Stage IV Colorectal Cancer AJCC v8 (DBCOND0110629)

Identifiers

Synonyms

Not Available

Associated Data

Indicated Drugs and Targets

Not Available

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04017650	Encorafenib, Cetuximab, and Nivolumab in Treating Patients With Microsatellite Stable, BRAFV600E Mutated Unresectable or Metastatic Colorectal Cancer	Cetuximab Encorafenib Nivolumab	treatment	1 / 2	active_not_recruiting
NCT04314401	National Cancer Institute "Cancer Moonshot Biobank"	No drug interventions	Not Available	Not Available	recruiting
NCT04535401	Testing the Addition of an Anticancer Drug, BAY 1895344, to the Usual Chemotherapy With FOLFIRI in Advanced or Metastatic Cancers of the Stomach and Intestines	Calcium Camptothecin Elimusertib Fluorouracil Irinotecan Leucovorin Levoleucovorin	treatment	1	active_not_recruiting
NCT04704661	Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Patients With Advanced Solid Tumors Expressing the HER2 Protein or Gene, The DASH Trial	Ceralasertib Trastuzumab deruxtecan	treatment	1	recruiting
NCT06102902	Testing the Addition of Anti-cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment, Cetuximab Plus Encorafenib, for Colorectal Cancer	Cetuximab Encorafenib	treatment	1	recruiting
NCT04511039	Trifluridine/Tipiracil and Talazoparib for the Treatment of Patients With Locally Advanced or Metastatic Colorectal or Gastroesophageal Cancer	TAS-102 Talazoparib Thymidine Tipiracil Trifluridine	treatment	1	recruiting
NCT06626256	STIL101 for Injection for the Treatment of Locally Advanced, Metastatic or Unresectable Pancreatic Cancer, Colorectal Cancer, Renal Cell Cancer, Cervical Cancer and Melanoma	Aldesleukin Cyclophosphamide Fludarabine	treatment	1	not_yet_recruiting
NCT05356897	Tucatinib Combined with Trastuzumab and TAS-102 for the Treatment of HER2 Positive Metastatic Colorectal Cancer in Molecularly Selected Patients, 3T Study	TAS-102 Tipiracil Trastuzumab Trifluridine Tucatinib	treatment	2	withdrawn
NCT05518032	Pembrolizumab and Autologous Dendritic Cells for the Treatment of Refractory Colorectal Cancer (CRC)	Pembrolizumab	treatment	2	withdrawn
NCT05672316	Botensilimab, Balstilimab and Regorafenib for the Treatment of Patients with Microsatellite Stable Metastatic Colorectal Cancer Who Have Progressed on Prior Chemotherapy	Balstilimab Botensilimab Regorafenib	treatment	1 / 2	active_not_recruiting
NCT06043713	Autologous CD8+ and CD4+ Transgenic T Cells Expressing High Affinity KRASG12V Mutation-Specific T Cell Receptors (FH-A11KRASG12V-TCR) in Treating Patients With Metastatic Pancreatic, Colorectal and Non-Small Cell Lung Cancers With KRAS G12V Mutations	Bendamustine Cyclophosphamide Fludarabine	treatment	1	recruiting
NCT06336902	Botensilimab Plus Balstilimab and Fasting Mimicking Diet Plus Vitamin C for Patients With KRAS-Mutant Metastatic Colorectal Cancer	Balstilimab Botensilimab	treatment	1	not_yet_recruiting
NCT05967533	The Immune Effects of Fermented Wheat Germ Nutritional Supplementation in Patients With Advanced Solid Tumor Cancers Being Treated With Standard of Care Checkpoint Inhibitors	No drug interventions	treatment	1	recruiting
NCT03563651	Collection of Blood, Urine, and Stool to Monitor MetastaticColorectal Cancers	No drug interventions	Not Available	Not Available	completed
NCT04117945	Regorafenib, With Cetuximab or Panitumumab, for the Treatment of Unresectable, Locally Advanced, or Metastatic Colorectal Cancer	Cetuximab Irinotecan Panitumumab Regorafenib	treatment	2	active_not_recruiting
NCT04616183	LY3214996 and Cetuximab Alone or in Combination With Abemaciclib for the Treatment of Unresectable or Metastatic Colorectal Cancer	Abemaciclib Cetuximab Temuterkib	treatment	1 / 2	active_not_recruiting
NCT04221893	Radiation Therapy for the Treatment of Metastatic Gastrointestinal Cancers	No drug interventions	treatment	Not Available	recruiting
NCT03983993	Niraparib and Panitumumab in Patients With Advanced or Metastatic Colorectal Cancer	Niraparib Panitumumab	treatment	2	active_not_recruiting
