Nausea and vomiting

Also known as: Nausea with or without vomiting / Nausea or vomiting / Nausea and vomiting symptoms / Nausea & vomiting / Nausea/Vomiting / Nausea and/or vomiting / Nausea with vomiting / [D]Retching / Vomiting / Vomiting NOS / Vomited / Emesis

DrugDrug NameDrug Description
DB01425AlizaprideA dopamine antagonist used to prevent nausea and vomiting associated with medical procedures, surgeries, and cancer therapies.
DB00477ChlorpromazineA phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children.
DB13511CleboprideA dopamine antagonist used to treat symptoms associated with functional gastrointestinal disorders. Clebopride may also be used to treat nausea and vomiting associated with chemotherapy.
DB00985DimenhydrinateA medication used to prevent and treat nausea, vomiting, vertigo, and motion sickness.
DB00450DroperidolA butyrophenone derivative and dopamine antagonist used to prevent and treat postoperative nausea and vomiting.
DB00889GranisetronA 5HT3 antagonist used to treat nausea and vomiting in cancer therapy and postoperatively.
DB00502HaloperidolAn antipsychotic agent used to treat schizophrenia and other psychoses, as well as symptoms of agitation, irritability, and delirium.
DB00557HydroxyzineAn antihistamine used to treat anxiety and tension associated with psychoneuroses, as well as allergic conditions such as pruritus and chronic urticaria.
DB04924ItoprideAn acetylcholine esterase inhibitor and dopamine D2 receptor antagonist used to treat symptoms of functional dyspepsia such as nausea and vomiting.
DB16021Levosulpirideindicated to treat dyspepsia, symptoms of Meniere's syndrome, and second line in the treatment of drug-induced nausea and vomiting.
DB01403MethotrimeprazineA phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder.
DB01233MetoclopramideAn antiemetic agent and dopamine D2 antagonist used in the treatment of gastroesophageal reflux disease, prevention of nausea and vomiting, and to stimulate gastric emptying.
DB00165PyridoxineA vitamin used to correct vitamin B6 deficiency and to treat nausea during pregnancy.
DB00372ThiethylperazineA drug used for the treatment of nausea and vomiting.
DB00662TrimethobenzamideAn antiemetic used to treat postoperative nausea and vomiting and nausea associated with gastroenteritis.
DrugDrug NameTargetType
DB01425AlizaprideDopamine D2 receptortarget
DB00477ChlorpromazineDopamine D2 receptortarget
DB00477Chlorpromazine5-hydroxytryptamine receptor 2Atarget
DB00477ChlorpromazineCytochrome P450 2D6enzyme
DB00477ChlorpromazineCholinesteraseenzyme
DB00477ChlorpromazineCytochrome P450 1A2enzyme
DB00477ChlorpromazineSerum albumincarrier
DB00477ChlorpromazineP-glycoprotein 1transporter
DB00477ChlorpromazineDopamine D1 receptortarget
DB00477Chlorpromazine5-hydroxytryptamine receptor 1Atarget
DB00477ChlorpromazineAlpha-1A adrenergic receptortarget
DB00477ChlorpromazineAlpha-1B adrenergic receptortarget
DB00477ChlorpromazineCytochrome P450 2E1enzyme
DB00477ChlorpromazineCytochrome P450 3A4enzyme
DB00477ChlorpromazineHistamine H1 receptortarget
DB00477ChlorpromazinePotassium voltage-gated channel subfamily H member 2target
DB00477ChlorpromazineD(1) dopamine receptortarget
DB00477ChlorpromazineDopamine D3 receptortarget
DB00477ChlorpromazineDopamine D4 receptortarget
DB00477ChlorpromazineDopamine D5 receptortarget
DB00477Chlorpromazine5-hydroxytryptamine receptor 2Ctarget
DB00477Chlorpromazine5-hydroxytryptamine 2 receptortarget
DB00477ChlorpromazineAlpha-1 adrenergic receptorstarget
DB00477ChlorpromazineAlpha-2 adrenergic receptorstarget
