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Displaying targets 1 - 25 of 27 in total
C-type lectin domain family 14 member A
Matched Polypeptides synonyms: … EGFR-5 …
Retinoic acid-induced protein 3
Matched Polypeptides specific function: … Functions as a negative modulator of EGFR signaling (By similarity). …
Activated CDC42 kinase 1
Matched Polypeptides specific function: … to the accumulation of EGFR at the limiting membrane of early endosomes. ... trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR ... Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing …
Tyrosine-protein phosphatase non-receptor type 6
Matched Polypeptides general function: … Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR …
Growth factor receptor-bound protein 2
Matched Polypeptides specific function: … the Ras signaling pathway.Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR …
Pro-epidermal growth factor
Matched Polypeptides specific function: … hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR …
G-protein coupled estrogen receptor 1
Matched Polypeptides specific function: … epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR ... Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR ... Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin …
Leukocyte tyrosine kinase receptor
Matched Polypeptides general function: … proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR …
Protein-tyrosine kinase 6
Matched Polypeptides specific function: … These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. ... Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth through enhancement …
Hepatocyte growth factor-regulated tyrosine kinase substrate
Matched Polypeptides specific function: … CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR …
Tyrosine-protein kinase Fer
Matched Polypeptides general function: … Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. ... Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. …
Tyrosine-protein kinase Yes
Matched Polypeptides specific function: … Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly …
Sorting nexin-3
Matched Polypeptides specific function: … Not involved in EGFR degradation. …
Tyrosine-protein kinase ABL1
Matched Polypeptides specific function: … Phosphorylation of CBL leads to increased EGFR stability. ... Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, …
Ras-related protein Rab-7a
Matched Polypeptides specific function: … Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. …
Zinc transporter 10
Matched Polypeptides general function: … The SLC30A3:SLC30A10 heterodimer is involved in zinc transport-dependent regulation of the EGFR/ERK transduction …
Mitogen-activated protein kinase 14
Matched Polypeptides specific function: … depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors. ... In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation ... ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR …
Cyclin-dependent kinase 1
Matched Polypeptides specific function: … proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR …
Mitogen-activated protein kinase 11
Matched Polypeptides specific function: … ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR …
Proto-oncogene tyrosine-protein kinase Src
Matched Polypeptides specific function: … Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin …
Displaying targets 1 - 25 of 27 in total