NCT06269978	Intraperitoneal Oxaliplatin and Fluorouracil for the Treatment of Patients With Peritoneal Metastases From Colorectal Cancer	Fluorouracil Oxaliplatin	treatment	1	recruiting
NCT03290937	Utomilumab, Cetuximab, and Irinotecan Hydrochloride in Treating Patients With Metastatic Colorectal Cancer	Camptothecin Cetuximab Irinotecan Utomilumab	treatment	1	active_not_recruiting
NCT03599752	Chemotherapy and/or Metastasectomy in Treating Patients With Metastatic Colorectal Adenocarcinoma With Lung Metastases	No drug interventions	treatment	2	active_not_recruiting
NCT02298959	Testing the PD-1 Antibody, MK3475, Given With Ziv-aflibercept in Patients With Advanced Cancer	Aflibercept Pembrolizumab	treatment	1	active_not_recruiting
NCT05627635	FOLFOX and Bevacizumab in Combination With Botensilimab and Balstilimab (3B-FOLFOX) for the Treatment of Microsatellite Stable (MSS) Metastatic Colorectal Cancer	Balstilimab Bevacizumab Botensilimab Calcium Fluorouracil Leucovorin Levoleucovorin Oxaliplatin	treatment	1 / 2	recruiting
NCT03576963	Guadecitabine and Nivolumab in Treating Refractory Metastatic Colorectal Cancer	Guadecitabine Nivolumab	treatment	1 / 2	withdrawn
NCT04832763	Medical and Psychosocial Issues in Adolescents and Young Adults With Colorectal Cancer	No drug interventions	other	Not Available	terminated
NCT04119830	Rintatolimod and Pembrolizumab for the Treatment of Refractory Metastatic or Unresectable Colorectal Cancer	Pembrolizumab Rintatolimod	treatment	2	withdrawn
NCT05673148	Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, The ERASur Study	No drug interventions	treatment	3	recruiting
NCT04771520	Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors	Avapritinib Benzalkonium	treatment	2	recruiting
NCT03993327	An Imaging Agent (I-124 M5A) in Detecting CEA-Positive Liver Metastases in Patients With Colorectal Cancer	Iodine	diagnostic	1	completed
NCT05130060	A Vaccine (PolyPEPI1018 Vaccine) and TAS-102 for the Treatment of Metastatic Colorectal Cancer	TAS-102 Tipiracil Trifluridine	treatment	1	completed
NCT04329494	PIPAC for the Treatment of Peritoneal Carcinomatosis in Patients With Ovarian, Uterine, Appendiceal, Colorectal, or Gastric Cancer	Chloride ion Cisplatin Daunorubicin Doxorubicin Fluorouracil Irinotecan Leucovorin Mitomycin Oxaliplatin Platinum	treatment	1	recruiting
NCT00862680	4D PET/CT in Diagnosing Participants With Lung and Colorectal Cancer With Liver and Lung Metastasis	No drug interventions	Not Available	Not Available	completed
NCT04111172	A Vaccine (Ad5.F35-hGCC-PADRE) for the Treatment of Gastrointestinal Adenocarcinoma	No drug interventions	treatment	2	suspended
NCT03981614	Binimetinib and Palbociclib or TAS-102 in Treating Patients With KRAS and NRAS Mutant Metastatic or Unresectable Colorectal Cancer	Binimetinib Palbociclib TAS-102 Tipiracil Trifluridine	treatment	2	completed
NCT03844750	Preoperative Immunotherapy (Pembrolizumab) for Patients With Colorectal Cancer and Resectable Hepatic Metastases	Pembrolizumab Vactosertib	treatment	2	recruiting
NCT03610490	Autologous Tumor Infiltrating Lymphocytes MDA-TIL in Treating Patients With Recurrent or Refractory Ovarian Cancer, Colorectal Cancer, or Pancreatic Ductal Adenocarcinoma	Cyclophosphamide Fludarabine Human interleukin-2 Lifileucel Teceleukin	treatment	2	terminated
NCT04449679	Real-Time Monitoring of Chemotherapy Side-Effects in Patients With Gastrointestinal Cancers, RT-CAMSS Study	No drug interventions	supportive_care	Not Available	completed
NCT04597151	Diet Education Program for Stage I-IV Colorectal Cancer Survivors	No drug interventions	supportive_care	Not Available	completed
NCT04693377	Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial	No drug interventions	supportive_care	Not Available	recruiting
NCT02983578	Danvatirsen and Durvalumab in Treating Patients With Advanced and Refractory Pancreatic, Non-Small Cell Lung Cancer, and Mismatch Repair Deficient Colorectal Cancer	Danvatirsen Durvalumab	treatment	2	active_not_recruiting