DB00477ChlorpromazineMuscarinic acetylcholine receptor M1target
DB00477ChlorpromazineMuscarinic acetylcholine receptor M3target
DB00477ChlorpromazineSphingomyelin phosphodiesterasetarget
DB00477ChlorpromazineCalmodulintarget
DB00477Chlorpromazinealpha1-acid glycoproteintarget
DB00477Chlorpromazine5-hydroxytryptamine receptor 6target
DB00477Chlorpromazine5-hydroxytryptamine receptor 7target
DB00477ChlorpromazineHistamine H4 receptortarget
DB00477ChlorpromazineBile salt export pumptransporter
DB00985DimenhydrinateHistamine H1 receptortarget
DB00450DroperidolDopamine D2 receptortarget
DB00450DroperidolAlpha-1A adrenergic receptortarget
DB00889Granisetron5-hydroxytryptamine receptor 3Atarget
DB00889GranisetronCytochrome P450 3A4enzyme
DB00889GranisetronCytochrome P450 1A1enzyme
DB00502HaloperidolDopamine D2 receptortarget
DB00502HaloperidolGlutamate receptor ionotropic, NMDA 2Btarget
DB00502HaloperidolDopamine D1 receptortarget
DB00502HaloperidolCytochrome P450 1A2enzyme
DB00502HaloperidolCytochrome P450 2D6enzyme
DB00502Haloperidol5-hydroxytryptamine receptor 2Atarget
DB00502HaloperidolDopamine D3 receptortarget
DB00502HaloperidolCytochrome P450 3A4enzyme
DB00502HaloperidolCytochrome P450 3A5enzyme
DB00502HaloperidolCytochrome P450 3A7enzyme
DB00502HaloperidolP-glycoprotein 1transporter
DB00502HaloperidolCarbonyl reductase [NADPH] 1enzyme
DB00502HaloperidolUDP-glucuronosyltransferase 1-9enzyme
DB00502HaloperidolCytochrome P450 2C19enzyme
DB00502HaloperidolCytochrome P450 2C9enzyme
DB00502HaloperidolMelanin-concentrating hormone receptor 1target
DB00502HaloperidolSynaptic vesicular amine transportertarget
DB00502Haloperidol5-hydroxytryptamine receptor 2Ctarget
DB00502HaloperidolSigma non-opioid intracellular receptor 1target
DB00502HaloperidolHistamine H1 receptortarget
DB00502HaloperidolMuscarinic acetylcholine receptor M3target
DB00502HaloperidolAlpha-1A adrenergic receptortarget
DB00502HaloperidolAlpha-2A adrenergic receptortarget
DB00502HaloperidolAlpha-2B adrenergic receptortarget
DB00502HaloperidolAlpha-2C adrenergic receptortarget
DB00502Haloperidol5-hydroxytryptamine receptor 1Atarget
DB00502Haloperidol5-hydroxytryptamine receptor 6target
DB00502Haloperidol5-hydroxytryptamine receptor 7target
DB00502HaloperidolCytochrome P450 1A1enzyme
DB00557HydroxyzineHistamine H1 receptortarget
DB00557HydroxyzineCytochrome P450 2D6enzyme
DB00557HydroxyzineCytochrome P450 3A4enzyme
DB00557HydroxyzineCytochrome P450 3A5enzyme
DB00557HydroxyzinePotassium voltage-gated channel subfamily H member 2target
DB00557HydroxyzineP-glycoprotein 1transporter
DB00557HydroxyzineSerum albumincarrier
DB04924ItoprideDopamine D2 receptortarget
DB04924ItoprideAcetylcholinesterasetarget
DB01403MethotrimeprazineDopamine D3 receptortarget
DB01403MethotrimeprazineHistamine H1 receptortarget
DB01403MethotrimeprazineMuscarinic acetylcholine receptor M1target
DB01403MethotrimeprazineMuscarinic acetylcholine receptor M2target
DB01403MethotrimeprazineMuscarinic acetylcholine receptor M3target
DB01403MethotrimeprazineMuscarinic acetylcholine receptor M4target
DB01403MethotrimeprazineMuscarinic acetylcholine receptor M5target
DB01403MethotrimeprazineAlpha-1A adrenergic receptortarget
DB01403MethotrimeprazineAlpha-1B adrenergic receptortarget
DB01403MethotrimeprazineAlpha-1D adrenergic receptortarget
DB01403MethotrimeprazineCytochrome P450 2D6enzyme
DB01403MethotrimeprazineDopamine D2 receptortarget
DB01403MethotrimeprazineDopamine D1 receptortarget
DB01403MethotrimeprazineDopamine D5 receptortarget
DB01403MethotrimeprazineDopamine D4 receptortarget
