Nicotine Dependence (DBCOND0030647)

Identifiers

Synonyms

Nicotine dependence / Nicotine dependence, unspecified / Nicotine dependence (disorder) / Nicotine addiction / Tabaquism / Tobacco Dependence / Tobacco dependence syndrome (disorder)

Associated Data

Indicated Drugs and Targets

Not Available

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05630781	Orexin s Role in the Neurobiology of Substance Use Disorder	Methylphenidate Suvorexant	basic_science	Not Available	recruiting
NCT01036581	Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging	No drug interventions	basic_science	Not Available	recruiting
NCT02974582	Understanding How Cigarette Direct Mail Marketing Influences Smoking Behaviors Among High and Low Socioeconomic Status Young Adult Smokers	No drug interventions	other	Not Available	recruiting
NCT05903014	Effectiveness of N-Acetylcysteine (NAC) in Motivational Enhancement Therapy for Nicotine Addiction	Acetylcysteine	treatment	4	completed
NCT05176418	IV Pulsed-Nicotine As a Model of Smoking: the Effects of Dose and Delivery Rate	Nicotine	health_services_research	0	recruiting
NCT06347055	NeuroControl of Nicotine Dependence	No drug interventions	basic_science	Not Available	recruiting
NCT05587361	Beta-Adrenergic Modulation of Drug Cue Reactivity	Nicotine Propranolol	basic_science	4	not_yet_recruiting
NCT05962229	Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine	Nicotine	basic_science	1	not_yet_recruiting
NCT06077240	Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction	No drug interventions	other	Not Available	recruiting
NCT01166464	Examining a Text Message Intervention for Smoking Cessation	No drug interventions	treatment	Not Available	completed
NCT01859364	Tobacco Cessation: Treatment Delivery and Predictors of Outcome	No drug interventions	Not Available	Not Available	withdrawn
NCT01031121	Breath Carbon Monoxide and Cotinine as Biomarkers to Distinguish Smokers From Nonsmokers	No drug interventions	Not Available	Not Available	completed
NCT03196102	Evaluation of a Brief Tobacco Intervention in the US Military	No drug interventions	prevention	Not Available	completed
NCT01806779	Combination Bupropion / Varenicline for Smoking Cessation in Male Smokers	Bupropion Nicotine Varenicline	treatment	2	completed
NCT04738643	Improving Tobacco Treatment Rates for Cancer Patients Who Smoke	No drug interventions	prevention	Not Available	completed
NCT01277887	Smoking Cessation for Smokers With Sleep Problems	No drug interventions	treatment	Not Available	completed
NCT00330187	Combined Pharmaco/Behavior Therapy in Adolescent Smokers	Bupropion	treatment	2	completed
NCT02845687	Study on Smoking Cessation and Cost Outcomes in the Duke Smoking Cessation Program	No drug interventions	Not Available	Not Available	terminated
NCT01642433	Prazosin for Smoking Cessation	Prazosin	treatment	2	terminated
NCT01656733	Nicotine Replacement for Smoking Cessation During Pregnancy	Eucalyptus oil Nicotine Peppermint Xylitol	treatment	4	completed
NCT01031433	Assessment of Craving in Nicotine-Dependent Patients With Schizophrenia Using Virtual Reality	No drug interventions	Not Available	Not Available	completed
NCT02448654	Treatment for Nicotine Addiction in Women	Tolcapone	treatment	Not Available	completed
NCT02470754	Clinical Pharmacology of Electronic Cigarettes	No drug interventions	basic_science	Not Available	completed
NCT05515354	Smoking Cessation and Menstrual Cycle Phase	Nicotine	treatment	4	recruiting
NCT00400751	Family Consultation for Health-Compromised Smokers	No drug interventions	treatment	1	completed
NCT03579953	Nicotine TMS EFT Smoking Pilot Study	No drug interventions	treatment	0	completed
NCT01037153	Effects of Nicotine on Brain Activity as Measured by fMRI	No drug interventions	Not Available	Not Available	completed
NCT00459953	Extended Cessation Treatment for Teen Smokers	Nicotine	treatment	2 / 3	completed
NCT00289653	Smoking While on Transdermal Nicotine Replacement Therapy: Effects on Craving and Cessation	Nicotine	treatment	Not Available	completed
NCT00297453	Smoking Treatment in HIV Clinical Care Settings	No drug interventions	treatment	3	completed
NCT01368653	Evaluation of Learning-Theory-Based Smoking Cessation Strategies	Nicotine	treatment	Not Available	completed
NCT03083353	Isradipine Enhancement of Virtual Reality Cue Exposure for Smoking Cessation	Isradipine	treatment	0	completed
NCT03325777	Approach Bias Retraining to Augment Smoking Cessation	No drug interventions	treatment	Not Available	completed
NCT00589277	Message Framing for Telephone Quitline Callers	No drug interventions	treatment	1 / 2	completed
NCT06534047	Transcranial Magnetic Stimulation for Nicotine Dependence: An Effectiveness-Implementation Trial	Nicotine	treatment	4	not_yet_recruiting
NCT02117947	Counseling to Reduce Children's SHS Exposure: A Trial With Maternal Smokers	No drug interventions	treatment	Not Available	completed
NCT05660798	Effects of Switching From Cigarettes to Tobacco Heating System on Coronary Atherosclerosis Progression	No drug interventions	supportive_care	Not Available	not_yet_recruiting
NCT01965405	Smoking Cessation for People Living With HIV/AIDS	Bupropion	treatment	Not Available	unknown_status
NCT01395797	Pioglitazone for Heroin and for Nicotine Dependence	Pioglitazone	basic_science	1 / 2	terminated
NCT02575183	Varenicline (Chantix) Treatment for Waterpipe Smoking Cessation	Varenicline	treatment	4	completed
NCT03473483	Cigarette Harm Reduction With Electronic Cigarette Use	No drug interventions	basic_science	Not Available	withdrawn
NCT04506528	COVID EHR COHORT at the University of Wisconsin	No drug interventions	Not Available	Not Available	completed
