Primary Axillary Hyperhidrosis (DBCOND0060333)

Identifiers

Synonyms

Hyperhidrosis Primary Focal Axilla / Primary Focal Hyperhidrosis, Axilla / Primary focal hyperhidrosis of axilla (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Glycopyrronium	An anticholinergic agent used to treat hyperhidrosis, severe drooling, COPD, used with other medications to treat ulcers, and used in anesthesia.	Muscarinic acetylcholine receptor M1target Muscarinic acetylcholine receptor M3target Muscarinic acetylcholine receptor M2target Cytochrome P450 2D6enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C18enzyme Cytochrome P450 2C19enzyme Cytochrome P450 3A4enzyme Solute carrier family 22 member 2transporter Multidrug and toxin extrusion protein 1transporter Muscarinic acetylcholine receptor M4target Muscarinic acetylcholine receptor M5target Albumincarrier alpha1-acid glycoproteincarrier
Sofpironium	A topical anticholinergic used to treat primary axillary hyperhidrosis.	Muscarinic acetylcholine receptor M3target Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme Muscarinic acetylcholine receptortarget Solute carrier family 22 member 1transporter Solute carrier family 22 member 2transporter Multidrug and toxin extrusion protein 1transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT03658616	Assessment of Efficacy and Safety of Topical Administration of 1% Glycopyrronium Bromide (GPB) in Patients With Primary Axillary Hyperhidrosis and the Assessment of Long-term Efficacy and Safety of Topical Administration of 1% GPB Cream in Patients With Primary Axillary Hyperhidrosis.	No drug interventions	treatment	3	completed
NCT03054480	Fractional Micro-Needle Radiofrequency and I Botulinum Toxin A for Primary Axillary Hyperhidrosis	Botulinum toxin type A	treatment	Not Available	completed
NCT02823340	Fractionated Microneedle Radiofrequency for Treatment of Primary Axillary Hyperhidrosis	No drug interventions	treatment	Not Available	completed
NCT05863104	Assessment of Safety, Tolerability, Systemic Exposure and Efficacy of GPB Cream in Adolescents With Severe Primary Hyperhidrosis	Glycopyrronium	treatment	2	completed
NCT03785587	A Safety Study of BBI-4000 Gel in Pediatric Patients With Axillary Hyperhidrosis	Sofpironium	treatment	2	completed
NCT01722461	A Study of the Ulthera® System for the Treatment of Axillary Hyperhidrosis	No drug interventions	treatment	Not Available	terminated
NCT03037788	Investigation of Ascending Concentrations of Glycopyrronium Bromide (GPB) in a Topical Formulation in Subjects With Axillary Hyperhidrosis	No drug interventions	treatment	1	completed
NCT04599907	Evaluation of N-SWEAT Patch for Treatment of Primary Axillary Hyperhidrosis or Excessive Axillary Sweating	No drug interventions	treatment	Not Available	completed
NCT01799824	Clinical Trial to Evaluate ANT-1403 in the Treatment of Primary Axillary Hyperhidrosis	Botulinum toxin type A	treatment	2	completed
NCT02286765	Ulthera® System for Treating Axillary Hyperhidrosis	No drug interventions	treatment	Not Available	completed
NCT03627468	A Safety Study of BBI-4000 Gel in Patients With Axillary Hyperhidrosis	Sofpironium	treatment	3	completed
NCT04159610	Assessment of Safety, Tolerability and Efficacy of 1% GPB Cream Versus Qbrexza® (Glycopyrronium) Cloth 2.4% Under Maximum-Use Conditions in Subjects With Primary Axillary Hyperhidrosis	Glycopyrronium	treatment	2	unknown_status
NCT04227691	Treatment of Axillary Hyperhidrosis With Long-pulsed Nd:YAG Laser or IPL	No drug interventions	treatment	Not Available	unknown_status
NCT05860972	Evaluation of Safety and Efficacy of Morpheus8 Applicator for the Treatment of Focal Hyperhidrosis of the Axillae Using Radio Frequency	No drug interventions	treatment	Not Available	recruiting
NCT03760198	Evaluate the Efficacy and Safety of MEDITOXIN in Treatment of Primary Axillary Hyperhidrosis	No drug interventions	treatment	3	completed
NCT05057117	Longevity of Microwave Thermolysis and Botulinum Toxin A for Treatment of Axillary Hyperhidrosis	Botulinum toxin type A	treatment	4	completed
NCT00931359	Efficacy and Safety of the DTS-G2 System in Patients With Axillary Hyperhidrosis	No drug interventions	treatment	Not Available	completed