Enzyme Activators

Name
Enzyme Activators
Accession Number
DBCAT003063
Description

Compounds or factors that act on a specific enzyme to increase its activity.

Drugs
DrugDrug Description
SRT-2104SRT2104 has been investigated for the basic science and treatment of Sepsis, PSORIASIS, Atrophy, Muscular, and Diabetes Mellitus, Type 2.
PlecanatideA laxative used to treat chronic idiopathic constipation and IBS with constipation.
LinaclotideA guanylate cyclase-C agonist used to treat constipation associated with irritable bowel syndrome or that is idiopathic in nature.
RiociguatA stimulator of soluble guanylate cyclase indicated for the management of persistent or recurrent chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension.
AtaciguatAtaciguat has been investigated for the basic science of Aortic Valve Stenosis.
PirnabinePirnabine has been used in trials studying the treatment of Chronic Idiopathic Constipation.
DolcanatideDolcanatide has been investigated in Exposure.
PraliciguatPraliciguat is under investigation in clinical trial NCT03254485 (A Study of the Effect of IW-1973 on the Exercise Capacity of Patients With Heart Failure With Preserved Ejection Fraction (Hfpef)).
Drugs & Drug Targets
DrugTargetType
PlecanatideGuanylate cyclase soluble subunit alpha-2target
LinaclotideHeat-stable enterotoxin receptortarget
RiociguatSerum albumincarrier
RiociguatAlpha-1-acid glycoprotein 1carrier
RiociguatGuanylate cyclase soluble subunit alpha-2target
RiociguatATP-binding cassette sub-family G member 2transporter
RiociguatCytochrome P450 1A1enzyme
RiociguatCytochrome P450 3A4enzyme
RiociguatCytochrome P450 2C8enzyme
RiociguatCytochrome P450 2J2enzyme