NCT04043728	Addressing Psychological Risk Factors Underlying Smoking Persistence in COPD Patients: The Fresh Start Study	No drug interventions	treatment	Not Available	completed
NCT01867411	Multimodal Neuroimaging Genetic Biomarkers of Nicotine AddictionSeverity	No drug interventions	Not Available	Not Available	recruiting
NCT02146911	The MATCH (Medication Aids for Tobacco Cessation and Health) Study	Bupropion Varenicline	treatment	Not Available	completed
NCT01745393	Kids Safe and Smokefree (KiSS)	No drug interventions	treatment	Not Available	completed
NCT02590393	The Role of Nicotine and Non-Nicotine Alkaloids in E-Cigarette Use and Dependence	Nicotine	basic_science	1 / 2	completed
NCT04709471	E-cigarette Nicotine Study	Nicotine	other	2	completed
NCT04159571	QuitFast: Evaluating Transcranial Magnetic Stimulation as a Tool to Reduce Smoking Directly Following a Quit Attempt	No drug interventions	treatment	Not Available	completed
NCT02599571	Effects of Nicotine Reduction on Smoking Behavior in ADHD Smokers	No drug interventions	basic_science	Not Available	terminated
NCT03165578	Neural Correlates of Neurofeedback Training	No drug interventions	basic_science	Not Available	unknown_status
NCT00921388	Exercise or Relaxation for Smoking Cessation	No drug interventions	treatment	Not Available	completed
NCT01699607	Test-retest Reproducibility of [11C]PHNO PET Using the Constant Infusion Paradigm	Amphetamine	other	Not Available	completed
NCT01989507	Very Low-Nicotine Cigarettes in Smokers With SUD	Nicotine	treatment	2	completed
NCT01299909	Study Two on the Effectiveness of Mindfulness Training for Smokers	No drug interventions	treatment	Not Available	completed
NCT02204956	Smoking Cessation Following Psychiatric Hospitalization	No drug interventions	health_services_research	Not Available	unknown_status
NCT00273156	A Brief Dental Office Intervention With Tobacco Quitline	No drug interventions	treatment	3	completed
NCT01756885	Extended Varenicline Treatment for Smoking Among Cancer Patients	Varenicline	treatment	3	completed
NCT03272685	Impact of Very Low Nicotine Content Cigarettes in a Complex Marketplace	Nicotine	basic_science	3	completed
NCT02348385	Imaging Extrastriatal Dopamine Release in Tobacco Smokers and Nonsmokers	Amphetamine	Not Available	Not Available	completed
NCT01034085	Effects of Nicotine on Areas of Impaired and Preserved Functioning in Schizophrenia	No drug interventions	Not Available	Not Available	completed
NCT02698215	Combining Varenicline and Naltrexone for Smoking Cessation	Naltrexone Varenicline	treatment	2	completed
NCT02433015	Neurophysiological and Immunological Effects of the Transition From Combustible to Electronic Cigarettes	No drug interventions	basic_science	Not Available	completed
NCT00644137	GABA (Gamma Amino Butyric Acid) Medication for Tobacco	Pregabalin	treatment	0	completed
NCT03077737	Reducing Tobacco Use Disparities Among Low-Income Adults	No drug interventions	treatment	Not Available	completed
NCT01093937	Study of Varenicline (Champix) for Smoking Cessation/Reduction in Patients With Bipolar Disorder	Varenicline	treatment	Not Available	completed
NCT00969137	Sensitivity to Intravenous Nicotine: Genetic Moderators	Nicotine	health_services_research	1	completed
NCT01710137	Varenicline for Nicotine Dependence Among Those With HIV/AIDS	Varenicline	treatment	3	completed
NCT02849652	Testing an Organizational Change Model to Address Smoking in Mental Healthcare	No drug interventions	health_services_research	Not Available	completed
NCT03968900	Racial Differences in Circadian and Sleep Mechanisms for Nicotine Dependence, Craving, and Withdrawal	No drug interventions	treatment	Not Available	recruiting
NCT00756275	Varenicline and Motivational Advice for Smokers With Substance Use Disorders	Nicotine Varenicline	treatment	Not Available	completed
NCT05271175	Accelerated iTBS in Smoking Cessation	No drug interventions	treatment	Not Available	completed
NCT05897242	A Smartphone Application (ACT on Vaping) for Vaping Cessation in Young Adults	No drug interventions	prevention	Not Available	completed
NCT00264342	Effectiveness of Using Reduced Nicotine Cigarettes in Men and Women Smokers to Combat Nicotine Addiction	No drug interventions	Not Available	Not Available	completed
NCT01067599	Novel Determinants and Measures of Smokeless Tobacco Use: Study 2	No drug interventions	treatment	Not Available	completed
NCT03999099	Targeting Orexin to Treat Nicotine Dependence	Suvorexant	basic_science	1	recruiting
NCT01782599	Electronic Cigarettes and Reactivity to Smoking Cues	No drug interventions	basic_science	Not Available	recruiting
NCT00936299	Bupropion for ADHD in Adolescents With Substance Use Disorder	Bupropion	treatment	4	completed
NCT02595749	Effects of Intranasal Oxytocin on Cigarette Smoking	Oxytocin	basic_science	4	completed
NCT00948649	Effects of Chantix on Relapse Prevention for Smoking Cessation	Varenicline	screening	4	completed
NCT01554436	Neuropsychological Prognosis Factors of Smoking Cessation	No drug interventions	diagnostic	4	completed
NCT03113136	Examination of Low Wattage and High Wattage E-Cigarettes	No drug interventions	basic_science	Not Available	completed
NCT01679236	Pilot Study on Mindfulness for Tobacco and Alcohol in University Students	No drug interventions	treatment	0	completed
NCT01636336	Effects of Progesterone on Smoked Nicotine Induced Changes in Hormones and Subjective Ratings of Stimulant Drug Effects	No drug interventions	Not Available	Not Available	suspended
NCT03248713	Glucocorticoid Antagonist Treatment for Tobacco Use Disorder	Mifepristone	health_services_research	0	terminated
NCT00439413	Selegiline for Smoking Cessation - 1	Selegiline	treatment	2	completed
