--cytochrome P450 reductaseenzyme
NitrofurantoinBile salt export pumptransporter
NitrofurantoinP-glycoprotein 1transporter
NitrofurantoinCanalicular multispecific organic anion transporter 1transporter
RanitidineHistamine H2 receptortarget
RanitidineCytochrome P450 1A2enzyme
RanitidineCytochrome P450 2D6enzyme
RanitidineSolute carrier family 22 member 1transporter
RanitidineP-glycoprotein 1transporter
RanitidineSolute carrier family 22 member 8transporter
RanitidineCytochrome P450 3A4enzyme
RanitidineSolute carrier family 22 member 2transporter
DarunavirHuman immunodeficiency virus type 1 proteasetarget
DarunavirCytochrome P450 3A4enzyme
DarunavirSolute carrier organic anion transporter family member 1B1transporter
DarunavirP-glycoprotein 1transporter
DarunavirSerum albumincarrier
DarunavirAlpha-1-acid glycoprotein 1carrier
DarunavirCytochrome P450 2D6enzyme
MonensinP-glycoprotein 1transporter
NifurtimoxATP-binding cassette sub-family G member 2transporter
NifurtimoxSerum albumincarrier
NifurtimoxGlyceraldehyde-3-phosphate dehydrogenase, glycosomaltarget
gamma-ButyrolactoneO-GlcNAcase NagJtarget
FurazolidoneAmine oxidase [flavin-containing] Benzyme
FurazolidoneAmine oxidase [flavin-containing] Aenzyme
Homoserine LactoneSodium/hydrogen exchanger 1target
FirocoxibProstaglandin G/H synthase 2target