NCT06031727
CRISPR/cas13-medIated RNA tarGeting tHerapy for the Treatment of Neovascular Age-related Macular Degeneration Investigator-initiated Trial (SIGHT-I) No drug interventions treatment 0 recruiting NCT06132035
Study to Evaluate the Safety of CG-P5 Peptide Eye Drops in Patients Diagnosed With Age-related Wet Macular Degeneration treatment 1 not_yet_recruiting NCT02089503
Monocentric Retrospective Observational Study on Patients With Macular Degeneration No drug interventions Not Available Not Available unknown_status NCT02732899
Sirolimus in Conjunction With Eylea vs Eylea Alone for Exudative AMD treatment 2 completed NCT01414153
Efficacy and Safety Study of iSONEP With & Without Lucentis/Avastin/Eylea to Treat Wet AMD treatment 2 completed NCT01404845
Macular Pigment Density Evolution in Unilateral Wet AMD Versus Non AMD Patients With or Without Lutein and Zeaxanthine Supplementation No drug interventions basic_science Not Available completed NCT02355028
LHA510 Proof-of-Concept Study as a Maintenance Therapy for Patients With Wet Age-Related Macular Degeneration treatment 2 completed NCT01810042
Indocyanine Angiographic Changes of Choroidal Neovascularization by Ranibizumab treatment 4 completed NCT01950741
Effect of Intravitreal VEGF-Trap Eye on Polypoidal Choroidal Vasculopathy treatment 4 completed NCT04200248
A Phase II Study of RBM-007 Alone and RBM-007 With Eylea® in Subjects With Wet Age-related Macular Degeneration treatment 2 completed NCT04075136
Optical Coherence Tomography Angiography (OCTA) - Directed PDT Triple Therapy treatment 4 withdrawn NCT01819415
Omega-3 Supplementation and Vitreal VEGF Levels in Wet-AMD No drug interventions treatment Not Available completed NCT00927303
The Spectralis-Cirrus Study No drug interventions Not Available Not Available completed NCT04138420
Evaluation of Retinal and Vascular Features in Macular Degeneration After Intravitreal Injections of Bevacizumab Not Available Not Available completed NCT02903576
Stem Cell Therapy for Outer Retinal Degenerations No drug interventions treatment 1 / 2 completed NCT01306591
Bevacizumab for Neovascular Age-related Macular Degeneration treatment Not Available completed NCT01849692
ESBA1008 Microvolume Study treatment 2 completed NCT00913744
Safety and Efficacy Study of Intravitreal Ocriplasmin in Subjects With AMD With Focal Vitreomacular Adhesion treatment 2 completed NCT04640272
A Multi-Center, Open Label, Extension Study Assessing the Efficacy and Safety of Additional Intravitreal Injections of RBM-007 in Subjects With Wet Age-related Macular Degeneration No drug interventions treatment 2 completed NCT01961414
Treat and Extend Therapy Study Using Intravitreal Aflibercept for Patients Exited From Protocol VGFT-OD 0910 treatment 4 unknown_status NCT00793923
A Prospective Study Comparing Ranibizumab Plus Dexamethasone Combination Therapy Versus Ranibizumab Monotherapy for Wet AMD supportive_care 1 / 2 completed NCT02125864
Plasma Levels of Vascular Endothelial Growth Factor Before and After Intravitreal Injection of Aflibercept No drug interventions basic_science 4 completed NCT01796964
Efficacy and Safety Study of ESBA1008 Versus EYLEA® treatment 2 completed NCT01304693
ESBA1008 Safety, Tolerability and Effects in Wet Age-Related Macular Degeneration (AMD) Patients treatment 1 / 2 completed NCT02328209
Evaluation of the Simplified Treat And Extend Regimen Using Ranibizumab in Exudative Age Related Macular Degeneration treatment Not Available unknown_status NCT01500915
FUSION Regimen: Combined Pro re Nata and Fixed Regimen Ranibizumab in Exudative Age-related Macular Degeneration treatment 4 completed NCT02348359
X-82 to Treat Age-related Macular Degeneration treatment 2 terminated NCT01526070
Study of Bimonthly VEGF Trap-Eye Compared to As-needed Administration or Other Therapy for Exudative Age-Related Macular Degeneration Not Available Not Available completed NCT03744806
Blood-aqueous Barrier Integrity in Eyes Undergoing Intravitreal Bevacizumab Therapy to Treat Neovascular AMD Not Available Not Available completed NCT01608113
Long-term Follow-up of Subfoveal Neovascular AMD No drug interventions Not Available Not Available unknown_status NCT03071055
Efficacy of Biweekly Ranibizumab (0.5 mg) for Exudative Macular Degeneration Retinal Edema Refractory to Anti-VEGF treatment 2 completed NCT04723160
Computer Aided Diagnosis of Multiple Eye Fundus Diseases From Color Fundus Photograph No drug interventions Not Available Not Available completed NCT01527435
Addition of 20mg/Day Zeaxanthin to Triple Therapy Treatment Options for Age Related Macular Degeneration (ARMD) No drug interventions Not Available Not Available completed NCT05539235
Efficacy and Safety of Intravitreal Conbercept With Modified Treat-and-Extend Regimens in Exudative AMD No drug interventions treatment 2 / 3 unknown_status NCT01157065
Evaluation of AL-78898A in Exudative Age-Related Macular Degeneration treatment 2 completed NCT01213082
ProspectiveTrial of Proton Beam Combined With Anti-VEGF Therapy for Exudative Age-related Macular Degeneration (AMD) No drug interventions treatment 1 / 2 completed NCT03169660
Intravitreal Aflibercept for Submacular Hemorrhage treatment 4 completed NCT01127360
LUCAS (Lucentis Compared to Avastin Study) treatment 4 completed NCT02976194
Intraocular Cytokine in Recurrence of Polypoidal Choroidal Vasculopathy basic_science 4 unknown_status NCT01983579
TF (SENSIMED Triggerfish) in Intraocular Anti-VEGF (Vascular Endothelial Growth Factor) Injection No drug interventions diagnostic 4 terminated NCT05476926
A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products Not Available Not Available recruiting NCT04239027