NCT03213418	Electroretinogram: a New Human Biomarker for Smoking Cessation Treatment	No drug interventions	basic_science	Not Available	terminated
NCT02635919	Stage Ib Trial of mSMART for Smoking Cessation Medication Adherence	No drug interventions	other	Not Available	unknown_status
NCT04262817	The Interaction of Flavor With Nicotine Form in Adult Smokers	Nicotine	other	1	completed
NCT01982617	Motivational Interviewing Compared to Psychoeducation for Smoking Precontemplators With SMI	No drug interventions	Not Available	Not Available	completed
NCT00511134	Study of Lunesta Versus Placebo for Sleep Problems Related to Smoking Cessation and Zyban	Bupropion Eszopiclone	treatment	4	terminated
NCT02905734	Nicotine Replacement Therapy in Nicotine-dependent Arrestees	Nicotine	treatment	4	completed
NCT05430334	Assess the Influence of Nicotine Flux and Nicotine Form on Subjective Effects Related to Dependency	Nicotine Salicylic acid	other	Not Available	recruiting
NCT00996034	Nicotine Vaccination and Nicotinic Receptor Occupancy	Nicotine	health_services_research	2	completed
NCT01860924	Vigorous Exercise for Depressed Smokers	No drug interventions	treatment	Not Available	completed
NCT00502216	Naltrexone and Varenicline: Weight Gain and Tolerability in Cigarette Smokers	Naltrexone Varenicline	treatment	1 / 2	completed
NCT03496116	The Influence of Electronic (ECIG) Heater Resistance on ECIG Acute Effects	No drug interventions	basic_science	Not Available	completed
NCT01685996	Zonisamide Augmentation of Varenicline Treatment for Smoking Cessation	Zonisamide	treatment	1 / 2	completed
NCT00254358	A Brain Imaging Study of Nicotine Release in Cigarette Smokers	No drug interventions	Not Available	Not Available	terminated
NCT03194958	Helping Poor Smokers Quit	No drug interventions	health_services_research	Not Available	completed
NCT02737358	N-acetylcysteine for Tobacco Use Disorder	Acetylcysteine	treatment	2	completed
NCT05206435	Methadone-Maintained Smokers Switching to E-Cigarettes	Nicotine	prevention	4	recruiting
NCT00563563	A Study of Naltrexone SR/ Bupropion SR in Overweight and Obese Subjects Who Are Nicotine-Dependent	Bupropion Naltrexone	treatment	2	completed
NCT00713063	Behavioral Exercise Intervention for Smoking Cessation	No drug interventions	treatment	2	completed
NCT03904186	Effectiveness of an Integrated Treatment to Address Smoking Cessation and Anxiety/ Depression in People Living With HIV	No drug interventions	treatment	Not Available	active_not_recruiting
NCT01162239	Maintaining Nonsmoking	Varenicline	treatment	3	completed
NCT01422239	A Smoking Cessation Treatment for Adult Women	No drug interventions	treatment	1	completed
NCT01811225	Smoking, Sex Hormones, and Pregnancy	Progesterone	prevention	2	completed
NCT01505725	Nicotine Reinforcement and Smoking-Cue Reactivity: Association With Genetic Polymorphisms	No drug interventions	Not Available	Not Available	completed
NCT03580525	Nicotine Delivery Rate and Its Abuse Potential: Impact of Menthol	Nicotine	health_services_research	0	completed
NCT01702948	Studying Nicotine Addiction With Transcranial Magnetic Stimulation	No drug interventions	Not Available	Not Available	completed
NCT01048957	The Neural Basis of Cue-Elicited Cigarette Craving and Its Control	No drug interventions	other	Not Available	completed
NCT06295757	Effects of Relighting on Smoke Toxicant Deliveries and Subjective Smoking Measures	No drug interventions	other	Not Available	not_yet_recruiting
NCT02108626	Electronic Cigarettes in Daily Dependent Smokers	Nicotine	treatment	4	completed
NCT01046526	fMRI Study of Nicotinic Effect on Neurophysiology of Schizophrenia	No drug interventions	Not Available	Not Available	completed
NCT01412866	Electronic Decision Support Systems for Smokers With Severe Mental Illness	No drug interventions	treatment	Not Available	completed
NCT01182766	New Treatment for Alcohol and Nicotine Dependence	Topiramate	treatment	2 / 3	unknown_status
NCT03177265	Text Messaging to Engage and Retain Veterans in Smoking Cessation Counseling	No drug interventions	treatment	Not Available	completed
NCT00218465	Effectiveness of GW468816, an NMDA Glycine Site Antagonist, for Prevention of Relapse to Smoking	GW-468816 Glycine	prevention	2	completed
NCT01576874	The Gender-Sex Hormone Interface With Craving & Stress-Related Changes in Smoking	Oxytocin	treatment	Not Available	completed
NCT03173274	Incentives to Promote Smoking Cessation in Low SES Women	No drug interventions	basic_science	Not Available	terminated
NCT02839382	The Northwest Coalition for Primary Care Practice Support	No drug interventions	health_services_research	Not Available	completed
NCT00108173	Brain Reaction to Treatment of Nicotine Dependence	Bupropion	diagnostic	1	completed
NCT02357173	A Trial of E-cigarettes in Current Cigarette Smokers	No drug interventions	other	Not Available	completed
NCT00134927	A Survey on Consumer Use of Over-the-Counter (OTC) Nicotine Patches	No drug interventions	Not Available	Not Available	completed
NCT01741376	Progesterone and Atomoxetine for Cocaine Cessation	Progesterone	treatment	Not Available	withdrawn
NCT00257894	Baclofen Effects on Smoking Urge and Withdrawal	Baclofen Quetiapine	treatment	2	terminated
NCT04602494	Varenicline For Nicotine Vaping Cessation In Non Smoker Vaper Adolescents	Varenicline	treatment	4	terminated
NCT01943994	Psilocybin-facilitated Smoking Cessation Treatment: A Pilot Study	Nicotine Psilocybin	treatment	Not Available	completed
NCT05796791	Ketamine and Motivational Enhancement Therapy for the Treatment of Tobacco Use Disorder	Ketamine	treatment	0	active_not_recruiting
NCT03719391	United States Pre-Market Tobacco Application Pharmacokinetics	No drug interventions	other	Not Available	completed
