Neovascular Age-Related Macular Degeneration (nAMD)

Also known as: Neovascular Age Related Macular Degeneration (AMD) / Neovascular Age-related Macular Degeneration(AMD) / Exudative Age Related Macular Degeneration / Age-Related Neovascular Macular Degeneration / Neovascular Age-Related Macular Degeneration / Exudative Age-Related Macular Degeneration / Neovascular Age Related Macular Degeneration / Exudative age-related macular degeneration (disorder) / Kuhnt-Junius degeneration (disorder) / Wet age-related macular degeneration / Disciform macular degeneration / Exudative senile macular retinal degeneration / Exudative senile macular degeneration of retina

Drug	Drug Name	Drug Description
DB08885	Aflibercept	A vascular endothelial growth factor (VEGF) inhibitor used to treat Neovascular (Wet) Age-Related Macular Degeneration (AMD), various types of macular edema and diabetic retinopathy.
DB14864	Brolucizumab	An anti VEGF-A monoclonal antibody indicated to treat neovascular age related macular degeneration.
DB15303	Faricimab	An IgG1-derived bispecific antibody against VEGF-A and Ang-2 for the treatment of age-related macular degeneration and diabetic macular edema.
DB04895	Pegaptanib	A selective vascular endothelial growth factor (VEGF) antagonist used for the treatment of neovascular (wet) age-related macular degeneration.
DB01270	Ranibizumab	A recombinant humanized monoclonal antibody and VEGF-A antagonist used for the management of macular edema after retinal vein occlusion, age-related macular degeneration (wet), and diabetic macular edema.

Drug	Drug Name	Target	Type
DB08885	Aflibercept	Vascular endothelial growth factor A	target
DB08885	Aflibercept	Placenta growth factor	target
DB08885	Aflibercept	Vascular endothelial growth factor B	target
DB14864	Brolucizumab	Vascular endothelial growth factor A	target
DB15303	Faricimab	Vascular endothelial growth factor A	target
DB15303	Faricimab	Angiopoietin-2	target
DB04895	Pegaptanib	Vascular endothelial growth factor A	target
DB01270	Ranibizumab	Vascular endothelial growth factor A	target