A Study to Assess the Effects of Brolucizumab in Adult Patients With Neovascular Age Related Macular Degeneration treatment 3 completed NCT04597632
An Extension Study Assessing the Efficacy and Safety of Brolucizumab in a Treat-to-Control Regimen in Patients With Neovascular Age-related Macular Degeneration Who Have Completed the CRTH258A2303 (TALON) Study treatment 3 completed NCT04985487
Regulatory Post-Marketing Surveillance Study for Brolucizumab No drug interventions Not Available Not Available recruiting NCT05562947
A Study Of The Efficacy, Safety, And Pharmacokinetics Of The Port Delivery System With Ranibizumab In Chinese Patients With Neovascular Age-Related Macular Degeneration treatment 3 recruiting NCT04777201
A Study to Evaluate the Long-Term Safety and Tolerability of Faricimab in Participants with Neovascular Age-Related Macular Degeneration treatment 3 completed NCT06439576
Real World Evidence in China: Faricimab Use in Diabetic Macular Edema, Retinal Vein Occlusion, and Neovascular Age-Related Macular Degeneration (The Farseeing Study) Not Available Not Available recruiting NCT05904028
Home OCT-Guided Treatment Versus Treat and Extend for the Management of Neovascular AMD treatment 3 recruiting NCT06190093
A 3-month Study to Assess the Safety and Effectiveness of ONS-5010 in Subjects with Neovascular Age-related Macular Degeneration (AMD) treatment 3 active_not_recruiting NCT06491914
A Single-Arm Study of Aflibercept 8 mg Dosed in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD) or Diabetic Macular Edema (DME) treatment 3 recruiting NCT06591598
A Study to Learn About the Blood Levels of Aflibercept When High-dose Aflibercept is Injected in Both Eyes of Participants With Diabetic Macular Edema or Neovascular Age-related Macular Degeneration other 4 not_yet_recruiting NCT02843490
Functional and Structural Outcomes in Neovascular Age-related Macular Degeneration basic_science 4 completed NCT03835884
A Study Assessing AR-13503 Implant in Subjects With nAMD or DME No drug interventions treatment 1 completed NCT04537884
Safety and Tolerability Study of UBX1325 in Patients With Diabetic Macular Edema or Neovascular Age-Related Macular Degeneration No drug interventions treatment 1 completed NCT03930641
Study of the Safety of Brolucizumab 6 mg in Prefilled Syringe in Patients With Neovascular Age Related Macular Degeneration treatment 3 completed NCT01942213
Observational Study to Evaluate and Compare the Rate and Extent of Inflammation After a Single Intravitreal Injection of Ranibizumab vs. a Single Intravitreal Injection of Aflibercept in Treatment Naive and Treatment Experienced Patients. No drug interventions Not Available Not Available completed NCT01863199
Impact of Home Monitoring to Decrease the Treatment Burden for Neovascular Age-related Macular Degeneration (AMD) treatment 4 completed NCT01678963
Efficacy and Safety of Squalamine Lactate Eye Drops in Subjects With Neovascular (Wet) Age-related Macular Degeneration (AMD) treatment 2 completed NCT00767949
Safety Study of iSONEP (Sonepcizumab/LT1009) to Treat Neovascular Age-related Macular Degeneration treatment 1 unknown_status NCT00574093
Efficacy and Safety Study of Lucentis (Ranibizumab) and Visudyne (Verteporfin) Combination Therapy in Neovascular AMD treatment 2 completed NCT00383370
Safety and Tolerability of Intravitreal VEGF Trap Formulations in Subjects With Neovacular AMD No drug interventions treatment 1 completed NCT03777254
Evaluation the Pharmacokinetics,Safety,Tolerability of Single Intravitreal Injection RC28-E in Subjects With Wet Age-Related Macular Degeneration treatment 1 completed NCT01242254
A Study Assessing the Safety and Efficacy of Multiple Intravitreal KH902 in Patients With CNV Due to AMD No drug interventions treatment 1 / 2 completed NCT03683251
Extension Study for the Port Delivery System With Ranibizumab (Portal) treatment 3 recruiting NCT04853251
A Study Assessing Corneal Endothelial Cells in Patients With Neovascular Age-related Macular Degeneration Treated With the Port Delivery System With Ranibizumab (PDS) treatment 4 recruiting NCT03834753
A Clinical Effectiveness Study Examining the Efficacy and Safety of ONS-5010 in Subjects With Neovascular Age-related Macular Degeneration (AMD) treatment 3 completed NCT01926977
Evaluation of Pain and Inflammation After Injection of Lucentis vs Eylea for Treatment of Wet Macular Degeneration treatment 1 / 2 completed NCT04642183
Single In-Clinic Encounter With the Notal Vision Home OCT No drug interventions Not Available Not Available completed NCT03594461
Intense Treatment Regimen With Intravitreal Aflibercept Injection treatment 1 / 2 unknown_status NCT05456828
A Study of ASKG712 in Patients With Neovascular Age-Related Macular Degeneration No drug interventions treatment 1 recruiting NCT04516278
A 3-month Study to Assess the Safety of ONS-5010 in Subjects With Visual Impairment Due to Retinal Disorders treatment 3 completed NCT02507388
Safety and Pharmacokinetics of RTH258 in Subjects With Age-Related Macular Degeneration other 2 completed NCT05961007
Evaluation of IBI302 Injection in nAMD or DME treatment 1 / 2 suspended NCT03065907
Timing of Low Vision Rehabilitation in Anti- Vascular Endothelial Growth Factor (VEGF) Therapy No drug interventions treatment Not Available completed NCT05105607
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of D-4517.2 After Subcutaneous Administration in Healthy Participants No drug interventions treatment 1 completed NCT04690556
Study to Compare Efficacy and Safety of LUBT010 and Lucentis® in Patients With Neovascular AMD treatment 3 completed NCT05941715