NCT02151591	New Approaches to Smoking Cessation in Heavy Drinkers	Varenicline	treatment	1	completed
NCT03168191	Flavors and E-cigarette Effects in Adolescent Smokers- STUDY 2	Nicotine	other	1	completed
NCT02527980	E-Cigarettes: Dynamic Patterns of Use and Health Effects	No drug interventions	Not Available	Not Available	completed
NCT01120080	Alcohol Counseling for Telephone Quitline Callers	No drug interventions	treatment	1 / 2	completed
NCT04974580	Research and Innovation to Stop E-cigarette/Vaping in Young Adults	Nicotine	treatment	4	completed
NCT04011280	Novel Pharmacotherapy Approaches in Smokers With Serious Mental Illness	Varenicline	treatment	4	completed
NCT04696380	Do Flavors Increase the Addiction Potential of Nicotine?	Nicotine	basic_science	2	completed
NCT05434429	Mobile Health for Problematic Behaviors and Substance Use	No drug interventions	treatment	Not Available	unknown_status
NCT02500589	Adjunctive Mood Management for Telephone-based Smoking Cessation	No drug interventions	health_services_research	Not Available	completed
NCT01632189	The Effect of Varenicline on D2/D3 Receptor Binding in Smokers	Varenicline	basic_science	Not Available	completed
NCT00332644	Smoking Cessation Medications: Efficacy, Mechanisms and Algorithms	Bupropion Nicotine	treatment	4	completed
NCT04161144	Enhancing Self Regulation Among Smokers	Sirolimus	treatment	2	completed
NCT02906644	Combination Nicotine Patch / Lorcaserin for Smoking Cessation	Lorcaserin Nicotine	treatment	2	completed
NCT02439944	Efficacy and Neural Correlates of Personalized Treatment With Transdermal Nicotine Replacement	Nicotine	treatment	2 / 3	terminated
NCT06053567	Community-based Smoking Cessation Treatment for Adults with High Stress Sensitivity.	Nicotine	treatment	3	recruiting
NCT03471767	AXS-05 Phase II Trial on Smoking Behavior	Bupropion Dextromethorphan	treatment	2	completed
NCT03506867	A Healthy People Initiative: Building the Socio-Economic Capital of Low Income Population At-Risk for HIV and Hepatitis-C	No drug interventions	other	Not Available	recruiting
NCT01145001	Enhancing a High School Based Smoking Cessation Program	Nicotine	treatment	Not Available	completed
NCT00844701	Cue Induced Imaging in Nicotine Dependent Smokers	No drug interventions	Not Available	Not Available	completed
NCT01120704	Evaluation of Treatments to Improve Smoking Cessation Medication Adherence	Nicotine	treatment	4	completed
NCT05513872	Overcoming Nicotine Dependence to Enable Quitting	Nicotine	treatment	1 / 2	recruiting
NCT02401672	Repetitive Transcranial Magnetic Stimulation (rTMS) for Nicotine Addiction	No drug interventions	treatment	Not Available	completed
NCT01280968	Improving the Efficacy of Anti-Nicotine Immunotherapy	Aluminum hydroxide Nicotine	basic_science	2	completed
NCT04429568	THC Crossover Study	No drug interventions	basic_science	Not Available	completed
NCT00578669	Sequential Use of Fluoxetine for Smokers With Elevated Depressive Symptoms	Dextrose, unspecified form Fluoxetine	treatment	3	completed
NCT06472869	Assessing E-Cigarettes for Tobacco Harm Reduction in the Context of Lung Cancer Screening	No drug interventions	treatment	Not Available	not_yet_recruiting
NCT00186446	Treatment of Nicotine Dependence and Acute Depression	Bupropion	treatment	4	completed
NCT02587312	Evaluation of Very Low Nicotine Content Cigarettes in Adolescent Smokers	No drug interventions	basic_science	Not Available	completed
NCT03700112	Clinical Study Comparing 7 ENDS Products and 1 Combustible Cigarette Using 2 Delivery Methods.	No drug interventions	other	Not Available	completed
NCT01783912	Helping Those With Mental Illness Quit Smoking	Nicotine	treatment	4	completed
NCT00802412	Topiramate to Aid Smoking Cessation in Alcohol Dependent Men	Topiramate	treatment	2	completed
NCT00405912	St. John's Wort for Tobacco Cessation	St. John's Wort	treatment	2	completed
NCT04084210	Impact of Alternative Nicotine-Delivery Products on Combustible Cigarette Use	Nicotine	basic_science	2	completed
NCT01169610	Varenicline and Alcohol in Inpatient Addictions Program (IAP)	Varenicline	treatment	3	terminated
NCT01982110	A Mindfulness Based Application for Smoking Cessation	No drug interventions	treatment	Not Available	completed
NCT01636310	Multiple Cigarette Induced Changes in Hormone Function, Mood States and Behavior	No drug interventions	Not Available	Not Available	suspended
NCT04449510	Short-Term Cardiovascular Effects of E-Cigarettes: Influence of E-Liquid pH	No drug interventions	basic_science	Not Available	completed
NCT02083081	Community Intervention to Reduce Tobacco Use in Pregnant Women	No drug interventions	treatment	Not Available	completed
NCT02378714	Behavioral Activation and Varenicline for Smoking Cessation in Depressed Smokers	Varenicline	treatment	4	completed
NCT00831155	Extinction Based Treatment for Nicotine Dependence	Nicotine	treatment	1	completed
NCT01186055	Brain Activity and Smoking Cessation	No drug interventions	Not Available	Not Available	completed
NCT00948155	Measuring Smoking Behaviors While Using Varenicline	Varenicline	treatment	4	completed
NCT01202955	Pilot Study of Tolcapone in Smokers	Tolcapone	treatment	2	completed
NCT01980550	Association of Functional COMT Val108/Met Polymorphism With Smoking Cessation in Nicotine Replacement Therapy	Nicotine	Not Available	4	completed
NCT06239350	Young Adult Tobacco/Nicotine and Cannabis Co-use	No drug interventions	treatment	Not Available	recruiting
NCT01204723	Medications Development for the Treatment of Cannabis Related Disorders	Aprepitant	basic_science	1	completed
NCT01342523	Evaluation of National Cancer Institute (NCI) Smoking Intervention Resources	No drug interventions	treatment	4	completed
