Refractory Multiple Myeloma (DBCOND0028542)

Identifiers

Synonyms
Multiple Myeloma, Refractory

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Carmustine
An alkylating agent used in the treatment of various malignancies, including brain tumours and multiple myeloma, among others.
Ciltacabtagene autoleucel
A BCMA-directed CAR T-cell therapy used in the treatment of relapsed or refractory multiple myeloma in previously treated patients.
Daratumumab
A CD38-directed cytolytic antibody used alone or as an adjunct drug in the treatment of multiple myeloma and light chain amyloidosis.
Elotuzumab
An antineoplastic agent and SLAMF7-directed immunostimulatory antibody used for the treatment of refractory multiple myeloma in combination with other antineoplastic agents.
Elranatamab
A bispecific antibody used to treat adults with relapsed or refractory multiple myeloma.
Idecabtagene vicleucel
An autologous T-cell therapy indicated to treat relapsed or refractory multiple myeloma.
Isatuximab
A chimeric monoclonal antibody targeted against surface CD38 glycoproteins for the treatment of multiple myeloma in patients who have failed previous therapies.
Panobinostat
A non-selective histone deacetylase inhibitor used to treat multiple myeloma in combination with other antineoplastic agents.
Selinexor
Selinexor is indicated in combination with bortezomib and dexamethasone for the treatment of multiple myeloma in adult patients who have received at least one prior therapy. Selinexor is also indicated...
Talquetamab
A bispecific antibody used to treat adults with relapsed or refractory multiple myeloma.
Teclistamab
A bispecific B-cell maturation antigen (BCMA)-directed CD3 T cell engager used to treat relapsed and refractory multiple myeloma in adults as monotherapy.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT05546723
LMY-920 for Treatment of Relapsed or Refractory MyelomaNo drug interventionstreatment1recruiting
NCT05121103
A Study of the Safety, Tolerability and Effectiveness of EZM0414 Investigative Product in Participants With Relapsed/Refractory Multiple Myeloma and Relapsed/Refractory Diffuse Large B Cell LymphomaNo drug interventionstreatment1active_not_recruiting
NCT05673083
Impact of a Health Technology Intervention on Patient Activation in Multiple MyelomaNo drug interventionsNot AvailableNot Availablerecruiting
NCT05749133
Safety and Efficacy of Anti-GPRC5D CAR-T Cells Therapy in the Treatment of r/r MMNo drug interventionstreatment1 / 2recruiting
NCT04813653
Cyclosporine in Combination With Carfilzomib and Dexamethasone in Relapsed Multiple Myeloma Refractory to Carfilzomib and High Expression of PPIA Gene in Myeloma Cellstreatment1recruiting
NCT05050305
Marizomib Central Nervous System (CNS)treatment2withdrawn
NCT06012383
Alvocade® (Bortezomib) Safety and Effectiveness StudyNot AvailableNot Availablecompleted
NCT05008536
Anti-BCMA CAR-NK Cell Therapy for the Relapsed or Refractory Multiple Myelomatreatment0unknown_status
NCT02176213
Study of Pomalidomide, Cyclophosphamide, Dexamethasone in Relapsed/Refractory Multiple Myelomatreatment2completed
NCT05493618
Pembrolizumab, Belantamab and Dexamethasone in Refractory Multiple Myeloma.treatment1 / 2withdrawn
NCT05836896
A Phase I Trial to Establish the Safety and Maximum Tolerated Dose of High-affinity Autologous BCMA-targeting Chimeric Antigen Receptor (CAR) T-cells in Patients With Relapsed and Refractory B-cell MalignanciesNo drug interventionstreatment1recruiting
