Cross-Linking Reagents

Name
Cross-Linking Reagents
Accession Number
DBCAT000713
Description

Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other.

Drugs
DrugDrug Description
MitomycinAn antimetabolite used as an adjunct to ab externo (outside approach) eye surgeries for the treatment of glaucoma and used as a chemotherapeutic agent for various malignancies.
CarboplatinA alkylating agent used to treat advanced ovarian cancer.
RimiducidA homodimerizing agent potentially used in combination with cellular immunotherapies for cancers and blood disorders to increase the therapeutic effectiveness.
GlutaralOne of the protein CROSS-LINKING REAGENTS that is used as a disinfectant for sterilization of heat-sensitive equipment and as a laboratory reagent, especially as a fixative.
CisplatinA platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors.
MethoxsalenA furocoumarin used to treat psoriasis and vitiligo.
1,10-PhenanthrolineNot Available
PlatinumPlatinum is under investigation for the treatment of Metastatic Breast Cancer, Non-small Cell Lung Cancer, Gastric Large Cell Neuroendocrine Carcinoma, Colorectal Large Cell Neuroendocrine Carcinoma, and Pancreatic Large Cell Neuroendocrine...
Methyl 2,5-dihydroxycinnamateNot Annotated
DiaziquoneNot Annotated
PsoralenNot Annotated
Drugs & Drug Targets
DrugTargetType
MitomycinDNAtarget
MitomycinNADPH--cytochrome P450 reductaseenzyme
CarboplatinDNAtarget
CarboplatinHigh affinity copper uptake protein 1transporter
CarboplatinProtein SLC31A2transporter
CarboplatinXanthine dehydrogenase/oxidaseenzyme
CarboplatinMyeloperoxidaseenzyme
CarboplatinGlutathione S-transferase theta-1enzyme
CarboplatinMetallothionein-1Aenzyme
CarboplatinMetallothionein-2enzyme
CarboplatinSuperoxide dismutase [Cu-Zn]enzyme
CarboplatinGlutathione S-transferase Penzyme
CarboplatinGlutathione S-transferase Mu 1enzyme
CarboplatinNAD(P)H dehydrogenase [quinone] 1enzyme
CarboplatinCopper-transporting ATPase 1transporter
CarboplatinCopper-transporting ATPase 2transporter
CarboplatinBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
CarboplatinATP-binding cassette sub-family C member 2transporter
RimiducidSerine/threonine-protein kinase mTORtarget
RimiducidPeptidyl-prolyl cis-trans isomerase FKBP1Atarget
CisplatinDNAtarget
CisplatinATP-binding cassette sub-family C member 3transporter
CisplatinATP-binding cassette sub-family C member 5transporter
CisplatinATP-binding cassette sub-family C member 2transporter
CisplatinSolute carrier family 22 member 2transporter
CisplatinHigh affinity copper uptake protein 1transporter
CisplatinProtein SLC31A2transporter
CisplatinATP-binding cassette sub-family C member 6transporter
CisplatinCopper-transporting ATPase 2transporter
CisplatinCopper-transporting ATPase 1transporter
CisplatinProstaglandin G/H synthase 2enzyme
CisplatinMyeloperoxidaseenzyme
CisplatinXanthine dehydrogenase/oxidaseenzyme
CisplatinArylamine N-acetyltransferaseenzyme
CisplatinCytochrome P450 2C9enzyme
CisplatinCytochrome P450 2B6enzyme
CisplatinCholinesteraseenzyme
CisplatinCytochrome P450 4A11enzyme
CisplatinBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
CisplatinGlutathione S-transferase theta-1enzyme
CisplatinMetallothionein-1Aenzyme
CisplatinMetallothionein-2enzyme
CisplatinSuperoxide dismutase [Cu-Zn]enzyme
CisplatinGlutathione S-transferase Penzyme
CisplatinNAD(P)H dehydrogenase [quinone] 1enzyme
CisplatinGlutathione S-transferase Mu 1enzyme
CisplatinDNA-3-methyladenine glycosylasetarget
CisplatinAlpha-2-macroglobulintarget
CisplatinAlbumincarrier
CisplatinSerotransferrintarget
CisplatinCopper transport protein ATOX1target
MethoxsalenDNAtarget
MethoxsalenCytochrome P450 2A6enzyme
MethoxsalenCytochrome P450 1A2enzyme
MethoxsalenCytochrome P450 1A1enzyme
MethoxsalenCytochrome P450 2A13enzyme
MethoxsalenCytochrome P450 2A6target
1,10-PhenanthrolineMethyl-accepting chemotaxis protein IItarget
1,10-PhenanthrolineMetallo-beta-lactamase L1target
PsoralenAmine oxidase [flavin-containing] Btarget
PsoralenAmine oxidase [flavin-containing] Atarget