Faricimab for High-frequent Aflibercept Treated Neovascular Age-related Macular Degeneration treatment 4 active_not_recruiting NCT05387837
Safety, Tolerability and PK of Subcutaneous D-4517.2 in Subjects With Wet AMD or DME treatment 2 active_not_recruiting NCT03630952
Efficacy and Safety Trial of Conbercept Intravitreal Injection for Neovascular AMD (PANDA-2) treatment 3 terminated NCT04820452
A Study of IBI302 in Patients With nAMD treatment 2 unknown_status NCT04635800
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of IVT MHU650 in Macular Edema Patients No drug interventions treatment 1 completed NCT02613559
Evaluation the Pharmacokinetics, Safety, Tolerability of TK001 in Patients With Neovascular Age-related Macular Degeneration No drug interventions treatment 1 unknown_status NCT02161575
Safety and Efficacy of Switching From Aflibercept to Ranibizumab in Patients With nAMD treatment 4 completed NCT00370370
Intravitreal Bevacizumab vs. Bevacizumab Combined With Triamcinolone for Neovascular AMD treatment 3 unknown_status NCT06178770
Injection Intervals in Real-world Neovascular Age-related Macular Degeneration (nAMD) Patients Switching to Brolucizumab With at Least 12 Months of Follow-up No drug interventions Not Available Not Available completed NCT00820742
Efficacy, Safety, Tolerability of Pegaptanib Sodium (Macugen) in Filipino Patients With Neovascular Age Related Macular Degeneration. Not Available Not Available withdrawn NCT03577899
Efficacy and Safety Trial of Conbercept Intravitreal Injection for Neovascular AMD (PANDA-1) treatment 3 terminated NCT04422899
Effect of Intravitreally Administered AIV007 in Subjects With nAMD No drug interventions treatment 1 completed NCT04563299
Effect on Pain and Inflammation With DEXTENZA Treatment in Patients Undergoing Intravitreal Anti-VEGF Injections treatment 4 terminated NCT04757636
OPT-302 With Aflibercept in Neovascular Age-related Macular Degeneration (nAMD) treatment 3 active_not_recruiting NCT01624636
Safety and Tolerability of Intravenous LFG316 in Wet Age-related Macular Degeneration (AMD). treatment 2 terminated NCT06198413
LX102 in Patients With Neovascular Age-Related Macular Degeneration (nAMD) No drug interventions treatment 1 recruiting NCT00967213
Combination of Ranibizumab and Verteporfin Therapy in Neovascular Age-related Macular Degeneration Not Available 3 completed NCT02530918
Study of DS-7080a for the Treatment of Macular Degeneration treatment 1 completed NCT03699618
Anti-VEGF Therapy for Subfoveal Hemorrhage in Patients With Neovascular Age-Related Macular Degeneration No drug interventions Not Available Not Available terminated NCT05643118
Evaluation of OLX10212 in Patients With Neovascular Age-related Macular Degeneration No drug interventions treatment 1 recruiting NCT06495918
Study to Evaluate the Efficacy and Safety of Intravitreal OTX-TKI (Axitinib Implant) in Subjects With Neovascular Age- Related Macular Degeneration treatment 3 recruiting NCT04864834
Phase III Study Assessing the Efficacy, Safety and Immunogenicity of SOK583A1 Versus Eylea® in Patients With Neovascular Age-related Macular Degeneration treatment 3 completed NCT04832724
RGX-314 Gene Therapy Pharmacodynamic Study for Neovascular Age-related Macular Degeneration (nAMD) No drug interventions treatment 2 completed NCT05611424
Gene Therapy for Wet AMD No drug interventions treatment 1 not_yet_recruiting NCT01775124
Efficacy and Safety of Ranibizumab 0.5 mg Administered as Two Alternative Dosing Regimens in Chinese Patients With nAMD (Age Related Macular Degeneration) treatment 4 completed NCT06223958
Study to Evaluate the Efficacy and Safety of Intravitreal OTX-TKI (Ocular Therapeutix) (Axitinib Implant) in Subjects With Neovascular Age-Related Macular Degeneration treatment 3 recruiting NCT05112835
Brolucizumab Treatment Experience Study of Patients With nAMD in UK Routine Clinical Practice No drug interventions Not Available Not Available terminated NCT06176963
A Study to Evaluate the Usability of the SB11 PFS in Subjects With Wet AMD or Macular Oedema Secondary to RVO treatment 2 completed NCT00370539
Combined PDT and Intravitreal Bevacizumab vs Combination of PDT, Intravitreal Bevacizumab and Triamcinolone for Neovascular AMD treatment 3 unknown_status NCT00599222
The Ranibizumab Plus Transpupillary Thermotherapy for Neovascular Age-Related Macular Degeneration (AMD) Study treatment 3 completed NCT04331730
A Study to Assess the Efficacy and Safety of AKST4290 With Aflibercept in Patients With Newly Diagnosed nAMD treatment 2 completed NCT05891548
Study to Evaluate Suprachoroidally Administered CLS-AX in the Treatment of Neovascular Age-Related Macular Degeneration treatment 2 active_not_recruiting NCT05569148
A Study in Patients With Neovascular Age-Related Macular Degeneration or Diabetic Macular Edema to Evaluate the Safety of the Faricimab Prefilled Syringe treatment 3 completed NCT02251366
NVAMD Satellite Study No drug interventions health_services_research Not Available completed NCT00685100
Retinal Effects After Combined Photodynamic Therapy (PDT) With Intravitreal Triamcinolone No drug interventions treatment 3 completed NCT00640640
The Effects of Bevacizumab and Ranibizumab on Ocular Pulse Amplitude in Neovascular Age Related Macular Degeneration (AMD) Not Available Not Available unknown_status NCT02457026
Adjunctive Photodynamic Therapy + Aflibercept vs. Afilbercept Alone for PDA in NV AMD treatment Not Available withdrawn NCT04774926
Study of Innovative Multimodal Imaging Biomarkers to Predict Anatomical Outcome in Naive Patients With wAMD Treated With Brolucizumab. treatment 4 completed NCT03387566