NCT06115135
A Study of Venetoclax in Combination With Isatuximab and Dexamethasone for Relapsed/Refractory Multiple Myelomatreatment2not_yet_recruiting
NCT05909826
Carfilzomib, Oral Cyclophosphamide, and Dexamethasone for RRMMtreatment2not_yet_recruiting
NCT06485076
Early Palliative Care for Patients With Multiple Myeloma and Aggressive LymphomaNo drug interventionssupportive_careNot Availablerecruiting
NCT04861480
Dual-target CAR-T Cells (C-4-29) in the Treatment of Relapsed/Refractory Multiple MyelomaNo drug interventionstreatment1enrolling_by_invitation
NCT06411301
A Phase I Study to Assess the Tolerability of 225Ac-DOTATATE in Patients With Refractory and Relapsing Multiple Myeloma Expressing Somatostatin Receptorstreatment1not_yet_recruiting
NCT04603872
CAR-T Cells Combined With Dasatinib for Patients With Relapsed and/or Refractory B-cell Hematological Malignanciestreatment0recruiting
NCT06225310
A Trial of Selinexor, Ruxolitinib and Methylprednisolonetreatment1not_yet_recruiting
NCT04688853
A Study to Investigate the Safety and Efficacy of TEG002 in Relapsed/Refractory Multiple Myeloma PatientsNo drug interventionsother1unknown_status
NCT04811898
A Dose Escalation Study of LNA-i-Mir-221 for Cancer TreatmentNo drug interventionstreatment1completed
NCT04657861
APRIL CAR-T Cell Therapy for Patients With BCMA/TACI Positive Relapsed and/or Refractory Multiple MyelomaNo drug interventionstreatment0recruiting
NCT05739188
Safety and Efficacy of Anti-GPRC5D CAR-T Cells Therapy in the Treatment of r/r MMNo drug interventionstreatment1 / 2recruiting
NCT04414475
A Study of Selinexor (Seli) + Low-dose Dexamethasone (LDD) in Penta-refractory Multiple Myeloma (MM), Seli and Bortezomib + LDD in Triple-class Refractory MM, and Seli and Pomalidomide + LDD in Relapsed Refractory MMtreatment2recruiting
NCT06242249
Anti-BCMA CAR-NK Therapy in Relapsed or Refractory Multiple MyelomaNo drug interventionstreatment1 / 2not_yet_recruiting
NCT05495620
Long-term KRd in Relapsed and/or Refractory Multiple MyelomaNot AvailableNot Availableunknown_status
NCT05555329
Alternative Dosing Scheme of Pomalidomide 4 mg Every Other Day Versus Pomalidomide 2 mg and 4 mg Every Day; the POMAlternative Studytreatment4not_yet_recruiting
NCT05191472
Pembrolizumab for the Treatment of Relapsed or Refractory Multiple Myeloma After Anti-BCMA CAR-T Therapiestreatment2terminated
NCT06158412
All-trans Retinoic Acid in Combination With a KPD Regimen for the Treatment of Refractory/Relapsed Multiple Myelomatreatment2recruiting
NCT04287855
Multicenter Open Label Phase 2 Study of Isatuximab Plus Pomalidomide and Dexamethasone With Carfilzomib in Relapsed or Refractory Multiple Myelomatreatment2active_not_recruiting
NCT05747586
BCMA CAR-NK For Patients With RRMMtreatmentNot Availablerecruiting
NCT04579523
²¹¹At-OKT10-B10 and Fludarabine Alone or in Combination With Cyclophosphamide and Low-Dose TBI Before Donor Stem Cell Transplant for the Treatment of Newly Diagnosed, Recurrent, or Refractory High-Risk Multiple Myelomatreatment1not_yet_recruiting
NCT06357975
Testing Crizotinib as Potentially Targeted Treatment in Cancers With MET Genetic Changes (MATCH - Subprotocol C1)treatment2active_not_recruiting
NCT06357988
Testing GDC-0449 (Vismodegib) as Potentially Targeted Treatment in Cancers With Smoothened or Patched 1 Mutant Tumors (MATCH - Subprotocol T)treatment2active_not_recruiting
NCT06360575
