Cachexia (DBCOND0004466)

Identifiers

Synonyms
Wasting syndrome / Cachectic / Wasting disease (disorder) / Wasting generalized / Wasting generalised / Cachexia (finding) / General health deterioration (finding)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Megestrol acetate
A progestin that is administered orally to treat anorexia and cachexia or serious unexplained weight loss and is also used as an antineoplastic agent to treat certain types of malignancy.
Somatotropin
A recombinant human growth hormone used as replacement therapy in various conditions of growth failure, growth hormone deficiency, and weakness in children and adults.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT05588375
The Effects of Home-based Physical Activity Telemonitoring Program in Patients With Heart Failure and Muscle WastingNo drug interventionspreventionNot Availableunknown_status
NCT03982082
Ultrasound in Evaluating Muscle-Glycogen Content in Cancer PatientsNo drug interventionsdevice_feasibilityNot Availableactive_not_recruiting
NCT04906746
Ruxolitinib for Cancer Cachexiatreatment0recruiting
NCT02798003
Food Reward in Cachexia Induced by Acute or Chronic DiseaseNo drug interventionsNot AvailableNot Availableterminated
NCT01865903
Nutritional Problems and Changes in Body Composition in Patients With Non-small Cell Lung Cancer (LEKS)No drug interventionsNot AvailableNot Availableterminated
NCT06028321
Study of Comparative Bioavailability and Pharmacokinetics of ACM-001.1) and Pindolol in Healthy Volunteers (HV)treatment1completed
NCT01694602
Non-Invasive Assessment of Skeletal Muscle Loss in Cancer Patients - Phase IINo drug interventionsNot AvailableNot Availablecompleted
NCT01962454
A Study to Evaluate a Skeletal-muscle Microbiopsy Technique With Dynamic Proteomic Measurement in Healthy Male Volunteersdiagnostic1completed
NCT04815551
A Phase 1 Study of AV-380 in Healthy SubjectsNo drug interventionstreatment1completed
NCT01419145
A Feasibility Study of Multimodal Exercise/Nutrition/Anti-inflammatory Treatment for Cachexia - the Pre-MENAC StudyNo drug interventionssupportive_careNot Availablecompleted
NCT02400398
Evaluating Weight Stability of Pancreatic Cancer Cachexia PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT00933361
Individual Dose-escalated Bi-daily Subcutaneously (sc) Ghrelin in Cancer Cachexia: a Phase I/II Studytreatment1 / 2completed
NCT02926261
Methods for Nutritional Assessment in CirrhosisNo drug interventionsNot AvailableNot Availableunknown_status
NCT04631978
Analysis of Retinochoroidal Vasculature in Underweight Women Using Optical Coherence Tomography AngiographyNo drug interventionsNot AvailableNot Availablecompleted
NCT01533909
Development of a Screening Tool to Detect and Stage Cachectic Cancer PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT00040885
Docetaxel With or Without Infliximab in Treating Weight Loss, Loss of Appetite, and Fatigue in Patients With Unresectable Non-Small Cell Lung Cancer (Infliximab Treatment Discontinued Effective 10/05/05)supportive_care3completed
NCT00535015
Safety and Efficacy Study of Betamarc to Treat Loss of Weight and Appetite in Non-Small Cell Lung CancerNo drug interventionstreatment2terminated
NCT00000737
A Phase I/II Study to Evaluate Single Agent and Combination Therapy With Megestrol Acetate and Dronabinol for the Treatment of HIV-Wasting Syndrometreatment1completed
NCT02650570
Mitochondrial Respiratory Function in Mammalian Skeletal MuscleNo drug interventionsNot AvailableNot Availableterminated
NCT02416570
Is Clarithromycin a Potential Treatment for Cachexia in People With Lung Cancer?supportive_care2terminated
NCT03570242
WB-EMS and Individualized Nutritional Support in Gynecological Cancer PatientsNo drug interventionssupportive_careNot Availableunknown_status
