Hyperaldosteronism (DBCOND0009405)

Identifiers

Synonyms

Hyperaldosteronism, unspecified / Aldosteronism (disorder) / Hyperaldosteronaemia / Aldosteronism / Aldosteronism NOS

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Furosemide	A loop diuretic used to treat hypertension and edema in congestive heart failure, liver cirrhosis, renal disease, and hypertension.	Solute carrier family 12 member 1target Albumincarrier Solute carrier family 22 member 6transporter Organic cation/carnitine transporter 2transporter Organic anion transporter 3transporter ATP-binding cassette sub-family C member 2transporter Solute carrier organic anion transporter family member 2A1transporter Solute carrier family 22 member 11transporter 6-phosphogluconate dehydrogenase, decarboxylatingenzyme Carbonic anhydrase 2target UDP-glucuronosyltransferase 1A1enzyme Thyroxine-binding globulincarrier G-protein coupled receptor 35target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04605549	A Study of CIN-107 in Adults With Primary Aldosteronism	No drug interventions	treatment	2	active_not_recruiting
NCT06246357	Evaluating the Functional Status of the Adrenal Glands With [68Ga]Ga-PentixaFor in Hyperaldosteronism and Hypercortisolism	Boclatixafortide gallium Ga-68	diagnostic	2	recruiting
NCT06029803	Antecubital Versus Femoral Approach for Adrenal Venous Sampling	No drug interventions	diagnostic	Not Available	recruiting
NCT02751021	Sleep Apnea Diagnosis Using a Novel Pacemaker Algorithm and Link With Aldosterone Plasma Level in Patients Presenting With Diastolic Dysfunction	No drug interventions	diagnostic	Not Available	completed
NCT06008184	Real-time Monitoring of Cortisol - Comparison of Cortisol Levels in Four Biological Fluids	No drug interventions	Not Available	Not Available	recruiting
NCT00004354	Study of Prevalence and Clinical Phenotype in Patients With Glucocorticoid-Remediable Aldosteronism	No drug interventions	Not Available	Not Available	completed
NCT02832388	Primary Aldosteronism in Western Norway	No drug interventions	Not Available	Not Available	recruiting
NCT01431326	Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care	Alfentanil Amikacin Aminocaproic acid Bosentan Cefepime Cidofovir Ciprofloxacin Clozapine Fosfomycin Haloperidol Labetalol Lurasidone Methylprednisolone Molindone Nafcillin Nifedipine Oxycodone Pentobarbital Piperacillin Rocuronium Sevelamer Spironolactone Tazobactam Tobramycin Tranexamic acid Vancomycin Vecuronium Warfarin Ziprasidone Zolpidem	Not Available	Not Available	completed
NCT01234220	Adrenal Vein Sampling International Study (AVIS Study)	No drug interventions	Not Available	Not Available	completed
NCT01897727	Etiology of Sleep Apnea-related Hyperaldosteronism - BP Treatment	Spironolactone	treatment	Not Available	completed
NCT00001176	Effects of Salt Intake on the Nervous Systems of Patients With Salt-Sensitive High Blood Pressure	No drug interventions	Not Available	Not Available	completed
NCT04328181	Comparison of Imaging Quality Between Spectral Photon Counting Computed Tomography (SPCCT) and Dual Energy Computed Tomography (DECT)	No drug interventions	diagnostic	Not Available	recruiting
NCT06192238	China National Study of Adrenal Venous Sampling	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT00155064	Kallikrein-kinin (KKS) and Renin-angiotensin-aldosterone System (RAAS) in Primary Aldosteronism	Captopril Losartan	diagnostic	4	completed
NCT00407784	Diagnostic Properties of Aldosterone-Renin Ratio in Primary Aldosteronism Among Hypertensives.	Eplerenone	Not Available	Not Available	unknown_status
NCT02030587	Laparoscopic Adrenalectomy Versus Radiofrequency Ablation	No drug interventions	treatment	Not Available	unknown_status
NCT01096654	SPARTACUS: Subtyping Primary Aldosteronism: a Randomized Trial Comparing Adrenal Vein Sampling and Computed Tomography Scan.	No drug interventions	diagnostic	3	completed
NCT03778645	Adrenal Venous Sampling Via an Antecubital Approach	No drug interventions	Not Available	Not Available	unknown_status
NCT03414918	Macrolides for KCNJ5 - Mutated Aldosterone-Producing Adenoma (MAPA)	Clarithromycin Roxithromycin	diagnostic	Not Available	unknown_status
NCT06090617	Water and Electrolytes Content in HYpertension (WHYSKI) in the SKIn	No drug interventions	Not Available	Not Available	recruiting
NCT00553722	Does Aldosterone Cause Hypertension by a Non-Renal Mechanism?	Eplerenone	diagnostic	4	unknown_status
NCT04150666	The Water Intake Trail and Primary Aldosteronism Postoperation(WIT-PAP)	No drug interventions	treatment	Not Available	withdrawn
NCT02945904	IS Metomidate PET-CT Superior to Adrenal Venous Sampling in Predicting Outcome From Adrenalectomy in Patients With Primary Hyperaldosteronism	No drug interventions	Not Available	Not Available	completed
NCT00451672	The Therapeutic Effect of Bromocriptin in Patients With Primary Aldosteronism	Bromocriptine	treatment	4	unknown_status
NCT05925569	Electronic Alert to Improve Testing For Primary Aldosteronism in Patients With Hypertension	No drug interventions	screening	Not Available	not_yet_recruiting