NCT01636323	Smoked Nicotine Induced Changes in Hormone Function, Mood States and Behaviors	No drug interventions	Not Available	Not Available	suspended
NCT00429208	Effect Of Nicotine on Neurocognitive Performance of Cigarette Smokers	Nicotine	diagnostic	Not Available	unknown_status
NCT01122238	Identifying Treatments to Motivate Smokers to Quit	Nicotine	treatment	4	completed
NCT02989038	Reactions to Reduced Nicotine Cigarettes in Young Adult Low-Frequency Smokers	No drug interventions	basic_science	Not Available	completed
NCT01040338	Effects of Nicotine on Brain Opioid Receptors	Nicotine	Not Available	Not Available	terminated
NCT00956943	Assessment of High Dose Transdermal Nicotine for Fast Metabolizers of Nicotine	Nicotine	treatment	2	completed
NCT00727103	Varenicline Treatment in Alcohol and Nicotine Dependent Patients With Schizophrenia	Varenicline	treatment	4	completed
NCT03080090	YMCA Exercise Intervention for Smoking Cessation Study	No drug interventions	treatment	Not Available	completed
NCT01569490	Striving to Quit: First Breath	No drug interventions	treatment	Not Available	completed
NCT01553084	A Comparative Effectiveness & Long Term Health Study in Wisconsin Smokers	Nicotine Varenicline	treatment	4	completed
NCT05095779	Incentives for Oklahoma Tobacco Helpline Engagement in Persistent Poverty Counties	Nicotine	treatment	2	completed
NCT01735279	Studying the Effects of Administration of Polyunsaturated Fatty Acids (PUFAS) of Omega-3 Series in Nicotine Dependence	Fish oil Mineral oil	treatment	3	completed
NCT00469079	Health Effects of SLT, Cigarette Smoking, and New Tobacco Products	Nicotine	treatment	2	completed
NCT01639079	Comparison of Internet Stop Smoking Intervention to Usual Care on Smoking Cessation at 6 Months	No drug interventions	treatment	Not Available	completed
NCT03000387	Personalized Dosing of Nicotine Replacement (NRT to Effect)	Nicotine	treatment	4	completed
NCT02129387	EEG & Behavioral Predictors of Changes in Smoking Trajectories in Young Light Smokers	No drug interventions	Not Available	Not Available	completed
NCT03262233	Stress Neuroadaptation in Tobacco Dependence	Nicotine	health_services_research	4	completed
NCT00865254	Prize Reinforcement for Smoking Cessation	No drug interventions	treatment	Not Available	completed
NCT02534454	TDCS and Cognitive Retraining to Augment Pharmacotherapy for the Treatment of Nicotine Dependence	Nicotine	treatment	Not Available	completed
NCT02046551	Atomoxetine's Effects On Nicotine Response And Stress Response In Smokers	Atomoxetine	treatment	1 / 2	withdrawn
NCT01784653	Trial of Computerized MET for Adolescent Substance Use	No drug interventions	treatment	1	withdrawn
NCT02487953	Electronic Nicotine Delivery Systems as a Smoking Cessation Treatment	Nicotine	treatment	2	withdrawn
NCT00407277	Neural Inhibition as a Mechanism of Nicotine Dependence Among Persons With Schizophrenia	Nicotine	basic_science	Not Available	completed
NCT01569477	Striving to Quit-Wisconsin Tobacco Quit Line	No drug interventions	treatment	Not Available	withdrawn
NCT04521647	Effects of Menthol in E-cigarettes on Smoking Behaviors	Nicotine	other	1	completed
NCT01509547	Varenicline for Adolescent Smoking Cessation	Varenicline	treatment	3	completed
NCT02498145	Short Term Effects of Electronic Cigarettes in Tobacco Dependent Adults	No drug interventions	other	Not Available	completed
NCT03839745	Short-Term Cardiovascular Effects of E-Cigarettes: Influence of Device Power	No drug interventions	basic_science	Not Available	completed
NCT00571805	Study of Varencline Effects on Cigarette Smoking Reward and Craving During a Model of Brief Quit Attempt	Varenicline	Not Available	1 / 2	withdrawn
NCT01566097	Intervention Trial of Culturally-Appropriate Decision Aids for Smoking Cessation	No drug interventions	treatment	Not Available	unknown_status
NCT01195597	Smoking Cessation and Reduction With an Electronic Nicotine Delivery Device (ENDD)	No drug interventions	treatment	Not Available	completed
NCT02164383	A Quit Smoking Study Using Smartphones	Nicotine	treatment	Not Available	completed
NCT00679861	Smoking Interventions in General Medical Practices	No drug interventions	health_services_research	2	unknown_status
NCT01303861	Concurrent Bupropion / Varenicline for Smoking Cessation	Bupropion Eucalyptus oil Nicotine Peppermint Varenicline Xylitol	treatment	3	completed
NCT01588561	Nicotine Related Brain Activity: The Influence of Smoking History and Blood Nicotine Levels	Nicotine	other	Not Available	completed
NCT03190161	Music to Reduce Use of Smoking in Patients With Schizophrenia	No drug interventions	supportive_care	Not Available	completed
NCT03072628	E-cigarettes, Nicotine Inhaler, and Blood Vessel Function	No drug interventions	basic_science	Not Available	completed
NCT01061528	Coping Skills Treatment for Smoking Cessation	Nicotine	treatment	Not Available	completed
NCT00860028	Varenicline for Smoking Cessation in Heavy Drinking Smokers	Varenicline	treatment	2	completed
NCT01036711	Effects of Nicotine on Cognitive Task Performance and Brain Activity as Measured by fMRI	No drug interventions	Not Available	Not Available	completed
NCT02431611	Biomarker Feedback to Motivate Cessation in Pregnancy	No drug interventions	treatment	2	completed
NCT01031693	Pilot Study of Transcranial Magnetic Stimulation (TMS) in Nicotine Addiction	No drug interventions	treatment	1	completed
NCT05658471	Pharmacokinetics and Pharmacodynamics of Nicotine With Use of Standardized Research Electronic Cigarette (SREC)	No drug interventions	basic_science	Not Available	recruiting
NCT01314378	Effects of Intensive Behavioral Training Program on Impulsivity and Inhibitory Control in Smokers	No drug interventions	treatment	Not Available	unknown_status