A Study of Single Intravitreal Injection HB002.1M in Subjects With Neovascular Age-Related Macular Degeneration No drug interventions treatment 1 completed NCT06021366
Treatment Patterns With Brolucizumab in Germany - a Retrospective Cohort Study Based on Longitudinal Prescription Data: REALIZE Study No drug interventions Not Available Not Available completed NCT02367365
Neovascular Morphology and Persistent Disease Activity Among Patients With NV AMD No drug interventions Not Available Not Available completed NCT03844074
A Clinical Effectiveness Study Examining the Efficacy and Safety of ONS-5010 in Subjects With Neovascular Age-related Macular Degeneration (AMD) treatment 3 completed NCT03386474
Study of Safety and Efficacy of Brolucizumab 6 mg Drug Product Intended for Commercialization in Patients With nAMD treatment 3 completed NCT03345082
A Dose Ranging Study of OPT-302 With Ranibizumab in Neovascular (Wet) AMD treatment 2 completed NCT02307682
Efficacy and Safety of RTH258 Versus Aflibercept - Study 1 treatment 3 completed NCT05536973
Safety and Efficacy of ADVM-022 in Treatment-Experienced Patients With Neovascular Age-related Macular Degeneration [LUNA] No drug interventions treatment 2 active_not_recruiting NCT00344227
Prospective OCT Study With Lucentis for Neovascular AMD (PrONTO Study) treatment 2 completed NCT06141460
Safety and Efficacy of RRG001 Gene Therapy in Subjects With Neovascular Age-related Macular Degeneration (nAMD) No drug interventions treatment 1 / 2 recruiting NCT04684394
A Multiple Dose Study of Repeat Intravitreal Injections of GEM103 in Neovascular Age-related Macular Degeneration treatment 2 terminated NCT04450329
A Study to Compare SB15 (Proposed Aflibercept Biosimilar) to Eylea in Subjects With Neovascular Age-related Macular Degeneration (AMD) treatment 3 completed NCT05604989
Associations Between the Oral and Intestinal Icrobiome and Neovascular Age-related Macular Degeneration supportive_care 3 recruiting NCT03249740
A Depot Formulation of Sunitinib Malate (GB-102) in Subjects With Neovascular (Wet) Age-related Macular Degeneration treatment 1 completed NCT06196840
Safety and Efficacy of LX102 Gene Therapy in Patients With Neovascular Age-related Macular Degeneration (nAMD) (VENUS) treatment 2 recruiting NCT03999801
Long-term Follow-Up Study of RGX-314 and Fellow Eye Substudy No drug interventions treatment 2 enrolling_by_invitation NCT02713204
Anti-angiOpoeitin 2 Plus Anti-vascular eNdothelial Growth Factor as a therapY for Neovascular Age Related Macular Degeneration: Evaluation of a fiXed Combination Intravitreal Injection treatment 2 completed NCT04047472
Study of Efficacy and Safety of Brolucizumab vs. Aflibercept in Chinese Patients With Neovascular Age-Related Macular Degeneration treatment 3 completed NCT03479372
Study of PAN-90806 Eye Drops, Suspension for Neovascular AMD No drug interventions treatment 1 / 2 completed NCT04757610
OPT-302 With Ranibizumab in Neovascular Age-related Macular Degeneration (nAMD) treatment 3 active_not_recruiting NCT02450981
Evaluation the Pharmacokinetics, Safety, Tolerability of BCD-021 in Patients With Neovascular Age-related Macular Degeneration Not Available 1 withdrawn NCT05266495
Effectiveness of Brolucizumab in Pre-treated Patients With nAMD in the Real-world Setting No drug interventions Not Available Not Available recruiting NCT06183814
A Study of EXG102-031 in Participants With wAMD No drug interventions treatment 1 / 2 recruiting NCT05637255
A Randomized, Double Masked, Parallel Group, Dose-finding Study to Evaluate SYL1801 in Patients With Neovascular Age-related Macular Degeneration (AMD) No drug interventions treatment 2 recruiting NCT00549055
A Study On The Efficacy Of Macugen Injections In Patients With Neovascular Age-Related Macular Degeneration In Real Life. Not Available Not Available completed NCT04304755
Zoledronic Acid as Adjuvant Therapy in Neovascular Age-related Macular Degeneration (Z-AMD) treatment 2 completed NCT03509623
Blood Coagulation Parameters in Patients Receiving Intravitreal Aflibercept for Age-related Macular Degeneration No drug interventions screening Not Available completed NCT00858208
Efficacy And Safety Of Macugen In Patients With Neovascular AMD In Routine Clinical Practice. Not Available Not Available completed NCT06213038
A Clinical Study Evaluating the Safety and Efficacy of SKG0106 in Patients With Neovascular Age-related Macular Degeneration (nAMD) No drug interventions treatment 1 recruiting NCT06495203
A Study to Understand the Usage of an Artificial Intelligence Technology Called DARWEN for Eye Disorders and to Find Out the Factors Influencing Treatment Frequencies in People With nAMD and RVO No drug interventions Not Available Not Available completed NCT03918590
Post Intravitreal Injection Topical NSAID vs. Patching treatment 4 unknown_status NCT05986864
Phase I/II Study of SKG0106 Intravitreal Injection in Patients With Neovascular Age-related Macular Degeneration (nAMD) No drug interventions treatment 1 / 2 recruiting NCT01997164
Study of Intravitreal (IVT) REGN910-3 and IVT REGN910 in Patients With Either Neovascular ("Wet") Age Related Macular Degeneration (AMD) or Diabetic Macular Edema (DME) basic_science 1 completed NCT01436864
A Randomized, Double-masked, Multicenter,Sham-controlled, Safety and Efficacy Study of KH902 in Patients With Wet AMD No drug interventions treatment 3 completed NCT06231121
Switching to Faricimab in Neovascular Age-related Macular Degeneration Resistant to Both Aflibercept and Ranibizumab Not Available Not Available completed NCT01291121