NCT03992456	Panitumumab, Regorafenib, or TAS-102, in Treating Patients With Metastatic and/or Unresectable RAS Wild-Type Colorectal Cancer	Panitumumab Regorafenib TAS-102 Tipiracil Trifluridine	treatment	2	active_not_recruiting
NCT06265285	Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program	Nivolumab	health_services_research	2	recruiting
NCT05733000	CPI-613 (Devimistat) in Combination With Hydroxychloroquine and 5-fluorouracil or Gemcitabine in Treating Patients With Advanced Chemorefractory Solid Tumors	Devimistat Fluorouracil Gemcitabine Hydroxychloroquine Lipoic acid	treatment	2	recruiting
NCT04501913	Remote Telemonitoring of Patient-Generated Physiologic Health Data and Patient-Reported Outcomes	No drug interventions	Not Available	Not Available	active_not_recruiting
NCT04796818	An Investigational Scan (Intravoxel Incoherent Motion Diffusion Weighted Imaging) for the Evaluation of Colorectal Cancer Liver Metastases Treatment Response	No drug interventions	diagnostic	Not Available	active_not_recruiting
NCT04096417	Pemigatinib for the Treatment of Metastatic or Unresectable Colorectal Cancer Harboring FGFR Alterations	Pemigatinib	treatment	2	active_not_recruiting
NCT04362839	Regorafenib, Ipilimumab and Nivolumab for the Treatment of Chemotherapy Resistant Microsatellite Stable Metastatic Colorectal Cancer	Ipilimumab Nivolumab Regorafenib	treatment	1	active_not_recruiting
NCT04729322	Fecal Microbiota Transplant and Re-introduction of Anti-PD-1 Therapy (Pembrolizumab or Nivolumab) for the Treatment of Metastatic Colorectal Cancer in Anti-PD-1 Non-responders	Fecal microbiota Metronidazole Neomycin Nivolumab Pembrolizumab Vancomycin	treatment	2	active_not_recruiting
NCT04430725	Microwave Ablation or Wedge Resection for the Treatment of Lung, Sarcoma and Colorectal Lesions, ALLUME Study	No drug interventions	Not Available	Not Available	recruiting
NCT06575725	Botensilimab, Balstilimab and Regorafenib or Botensilimab and Balstilimab for the Treatment of Advanced or Metastatic Microsatellite Stable Colorectal Cancer	Balstilimab Botensilimab Regorafenib	treatment	2	not_yet_recruiting
NCT03707574	Genetic Analysis of Blood and Tissue Samples From Patients With Advanced Cancer, Moonshot Study	No drug interventions	Not Available	Not Available	active_not_recruiting
NCT03844620	Circulating Cell-Free Tumor DNA Testing in Guiding Treatment for Patients With Advanced or Metastatic Colorectal Cancer	Regorafenib TAS-102 Tipiracil Trifluridine	treatment	2	active_not_recruiting
NCT05803382	Testing the Addition of an Anti-Cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment (Capecitabine) for Metastatic or Unresectable Cancers	Capecitabine	treatment	1	recruiting
NCT02595931	M6620 and Irinotecan Hydrochloride in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery	Berzosertib Camptothecin Irinotecan	treatment	1	active_not_recruiting
NCT04067960	Pharmacogenomics Testing in the Optimal Use of Supportive Care Medications in Stage III-IV Cancer	No drug interventions	screening	0	completed
NCT05691491	Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and Effectiveness	Temozolomide Tuvusertib	treatment	1 / 2	recruiting
NCT03823144	Intravital Microscopy in Human Solid Tumors	Fluorescein	diagnostic	Not Available	completed
NCT04164069	Dasatinib for the Prevention of Oxaliplatin-Induced Neuropathy in Patients With Metastatic Gastrointestinal Cancer Receiving FOLFOX Chemotherapy With or Without Bevacizumab	Bevacizumab Calcium Dasatinib Fluorouracil Leucovorin Levoleucovorin Oxaliplatin	prevention	1	active_not_recruiting
NCT05863195	Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial	Bevacizumab Cetuximab Floxuridine Fluorouracil Irinotecan Leucovorin Oxaliplatin Panitumumab	treatment	3	recruiting
NCT04761614	Riluzole in Combination With mFOLFOX6 and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer	Bevacizumab Calcium Fluorouracil Leucovorin Levoleucovorin Oxaliplatin Riluzole	treatment	1	active_not_recruiting