Antiemetics and Antinauseants

Name
Antiemetics and Antinauseants
Accession Number
DBCAT002342
Description

Not Available

ATC Classification
Drugs
DrugDrug Description
PalonosetronA serotonin antagonist used in the prophylaxis or management of vomiting that results from emetogenic chemotherapy, and for the management of postoperative nausea and vomiting.
DronabinolA synthetic delta-9-THC used in the treatment of anorexia and weight loss in HIV patients as well as nausea and vomiting in cancer chemotherapy.
NabiloneA synthetic delta-9-THC used in the treatment of anorexia and weight loss in HIV patients as well as nausea and vomiting in cancer chemotherapy.
AprepitantA substance P/neurokinin 1 receptor antagonist used to treat nausea and vomiting caused by chemotherapy and surgery.
ScopolamineA belladonna alkaloid with anticholinergic effects indicated for the treatment of nausea and vomiting associated with motion sickness and postoperative nausea and vomiting (PONV).
DolasetronAn antinauseant and antiemetic used in chemotherapy and postoperatively.
GranisetronA 5HT3 antagonist used to treat nausea and vomiting in cancer therapy and postoperatively.
OndansetronA serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively.
CasopitantInvestigated for use/treatment in urinary incontinence and adverse effects (chemotherapy).
ChlorobutanolNo approved therapeutic indications on its own.
TropisetronA 5HT-3 receptor antagonist used as an antiemetic in the treatment of chemotherapy-induced nausea and vomiting.
Cerium oxalateNot Annotated
MetopimazineNot Annotated
RolapitantA neurokinin-1 (NK-1) receptor antagonist used in combination with other antiemetics for the prevention of delayed nausea and vomiting associated with emetogenic chemotherapy.
Drugs & Drug Targets
DrugTargetType
Palonosetron5-hydroxytryptamine receptor 3Atarget
PalonosetronCytochrome P450 2D6enzyme
PalonosetronCytochrome P450 3A4enzyme
PalonosetronCytochrome P450 1A2enzyme
DronabinolCannabinoid receptor 1target
DronabinolCytochrome P450 3A4enzyme
DronabinolCytochrome P450 2C9enzyme
DronabinolCannabinoid receptor 2target
DronabinolP-glycoprotein 1transporter
DronabinolATP-binding cassette sub-family G member 2transporter
DronabinolProstaglandin G/H synthase 1enzyme
NabiloneCannabinoid receptor 2target
NabiloneCannabinoid receptor 1target
NabiloneCytochrome P450 2E1enzyme
NabiloneCytochrome P450 2C8enzyme
NabiloneCytochrome P450 2C9enzyme
AprepitantNeurokinin 1 receptortarget
AprepitantCytochrome P450 3A4enzyme
AprepitantCytochrome P450 2C9enzyme
AprepitantCytochrome P450 2C19enzyme
ScopolamineMuscarinic acetylcholine receptor M1target
ScopolamineSucrase-isomaltase, intestinaltarget
ScopolamineMuscarinic acetylcholine receptor M2target
ScopolamineMuscarinic acetylcholine receptor M3target
ScopolamineMuscarinic acetylcholine receptor M4target
ScopolamineMuscarinic acetylcholine receptor M5target
ScopolamineNeuronal acetylcholine receptor subunit alpha-4target
ScopolamineNeuronal acetylcholine receptor subunit beta-2target
ScopolamineCytochrome P450 3A4enzyme
Dolasetron5-hydroxytryptamine receptor 3Atarget
DolasetronCytochrome P450 3A4enzyme
DolasetronCytochrome P450 2D6enzyme
DolasetronCytochrome P450 2C9enzyme
Granisetron5-hydroxytryptamine receptor 3Atarget
GranisetronCytochrome P450 3A4enzyme
GranisetronCytochrome P450 1A1enzyme
Ondansetron5-hydroxytryptamine receptor 3Atarget
OndansetronCytochrome P450 3A4enzyme
OndansetronCytochrome P450 1A2enzyme
OndansetronCytochrome P450 2D6enzyme
OndansetronCytochrome P450 3A5enzyme
OndansetronCytochrome P450 3A7enzyme
Ondansetron5-hydroxytryptamine receptor 4target
Ondansetron5-hydroxytryptamine receptor 1Atarget
Ondansetron5-hydroxytryptamine receptor 1Btarget
OndansetronMu-type opioid receptortarget
OndansetronCytochrome P450 2C9enzyme
OndansetronCytochrome P450 2E1enzyme
CasopitantCytochrome P450 3A4target
CasopitantNeurokinin 1 receptortarget
ChlorobutanolPotassium voltage-gated channel subfamily H member 2target
Tropisetron5-hydroxytryptamine receptor 3Atarget
RolapitantNeurokinin 1 receptortarget
RolapitantCytochrome P450 2D6enzyme
RolapitantCytochrome P450 3A4enzyme
RolapitantATP-binding cassette sub-family G member 2transporter
RolapitantP-glycoprotein 1transporter