Tuberculosis Active (DBCOND0157213)

Identifiers

Synonyms

Active Tuberculosis / Active tuberculosis (disorder) / Tuberculosis / Tuberculosis (disorder) / Tuberculosis NOS / Infection TBC / Infection tuberculosis / Infection caused by Mycobacterium tuberculosis (disorder) / TB / Tuberculous (qualifier value) / Tuberculous infections

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Ethionamide	A second line antitubercular agent used to treat tuberculosis when other treatments have failed.	Catalase-peroxidasetarget Enoyl-[acyl-carrier-protein] reductase [NADH]target Nuclear factor erythroid 2-related factor 2target
Isoniazid	An antibiotic used to treat mycobacterial infections; most commonly use in combination with other antimycobacterial agents for the treatment of active or latent tuberculosis.	Catalase-peroxidasetarget Enoyl-[acyl-carrier-protein] reductase [NADH]target Cytochrome P450 2E1enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2D6enzyme Cytochrome P450 2C19enzyme Arylamine N-acetyltransferase 2enzyme Arylamine N-acetyltransferaseenzyme Cytochrome P450 2A6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C8target Cytochrome P450 1A2target Cytochrome P450 3A4target Cytochrome P450 2C19target Dihydrofolate reductasetarget Albumincarrier Cytochrome P450 3A4enzyme
Morinamide	A second-line pyrazine anti-tuberculosis agent.	No drug targets
Pyrazinamide	An antituberculosis agent used as a component of tuberculosis (TB) treatment.	Xanthine dehydrogenase/oxidaseenzyme Probable fatty acid synthase Fas (Fatty acid synthetase)target Aldehyde oxidaseenzyme Enoyl-[acyl-carrier-protein] reductase [NADH]target
Rifapentine	An antibiotic agent used in the treatment of pulmonary tuberculosis.	DNA-directed RNA polymerase subunit beta'target Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2B6enzyme Cytochrome P450 3A Subfamilyenzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05840809	Pharmacokinetics of Drugs Used to Treat Drug Sensitive Tuberculosis in Breastfeeding Mother-infant Pairs	BCG vaccine	Not Available	Not Available	active_not_recruiting
NCT05981495	Clinical Evaluation of the NanoDetect-TB Mycobacterium Tuberculosis Detection Kit for the Diagnosis of Tuberculosis Disease	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT06574529	Video-observed Therapy for Active Tuberculosis: a Feasibility Study	No drug interventions	other	Not Available	completed
NCT02512484	Improving the Detection of Active Tuberculosis in Accident and Emergency Departments	No drug interventions	Not Available	Not Available	unknown_status
NCT02639936	New Generation IGRA in Immunocompromised Individuals	No drug interventions	Not Available	Not Available	unknown_status
NCT04048018	Performance Evaluation of the VIDAS TB-IGRA Assay.	No drug interventions	Not Available	Not Available	completed
NCT06408129	COMPArison of Screening Strategies for Active TuBerculosis (COMPASS-TB)	No drug interventions	Not Available	Not Available	completed
NCT01269268	Characterization and Evaluation of Diagnostic Biomarkers for Tuberculosis	No drug interventions	Not Available	Not Available	completed
NCT02042261	The Role of Therapeutic Drug Monitoring in Tuberculosis - a Pilot Study	No drug interventions	Not Available	Not Available	completed
NCT05045391	Pulmonary Aspergillosis in Tuberculosis Patients	No drug interventions	Not Available	Not Available	active_not_recruiting
NCT03271567	Nanodisk-MS Assay for the Diagnosis of Active Pulmonary and Extrapulmonary Tuberculosis in Hospitalized Patients	No drug interventions	Not Available	Not Available	completed
NCT05048381	miRNA in Sweat, a Novel Digital Biomarker for Detection of Active Tuberculosis (TB)	No drug interventions	Not Available	Not Available	withdrawn
NCT02898623	Serological Test for the Diagnosis of TB	No drug interventions	Not Available	Not Available	terminated