Intravitreal Ranibizumab in Exudative Age-related Macular Degeneration With Posterior Vitreomacular Adhesion No drug interventions treatment Not Available completed NCT03748784
ADVM-022 Intravitreal Gene Therapy for Wet AMD treatment 1 completed NCT04370379
Trial to Evaluate the Safety and Tolerability of Repeated Intravitreal Injection of IBI302 in Neovascular AMD Patients treatment 1 completed NCT03953079
A Depot Formulation of Sunitinib Malate (GB-102) Compared to Aflibercept in Subjects With Wet AMD treatment 2 completed NCT05202587
The Evaluation of the Agreement Between the NVHO in the Automatic Fluid Quantification and Cirrus OCT No drug interventions Not Available Not Available completed NCT02418754
Study of Intravitreal REGN2176-3 in Participants With Neovascular ("Wet") Age-Related Macular Degeneration (AMD) treatment 2 terminated NCT04101877
The Sahlgrenska Anti-VEGF Study treatment 2 recruiting NCT06124677
Single Injection of Faricimab for nAMD With Persisting Fluid Despite Frequent Aflibercept Treatments Not Available Not Available completed NCT05275205
Safety, Tolerability, and Efficacy Study of UBX1325 in Patients With Neovascular Age-Related Macular Degeneration (ENVISION) treatment 2 completed NCT05112861
A 3-month Study to Compare the Safety of ONS-5010 in Vials Versus Pre-filled Syringe in Subjects With Visual Impairment Due to Retinal Disorders treatment 3 active_not_recruiting NCT04626128
Safety and Tolerability Study of Suprachoroidal Injection of CLS-AX Following Anti-VEGF Therapy in Neovascular AMD treatment 1 / 2 completed NCT02434328
Efficacy and Safety of RTH258 Versus Aflibercept - Study 2 treatment 3 completed NCT04935411
Russian Registry of Patients With nAMD No drug interventions Not Available Not Available terminated NCT02461771
Assessment of Safety, Tolerability and Pharmacokinetics of Intravitreal Pegcetacoplan (APL-2) for Patients With Wet AMD treatment 1 completed NCT01918878
Aflibercept (EYLEA)as Secondary or Third Line Treatment for Neovascular Age-related Macular Degeneration. treatment 4 unknown_status NCT01485588
Safety and Tolerability Study for Age-Related Macular Degeneration No drug interventions treatment 1 / 2 completed NCT05831007
Safety and Efficacy Study of LX102-C01 Treatment of Neovascular Age-Related Macular Degeneration (nAMD) No drug interventions treatment Not Available active_not_recruiting NCT04907409
Home OCT Fluid Visualization Agreement Study No drug interventions Not Available Not Available unknown_status NCT03465709
Pegcetacoplan (APL-2) in Neovascular AMD treatment 1 / 2 terminated NCT03679156
Retinal Pigment Epithelial Characteristics in Eyes With Neovascular Age-related Macular Degeneration Following Long-term Treatment With Anti Neovascular Endothelial Growth Factor No drug interventions Not Available Not Available completed NCT04632056
A 52-weeks Observational Study to Evaluate the Safety of Brolucizumab in Patients With nAMD Not Available Not Available completed NCT02510885
SD-OCT Angiography No drug interventions other Not Available terminated NCT03021785
A Study of Multiple Intravitreal Injection TK001 in Patients With Neovascular Age-related Macular Degeneration treatment 1 unknown_status NCT01157715
A Randomized, Double-masked, Multicenter, Controlled Study of Intravitreal KH902 in Patients With Neovascular AMD No drug interventions treatment 2 completed NCT03630315
CLN-0046: Treatment of AMD Subjects With OTX-TKI treatment 1 completed NCT00373659
An OCT-Guided Variable Dosing Regimen With Ranibizumab for the Treatment of Neovascular AMD treatment 2 completed NCT05281042
Home OCT Repeatability and Reproducibility of Automatic Fluid Quantification Study No drug interventions Not Available Not Available completed NCT04989699
Study Evaluating the Treatment of OTX-TKI for Subjects With Neovascular Age-related Macular Degeneration treatment 1 completed NCT04455399
Time Efficiency Comparison of Two IntraVitreal Injection Techniques No drug interventions treatment Not Available completed NCT05403749
A Study of Longer Interval of IVT IBI302 in Subjects With nAMD treatment 2 completed NCT00764738
Study Investigating OCT, Multifocal ERG, and Microperimetry in Monthly Versus PRN Ranibizumab in Neovascular Age-Related Macular Degeneration treatment 2 / 3 completed NCT01958918
Efficacy of Ranibizumab Prn Treatment Compared to Aflibercept Bimonthly Intravitreal Injections on Retinal Thickness Stability in Patients With Wet AMD treatment 4 completed NCT04423718
Study of the Effects of High Dose Aflibercept Injected Into the Eye of Patients With an Age-related Disorder That Causes Loss of Vision Due to Growth of Abnormal Blood Vessels at the Back of the Eye treatment 3 active_not_recruiting NCT04264819
Study of Brolucizumab in Adult Patients With Suboptimal Anatomically Controlled Neovascular Age-related Macular Degeneration treatment 3 completed NCT03677934
A Phase III Study to Evaluate the Port Delivery System With Ranibizumab Compared With Monthly Ranibizumab Injections in Participants With Wet Age-Related Macular Degeneration treatment 3 completed NCT04641234
A Study Reviewing Medical Records to Learn More About Treat-and-extend With Eylea in Patients With Neovascular Age-related Macular Degeneration (nAMD). Not Available Not Available completed NCT00893724
Supplemental Adjuvants for Intracellular Nutrition and Treatment treatment Not Available unknown_status NCT03468296
Two-week Retreatment Interval Study for Treated Age-related Macular Degeneration Refractory to Monthly Aflibercept treatment 4 unknown_status NCT03066258
Safety and Tolerability of RGX-314 (Investigational Product) Gene Therapy for Neovascular AMD Trial No drug interventions treatment 1 / 2 completed NCT04058535
