Trypanocidal Agents

Name
Trypanocidal Agents
Accession Number
DBCAT001101
Description

Agents destructive to the protozoal organisms belonging to the suborder TRYPANOSOMATINA.

Drugs
DrugDrug Description
PentamidineAn antifungal agent used to treat Pneumocystis pneumonia in patients infected with HIV.
PosaconazoleA triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients.
DiminazeneDiminazene, also known as Diminazine, 4,4'-(Diazoamino)benzamidine, 4,4'-(1-triazene-1,3-diyl)bis-benzenecarboximidamide, diminazine aceturate, or Diminazene aceturate, is a trypanocidal agent. Major brands of Diminazene are Berenil, Pirocide, Ganasag, and Azidin. This substance is a...
EflornithineA medication used topically to reduce unwanted facial hair growth in women. The postulated mechanism of action is through irreversible inhibition of ornithine decarboxylase (ODC) in the skin.
PuromycinPuromycin is an antibiotic that prevents bacterial protein translation. It is utilized as a selective agent in laboratory cell cultures. Puromycin is toxic to both prokaryotic and eukaryotic cells, resulting...
NifurtimoxAn antiparasitic drug used for the treatment of Chagas disease (Trypanosoma cruzi infection).
BenznidazoleA trypanocidal agent used to treat Chagas disease.
MelarsoprolMelarsoprol is under investigation in clinical trial NCT00330148 (Randomized Clinical Trial of Three Drug Combinations for Late-Stage Gambiense Human African Trypanosomiasis).
PafuramidineInvestigated for use/treatment in pneumonia, trypanosomiasis, malaria, HIV infection, and infectious and parasitic disease (unspecified).
Salicylhydroxamic AcidNot Available
SuraminFor treatment of human sleeping sickness, onchocerciasis and other diseases caused by trypanosomes and worms.
LonidamineInvestigated for use/treatment in benign prostatic hyperplasia, prostate disorders, and cancer/tumors (unspecified).
HomidiumHomidium is a group II compound with trypanocidal effects.
Drugs & Drug Targets
DrugTargetType
PentamidineDNAtarget
PentamidineCytochrome P450 2C19enzyme
PentamidinetRNA (cytosine(38)-C(5))-methyltransferasetarget
PentamidineCytochrome P450 2D6enzyme
PentamidineCytochrome P450 1A1enzyme
PentamidineCytochrome P450 3A5enzyme
PentamidineCytochrome P450 4A11enzyme
PosaconazoleCytochrome P450 3A4enzyme
PosaconazoleP-glycoprotein 1transporter
PosaconazoleCytochrome P450 51target
DiminazenePeroxiredoxin-5, mitochondrialtarget
DiminazeneHTH-type transcriptional regulator QacRtarget
DiminazeneTrypsin-1target
DiminazeneAmiloride-sensitive amine oxidase [copper-containing]target
EflornithineOrnithine decarboxylasetarget
Puromycin60S ribosomal protein L10-liketarget
Puromycin60S ribosomal protein L13atarget
Puromycin60S ribosomal protein L23target
Puromycin60S ribosomal protein L15target
Puromycin60S ribosomal protein L19target
Puromycin60S ribosomal protein L23atarget
PuromycinProbable ribosome biogenesis protein RLP24target
Puromycin60S ribosomal protein L26-like 1target
Puromycin60S ribosomal protein L8target
Puromycin60S ribosomal protein L37target
Puromycin60S ribosomal protein L3target
Puromycin60S ribosomal protein L11target
PuromycinLeucyl/phenylalanyl-tRNA--protein transferasetarget
NifurtimoxATP-binding cassette sub-family G member 2transporter
NifurtimoxNitroreductasestarget
NifurtimoxNitroreductasesenzyme
NifurtimoxSerum albumincarrier
NifurtimoxGlyceraldehyde-3-phosphate dehydrogenase, glycosomaltarget
SuraminNAD-dependent protein deacylase sirtuin-5, mitochondrialtarget
SuraminComplement control protein C3target
SuraminPhospholipase A2, membrane associatedtarget
SuraminProthrombintarget
SuraminP2Y purinoceptor 2target
SuraminFollicle-stimulating hormone receptortarget
SuraminRyanodine receptor 1target
SuraminArylsulfatase Aenzyme
SuraminCytosolic phospholipase A2enzyme
LonidamineCystic fibrosis transmembrane conductance regulatortarget
LonidamineHexokinase-1target