Cyclin-Dependent Kinases, antagonists & inhibitors

Cyclin-Dependent Kinases, antagonists & inhibitors
Accession Number

Not Available

DrugDrug Description
OlomoucineNot Available
AlvocidibInvestigated for use/treatment in esophageal cancer, leukemia (lymphoid), lung cancer, liver cancer, and lymphoma (unspecified).
AT-7519Investigated for use/treatment in leukemia (unspecified), lymphoma (unspecified), myelodysplastic syndrome, and solid tumors.
PalbociclibAn endocrine-based chemotherapeutic agent used in combination with other antineoplastic agents to treat HER2-negative and HR-positive advanced or metastatic breast cancer.
DinaciclibDinaciclib has been used in trials studying the treatment of rrMM, rrCLL, rrDLBCL, Solid Tumors, and Solid Neoplasm, among others.
PHA-793887PHA-793887 has been used in trials studying the treatment of Advanced/Metastatic Solid Tumors.
TrilaciclibA CDK4 and CDK6 inhibitor to reduce the risk of chemotherapy induced myelosuppression.
ZotiraciclibZotiraciclib is under investigation in clinical trial NCT02942264 (Zotiraciclib (TG02) Plus Dose-dense or Metronomic Temozolomide Followed by Randomized Phase II Trial of Zotiraciclib (TG02) Plus Temozolomide Versus Temozolomide Alone in...
Drugs & Drug Targets
OlomoucineCyclin-dependent kinase 2target
OlomoucineCyclin-dependent kinase 5target
OlomoucineCyclin-dependent kinase 1target
OlomoucineMitogen-activated protein kinase 1target
AlvocidibGlycogen phosphorylase, muscle formtarget
AlvocidibCyclin-dependent kinase 7target
AlvocidibCyclin-dependent kinase 5target
AlvocidibCyclin-dependent kinase 9target
AlvocidibCyclin-dependent kinase 1target
AlvocidibCyclin-dependent kinase 6target
AlvocidibEpidermal growth factor receptortarget
AlvocidibCyclin-dependent kinase 4target
AlvocidibCyclin-dependent kinase 8target
AlvocidibCyclin-dependent kinase 2target
AlvocidibATP-binding cassette sub-family G member 2transporter
AlvocidibGlycogen phosphorylase, brain formtarget
AlvocidibGlycogen phosphorylase, liver formtarget
AlvocidibUDP-glucuronosyltransferase 1-1enzyme
OLOMOUCINE IICyclin-dependent kinase 2target
AT-7519Cyclin-dependent kinase 1target
AT-7519Cyclin-dependent kinase 2target
PalbociclibCyclin-dependent kinase 4target
PalbociclibCyclin-dependent kinase 6target
PalbociclibCytochrome P450 3A4enzyme
PalbociclibBile salt sulfotransferaseenzyme
PalbociclibP-glycoprotein 1transporter
PalbociclibATP-binding cassette sub-family G member 2transporter
PalbociclibSerum albumincarrier
PalbociclibSolute carrier family 22 member 1transporter
TrilaciclibSolute carrier family 22 member 2transporter
TrilaciclibMultidrug and toxin extrusion protein 1transporter
TrilaciclibMultidrug and toxin extrusion protein 2transporter
TrilaciclibCytochrome P450 1A2enzyme
TrilaciclibATP-binding cassette sub-family G member 2transporter
TrilaciclibP-glycoprotein 1transporter
TrilaciclibCyclin-dependent kinase 4target
TrilaciclibCyclin-dependent kinase 6target
TrilaciclibCyclin-dependent kinase 9target
TrilaciclibCyclin-dependent kinase 2target
TrilaciclibCyclin-dependent kinase 5target
TrilaciclibCyclin-dependent kinase 7target
ZotiraciclibCyclin-dependent kinase 9target
ZotiraciclibTyrosine-protein kinase Fyntarget
ZotiraciclibTyrosine-protein kinase Lcktarget