Clinical Study of ALT-L9 to Determine Safety, Efficacy and Pharmacokinetics in Neovascular AMD treatment 1 completed NCT01712035
Neovascular Age-related Macular Degeneration No drug interventions Not Available Not Available completed NCT01780935
Efficacy and Safety of Two Treatment Regimens of 0.5 mg Ranibizumab Intravitreal Injections Guided by Functional and/or Anatomical Criteria, in Patients With Neovascular Age-related Macular Degeneration treatment 3 completed NCT02867735
A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamic Activity of Intravitreal LKA651 in Patients With Macular Edema No drug interventions treatment 1 completed NCT06492863
Gene Therapy(FT-003) for Wet AMD No drug interventions treatment 1 / 2 recruiting NCT04480463
A Study to Comparing SCD411 and Eylea® in Subjects With Wet Age-related Macular Degeneration (AMD) treatment 3 completed NCT05461339
TAB014 Compared to Lucentis® in Patients With Neovascular Age-related Macular Degeneration treatment 3 recruiting NCT02321839
Evaluation of the Usefulness of a Treat and Extend Regimen Using Ranibizumab for Neovascular AMD. treatment 4 completed NCT03909425
Defining Disease Activity in Neovascular AMD With Optical Coherence Tomography Angiography No drug interventions Not Available Not Available completed NCT05639530
A Dose Escalation Study of IBI333 in Subjects With Neovascular Age-related Macular Degeneration No drug interventions treatment 1 completed NCT03833830
Vessel Density in nAMD After Longterm Anti-VEGF Treatment Compared to Recently Started Anti-VEGF Treatment No drug interventions Not Available Not Available completed NCT04287348
Intravitreal Brolucizumab in Neovascular Age-related Macular Degeneration With Limited Response to Aflibercept treatment 4 terminated NCT05342857
Maximum Treatment Interval With Aflibercept T&E Not Available Not Available recruiting NCT05126966
A Study Of The Effectiveness And Safety Of A 36-Week Refill Regimen For The Port Delivery System With Ranibizumab Vs Aflibercept Treat & Extend In Subjects With Neovascular Age-Related Macular Degeneration treatment 3 withdrawn NCT05208931
Development of an Optimal Algorithm for the Management of Patients With Retinal Pigment Epithelium Detachment in Neovascular Age-related Macular Degeneration Using Artificial Intelligence No drug interventions Not Available Not Available completed NCT05972473
A Study to Evaluate the Efficacy and Safety of IBI302 in Subjects With nAMD treatment 3 recruiting NCT05859776
Safety and Bioactivity of AXT107 in Subjects With Neovascular Age-Related Macular Degeneration (nAMD) No drug interventions treatment 1 / 2 active_not_recruiting NCT05099094
VEGFA-targeting Gene Therapy to Treat Retinal and Choroidal Neovascularization Diseases No drug interventions treatment 0 unknown_status NCT03814291
A Dose Escalation Study of IBI302 in Patients With Wet Age-related Macular Degeneration No drug interventions treatment 1 unknown_status NCT05587062
Efficacy and Safety of Aflibercept in Patients With Neovascular Age-related Macular Degeneration treatment 3 completed NCT05698329
Effect of AIV007 by Periocular Administration in Subjects With nAMD or DME No drug interventions treatment 1 recruiting NCT00696592
Photodynamic Therapy Combined With Bevacizumab vs Bevacizumab Alone for Neovascular Age-Related Macular Degeneration treatment 2 unknown_status NCT04662944
A Non-interventional Study to Assess the Influence of Automated Optical Coherence Tomography Image Enrichment With Segmentation Information on Disease Activity Assessment in Patients Treated With Licensed Anti- VEGF Injections Not Available Not Available completed NCT02452840
Photodynamic Therapy for PDA in NV AMD No drug interventions Not Available Not Available completed NCT04522167
Efficacy and Safety of the Aflibercept FYB203 Biosimilar in Comparison to Eylea® in Patients With Neovascular Age-Related Macular Degeneration treatment 3 completed NCT03744767
Adjuvant Anti-Mineralocorticoid-Receptor Treatment in Anti-VEGF Refractory Neovascular Age-Related Macular Degeneration treatment 2 completed NCT03034772
Dorzolamide-timolol in Combination With Anti-vascular Endothelial Growth Factor Injections for Wet Age-related Macular Degeneration treatment 2 / 3 completed NCT01027468
Long-term Results After Intravitreal Bevacizumab Treatment Of Neovascular Age-related Macular Degeneration treatment Not Available completed NCT05345769
Safety and Efficacy of AM712 in Patients With nAMD No drug interventions treatment 1 recruiting NCT05131646
Extension Study to Evaluate the Long-term Outcomes of Subjects in the CLS-AX CLS1002-101 Study Not Available Not Available completed NCT04645212
Long-term Study of ADVM-022 in Neovascular (Wet) AMD [OPTIC-EXT] Not Available Not Available active_not_recruiting NCT05953012
Study to Assess Safety and Tolerability of PMC-403 in Subjects With Neovascular Age-related Macular Degeneration treatment 1 recruiting NCT02309281
Intravitreal Aflibercept in Neovascular AMD With Limited Response to Ranibizumab treatment 4 completed NCT00964795
Open-label Extension Study of Intravitreal Aflibercept Injection (IAI; EYLEA®; BAY86-5321) in Neovascular ("Wet") Age-related Macular Degeneration (AMD) treatment 3 completed NCT02591914
An Open-Label Investigator Sponsored Trial to Investigate the Safety, Tolerability and Development of Subfoveal Fibrosis By Intravitreal Administration of Altering Regimens of Fovista and Anti-VEGF Therapy in Subjects With Neovascular Age-Related Macular Degeneration treatment 1 completed NCT02810808
Safety and Efficacy of Two Regimens of Ranibizumab 0.5 mg in Chinese Patients With Neovascular AMD treatment 4 unknown_status NCT03216538
