severe alcoholic liver disease (DBCOND0022384)

Identifiers

Synonyms
Liver Disease, Alcoholic / Alcoholic Liver Disease / Alcoholic Liver Disease (ALD) / Liver Diseases, Alcoholic / Alcoholic Liver Diseases / ALD - Alcoholic Liver Disease / Severe Alcoholic Liver Disease / Alcoholic liver disease, unspecified / Alcoholic liver damage (disorder) / Alcoholic liver disease NOS / Hepatopathy alcoholic / Alcoholic liver damage, unspecified

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Pentoxifylline
A methylxanthine derivative used to treat intermittent claudication caused by chronic occlusive arterial disease of the limbs.
Prednisolone
A glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers.
Silibinin
A flavonolignan with hepatoprotective effects used to treat toxic liver damage and as an adjunct in the management of chronic conditions such as cirrhosis and hepatitis.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT01701687
Biomarkers for the Prognosis of Decompensated Alcoholic Liver DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT03938662
S-adenosylmethionine Plus Choline in Treatment of Patients With Alcoholic Liver DiseaseNo drug interventionstreatmentNot Availableunknown_status
NCT06613698
A Study to Investigate the Safety and Efficacy of GSK4532990 Compared With Placebo in Adult Participants Aged 18 to 65 Years With Alcohol-related Liver DiseaseNo drug interventionstreatment2not_yet_recruiting
NCT03265249
BRIDGE Device for Post-operative Pain ControlNo drug interventionstreatmentNot Availableterminated
NCT03308916
Screening At-risk Populations for Hepatic Fibrosis With Non-invasive MarkersNo drug interventionsdiagnosticNot Availablerecruiting
NCT04234139
Cohort/Ethics Study of Patients With Severe Alcoholic Hepatitis Undergoing Early Liver TransplantationNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT03388320
Using Addiction Comprehensive Health Enhancement Support System (ACHESS) in an Alcoholic Liver Disease PopulationNo drug interventionshealth_services_researchNot Availableunknown_status
NCT02319252
Gastric- Versus Jejunal Feeding Tubes in Alcoholic Liver DiseasesNo drug interventionstreatmentNot Availablecompleted
NCT01237574
Multicentre Prospective Cohort Study of Patients With Chronic Alcoholic and/or Metabolic Liver DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT06493773
Systematic Referral to Alcohol Use Dependency Treatment in Patients With Alcohol-related Liver Disease: a RCTNo drug interventionstreatmentNot Availablerecruiting
NCT01410123
Integrated Stepped Care for Unhealthy Alcohol Use in HIVNo drug interventionstreatmentNot Availablecompleted
NCT05699018
Screening in Primary Care of Advanced Liver Fibrosis in NAFLD and/or Alcoholic PatientsNo drug interventionsscreeningNot Availablerecruiting
NCT05007470
Alcoholic Liver Disease and the Gut MicrobiometreatmentNot Availableactive_not_recruiting
NCT05793190
Gut Mycobiome Profile in Alcoholic Liver Disease.No drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT05895890
French National MICMAF CohortNo drug interventionsNot AvailableNot Availablerecruiting
NCT06307964
Intra-Hepatic Microbiota in Alcoholic HepatitisNo drug interventionsNot AvailableNot Availablerecruiting
NCT03915002
Integrated Approaches for Identifying Molecular Targets in Liver DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT04666402
Integrated Diagnostics for Early Diagnosis of Liver DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT02331745
RCT Study on Granulocyte Colony-stimulating Factor(G-CSF) Treatment of Hepatic Failuretreatment4unknown_status
NCT00610597
Study of T Cell Phenotype Activation Pathway in Human Alcoholic Liver DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT03508388
Value on Survival of Liver Volume After an Acute Decompensation of an Alcoholic CirrhosisNo drug interventionsNot AvailableNot Availableterminated
NCT03402256
Text Messaging to Reduce Alcohol Relapse in Liver Transplant PatientsNo drug interventionstreatmentNot Availablecompleted
NCT04320199