Testing Crizotinib as Potentially Targeted Treatment in Cancers With MET Exon 14 Deletion Genetic Changes (MATCH - Subprotocol C2)treatment2active_not_recruiting
NCT06421675
Outpatient and Intermittent Dosing of Elranatamab in Relapsed/Refractory Multiple Myelomatreatment2not_yet_recruiting
NCT06433947
Study to Assess Safety and Tolerability of OPN-6602 in Subjects with Relapsed And/or Refractory Multiple Myelomatreatment1recruiting
NCT06500884
A Study to Evaluate Preventive Treatments for Talquetamab-related Oral Toxicitytreatment2active_not_recruiting
NCT02465060
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)screening2active_not_recruiting
NCT06622005
SX-682 in Combination With Carfilzomib, Daratumumab-Hyaluronidase, and Dexamethasone in Patients With Relapsed or Refractory Multiple Myelomatreatment1not_yet_recruiting
NCT06627751
Mezigdomide, Carfilzomib, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma in Patients With Extramedullary Diseasetreatment2not_yet_recruiting
NCT06119685
IDP-023 as a Single Agent and in Combination With Antibody Therapies in Patients With Advanced Hematologic Cancerstreatment1 / 2recruiting
NCT04790474
Ixazomib-pomalidomide-dexamethasone As Second or Third-line Combination Treatment for Patients with Relapsed and Refractory Multiple Myeloma Previously Treated with Daratumumab, Lenalidomide and Bortezomibtreatment2active_not_recruiting
NCT05228470
A Study of Elranatamab (PF-06863135) in Chinese Participants With Refractory Multiple Myeloma.treatment1 / 2active_not_recruiting
NCT06303167
Testing AZD9291 as Potentially Targeted Treatment in Cancers With EGFR Genetic Changes (MATCH-Subprotocol E)treatment2active_not_recruiting
NCT06308822
Testing JNJ-42756493 (Erdafitinib) as Potentially Targeting Treatment in Cancers With FGFR Amplifications (MATCH-Subprotocol K1)treatment2active_not_recruiting
NCT06518551
Elotuzumab + Iberdomide + Dexamethasone Post Ide-Cel in RRMMtreatment1 / 2not_yet_recruiting
NCT06588660
ST-067 and Teclistamab for the Treatment of Relapsed or Refractory Multiple Myelomatreatment1not_yet_recruiting
NCT00047203
Flavopiridol in Treating Patients With Relapsed or Refractory Multiple Myelomatreatment2completed
NCT01233921
Palifermin in Preventing Chronic Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancersupportive_careNot Availablecompleted
NCT00028821
2-Methoxyestradiol in Treating Patients With Advanced Solid Tumorstreatment1completed
NCT03618602
Safety, Pharmacokinetics and Efficacy Study of Bisthianostat in Refractory or Recurrent Multiple Myeloma PatientsNo drug interventionstreatment1unknown_status
NCT00619684
Lenalidomide in Treating Patients With Progressive or Recurrent Multiple Myeloma After a Donor Stem Cell Transplanttreatment2completed
NCT04843579
Treatment of Selinexor in Combination With Clarithromycin, Pomalidomide and Dexamethasone for Relapsed Refractory Multiple Myeloma Patientstreatment2terminated
NCT04439279
Testing Trametinib as a Potential Targeted Treatment in Cancers With BRAF Genetic Changes (MATCH-Subprotocol R)treatment2active_not_recruiting
NCT01534143
High Dose Busulfan and Bortezomib in Treating Patients With High Risk Multiple Myeloma Undergoing Stem Cell Transplanttreatment2terminated
NCT00002787
Vaccine Therapy in Treating Patients With Multiple Myeloma Who Have Undergone Stem Cell Transplantationtreatment1completed
NCT00153933
Bortezomib in Combination With CC-5013 in Patients With Relapsed/Refractory Multiple Myelomatreatment1completed
NCT00693433