NCT03042442
Relation Between Cachexia, Diabetes and periNeural Invasion in PANcreatic Cancer- Biomarkers SubstudyNo drug interventionsNot AvailableNot Availablecompleted
NCT03162042
Role of Myostatin, Activin A and Follistatin Cachexia of ENT CancersNo drug interventionsNot AvailableNot Availablecompleted
NCT00625742
Multimodal Treatment Strategy for Cancer CachexiatreatmentNot Availableterminated
NCT05023499
Perioperative Glutamine Supplementation and CachexiaNot AvailableNot Availablecompleted
NCT00006799
Megestrol to Limit Weight Loss and Improve Quality of Life in Treating Patients With Head and Neck Cancersupportive_care3completed
NCT00637806
Treatment of Cancer-associated Anorexia Using Megestrol Acetate Concentrated Suspensiontreatment3terminated
NCT00527319
Regimen for the Treatment of Cachexia in Subjects With NSCLCNo drug interventionssupportive_care2completed
NCT04585841
The Effect of Cannabidiol on Lean Body Mass in Patients Receiving Chemotherapysupportive_care1completed
NCT01647841
Maternal Determinants of HIV-exposed and HIV-unexposed Fetal Growth, Birth Outcomes and Early Infant GrowthNo drug interventionsNot AvailableNot Availablecompleted
NCT03606317
Retrospective Review of Cachexia in Lung and Gastrointestinal Cancer PatientsNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT06077734
Muscle Stem Cell Quality in AtrophyNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT00972634
Computerized Questionnaires in Assessing Symptoms, Pain, Depression, and Physical Function in Patients With Metastatic and/or Advanced Locoregional CancerNo drug interventionsNot AvailableNot Availablecompleted
NCT03392116
Single and Multiple Ascending Dose Study of NGM120 in Healthy Adult SubjectsNo drug interventionstreatment1completed
NCT00899158
Biological Markers in Patients With Pancreatic Cancer Experiencing Weight LossNo drug interventionsNot AvailableNot Availablecompleted
NCT01395563
Strength Training on Pancreatic CancerNo drug interventionstreatmentNot Availablewithdrawn
NCT01433263
Clinical Study of BYM338 for the Treatment of Unintentional Weight Loss in Patients With Cancer of the Lung or the Pancreastreatment2completed
NCT04594863
The Investigation of the Mechanism of Cachexia Occurrence for Patients With Gastrointestinal CancerNo drug interventionsNot AvailableNot Availableunknown_status
NCT06277986
Early Diagnosis of Gastric Cancer CachexiaNo drug interventionsNot AvailableNot Availablerecruiting
NCT02580422
Pilot Project for Cardiopulmonary and Functional Evaluation in Patients With Pancreatic Cancer Associated CachexiaNo drug interventionsNot AvailableNot Availableterminated
NCT00851448
Safety, Tolerance and Efficacy of an Oral Nutritional Supplement in Lung Cancer PatientsNo drug interventionssupportive_careNot Availableterminated
NCT02686866
Body Composition Measurements in Chronic Heart FailureNo drug interventionsdiagnostic4unknown_status
NCT00852020
Safety, Tolerance and Efficacy of an Oral Nutritional Supplement in Chronic Heart Failure and Chronic Obstructive Pulmonary Disease PatientsNo drug interventionssupportive_careNot Availablecompleted
NCT03359473
Study to Evaluate the Safety and Efficacy of 13 Weeks of the Selective Androgen Receptor Modulator (SARM) GSK2881078 in Chronic Obstructive Pulmonary Disease (COPD)treatment2completed
NCT02567773
Safety, Tolerability, Pharmacokinetic (PK), and Pharmacodynamic Study of GSK2881078 and Study to Evaluate the Effect of CYP3A4 Inhibition on PK of GSK2881078treatment1completed
NCT05546476
Study of the Efficacy and Safety of Ponsegromab in Patients With Cancer, Cachexia and Elevated GDF-15treatment2active_not_recruiting
NCT04627376