DB01403MethotrimeprazineAlpha-2A adrenergic receptortarget
DB01403MethotrimeprazineAlpha-2B adrenergic receptortarget
DB01403MethotrimeprazineAlpha-2C adrenergic receptortarget
DB01403Methotrimeprazine5-hydroxytryptamine receptor 2Atarget
DB01403Methotrimeprazine5-hydroxytryptamine receptor 2Ctarget
DB01403MethotrimeprazineCytochrome P450 2E1enzyme
DB01233MetoclopramideMuscarinic acetylcholine receptor M1target
DB01233MetoclopramideDopamine D2 receptortarget
DB01233MetoclopramideCytochrome P450 2D6enzyme
DB01233Metoclopramide5-hydroxytryptamine receptor 4target
DB01233Metoclopramide5-hydroxytryptamine receptor 3Atarget
DB01233MetoclopramideCytochrome P450 3A4enzyme
DB01233MetoclopramideCytochrome P450 1A2enzyme
DB01233MetoclopramideP-glycoprotein 1transporter
DB01233MetoclopramideAlpha-1-acid glycoprotein 1carrier
DB00165PyridoxinePyridoxal kinasetarget
DB00165PyridoxineCytochrome P450 1A1enzyme
DB00165PyridoxineSerum albumincarrier
DB00165PyridoxinePyridoxal kinaseenzyme
DB00165PyridoxinePyridoxal phosphate phosphataseenzyme
DB00165PyridoxineAlkaline phosphatase, tissue-nonspecific isozymetransporter
DB00165PyridoxineAlkaline phosphatase, tissue-nonspecific isozymeenzyme
DB00372ThiethylperazineDopamine D2 receptortarget
DrugDrug NamePhaseStatusCount
DB00673Aprepitant1Completed1
DB00531Cyclophosphamide1Completed1
DB00333Methadone1Terminated1
DB00673Aprepitant2Completed2
DB04690Camptothecin2Completed1
DB06634Casopitant2Completed1
DB00515Cisplatin2Terminated1
DB01234Dexamethasone2Completed2
DB01234Dexamethasone2Terminated1
DB00757Dolasetron2Completed1
DB00544Fluorouracil2Completed1
DB06717Fosaprepitant2Completed1
DB06717Fosaprepitant2Terminated1
DB00889Granisetron2Completed1
DB00762Irinotecan2Completed1
DB00650Leucovorin2Completed1
DB00104Octreotide2Completed1
DB00904Ondansetron2Completed3
DB00526Oxaliplatin2Completed1
DB00377Palonosetron2Completed1
DB00377Palonosetron2Terminated2
DB00433Prochlorperazine2Completed1
DB00296Ropivacaine2Recruiting1
DB11699Tropisetron2Completed1
DB00673Aprepitant3Completed1
DB06634Casopitant3Withdrawn1
DB00515Cisplatin3Completed1
DB00531Cyclophosphamide3Completed1
DB01234Dexamethasone3Completed4
DB01234Dexamethasone3Withdrawn1
DB01248Docetaxel3Completed1
DB00757Dolasetron3Completed1
DB01184Domperidone3Recruiting1
DB00997Doxorubicin3Completed1
DB06717Fosaprepitant3Completed1
DB00996Gabapentin3Completed1
DB00889Granisetron3Completed4
DB00889Granisetron3Unknown Status1
DB12964Lerisetron3Unknown Status1
DB01233Metoclopramide3Completed1
DB00334Olanzapine3Completed1
DB00904Ondansetron3Completed3
DB00904Ondansetron3Withdrawn1
DB00377Palonosetron3Completed2
DB00433Prochlorperazine3Completed1
DB00486Nabilone4Terminated1
DB00904Ondansetron4Terminated1
DB00818Propofol4Completed1
DB00673AprepitantNot AvailableCompleted1
DB00673AprepitantNot AvailableTerminated2
DB00673AprepitantNot AvailableWithdrawn1
DB06698BetahistineNot AvailableCompleted1
DB00958CarboplatinNot AvailableTerminated1
DB14547Chloride ionNot AvailableTerminated1
DB00515CisplatinNot AvailableTerminated1
DB00531CyclophosphamideNot AvailableCompleted2
DB01234DexamethasoneNot AvailableCompleted2
DB01234DexamethasoneNot AvailableTerminated2
DB00757DolasetronNot AvailableTerminated1
DB00997DoxorubicinNot AvailableCompleted1
DB00889GranisetronNot AvailableCompleted1
DB00889GranisetronNot AvailableTerminated1
DB00904OndansetronNot AvailableCompleted3
DB00904OndansetronNot AvailableUnknown Status1
DB00904OndansetronNot AvailableWithdrawn1
DB00377PalonosetronNot AvailableCompleted1
DB12257PlatinumNot AvailableTerminated1
DB09290RamosetronNot AvailableUnknown Status1