Cholesterol, LDL (DBCOND0037106)

Identifiers

Synonyms

LDL-cholesterol / LDL Cholesterol / LDL cholesterol (substance) / LDL / Low density lipoprotein / Low density lipoprotein cholesterol / Low density lipoprotein cholesterol measurement (procedure)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Lovastatin	An HMG-CoA reductase inhibitor used to lower LDL cholesterol and reduce the risk of cardiovascular disease and associated conditions, including myocardial infarction and stroke.	3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme Integrin alpha-Ltarget Histone deacetylase 2target Serum paraoxonase/lactonase 3enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Solute carrier organic anion transporter family member 1B1transporter UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1A3enzyme UDP-glucuronosyltransferase 2B7enzyme ATP-binding cassette sub-family C member 2transporter Bile salt export pumptransporter Albumincarrier Cytochrome P450 2C19enzyme Solute carrier organic anion transporter family member 2B1transporter Solute carrier organic anion transporter family member 1B3transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06626126	Efficacy of Lipid-Lowering Therapy Based on Apolipoprotein B Versus LDL-Cholesterol Levels in Patients Undergoing Percutaneous Coronary Intervention	No drug interventions	treatment	Not Available	not_yet_recruiting
NCT05587621	Intensive Lipid-lowering in Patients With STEMI and NSTEMI (Germany on Target)	Alirocumab Bempedoic acid Evolocumab Ezetimibe Inclisiran	prevention	Not Available	not_yet_recruiting
NCT04029818	Evaluation of a Probiotic on LDL-cholesterol Levels	Bifidobacterium longum Bifidobacterium spp. Lactobacillus acidophilus	prevention	1	completed
NCT06649240	Optimal Target Low-density Lipoprotein Cholesterol Level for Small Vessel Occlusion Stroke	No drug interventions	prevention	Not Available	recruiting
NCT03528252	Effectiveness of Written Dietary Advice on Lipoproteins - a Pragmatic Randomized Controlled Trial	No drug interventions	prevention	Not Available	completed
NCT04841460	Impact of Beef's Unique Food Matrix on Human Health	No drug interventions	basic_science	Not Available	completed
NCT03967990	Corn and Heart Health Study	No drug interventions	prevention	Not Available	completed
NCT01610609	Reducing Disparities in Primary Prevention of Cardiovascular Disease	No drug interventions	prevention	Not Available	completed
NCT01418716	TRANSforming InTerprofessional Cardiovascular Prevention in Primary Care	No drug interventions	health_services_research	Not Available	completed
NCT00461968	Comparison of Efficacy and Safety of Ezetimibe or Statin Monotherapy to Co-Administration of Both	Ezetimibe Simvastatin	treatment	Not Available	completed
NCT05777746	The Effect of an Online Plant-Based Dietary Program on Cardiovascular Risk Factors in Persons With Type 2 Diabetes Mellitus: A Randomized Controlled Trial	No drug interventions	treatment	Not Available	recruiting
NCT05778656	Cardiovascular Risk Prevention With a Mediterranean Dietary Pattern Reduced in Saturated Fat	No drug interventions	prevention	Not Available	recruiting
NCT01028274	Safety and Efficacy of a Natural Health Product in Reducing Cholesterol and Triglyceride Levels.	No drug interventions	treatment	1 / 2	completed
NCT01859455	Safety, Pharmacokinetics and Pharmacodynamics of LGT209 in Healthy Volunteers With Elevated Cholesterol and in Hypercholesterolemic Patients Treated With Statins	Atorvastatin Simvastatin	treatment	1	completed
NCT05765370	LDL Cholesterol TARGETs in OLDer Patients (Age≥75 Years) With ASCVD (TARGET OLD)	No drug interventions	treatment	Not Available	recruiting
NCT02330406	Randomized Evaluation of Anagliptin Versus Sitagliptin On Low-density lipoproteiN Cholesterol in Diabetes Trial	Anagliptin Sitagliptin	treatment	4	completed
NCT00233649	DIALOOG: Crestor in Patients With Diabetes Mellitus Type 2: Lowering of LDL-C Levels to New European Guidelines	No drug interventions	Not Available	Not Available	completed
NCT00522158	Effects of Achieving Very Low LDL-Cholesterol After Treatment With Statins on Steroidogenesis and Cognition	Atorvastatin Simvastatin	Not Available	4	completed
NCT03346486	Dietary Intervention With Brain-friendly Diet	No drug interventions	other	Not Available	completed
NCT02068248	Effect of Viscous Soluble Fibers on Serum Cholesterol Levels	No drug interventions	Not Available	Not Available	unknown_status
NCT03549260	Study to Evaluate Efficacy and Safety of LIB003 in Patients on Lipid-Lowering Therapy Needing Additional LDL-C Reduction	No drug interventions	treatment	2	completed