Multimodal Program for Cancer Related Cachexia PreventionNo drug interventionspreventionNot Availablerecruiting
NCT05376592
Assoc. of Genomic Polymorphisms With Cancer Cachexia in Subjects With Panc AdenocarcinomaNo drug interventionsNot AvailableNot Availablerecruiting
NCT01939340
Prevalence of Cachexia in Patients Undergoing ChemotherapyNo drug interventionsNot AvailableNot Availablecompleted
NCT02045940
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Study of GSK2881078 in Single and Repeat Dosestreatment1completed
NCT02802540
Nabilone Effect on the Attenuation of Anorexia, Nutritional Status and Quality of Life in Lung Cancer Patientstreatment2 / 3unknown_status
NCT00002067
A Study Comparing Megestrol Acetate at 800 mg/Day, and Placebo in AIDS Patients With Anorexia and Cachexiatreatment3completed
NCT02500004
Brown Adipose Tissue Activity and Energy Metabolism in CachexiaNo drug interventionsdiagnosticNot Availablecompleted
NCT00163072
Pharmacokinetics and Safety of Transdermal Megestrol Acetatetreatment4withdrawn
NCT00994669
Development of a Non-invasive Assessment of Skeletal Muscle Loss in Cancer PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT00004912
Megestrol and Exercise in Treating Patients With Cancer-Related Weight Losssupportive_care2completed
NCT01941810
Bovine Lactoferrin Supplement in Improving Taste in Patients With Cancer Receiving ChemotherapyNo drug interventionssupportive_careNot Availablecompleted
NCT00172614
The Roles of Cytokines in the Mechanism of Insulin Resistance and Energy BalanceNo drug interventionsNot AvailableNot Availableunknown_status
NCT01397214
Pharmacokinetics of Megace F and Megace OS Under Fasting and Fed Conditions in Healthy Male Volunteerstreatment1completed
NCT03191955
Muscle Wasting in Cancer (MWIC)No drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT05063955
Mechanism of Sarcopenia in Heart FailureNo drug interventionsNot AvailableNot Availablerecruiting
NCT05606523
Microbiota and Pancreatic Cancer CachexiaNo drug interventionsNot AvailableNot Availablerecruiting
NCT02561143
Effectiveness of Nutritional Counselling and "Improved Atta" Supplementation in Cachexic Adult Indian Cancer PatientsNo drug interventionssupportive_careNot Availablecompleted
NCT01262690
A Study In Healthy Subjects Of Single Doses of PF-05230901 Injected Under The SkinNo drug interventionstreatment1terminated
NCT01692990
Study on the Effect of Fish Oil and AppetiteNo drug interventionsbasic_science0completed
NCT04907864
Effect of Multi-modal Intervention Care on Cachexia in Patients With Advanced Cancer Compared to Conventional Management (MIRACLE)supportive_care2unknown_status
NCT06112964
Neurobehavioural and Cognitive Changes in Cancer Cachexia (CANCOG)No drug interventionsNot AvailableNot Availablerecruiting
NCT00060502
A Study of the Safety and Effectiveness of Infliximab (Remicade) in Patients With Pancreatic Cancer Related Cachexiatreatment2completed
NCT02968979
Non-interventional Study to Assess the Frequency of Cachexia in Patients With Non-small Cell Lung Cancer.No drug interventionsNot AvailableNot Availablecompleted
NCT04600154
MS-20 on Gut Microbiota and Risk/Severity of Cachexia in Pancreatic Cancer PatientsNo drug interventionstreatmentNot Availablerecruiting
NCT00053053
Comparison of Nutritional Supplements in Preventing Weight Loss in Patients With CancerNo drug interventionssupportive_care3completed
NCT00002345
The Safety and Effectiveness of Megace in HIV-Infected Womentreatment4completed
NCT04698798
Skeletal Muscle Wasting in SARS-CoV-2No drug interventionsbasic_scienceNot Availablecompleted
NCT05899205
Patient Recorded Indexing MeasurementsNo drug interventionsNot AvailableNot Availablerecruiting
NCT04803305