NCT00960778	Gender Differences in Response to Nicotine Replacement Therapy and De-Nicotinized Cigarettes	Nicotine	treatment	2	completed
NCT02602288	Babies Living Safe and Smokefree	Nicotine	treatment	Not Available	completed
NCT04461288	Engaging Sexual and Gender Minority Cigarette Smokers Into Social Media-based Treatment	No drug interventions	treatment	Not Available	completed
NCT04170907	Pharmacokinetics and Pharmacodynamics of Different Nicotine Salt Concentration Vape System Pods and Free-base Nicotine	No drug interventions	other	Not Available	completed
NCT01411007	The Impact of Real-time Functional Magnetic Resonance Imaging (fMRI) Feedback on Response to Nicotine Cues	No drug interventions	Not Available	Not Available	terminated
NCT01560507	Tailored Smoking Cessation Treatment for LIVE FOR LIFE® Participants	Bupropion Nicotine Varenicline	treatment	2 / 3	terminated
NCT05487807	Adapting and Evaluating a Tobacco Use Cessation Program for People Living With HIV in Uganda and Zambia	Nicotine	treatment	1	recruiting
NCT03352609	Accelerated rTMS for the Reduction of Nicotine Craving	No drug interventions	treatment	Not Available	terminated
NCT01557556	Pexacerfont to Reduce Stress-induced Tobacco Craving	No drug interventions	Not Available	Not Available	withdrawn
NCT01036685	Cognitive Task Development and Implementation for Functional MRI Studies	No drug interventions	Not Available	Not Available	recruiting
NCT05473585	Impact of New Standards for Tobacco Products Among Dual E-Cigarette/Combusted Cigarette Users - Project 2	No drug interventions	other	Not Available	completed
NCT04857515	Clinical Learning Study for a Mobile Smoking Cessation Program	No drug interventions	Not Available	Not Available	completed
NCT00770237	Effects of Smoking Cues on Tobacco Craving Responses and the Reinforcing Efficacy of Cigarettes in Smokers With and Without Schizophrenia	No drug interventions	diagnostic	Not Available	completed
NCT01480232	A Safety and Cognitive Function Study of EVP-6124 Versus Placebo in Subjects With Nicotine Dependence	Encenicline Nicotine	treatment	2	terminated
NCT02048852	Manipulating Tobacco Constituents in Female Menthol Smokers	No drug interventions	basic_science	Not Available	completed
NCT02102100	The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users	Levomenthol Nicotine	other	Not Available	completed
NCT03707600	State and Trait Mediated Response to TMS in Substance Use Disorder	No drug interventions	basic_science	Not Available	withdrawn
NCT05041959	Nicotine Withdrawal and Reward Processing	No drug interventions	basic_science	Not Available	completed
NCT00901459	A Controlled Laboratory Study of the Effects on Cue-Induced Craving in Dependent Smokers	No drug interventions	treatment	2	completed
NCT02188459	Placebo-controlled Trial of Bupropion for Smoking Cessation in Pregnant Women	Bupropion	treatment	2	completed
NCT01292642	Cognitive Behavioral Therapy and the Nicotine Transdermal Patch for Cannabis Dependence and Nicotine Dependence	Nicotine	treatment	2	completed
NCT01136642	Assessing Top Down and Bottom Up Attention Mechanisms in Smokers Using Nicotine Nasal Spray	Nicotine	other	1	completed
NCT01093599	Trial on the Effectiveness of Mindfulness Training for Smokers	No drug interventions	treatment	Not Available	completed
NCT01880099	A Study to Help People Quit Smoking.	Galantamine	treatment	Not Available	completed
NCT03720899	Comparing NicoBloc to Nicotine Lozenges	Nicotine	treatment	2 / 3	completed
NCT02520349	Lab to Real World Assessment of E-cigarette Abuse Liability and Appeal	No drug interventions	Not Available	Not Available	completed
NCT04047836	Vaping High vs. Low Nicotine E-Liquid	No drug interventions	basic_science	Not Available	withdrawn
NCT01892813	Dissemination of a Tailored Tobacco Quitline for Rural Veteran Smokers	Bupropion Nicotine Varenicline	treatment	3	unknown_status
NCT01046513	PET Imaging of Nicotinic Acetylcholine Receptors	No drug interventions	Not Available	Not Available	completed
NCT00267813	The Effects of Craving and Abstinence From Cigarettes on Brain Metabolism in Smokers	Bupropion	treatment	Not Available	completed
NCT02941718	Examination of Sleep, Smoking Cessation, and Cardiovascular Health	No drug interventions	treatment	3	completed
NCT01188018	Testing Counseling Styles to Motivate Smokers to Quit	No drug interventions	prevention	3	completed
NCT03419741	Brain Stimulation For Cancer Smokers	No drug interventions	treatment	Not Available	completed
NCT01664741	Nicotine Dependence, Withdrawal and Replacement Therapy Assessed by PET Imaging	Nicotine	treatment	4	completed
NCT01753141	Smoking Treatment and Anxiety Management Program	No drug interventions	treatment	Not Available	completed
NCT02724241	E-Cigarettes and SNA	No drug interventions	basic_science	Not Available	completed
NCT00813917	Varenicline for the Treatment of Smokeless Tobacco	Varenicline	treatment	Not Available	completed
NCT00456534	The Effect of Smoking on Perception	No drug interventions	Not Available	Not Available	unknown_status
NCT01842334	D-cycloserine (DCS) Pretreatment + CBT + Nicotine Replacement Therapy for Smoking Cessation (DCS)	Nicotine	treatment	1 / 2	terminated
NCT05159934	Nicotine Differences in Smokers	Nicotine	health_services_research	1	completed
NCT01077024	Smoking-Cessation and Stimulant Treatment (S-CAST)	No drug interventions	treatment	3	completed
NCT00934024	Impact of Varenicline on Blood-Oxygen-Level Dependent (BOLD) Functional Magnetic Resonance Imaging (fMRI) Activation on Smokers	Varenicline	treatment	Not Available	completed
NCT04571216	Study Assessing Efficacy and Safety of NFL-101 as a Tobacco Cessation Therapy	No drug interventions	treatment	2	recruiting