Safety and Efficacy of AS101 1% Oral Solution in Patients With Neovascular Age-Related Macular Degeneration (AMD) treatment 1 / 2 completed NCT00559715
Prevention of Vision Loss in Patients With Age-Related Macular Degeneration (AMD) by Intravitreal Injection of Bevacizumab and Ranibizumab treatment 3 unknown_status NCT06075147
The SPECTRUM Study: An Observational Study to Learn More About How Well Aflibercept 8 mg Works in Treating Visual Impairment Due to Neovascular Age-related Macular Degeneration or Diabetic Macula Edema Not Available Not Available recruiting NCT06623279
Open-laBel Dose-escalation Study for CRISPR/cas13- Rna TargetInG THerapy for the Treatment of Neovascular Age-related Macular Degeneration in Phase I Trial No drug interventions treatment 1 not_yet_recruiting NCT04657289
A Study of the Efficacy, Safety, and Pharmacokinetics of A 36-Week Refill Regimen for the Port Delivery System With Ranibizumab in Patients With Neovascular Age-Related Macular Degeneration (Velodrome) treatment 3 recruiting NCT06116890
Study to Assess the Efficacy & Safety of KHK4951 in Patients With Neovascular Age-Related Macular Degeneration treatment 2 recruiting NCT04514653
RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Neovascular Age-Related Macular Degeneration (nAMD) (AAVIATE) treatment 2 recruiting NCT04764656
Observational Study to Evaluate Fluid Resolution and Effectiveness of Brolucizumab for nAMD in Portugal Not Available Not Available completed NCT04746963
Safety and Bioactivity of AXT107 in Subjects With Neovascular Age-Related Macular Degeneration No drug interventions treatment 1 / 2 terminated NCT06487039
Trial to Evaluate the Safety and Efficacy of EB-203 in Patients With Neovascular Age-related Macular Degeneration No drug interventions treatment 2 recruiting NCT05989126
Study to Evaluate an 8 mg Aflibercept (EYLEA®) Prefilled Syringe (PFS) treatment 3 completed NCT05269966
Study to Evaluate the Safety and Effectiveness of Intravitreal Injections (IVI) of Brolucizumab in Patients With Neovascular Age-related Macular Degeneration (nAMD) treatment 4 completed NCT06398080
An Observational Study to Investigate the Use of Aflibercept 8 mg to Treat Adult Patients With Neovascular Age-Related Macular Degeneration (nAMD) and Diabetic Macular Edema (DME) in a Real-World Setting Not Available Not Available not_yet_recruiting NCT05282004
Study of the Safety of Use of Intravitreal SOK583A1 Provided in a Vial Kit No drug interventions treatment 3 completed NCT05210803
Long-Term Follow-Up Study of RGX-314 Administered in the Suprachoroidal Space for Participants With nAMD No drug interventions Not Available Not Available enrolling_by_invitation NCT05769153
Study of AR-14034 in Participants With Neovascular Age-Related Macular Degeneration (nAMD) treatment 1 / 2 recruiting NCT05161806
Study of the Safety of Use of Intravitreal SOK583A1 Provided in a Prefilled Syringe treatment 3 completed NCT04543331
Observational Study to Evaluate Fluid Resolution and Effectiveness in Patients Receiving Beovu in Neovascular Age-related Macular Degeneration and Visual Impairment Due to Diabetic Macular Edema Not Available Not Available active_not_recruiting NCT06470373
A Phase 3 Clinical Trial to Compare RBS-001 to Eylea® in Subjects With Neovascular Age-Related Macular Degeneration treatment 3 not_yet_recruiting NCT05904691
Safety and Tolerability of OCU-10-C-110 for Injection in Subjects With Neovascular Age-related Macular Degeneration No drug interventions treatment 1 recruiting NCT03054818
Safety Evaluation of China Patients: Long-term Treatment Outcome of Conbercept Ophthalmic Injection in Real Word（STONE） No drug interventions Not Available Not Available unknown_status NCT01318941
Observe the Effectiveness and Safety of Ranibizumab in Real Life Setting Not Available Not Available completed NCT01986907
Safety and Tolerability of Ranibizumab in Mono/Bilateral Wet Age Related Macular Degeneration (w-AMD) Patients in Eyes With BCVA<2/10 and/or 2nd Affected Eye treatment 4 completed NCT01899963
Time to Treatment Utilizing a Tele-Retinal Referral System for wAMD and DME: A Pilot Study No drug interventions Not Available Not Available completed NCT00139282
A Safety and Efficacy Study of Squalamine Lactate for Injection (MSI-1256F) for "Wet" Age-Related Macular Degeneration treatment 3 terminated NCT05407636
Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD No drug interventions treatment 3 recruiting NCT06556368
A Study to Evaluate the Efficacy and Safety of Tarcocimab Tedromer and Tabirafusp Tedromer Compared to Aflibercept in Participants with Neovascular (Wet) Age-related Macular Degeneration (wAMD) - DAYBREAK treatment 3 recruiting NCT05381948
Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD) treatment 2 completed NCT03362190
ZIMURA in Combination With LUCENTIS in Patients With Neovascular Age Related Macular Degeneration (NVAMD) treatment 2 completed NCT03382587
Observational Study to Assess Intravitreal Aflibercept Injections Used in a "Treat and Extend" Regimen in Treatment-naïve Wet Age-related Macular Degeneration Patients Not Available Not Available completed NCT00679445
A Study to Evaluate the Neovista Ophthalmic System for the Treatment of Subfoveal CNV in Patients With AMD That Have Failed Primary Anti-VEGF Therapy No drug interventions treatment 2 completed NCT04468997
The Study of Drug 601 in Patients With Wet Age-related Macular Degeneration (wAMD) No drug interventions treatment 1 unknown_status NCT03312283
Evaluating of the Safety, Pharmacokinetics and Pharmacodynamics of QL1205 and Lucentis® in Patients With Wet AMD treatment 1 completed NCT03558061