Study to Compare the Effects of Repeated Doses of an Investigational New Drug and a Placebo on Appetite in Advanced Cancer and Anorexiatreatment1completed
NCT00637728
Treatment of Cancer-anorexia Using Megestrol Acetate Concentrated Suspension in Lung or Pancreatic Cancer Patientstreatment3terminated
NCT00698828
SUN11031 in Cachexia Associated With Chronic Obstructive Pulmonary Disease (COPD)No drug interventionstreatment2completed
NCT03111771
Mitochondrial Activity and Myosteatosis in the Cachexia of Cancers of the Upper Aerodigestive TractNo drug interventionsNot AvailableNot Availableunknown_status
NCT00093678
Celecoxib in Managing Pain, Weight Loss, and Weakness in Patients With Advanced Cancersupportive_careNot Availablewithdrawn
NCT00031707
Comparison of Megestrol and/or Omega-3 Fatty Acid-Enriched Nutritional Supplement in Treating Patients With Cancer-Related Weight Loss and Lack of Appetitesupportive_care3completed
NCT05603585
Optimal Protein Supplementation and Early Exercise In Mechanically Ventilated PatientsNo drug interventionspreventionNot Availablerecruiting
NCT00031785
Megestrol in Treating Patients Who Are Undergoing Radiation Therapy for Lung Cancersupportive_care3completed
NCT06206785
Resting Energy Expenditure in Palliative Cancer PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT00710632
Screening to Predict Weight Loss in Patients With CancerNo drug interventionssupportive_careNot Availableunknown_status
NCT02515032
Pilot Study of Safety and Tolerability of Nutrifriend Cachexia in NSCLC CachexiaNo drug interventionstreatmentNot Availablecompleted
NCT05623852
The Impact of Oligo-Fucoidan in Cancer Cachexia and SarcopeniaNo drug interventionstreatmentNot Availablerecruiting
NCT00004400
Phase II Randomized Study of Physiologic Testosterone Replacement in Premenopausal, HIV-Positive Womentreatment2completed
NCT00002300
A Study of Different Doses of Megestrol Acetate in Patients With AIDS Who Have Anorexia and Malnutritiontreatment2completed
NCT04628975
PeRfusion Emergency VEiNlite TransilluminationNo drug interventionsotherNot Availableunknown_status
NCT05161975
Vitamin K2 Supplements for Muscle RecoveryNo drug interventionspreventionNot Availableunknown_status
NCT00866970
Safety, Efficacy and Pharmacokinetics of ALD518 in Patients With Non-Small Cell Lung Cancer-related Fatigue and CachexiaNo drug interventionstreatment2completed
NCT06517199
Olanzapine for Cancer Related Anorexia-cachexia Syndrometreatment3recruiting
NCT05529849
A Study to Assess the Safety, Tolerability and Pharmacokinetics of TCMCB07 in Single and Multiple Ascending Doses in Health SubjectsNo drug interventionstreatment1completed
NCT05723718
MalnutritiOn Assessment With biOelectrical impedaNce Analysis in gastRic Cancer patIentS Undergoing Multimodal trEatmentNo drug interventionsNot AvailableNot Availablerecruiting
NCT05128318
TuLip : Role of the Tumor Environment in Cancer-related Fat LossNo drug interventionsbasic_scienceNot Availableterminated
NCT05642819
REVOLUTION Surgery (REVOLUTION Surgery)No drug interventionsNot AvailableNot Availablerecruiting
NCT00962234
Metabolism of Lipids in Advanced CancerNot AvailableNot Availableterminated
NCT03207724
Study of Onivyde and 5-FU in Combination With Xilonix for Pancreatic Cancer With Cachexiatreatment1completed
NCT00558558
Haelan and Nutrition in Cancer Patientstreatment2terminated
NCT05865535
A Dose Escalation Study of AV-380 in Metastatic Cancer Patients With CachexiaNo drug interventionstreatment1recruiting
NCT04802486
The Effects of a 12 Week Home-based Exercise Intervention on Physical Performance in Patients With Cancers of the Gastrointestinal Tract With Pre- Cachexia or CachexiaNo drug interventionssupportive_careNot Availablecompleted
NCT02017925