NCT01240616	Nicotinic Modulation of the Default Network of Resting Brain Function	No drug interventions	Not Available	Not Available	completed
NCT01784016	Concurrent PET D2/D3 Receptor Imaging and fMRI Smoking Cue Reactivity in Smokers	No drug interventions	basic_science	1	withdrawn
NCT00709696	Human Laboratory Study Of Varenicline in Smokers	Varenicline	other	Not Available	completed
NCT06291558	Exercise Training for Smoking Students	No drug interventions	prevention	Not Available	recruiting
NCT00749658	Human Laboratory Study of Varenicline and Bupropion for Nicotine Dependence	Bupropion Varenicline	treatment	2 / 3	completed
NCT00937235	Treatment of Smoking Among Individuals With PTSD	Varenicline	treatment	2	completed
NCT02840435	Study on Sit to Quit Phone Intervention	No drug interventions	treatment	Not Available	completed
NCT01116986	Identifying Optimal Smoking Cessation Intervention Components (Cessation)	Nicotine	treatment	4	completed
NCT00830739	A Multi-Modal Investigation of the Smoking Cessation Medication Varenicline: Dopaminergic Modulation of Reward Processing and Cognitive Control	No drug interventions	Not Available	Not Available	completed
NCT04231539	Pharmacokinetics, Subjective Effects, and Abuse Liability of Nicotine Salt-Based Vaping Products With Tobacco or Unflavored E-liquids, SALTVAPE Study	Nicotine	prevention	Not Available	active_not_recruiting
NCT05327439	Using ANDS to Reduce Harm for Low SES Cigarette Smokers	No drug interventions	treatment	Not Available	active_not_recruiting
NCT03593239	Comparing the Pharmacokinetics of Nicotine Salt Based ENDS in Healthy Smokers	No drug interventions	other	Not Available	completed
NCT02358330	Project 1: Evaluating EHR-Based Health System Modifications for the Chronic Care of Smoking	No drug interventions	Not Available	Not Available	completed
NCT01690130	Transcranial Magnetic Stimulation Effects on Nicotine Craving	No drug interventions	treatment	Not Available	completed
NCT03243630	Effects of Flavors on Nicotine Reinforcement in Smokers	Levomenthol Nicotine Salicylic acid	health_services_research	0	completed
NCT01047930	The Effect of Exercise on Acute Nicotine Withdrawal	No drug interventions	basic_science	Not Available	completed
NCT02139930	Project 2: Strategies for Reducing Nicotine Content in Cigarettes	No drug interventions	basic_science	Not Available	completed
NCT00133757	Use of Pharmacotherapy to Reduce Cue-responsiveness in Smokers	Bupropion	Not Available	1	completed
NCT00751257	N-Acetylcysteine and Smoking Reduction	Acetylcysteine	treatment	2	completed
NCT06091826	Study Assessing Efficacy and Safety of NFL-101 on Reduction of Reinforcing Properties of Cigarettes (PRECESTO)	Water	treatment	2	completed
NCT01926626	Evaluation of Moclobemide, a Reversible MAO-A Inhibitor, as an Adjunct to Nicotine Replacement Therapy in Female Smokers	Moclobemide Nicotine	treatment	2	completed
NCT00301626	ROSCAP: Reduction of Smoking in Cardiac Patients Study	No drug interventions	Not Available	Not Available	completed
NCT06389266	Network-Targeted Neuromodulation for Nicotine Dependence in Schizophrenia	No drug interventions	basic_science	Not Available	recruiting
NCT01954966	Progesterone and Brain Imaging Study	Progesterone	treatment	4	completed
NCT00408265	Smoking Cessation in Substance Abuse Treatment Patients: A Feasibility Study	No drug interventions	treatment	3	completed
NCT02501265	Adaptive Pharmacotherapy for Smoking Cessation	Nicotine Varenicline	treatment	2	completed
NCT04646174	Addressing Psychological Risk Factors Underlying Smoking Persistence in COPD Patients: The Fresh Start-II Study	No drug interventions	treatment	Not Available	completed
NCT00682474	School Nurse-Delivered Smoking Cessation Intervention	No drug interventions	treatment	2 / 3	completed
NCT00567320	Efficacy of Varenicline in Methadone-Stabilized Cocaine Users	Varenicline	health_services_research	Not Available	completed
NCT01034020	Effects of Nicotine on Elements of Attentions in Smokers and Nonsmokers	Nicotine	treatment	1	completed
NCT02514720	Nicotine Metabolizers and [11C]-(+)-PHNO	No drug interventions	basic_science	Not Available	completed
NCT02994082	Treating Smokeless Tobacco Use in Rural Veterans	Bupropion Nicotine Varenicline	treatment	Not Available	unknown_status
NCT00105482	Targeted Interventions for Weight-Concerned Smokers	Naltrexone Nicotine	treatment	2	completed
NCT00816231	Drug /Cue Interactions In Alcohol-Tobacco Comorbidity	No drug interventions	prevention	Not Available	completed
NCT04737031	Improving Tobacco Treatment Rates for Outpatient Cancer Patients Who Smoke	No drug interventions	prevention	Not Available	completed
NCT04188873	Cessation Screening Project	Varenicline	treatment	4	active_not_recruiting
NCT01047527	An Effectiveness Trial of Maintenance Therapy for Nicotine Dependence	Nicotine	treatment	4	completed
NCT00602927	Effects of Varenicline on Brain Activity During Nicotine Abstinence	Varenicline	treatment	Not Available	completed
NCT01784627	Trial of Computerized SBI to Reduce Teen Alcohol Use	No drug interventions	prevention	1	withdrawn
NCT01524627	Effects of Varenicline on Smoking Reminders	Varenicline	treatment	2	completed
NCT01821560	Baclofen Effects in Cigarette Smokers	Baclofen	treatment	2	completed
NCT00508560	Contingency Management for Smoking Cessation Among Veterans With Psychotic Disorders	No drug interventions	treatment	Not Available	terminated
NCT04832360	Testing Financial Incentive Interventions in Dyadic-Smoker Couples	No drug interventions	other	Not Available	completed
NCT05852860	A Patient-Oriented Research Mentoring Program in Tobacco Dependence and Implementation Science Research	No drug interventions	prevention	Not Available	enrolling_by_invitation
