Neurotransmitter Uptake Inhibitors
- Neurotransmitter Uptake Inhibitors
- Accession Number
Drugs that inhibit the transport of neurotransmitters into axon terminals or into storage vesicles within terminals. For many transmitters, uptake determines the time course of transmitter action so inhibiting uptake prolongs the activity of the transmitter. Blocking uptake may also deplete available transmitter stores. Many clinically important drugs are uptake inhibitors although the indirect reactions of the brain rather than the acute block of uptake itself is often responsible for the therapeutic effects.
Drug Drug Description Fluvoxamine A selective serotonin-reuptake inhibitor used to treat obsessive-compulsive disorder. Amphetamine A CNS stimulant and sympathomimetic agent indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). Citalopram A selective serotonin reuptake inhibitor (SSRI) used in the treatment of depression. Benzatropine An anticholinergic drug used to treat Parkinson's disease (PD) and extrapyramidal symptoms, except tardive dyskinesia. Atomoxetine A selective norepinephrine reuptake inhibitor (SNRI) used in the management of Attention Deficit Hyperactivity Disorder (ADHD). Amitriptyline A tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety. Methylphenidate A stimulant used in the management of Attention Deficit Hyperactivity Disorder (ADHD). Imipramine A tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis. Fluoxetine A selective serotonin reuptake inhibitor used to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I. Duloxetine A serotonin norepinephrine reuptake inhibitor used to treat generalized anxiety disorder, neuropathic pain, osteoarthritis, and stress incontinence. Nortriptyline A tricyclic antidepressant used in the treatment of depression. Amoxapine A tricyclic antidepressant used in the treatment of neurotic or reactive depressive disorders and endogenous or psychotic depression. Fenfluramine Fenfluramine is a phenethylamine that is structurally similar to serotonin. Due to its ability to increase extracellular serotonin levels, modulate serotonergic and other neurologic receptors, and control neurotransmission, it is effective in treating pharmacoresistant seizures. Trazodone A serotonin uptake inhibitor used to treat major depressive disorder. Paroxetine A selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder. Cocaine An ester local anesthetic used during diagnostic procedures and surgeries in or through the nasal cavities. Sertraline A selective serotonin reuptake inhibitor (SSRI) indicated to treat major depressive disorder, social anxiety disorder and many other psychiatric conditions. Bupropion A norepinephrine and dopamine reuptake inhibitor used in the treatment of major depressive disorder (MDD), seasonal affective disorder (SAD), and as an aid to smoking cessation. Escitalopram A selective serotonin re-uptake inhibitor used in the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), and other select psychiatric disorders such as obsessive-compulsive disorder (OCD). Lisdexamfetamine A central nervous system (CNS) stimulant used to treat attention deficit hyperactivity disorder (ADHD) and moderate to severe eating disorders. Dextroamphetamine A sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. Milnacipran A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of fibromyalgia and a short-term treatment of major depressive disorder. NS-2359 Investigated for use/treatment in addictions, attention deficit/hyperactivity disorder (ADHD), and depression. Vilazodone An antidepressant agent used for the treatment of major depressive disorder that targets the 5-HT transporter and 5-HT1A receptors. Desvenlafaxine An antidepressant agent and SNRI used for the treatment of major depressive disorders in adults. Dexmethylphenidate A norepinephrine-dopamine reuptake inhibitor used in the treatment of ADHD in conjunction with other therapies. Cyclo(his-pro) Not Available Serdexmethylphenidate A prodrug of the CNS stimulant dexmethylphenidate used as a first-line treatment for Attention Deficit Hyperactivity Disorder (ADHD). Reserpine For the treatment of hypertension Reboxetine A drug used for the acute treatment of major depression and for maintenance therapy of depression. Venlafaxine A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of major depression. Protriptyline A tricyclic antidepressant that is indicated in the treatment of depression only under close clinical supervision. Mazindol A sympathomimetic used to treat obesity in combination with lifestyle modifications. Trimipramine A tricyclic antidepressant used to treat depression. Benzphetamine A sympathomimetic used to manage exogenous obesity short term. Tiagabine An antiepileptic used to treat partial seizures. Maprotiline A tetracyclic antidepressant used to treat depressive illness, major depressive disorder, bipolar disorder, and anxiety associated with depression. Nefazodone An antidepressant used in the treatment of depression. Desipramine A tricyclic antidepressant used in the treatment of depression. Clomipramine A tricyclic antidepressant used in the treatment of obsessive-compulsive disorder and disorders with an obsessive-compulsive component, such as depression, schizophrenia, and Tourette’s disorder. Midomafetamine Clinical trials are now testing the therapeutic potential of MDMA for post-traumatic stress disorder (PTSD) and anxiety associated with terminal cancer. MDMA is one of the four most widely used... Tenamfetamine An amphetamine derivative that inhibits uptake of catecholamine neurotransmitters. It is a hallucinogen. It is less toxic than its methylated derivative but in sufficient doses may still destroy serotonergic neurons... Methylenedioxyethamphetamine Not Available Metamfetamine A sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and exogenous obesity. Vanoxerine An investigational dopamine transporter antagonist suggested to be beneficial in the treatment of cocaine addiction. Nomifensine Nomifensine, formerly marketed as Merital capsules, was associated with an increased incidence of hemolytic anemia. The approved application holder removed Merital capsules from the market on January 23, 1986. FDA... Zimelidine For the treatment of depression. Tetrabenazine A vesicular monoamine transporter 2 (VMAT) inhibitor used for the management of chorea associated with Huntington's Disease. Tapentadol An opioid used to manage severe pain that has not responded to non-opioid medications, and for which opioid analgesic therapy is appropriate. Tyramine Tyramine (4-hydroxyphenethylamine; para-tyramine, mydrial or uteramin) is a naturally occurring monoamine compound and trace amine derived from the amino acid tyrosine. Tyramine acts by inducing the release of catecholamine. An... Levomilnacipran A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used to treat major depressive disorder (MDD). Indalpine Indalpine was one of the first selective serotonin reuptake inhibitors to reach the American market. It was initially marketed by Pharmuka. However, after the emergence of widespread concern regarding adverse... Vortioxetine A serotonin modulating antidepressant indicated for the treatment of major depressive disorder (MDD). Dosulepin A tricyclic antidepressant commonly used only in patients for whom alternative therapies are ineffective due to its toxicity potential. Viloxazine A selective norepinephrine reuptake inhibitor indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in adults in children. Opipramol A medication to treat general anxiety and somatoform disorders. Alaproclate Alaproclate was developed as one of the first selective serotonin reuptake inhibitor (SSRI) antidepressants by Astra AB (now AstraZeneca) in the 1970s. Development was discontinued due to concerns over hepatotoxicity...
- Drugs & Drug Targets