Acute Leukemia of Ambiguous Lineage (DBCOND0051910)

Identifiers

Synonyms

Acute Leukemias of Ambiguous Lineage / Acute leukemia of ambiguous lineage / Acute leukemia of ambiguous lineage (disorder) / Acute leukemia of ambiguous lineage (morphologic abnormality)

Associated Data

Indicated Drugs and Targets

Not Available

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01371656	Levofloxacin in Preventing Infection in Young Patients With Acute Leukemia Receiving Chemotherapy or Undergoing Stem Cell Transplantation	Levofloxacin	supportive_care	3	completed
NCT00933985	Obatoclax Mesylate, Vincristine Sulfate, Doxorubicin Hydrochloride, and Dexrazoxane Hydrochloride in Treating Young Patients With Relapsed or Refractory Solid Tumors, Lymphoma, or Leukemia	Dexrazoxane Doxorubicin Obatoclax Vincristine	treatment	1	terminated
NCT01132573	Entinostat and Clofarabine in Treating Patients With Newly Diagnosed, Relapsed, or Refractory Poor-Risk Acute Lymphoblastic Leukemia or Bilineage/Biphenotypic Leukemia	Clofarabine Entinostat	treatment	1	completed
NCT01231919	MK2206 in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Leukemia	No drug interventions	treatment	1	completed
NCT01925131	S1312, Inotuzumab Ozogamicin and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Leukemia	Cyclophosphamide Inotuzumab ozogamicin Prednisone Sulfate ion Vincristine	treatment	1	completed
NCT06317662	Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia	Asparaginase Erwinia chrysanthemi Asparaginase Escherichia coli Benzalkonium Blinatumomab Calaspargase pegol Carbonate ion Cortisone Cyclophosphamide Cytarabine Daunorubicin Dexamethasone Doxorubicin Hydrocortisone Hydrocortisone acetate Leucovorin Mercaptopurine Methopterin Methotrexate Muromonab Pegaspargase Prednisolone Prednisone Tioguanine Venetoclax Vincristine	treatment	2	not_yet_recruiting
NCT05292664	Venetoclax Basket Trial for High Risk Hematologic Malignancies	Asparaginase Erwinia chrysanthemi Azacitidine Calaspargase pegol Calcium Cortisone Cytarabine Dexamethasone Dexrazoxane Doxorubicin Hydrocortisone Hydrocortisone phosphate Hydrocortisone succinate Leucovorin Methotrexate Venetoclax Vincristine	treatment	1	recruiting
NCT06575296	Revumenib for the Treatment of Acute Leukemia in Patients Post-Allogeneic Stem Cell Transplant	Revumenib	treatment	1	not_yet_recruiting
NCT01319864	POETIC Plerixafor as a Chemosensitizing Agent for Relapsed Acute Leukemia and MDS in Pediatric Patients	Plerixafor	treatment	1	completed
NCT05521087	A Study of JNJ-75276617 in Combination With Conventional Chemotherapy for Pediatric and Young Adult Participants With Relapsed/Refractory Acute Leukemias	Cytarabine Dexamethasone Fludarabine JNJ-75276617 Pegaspargase Vincristine	treatment	1	withdrawn
NCT06355583	Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) Trial	No drug interventions	prevention	2	not_yet_recruiting
NCT04067336	First in Human Study of Ziftomenib in Relapsed or Refractory Acute Myeloid Leukemia	Ziftomenib	treatment	1 / 2	recruiting
NCT02135874	Clofarabine, Idarubicin, Cytarabine, Vincristine Sulfate, and Dexamethasone in Treating Patients With Newly Diagnosed or Relapsed Mixed Phenotype Acute Leukemia	Clofarabine Cytarabine Dexamethasone Idarubicin Rituximab Sorafenib Sulfate ion Vincristine	treatment	2	completed
NCT01858740	Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts in Preventing GVHD in Children	Fludarabine Methopterin Methotrexate Tacrolimus Thiotepa Tromethamine	treatment	2	completed
NCT06013423	Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With High-Risk Hematologic Diseases	Cyclophosphamide Cyclosporine Fludarabine Mycophenolate mofetil Thiotepa Tromethamine	treatment	2	recruiting
NCT03779854	Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant	Busulfan Cyclophosphamide Fludarabine Methopterin Methotrexate Tacrolimus Thiotepa	treatment	2	recruiting
NCT02220985	Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts From HLA-Matched Related and Unrelated Donors in Preventing GVHD	Cyclophosphamide Fludarabine Methopterin Methotrexate Mycophenolate mofetil Tacrolimus Thiotepa Tromethamine	treatment	2	active_not_recruiting
NCT04065399	A Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation	Cobicistat Revumenib	treatment	1 / 2	recruiting
NCT02828358	Azacitidine and Combination Chemotherapy in Treating Infants With Acute Lymphoblastic Leukemia and KMT2A Gene Rearrangement	Asparaginase Escherichia coli Azacitidine Calcium Cyclophosphamide Cytarabine Daunorubicin Dexamethasone Ethanol Hydrocortisone Hydrocortisone succinate Leucovorin Levoleucovorin Mercaptopurine Methopterin Methotrexate Pegaspargase Prednisolone Prednisone Sodium succinate Sulfate ion Tioguanine Vincristine	treatment	2	active_not_recruiting
NCT05901974	Venetoclax Combined With Azactidine in the Treatment of ALAL	Venetoclax	treatment	2	recruiting
NCT04440267	Efficacy of Acute Lymphoblastic Leukemia-Based Therapy in Treating Patients With Acute Leukemia of Ambiguous Lineage	Asparaginase Escherichia coli Cyclophosphamide Daunorubicin Dexamethasone Mercaptopurine Methotrexate Prednisone Tyrosine Vincristine	treatment	2	not_yet_recruiting
NCT06177067	Study of Revumenib, Azacitidine, and Venetoclax in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia	Azacitidine Cytarabine Hydrocortisone Methotrexate Revumenib Venetoclax	treatment	1	recruiting
NCT03012672	Higher or Lower Dose Cladribine, Cytarabine, and Mitoxantrone in Treating Medically Less Fit Patients With Newly Diagnosed Acute Myeloid Leukemia or Myeloid Neoplasm	Cladribine Cytarabine Filgrastim Mitoxantrone	treatment	2	completed
NCT01701323	Expanded Cord Blood Cell Infusion Following Combination Chemotherapy in Younger Patients With Relapsed or Refractory Acute Myeloid Leukemia	Cytarabine Dilanubicel Filgrastim Fludarabine	treatment	1	terminated