Drug	Drug Name	Phase	Status	Count
DB08885	Aflibercept	1	Active Not Recruiting	3
DB08885	Aflibercept	1	Completed	5
DB14131	Basic Fibroblast Growth Factor	1	Completed	1
DB00112	Bevacizumab	1	Active Not Recruiting	1
DB00112	Bevacizumab	1	Completed	1
DB00112	Bevacizumab	1	Unknown Status	1
DB00112	Bevacizumab	1	Withdrawn	1
DB16817	Ixoberogene soroparvovec	1	Active Not Recruiting	1
DB15330	Nesvacumab	1	Completed	1
DB16694	Pegcetacoplan	1	Completed	1
DB01270	Ranibizumab	1	Active Not Recruiting	1
DB01270	Ranibizumab	1	Completed	2
DB06305	Sonepcizumab	1	Unknown Status	1
DB01268	Sunitinib	1	Completed	1
DB08885	Aflibercept	1 / 2	Completed	2
DB08885	Aflibercept	1 / 2	Unknown Status	1
DB03006	Arsanilic acid	1 / 2	Completed	1
DB06626	Axitinib	1 / 2	Completed	1
DB14864	Brolucizumab	1 / 2	Completed	1
DB01234	Dexamethasone	1 / 2	Completed	1
DB16694	Pegcetacoplan	1 / 2	Terminated	1
DB01270	Ranibizumab	1 / 2	Completed	3
DB16081	Acrizanib	2	Completed	1
DB08885	Aflibercept	2	Active Not Recruiting	2
DB08885	Aflibercept	2	Completed	7
DB08885	Aflibercept	2	Not Yet Recruiting	1
DB08885	Aflibercept	2	Recruiting	1
DB08885	Aflibercept	2	Terminated	3
DB00112	Bevacizumab	2	Completed	1
DB00112	Bevacizumab	2	Recruiting	1
DB00112	Bevacizumab	2	Terminated	1
DB00112	Bevacizumab	2	Unknown Status	1
DB14864	Brolucizumab	2	Completed	3
DB15330	Nesvacumab	2	Completed	1
DB08888	Ocriplasmin	2	Completed	1
DB01270	Ranibizumab	2	Completed	9
DB01270	Ranibizumab	2	Recruiting	1
DB01270	Ranibizumab	2	Terminated	1
DB16313	Rinucumab	2	Terminated	1
DB00877	Sirolimus	2	Completed	1
DB06305	Sonepcizumab	2	Completed	1
DB00421	Spironolactone	2	Completed	1
DB06461	Squalamine	2	Completed	1
DB01268	Sunitinib	2	Completed	1
DB11926	Tesidolumab	2	Terminated	1
DB00460	Verteporfin	2	Completed	1
DB00460	Verteporfin	2	Unknown Status	1
DB00399	Zoledronic acid	2	Active Not Recruiting	1
DB00869	Dorzolamide	2 / 3	Completed	1
DB01270	Ranibizumab	2 / 3	Completed	1
DB00373	Timolol	2 / 3	Completed	1
DB08885	Aflibercept	3	Active Not Recruiting	3
DB08885	Aflibercept	3	Completed	8
DB08885	Aflibercept	3	Recruiting	2
DB08885	Aflibercept	3	Suspended	1
DB08885	Aflibercept	3	Terminated	2
DB00112	Bevacizumab	3	Active Not Recruiting	1
DB00112	Bevacizumab	3	Completed	3
DB00112	Bevacizumab	3	Unknown Status	3
DB14864	Brolucizumab	3	Active Not Recruiting	1
DB14864	Brolucizumab	3	Completed	6
DB14864	Brolucizumab	3	Recruiting	1
DB12460	Conbercept	3	Terminated	2
DB15303	Faricimab	3	Active Not Recruiting	1
DB15303	Faricimab	3	Completed	1
DB01270	Ranibizumab	3	Completed	6
DB01270	Ranibizumab	3	Not Yet Recruiting	1
DB01270	Ranibizumab	3	Recruiting	5
DB01270	Ranibizumab	3	Suspended	1
DB01270	Ranibizumab	3	Unknown Status	1
DB00620	Triamcinolone	3	Unknown Status	2
DB00460	Verteporfin	3	Unknown Status	1
DB08885	Aflibercept	4	Completed	4
DB08885	Aflibercept	4	Unknown Status	3
DB00112	Bevacizumab	4	Completed	1
DB14864	Brolucizumab	4	Active Not Recruiting	1
DB14864	Brolucizumab	4	Recruiting	1
DB14864	Brolucizumab	4	Terminated	1
DB11059	Carboxymethylcellulose	4	Unknown Status	1
DB01234	Dexamethasone	4	Terminated	1
DB06802	Nepafenac	4	Unknown Status	1
DB15566	Prednisolone acetate	4	Terminated	1
DB01270	Ranibizumab	4	Completed	9
DB01270	Ranibizumab	4	Recruiting	2
DB01270	Ranibizumab	4	Unknown Status	2
DB00620	Triamcinolone	4	Recruiting	1
DB00460	Verteporfin	4	Recruiting	1
DB08885	Aflibercept	Not Available	Active Not Recruiting	2
DB08885	Aflibercept	Not Available	Completed	2
DB08885	Aflibercept	Not Available	Recruiting	1
DB08885	Aflibercept	Not Available	Withdrawn	1
DB00126	Ascorbic acid	Not Available	Unknown Status	1
DB06626	Axitinib	Not Available	Completed	1
DB00112	Bevacizumab	Not Available	Completed	4
DB00112	Bevacizumab	Not Available	Unknown Status	1
DB14864	Brolucizumab	Not Available	Active Not Recruiting	1
DB14864	Brolucizumab	Not Available	Completed	1
DB14864	Brolucizumab	Not Available	Recruiting	2
DB00151	Cysteine	Not Available	Unknown Status	1
DB15303	Faricimab	Not Available	Recruiting	1
DB04335	Inosine	Not Available	Unknown Status	1
DB16817	Ixoberogene soroparvovec	Not Available	Active Not Recruiting	1
DB01017	Minocycline	Not Available	Unknown Status	1
DB02701	Nicotinamide	Not Available	Unknown Status	1
DB04895	Pegaptanib	Not Available	Completed	2
DB04895	Pegaptanib	Not Available	Withdrawn	1
DB01270	Ranibizumab	Not Available	Active Not Recruiting	1
DB01270	Ranibizumab	Not Available	Recruiting	1
DB01270	Ranibizumab	Not Available	Unknown Status	2
DB11251	Tocopherol	Not Available	Unknown Status	1
DB12647	Tocotrienol	Not Available	Unknown Status	1
DB00620	Triamcinolone	Not Available	Withdrawn	1
DB09270	Ubidecarenone	Not Available	Unknown Status	1
DB00460	Verteporfin	Not Available	Withdrawn	1