Enzyme Activators

Enzyme Activators
Accession Number

Compounds or factors that act on a specific enzyme to increase its activity.

DrugDrug Description
SRT-2104SRT2104 has been investigated for the basic science and treatment of Sepsis, PSORIASIS, Atrophy, Muscular, and Diabetes Mellitus, Type 2.
RiociguatA stimulator of soluble guanylate cyclase indicated for the management of persistent or recurrent chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension.
AtaciguatAtaciguat has been investigated for the basic science of Aortic Valve Stenosis.
LY-2608204LY2608204 has been used in trials studying the treatment of Diabetes Mellitus, Type 2.
LinaclotideA guanylate cyclase-C agonist used to treat different types of constipation, such as irritable bowel syndrome-related constipation, idiopathic constipation, and functional constipation.
PirnabinePirnabine has been used in trials studying the treatment of Chronic Idiopathic Constipation.
DolcanatideDolcanatide has been investigated in Exposure.
PlecanatideA laxative used to treat chronic idiopathic constipation and IBS with constipation.
PraliciguatPraliciguat is under investigation in clinical trial NCT03254485 (A Study of the Effect of IW-1973 on the Exercise Capacity of Patients With Heart Failure With Preserved Ejection Fraction (Hfpef)).
MitapivatA pyruvate kinase activator used to treat hemolytic anemia in adults with pyruvate kinase (PK) deficiency.
Drugs & Drug Targets
RiociguatSerum albumincarrier
RiociguatAlpha-1-acid glycoprotein 1carrier
RiociguatGuanylate cyclase soluble subunit alpha-2target
RiociguatATP-binding cassette sub-family G member 2transporter
RiociguatCytochrome P450 1A1enzyme
RiociguatCytochrome P450 3A4enzyme
RiociguatCytochrome P450 2C8enzyme
RiociguatCytochrome P450 2J2enzyme
RiociguatP-glycoprotein 1transporter
LY-2608204Serine/threonine-protein kinase Chk1target
LinaclotideHeat-stable enterotoxin receptortarget
PlecanatideGuanylate cyclase soluble subunit alpha-2target
MitapivatCytochrome P450 3A4enzyme
MitapivatCytochrome P450 2B6enzyme
MitapivatCytochrome P450 2C8enzyme
MitapivatCytochrome P450 2C9enzyme
MitapivatCytochrome P450 2C19enzyme
MitapivatUDP-glucuronosyltransferase 1-1enzyme
MitapivatP-glycoprotein 1transporter
MitapivatCytochrome P450 1A2enzyme
MitapivatPyruvate kinase PKLRtarget
MitapivatCytochrome P450 19A1target