Effect of Fermented Protaetia Brevitarsis Seulensis Powder on Alcohol-induced Liver DiseaseNo drug interventionstreatmentNot Availablerecruiting
NCT00708617
FIBROSCAN Validation and Interest of Fibrotest - FIBROSCAN Association for Fibrosis Diagnosis in Alcoholic Liver DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT02140294
Long Term Effect of Aggressive Nutritional Management on Survival in Patients With Alcoholic Liver DiseaseNo drug interventionstreatmentNot Availablecompleted
NCT01501162
Effect of Probiotics on Gut-Liver Axis of Alcoholic Liver Diseasetreatment4completed
NCT03113929
Quantitative MRI for Non-invasive Assessment of Severity of Alcoholic Liver Disease (ALD)No drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT02281929
Efficacy of Antibiotic Therapy in Severe Alcoholic Hepatitis Treated With Prednisolonetreatment3completed
NCT05428072
Alcohol, Gut Leakiness, & Liver Diseasebasic_science0completed
NCT03267069
Evaluating Alcohol Use in Alcoholic Liver DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT01504295
A Novel Pharmacotherapy for Alcoholism and Alcohol Liver Diseasetreatment2completed
NCT00770198
sgp130 in Chronic Human Liver DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT01122797
Influence of Adiponutrin in Chronic Liver DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT02335632
Effect of Probiotics on Gut-Liver Axis of Alcoholic HepatitisNo drug interventionstreatment4unknown_status
NCT04106518
Study of Genetic Determinants in Alcoholic Hepatitis and Establishment of a Multicenter Prospective Cohort of Patients With Alcoholic Liver DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT00990639
Effect of Candesartan in Alcoholic Liver Fibrosistreatment1 / 2completed
NCT05473325
Benchtop NMR Spectroscopy for Assessment of Clinical Human Pathologies (BRANCH-P STUDY)No drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT01711125
Baclofen in the Treatment of Alcohol Dependence With or Without Alcoholic Liver Diseasetreatment3completed
NCT03863730
Profermin®: Prevention of Progression in Alcoholic Liver Disease by Modulating Dysbiotic MicrobiotaNo drug interventionspreventionNot Availableactive_not_recruiting
NCT01214226
Double-blind Randomized Controlled Trial in Severe Alcoholic Hepatitistreatment3completed
NCT04736966
Guselkumab (Anti-IL 23 Monoclonal Antibody) for Alcohol Associated Liver Diseasetreatment1completed
NCT04557774
Cognitive Function of Alcoholic Compensated Liver CirrhosisNo drug interventionsNot AvailableNot Availablecompleted
NCT05855031
The Liver Care TrialNo drug interventionsscreeningNot Availablerecruiting
NCT03209791
Ethanol Induces Skeletal Muscle AutophagyNo drug interventionsNot AvailableNot Availablerecruiting
NCT04400604
Study of Alcohol-related Liver Disease in EuropeNo drug interventionsNot AvailableNot Availablerecruiting
NCT02796469
Meta-Analysis of Drug Therapy in Patients With Severe Alcoholic HepatitisNot AvailableNot Availablecompleted
NCT02381769
THE IMMUNOLOGICAL EFFECTS AND METABOLIC TOLERANCE OF LIPID INFUSION IN PATIENTS WITH CIRRHOSIS.No drug interventionssupportive_careNot Availablecompleted
NCT03295812
Stratification of Chronic Alcoholic Liver Diseases (SCALE Study)No drug interventionsNot AvailableNot Availableunknown_status
NCT04858412
Study of HMB-enriched Amino Acid Supplementation in Patients With Alcoholic Liver Disease and COVID-19No drug interventionsbasic_scienceNot Availablerecruiting
NCT01128010
Role of CCL2 in Alcoholic Liver DiseasesNo drug interventionsNot AvailableNot Availablecompleted
NCT04070508
Early Detection of Alcoholic Liver DiseaseNo drug interventionsNot AvailableNot Availablewithdrawn
NCT03503708
Herbal Supplements for Improvement of Liver Function in Participants With Alcoholic Liver DiseaseNo drug interventionssupportive_careNot Availablenot_yet_recruiting
NCT00573313
Effects of SAMe in Patients With Alcoholic Liver Diseasetreatment3completed
NCT03224949
Comparison of ALD, NASH, and Healthy Control PatientsNo drug interventionsNot AvailableNot Availablerecruiting