NCT02713594	Wisconsin Tobacco Quit Line Medicaid Incentive Evaluation	No drug interventions	health_services_research	Not Available	completed
NCT01228994	Baclofen for Smoking Cessation in a Non-Psychiatric Population	Baclofen	treatment	2	terminated
NCT04535362	Nicotine's Potential Abuse With Menthol	Nicotine	health_services_research	0	completed
NCT06506162	Abuse Liability and Appeal of Oral Nicotine Products	No drug interventions	prevention	Not Available	recruiting
NCT01550029	Targeted Intervention for Bipolar Smokers	No drug interventions	treatment	Not Available	unknown_status
NCT01144689	Mindfulness Training for Smoking Cessation	No drug interventions	treatment	Not Available	completed
NCT00484692	Randomized Trial of Ultrashort Psychotherapy vs Sustained-Release Bupropion for Smoking Cessation	Bupropion	treatment	4	completed
NCT05367492	Varenicline for Nicotine Vaping Cessation in Adolescents	Varenicline	treatment	4	completed
NCT01393392	Developing a Smoking Cessation Intervention for Methadone Maintained Smokers	No drug interventions	treatment	1	completed
NCT01048944	Nicotine Replacement Therapy (NRT) and Bupropion Mechanisms of Effectiveness in Smokers	Bupropion Nicotine	basic_science	4	completed
NCT00596440	Assessment of a Teachable Moment for Smoking Cessation	Nicotine	Not Available	Not Available	completed
NCT01576640	Extended Duration Nicotine Replacement Therapy and Bupropion in Smokers With Schizophrenia	Bupropion	treatment	4	terminated
NCT01188967	Effectiveness of GSK598809, a Selective D3 Antagonist, Added to CBT and NRT for Smoking Cessation and Relapse Prevention	No drug interventions	prevention	2	completed
NCT01393301	Integrated Treatment for Smoking Cessation & Anxiety in People With HIV	No drug interventions	treatment	Not Available	completed
NCT02592772	Manipulating Tobacco Constituents in Male Menthol Smokers	No drug interventions	other	Not Available	completed
NCT04176172	Optimizing Tobacco Use Treatment for PLWHA	Nicotine Varenicline	treatment	3	recruiting
NCT06163872	Doctors' Perspective on Tobacco Addiction	No drug interventions	Not Available	Not Available	completed
NCT03069768	Stage Ib Trial of mSMART With Varenicline	Varenicline	other	1	withdrawn
NCT01924468	Brain Networks and Addiction Susceptibility	Haloperidol Methylphenidate	prevention	1	completed
NCT01589068	Effects of Progesterone on IV Nicotine Induced Changes on BOLD fMRI Signal, Hormones and Subjective Ratings of Stimulant Drugs	Nicotine Progesterone	other	Not Available	withdrawn
NCT00497068	Tobacco Use in Opioid Agonist Treated Pregnant Women	No drug interventions	treatment	2 / 3	completed
NCT00595868	Efficacy of Varenicline in Ambivalent Smokers	Varenicline	treatment	2	completed
NCT01898169	Evaluation of Short-term Safety and Use Patterns of an Electronic Nicotine Delivery System	No drug interventions	basic_science	Not Available	unknown_status
NCT00129246	Low-Dose Naltrexone Combined With Bupropion to Stop Smoking With Less Weight Gain	Bupropion Naltrexone	treatment	1 / 2	completed
NCT01304810	A Follow-up Study to Assess Long-term Immunogenicity and Safety of NicVAX/Placebo as an Aid to Smoking Cessation	No drug interventions	Not Available	Not Available	completed
NCT01710410	Transcranial Direct Current Stimulation in a Smoking Cessation Trial	No drug interventions	treatment	2	withdrawn
NCT01876810	Initial Screening of Gemfibrozil as a Novel Treatment for Tobacco Addiction	Gemfibrozil Lactose	treatment	2	completed
NCT01589081	Effects of Progesterone on IV Nicotine-Induced Changes in Hormones and Subjective Ratings of Stimulant Drug Effect	Nicotine Progesterone	other	Not Available	withdrawn
NCT00344695	Bupropion Treatment for Youth Smoking Cessation	Bupropion	treatment	3	completed
NCT02740595	E-cigarettes and Blood Vessel Function	No drug interventions	basic_science	Not Available	completed
NCT01511614	Nicotine Withdrawal Symptoms and Smoking Relapse	Nicotine Varenicline	basic_science	Not Available	completed
NCT04645914	Influence of the Consumption of Conventional and Electric Cigarettes on Skin Circulation	No drug interventions	basic_science	Not Available	unknown_status
NCT03847155	Prevention of Nicotine Abstinence in Critically Ill Patients After Major Surgery	Nicotine	prevention	Not Available	completed
NCT00731055	Effects of Varenicline on Cigarette Self Administration	Varenicline	treatment	2	completed
NCT01148355	Effects of Smoking Cues on Tobacco Craving Responses and the Reinforcing Efficacy of Cigarettes in Adolescent Smokers	No drug interventions	Not Available	Not Available	completed
NCT00736255	Attention Deficit Hyperactivity Disorder (ADHD) Smoking Cessation Study	Dextroamphetamine Lisdexamfetamine Nicotine	treatment	Not Available	completed
NCT01589055	IV Nicotine Induced Changes in Hormone Function, Mood States and Behavior	Nicotine	other	Not Available	withdrawn
NCT00664755	Menstrual Cycle Effects on Smoking Cessation and Cue Reactivity	Varenicline	treatment	2	completed
NCT01406223	Mechanistic Evaluations of Pre-Cessation Therapies for Smoking Cessation	Bupropion Nicotine Varenicline	treatment	3	completed
NCT06027723	Nicotine and Pavlovian Bias	Nicotine	basic_science	0	recruiting
NCT00390923	Testing a Full Substitution Therapy Approach As Treatment of Tobacco Dependence	Nicotine Selegiline	treatment	Not Available	terminated
NCT01780038	Smokers' Response to Nicotine Dependence Genotyping	No drug interventions	treatment	Not Available	completed
NCT02665338	TMS-fMRI for Neural Pathway in Smokers	No drug interventions	treatment	Not Available	terminated
NCT03450941	AXS-05 Phase II Trial on Smoking Behavior	Bupropion Dextromethorphan	treatment	2	not_yet_recruiting