Evaluate the Effects and Safety of ALK4290 in Patients With Newly Diagnosed Wet Age-Related Macular Degeneration treatment 2 completed NCT01086761
Study of MP0112 Intravitreal Injection in Patients With Wet Age Related Macular Degeneration No drug interventions treatment 1 terminated NCT05480293
This Study Will Compare the Efficacy and Safety of SCT510A Administered by Intravitreal Injection (IVT) With Ranibizumab in Patients With wAMD treatment 3 recruiting NCT03790852
Exploratory Study to Investigate the Bioactivity, Ocular and Systemic Safety, Tolerability, and Pharmacokinetics Following Single and Multiple Intravitreal Administrations of KSI-301 in Subjects With wAMD, DME and RVO treatment 1 terminated NCT04884399
Phase I Study to Compare CMAB818 Injection and Lucentis® in Patients With Wet AMD treatment 1 completed NCT01339949
Study to Evaluate the Safety and Effectiveness of IRay in Wet Age-related Macular Degeneration (AMD) Patients With Recurrent Leakage Secondary to Choroidal Neovascularisation (CNV) No drug interventions treatment Not Available withdrawn NCT00503022
Safety and Tolerability of an Intravenous Infusion of ACZ885 in Patients With Wet Age-Related Macular Degeneration treatment 1 completed NCT03558074
Evaluate the Therapeutic Effects and Safety of ALK4290 in Patients With Refractory Wet Age-Related Macular Degeneration treatment 2 completed NCT01914380
Investigating the Effectiveness of Eylea in Patients With Wet Age-related Macular Degeneration Not Available Not Available completed NCT04270669
Evaluation of RC28-E Injection in Wet Age-related Macular Degeneration No drug interventions treatment 1 / 2 completed NCT06518512
Automated Vision Assessment and Impairment Detection Through Gaze Analysis in Wet AMD Patients No drug interventions Not Available Not Available active_not_recruiting NCT04594681
A Safety Study of KHK4951 in Healthy Volunteers and Patients With Wet Age-Related Macular Degeneration No drug interventions treatment 1 terminated NCT03423823
Ziv-aflibercept Efficacy in Better Regulating AMD treatment 2 completed NCT02036723
Safety and Efficacy Study of BCD-021 Compared to Lucentis® in Patients With Neovascular Wet Age-related Macular Degeneration treatment 3 withdrawn NCT04113538
Treat and Extend Analysis Trial With Aflibercept in Wet-AMD treatment 3 unknown_status NCT04704921
Pivotal 1 Study of RGX-314 Gene Therapy in Participants With nAMD treatment 2 / 3 recruiting NCT02005133
A Prospective, Observational, Multicentre, 2 Year Study Evaluating the Use of Eylea (Aflibercept) for the Treatment of Neovascular (Wet) Age-related Macular Degeneration in UK NHS Opthalmology Clinics No drug interventions Not Available Not Available terminated NCT05727397
Efficacy and Safety of RC28-E Versus Aflibercept treatment 3 recruiting NCT04747197
First in Human Study to Evaluate the Safety and Tolerability of EYP-1901 in Patients With Wet Age Related Macular Degeneration (wAMD) No drug interventions treatment 1 completed NCT03585556
AAVCAGsCD59 for the Treatment of Wet AMD treatment 1 completed NCT04564937
The Study of Drug SCT510A in Patients With Wet Age-related Macular Degeneration (wAMD) No drug interventions treatment 1 / 2 unknown_status NCT00138632
Safety and Efficacy of Oral PTK787 in Patients With Subfoveal Choroidal Neovascularization Secondary to Age-Related Macular Degeneration (AMD) treatment 1 / 2 completed NCT02257632
Systemic Vascular Endothelial Growth Factor (VEGF) Protein Dynamics Following Intravitreal Injections of Ranibizumab Versus Aflibercept in Patients With Neovascular Age-related Macular Degeneration treatment 4 completed NCT01025232
A Study of Intravitreal Injections of 2.0mg Ranibizumab in Subjects With Chronic Fluid On OCT Post Multiple Injections With Ranibizumab (Super-dose Anti-VEgf SAVE Trial) treatment 1 / 2 terminated NCT05345236
A Study to Compare QL1207 to Eylea® in Subjects With Wet Age-related Macular Degeneration (wAMD) treatment 3 completed NCT04919096
Study of SCB-420 in Subjects With Neovascular Age-related Macular Degeneration treatment 1 withdrawn NCT01016873
INTREPID - IRay Plus Anti-VEGF Treatment For Patients With Wet AMD No drug interventions treatment 2 completed NCT03290794
Structured Post-marketing Surveillance to Collect the Safety Data of Intravitreal Aflibercept Injection (IVT-AFL) in Patients of Wet Age-related Macular Degeneration During Real World Clinical Practice Not Available Not Available completed NCT05141994
Clinical Study on the Efficacy and Safety of BAT5906 Injection No drug interventions treatment 2 completed NCT01217762
Safety & Tolerability of the IRay System in Subjects With Exudative Choroidal Neovascularization (CNV) Secondary to Age-Related Macular Degeneration (AMD) No drug interventions treatment 1 unknown_status NCT04932980
Comparison of Rapid Aflibercept and Brolucizumab T&E in wAMD treatment Not Available enrolling_by_invitation NCT04964089
A Study to Evaluate the Efficacy and Safety of Intravitreal KSI-301 Compared With Intravitreal Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneration (wAMD) treatment 3 completed NCT05297292
A Study to Evaluate the Efficacy and Safety of MW02 in the Treatment of nAMD treatment 2 / 3 unknown_status NCT03939767
Assessment of Proactive Treatments in Patients With Wet Age-related Macular Degeneration (wAMD) Which Have Never Undergone Treatment of This Particular Disease Not Available Not Available completed NCT04685369
Effectiveness of Anti-VEGF Treatments in Wet AMD in Active Smokers No drug interventions Not Available Not Available completed NCT04504123
MMP-9 Inhibition for Recalcitrant Wet AMD treatment 2 recruiting