Progressive autonomic failure (DBCOND0089527)

Identifiers

Synonyms

Pure Autonomic Failure (PAF) / Pure Autonomic Failure / Shy-Drager syndrome / Autonomic failure progressive / Pure autonomic failure (disorder) / Autonomic failure syndrome

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Droxidopa	A medication used to treat symptomatic neurogenic orthostatic hypotension (nOH) caused by dopamine beta-hydroxylase deficiency, non-diabetic autonomic neuropathy and primary autonomic failure caused by conditions such as Parkinson's disease.	Phenylalanine-4-hydroxylasetarget Alpha-1A adrenergic receptortarget Alpha-1B adrenergic receptortarget Alpha-1D adrenergic receptortarget Alpha-2A adrenergic receptortarget Alpha-2B adrenergic receptortarget Alpha-2C adrenergic receptortarget Beta-1 adrenergic receptortarget Beta-2 adrenergic receptortarget Beta-3 adrenergic receptortarget Aromatic-L-amino-acid decarboxylaseenzyme Monocarboxylate transporter 10transporter Sodium-dependent noradrenaline transportertransporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT03829657	Phase 3 Clinical Effect Durability of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure	Ampreloxetine	treatment	3	terminated
NCT05489575	CPAP for the Treatment of Supine Hypertension	No drug interventions	treatment	Not Available	recruiting
NCT00775853	Biomarkers of Risk of Parkinson Disease	Ammonia	Not Available	Not Available	completed
NCT04620382	Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients	Midodrine	other	0	recruiting
NCT03482297	Automated Abdominal Binder for Orthostatic Hypotension	Midodrine	treatment	1 / 2	recruiting
NCT01044693	Nebivolol in the Supine Hypertension of Autonomic Failure	Metoprolol Nebivolol Sildenafil	Not Available	Not Available	completed
NCT02417415	Local Heat Stress in Autonomic Failure Patients With Supine Hypertension	No drug interventions	other	Not Available	completed
NCT04246437	[18F]F-DOPA Imaging in Patients With Autonomic Failure	Carbidopa Entacapone	basic_science	1	recruiting
NCT00178919	Nitric Oxide and the Autonomic Nervous System	Tilarginine Trimethaphan	Not Available	Not Available	completed
NCT01119417	The Role of Endothelin in the Supine Hypertension of Autonomic Failure	BQ-123 Sodium chloride	other	1	withdrawn
NCT00742586	Autonomic Failure Patients for RNA Blood Sampling	No drug interventions	Not Available	Not Available	completed
NCT02640339	Retinal Abnormalities as Biomarker of Disease Progression and Early Diagnosis of Parkinson Disease	No drug interventions	Not Available	Not Available	completed
NCT04700722	Synuclein-One Study	No drug interventions	Not Available	Not Available	completed
NCT02429557	Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure	Midodrine	other	1	recruiting
NCT01316666	Norepinephrine Transporter Blockade as a Pathological Biomarker in Neurogenic Orthostatic Hypotension	No drug interventions	Not Available	Not Available	completed
NCT02591173	Blood Pressure Lowering Effects of Angiotensin-(1-7) in Primary Autonomic Failure	Angiotensin 1-7 Angiotensin II Sodium chloride	treatment	0	terminated
NCT03681080	Concentration and Attentional Deficits in POTS and Other Autonomic Neuropathies	No drug interventions	supportive_care	Not Available	completed
NCT01927055	A Clinical Study of Patients With Symptomatic NOH to Assess Sustained Effects of Droxidopa Therapy	Droxidopa Mannitol	treatment	3	terminated
NCT03042988	Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension	No drug interventions	treatment	Not Available	recruiting
NCT01799915	Natural History Study of Synucleinopathies	No drug interventions	Not Available	Not Available	recruiting
NCT04875949	Anti-Cholinergic Receptors Antibodies, Autonomic Profile and Dysautonomia Symptoms in PAF, ALS and POTS (DISAUT-AB)	No drug interventions	supportive_care	Not Available	completed
NCT02897063	Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure	Droxidopa Midodrine	basic_science	1	recruiting
NCT04782830	Use of Accelerometer for Quantification of Neurogenic Orthostatic Hypotension Symptoms	Atomoxetine Midodrine	other	Not Available	recruiting
NCT01292694	Contribution of Angiotensin II to Supine Hypertension in Autonomic Failure	Captopril Losartan	basic_science	1	terminated
NCT01607268	Magnetic Resonance Spectroscopy in Autonomic Failure	No drug interventions	Not Available	Not Available	terminated
NCT02705755	TD-9855 Phase 2 in Neurogenic Orthostatic Hypotension (nOH)	Ampreloxetine	treatment	2	completed
NCT00179023	The Autonomic Nervous System and Obesity	Pseudoephedrine Trimethaphan	diagnostic	1	completed