Pulmonary Rehabilitation in Improving Lung Function in Patients With Locally Advanced Non-Small Cell Lung Cancer Undergoing ChemoradiationNo drug interventionssupportive_careNot Availablewithdrawn
NCT04299048
Study to Assess the Safety and Tolerability of Repeated Doses of an Investigational New Drug in Patients With Cancer and Cachexia.treatment1completed
NCT00014248
Adenosine Triphosphate in Treating Patients With Advanced Solid Tumorssupportive_care1completed
NCT00066248
Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatmentsupportive_care2completed
NCT03881826
Investigation of the Gut Microbiota in Patients With Acute Myeloid LeukemiaNo drug interventionsbasic_scienceNot Availablecompleted
NCT02330926
Multimodal Intervention for Cachexia in Advanced Cancer Patients Undergoing Chemotherapyprevention3completed
NCT05912465
Predicting Lung Cancer-Associated Cachexia With PET ImagingNo drug interventionsdiagnosticNot Availablerecruiting
NCT01015274
Non-invasive Assessment of Skeletal Muscle Loss in Cancer PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT01387282
Safety and Efficacy of Anamorelin HCl in Patients With Non-Small Cell Lung Cancer-Cachexia (ROMANA 2)treatment3completed
NCT01829880
Impact of Body Composition on Bisoprolol and Ramipril Pharmacokinetics in Patients With Chronic Heart FailureNo drug interventionsNot AvailableNot Availableunknown_status
NCT00244192
Effects of Infliximab (Remicade) on Fat Free Mass in Patients With Moderate to Severe COPD Suffering From Cachexiatreatment2completed
NCT05028192
Mitochondria Preservation by Exercise Training: a Targeted Therapy for Cancer and Chemotherapy-induced CachexiaNo drug interventionsNot AvailableNot Availableunknown_status
NCT00467844
Study of GTx-024 on Muscle Wasting (Cachexia) Cancer.supportive_care2completed
NCT06516367
Screening Tool for Malnutrition, Sarcopenia, and CachexiaNo drug interventionsNot AvailableNot Availablecompleted
NCT05307367
Cancer-associated Muscle Mass - Molecular Factors and Exercise MechanismsNo drug interventionsbasic_scienceNot Availablerecruiting
NCT00046904
Etanercept in Treating Cancer-Related Cachexia and Anorexia in Patients With Advanced Cancersupportive_care3completed
NCT00486304
Low Antioxidant Diet in Controlling Cachexia in Patients With Oropharyngeal Cancer Receiving Chemotherapy and Radiation TherapyNo drug interventionssupportive_care1completed
NCT01696604
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GSK2849466 in Healthy Male SubjectsNo drug interventionsother1completed
NCT00637572
Evaluate Weight Gain Using 2 Different Formulations of Megestrol Acetate Oral Suspension for AIDS-related Weight Losstreatment2completed
NCT01387269
Safety and Efficacy of Anamorelin HCl in Patients With Non-Small Cell Lung Cancer-Cachexia (ROMANA 1)treatment3completed
NCT02418546
Electronic-health Application To Measure Outcomes REmotely Clinical TrialNo drug interventionssupportive_careNot Availablecompleted
NCT03561610
Novel Form of Nutritional Supplementation in Cancer PatientsNo drug interventionssupportive_careNot Availableunknown_status
NCT00878995
Testosterone for Treating Cachexia in Patients With Squamous Cell Carcinomasupportive_care1completed
NCT01395914
Anamorelin HCl in the Treatment of Non-Small Cell Lung Cancer-Cachexia (NSCLC-C): An Extension Study (ROMANA 3)treatment3completed
NCT02350855
Impact of Nutritional Intervention in Indian Female Cancer Cachexia PatientsNo drug interventionssupportive_care2completed
NCT00081250
Creatine in Treating Patients With Cancer-Associated Weight LossNo drug interventionssupportive_care3completed
NCT02442908
Pilot Study of Safety and Tolerability of Nutrifriend Cachexia in COPD CachexiaNo drug interventionstreatmentNot Availablecompleted