Eye Pain (DBCOND0001124)

Identifiers

Synonyms

Pain, Eye / Pain in eyes / Ocular Pain / Pain in eye / Eye pain / Ocular pain, unspecified eye / Pain eye / Pain in eye (finding) / Eye ache

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Bromfenac	An NSAID used to treat postoperative pain and inflammation of the eye.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Prostaglandin G/H synthase 2enzyme
Difluprednate	A topical corticosteroid used for the symptomatic treatment of inflammation and pain associated with ocular surgery.	Glucocorticoid receptortarget Cytochrome P450 3A4enzyme Annexin A1target
Ketorolac	An NSAID used to treat moderate to severe pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders, and headaches.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target UDP-glucuronosyltransferase 2B7enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme
Loteprednol etabonate	A corticosteroid used to treat allergic conjunctivitis as well as inflammation and pain after ocular surgery.	Glucocorticoid receptortarget Cytochrome P450 3A4enzyme Serum paraoxonase/arylesterase 1enzyme Steroid hormone receptor ERR1target Steroid hormone receptor ERR2target Estrogen-related receptor gammatarget
Naphazoline	A sympathomimetic vasoconstrictor used for the symptomatic relief of redness and itching of the eye, and nasal congestion.	Alpha-1A adrenergic receptortarget Alpha-2A adrenergic receptortarget D(2) dopamine receptortarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05830409	Multisensory Stimulation in Infants for Eye Examination	No drug interventions	supportive_care	Not Available	completed
NCT06624384	Efficacy and Safety of Topical Cyclosporine 0.05% and Lifitgrast on the Ocular Surface Symptom After Photorefractive Keratectomy in Feiz Hospital, Isfahan, 2024	Cyclosporine	treatment	1	not_yet_recruiting
NCT05531643	Pilot Study of TENS for Ocular Pain	No drug interventions	treatment	Not Available	active_not_recruiting
NCT03652415	DRy Eye Outcome and Prescription Study	No drug interventions	Not Available	Not Available	unknown_status
NCT06479382	Study of the ETX-4143 2.0 Device in Subjects With Eye Pain	No drug interventions	treatment	Not Available	not_yet_recruiting
NCT01824927	Pain Expression in the Perioperative Period of Cataract Surgery	No drug interventions	supportive_care	Not Available	unknown_status
NCT05931250	Alternating and Direct Current Stimulation for Neuropathic Eye Pain	No drug interventions	treatment	Not Available	recruiting
NCT04648085	Effect of Trigeminal Nerve Stimulation on Corneal Nerves and Chronic Ocular Pain	No drug interventions	supportive_care	Not Available	completed
NCT05832996	Cool vs Room-temperature Artificial Tears	Polyethylene glycol 400 Propylene glycol	prevention	4	completed
NCT03063489	Evaluation of the Safety, Systemic Pharmacokinetics, and Tolerability	Loteprednol etabonate	supportive_care	1	completed
NCT05626478	Assessing eFficacy and Safety of DEXTENZA 0.4 mg inseRt, Following Cataract Surgery	Bromfenac Dexamethasone Prednisolone acetate	treatment	4	active_not_recruiting
NCT06085352	Evaluate the TetraLens, a Tetracaine Releasing Therapeutic Bandage Contact Lens in Patients Undergoing PRK Procedure	No drug interventions	treatment	0	completed
NCT02455999	Dose-finding Study to Assess the Safety and Effect of SYL1001 in Patients With Ocular Pain	Tivanisiran	treatment	2	completed
NCT02128113	RTA 408 Ophthalmic Suspension for the Prevention of Corneal Endothelial Cell Loss Following Cataract Surgery - GUARD	Omaveloxolone	prevention	2	completed
NCT04521140	Assessing eFficacy and Safety of DEXTENZA 0.4 mg inseRt, Following Corneal Transplant Surgery	Dexamethasone Prednisolone acetate	treatment	4	completed
NCT01438281	Study to Evaluate the Ocular Tolerance of SYL1001 in Healthy Volunteers	Tivanisiran	treatment	1	completed
NCT04975971	A Retrospective Review of DEXTENZA 0.4 mg inseRt Following Corneal Transplant or Cataract Surgery	Dexamethasone	Not Available	Not Available	completed
NCT01776658	Pilot Study to Evaluate SYL1001 Safety and Effect in Patients With Ocular Pain	Tivanisiran	treatment	1 / 2	completed
NCT03521791	Efficacy and Safety of PRO-155 on Inflammation of the Conjunctival Surface in Subjects With Grade I-III Pterygium vs Placebo.	Bromfenac	treatment	4	completed