Temsirolimus and Dexamethasone in Treating Patients With Recurrent or Refractory Multiple Myelomatreatment1completed
NCT00006251
Fludarabine Phosphate, Low-Dose Total-Body Irradiation, and Donor Stem Cell Transplant Followed by Cyclosporine, Mycophenolate Mofetil, Donor Lymphocyte Infusion in Treating Patients With Hematopoietic Cancertreatment1 / 2completed
NCT00054353
Reduced-Intensity Conditioning Followed By Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Multiple Myelomatreatment1 / 2completed
NCT00890747
Sunitinib Malate in Treating HIV-Positive Patients With Cancer Receiving Antiretroviral Therapytreatment1completed
NCT00303797
Sorafenib and Bortezomib in Treating Patients With Advanced Cancertreatment1completed
NCT00054483
Bortezomib in Treating Patients With Advanced Cancer and Kidney Dysfunctionbasic_science1completed
NCT06385483
Testing Afatinib as Potentially Targeted Treatment in Cancers With EGFR Genetic Changes (MATCH - Subprotocol A)treatment2active_not_recruiting
NCT01676961
Romiplostim in Increasing Low Platelet Counts in Patients With Multiple Myeloma Receiving Chemotherapysupportive_care2terminated
NCT05896228
Iberdomide, Daratumumab, Carfilzomib, and Dexamethasone (Iber-KDd) in Patients With Relapsed/Refractory Multiple Myelomatreatment2recruiting
NCT01129193
AR-42 in Treating Patients With Advanced or Relapsed Multiple Myeloma, Chronic Lymphocytic Leukemia, or Lymphomatreatment1completed
NCT05490771
Testing Copanlisib as a Potential Targeted Treatment in Cancers With PIK3CA Mutations (MATCH-Subprotocol Z1F)treatment2active_not_recruiting
NCT01177371
High-Dose Busulfan and High-Dose Cyclophosphamide Followed By Donor Bone Marrow Transplant in Treating Patients With Leukemia, Myelodysplastic Syndrome, Multiple Myeloma, or Recurrent Hodgkin or Non-Hodgkin Lymphomatreatment2completed
NCT03798678
CB-839 HCl in Combination With Carfilzomib and Dexamethasone in Treating Patients With Recurrent or Refractory Multiple Myelomatreatment1active_not_recruiting
NCT04439188
Testing GSK2636771 as a Potential Targeted Treatment in Cancers With PTEN Loss of Expression (MATCH-Subprotocol P)treatment2active_not_recruiting
NCT05053607
Real World Insights During Treatment for Relapsed/Refractory Multiple Myeloma With IsatuximabNo drug interventionsotherNot Availablerecruiting
NCT00079456
Temsirolimus in Treating Patients With Relapsed or Refractory Multiple Myelomatreatment2completed
NCT04398485
A Study of ION251 Administered to Patients With Relapsed/Refractory Multiple MyelomaNo drug interventionstreatment1active_not_recruiting
NCT00398515
Lenalidomide and Temsirolimus in Treating Patients With Previously Treated Multiple Myelomatreatment1completed
NCT00025415
Imatinib Mesylate in Treating Patients With Advanced Cancer and Liver Dysfunctiontreatment1completed
NCT00514137
Sunitinib in Treating Patients With Relapsed Multiple Myelomatreatment2completed
NCT06390852
Testing LOXO-101 as Potentially Targeted Treatment in Cancers With NTRK Genetic Changes (MATCH - Subprotocol Z1E)treatment2active_not_recruiting
NCT00118352
Alemtuzumab, Fludarabine Phosphate, and Total-Body Irradiation Followed by Cyclosporine and Mycophenolate Mofetil in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancertreatment2completed
NCT05577000
Anti-BCMA Chimeric Antigen Receptor T Cells for Relapsed or Refractory Multiple Myelomatreatment1active_not_recruiting
NCT00995059
Bortezomib Before Donor Stem Cell Transplant in Treating Patients With Multiple Myelomatreatment1 / 2withdrawn
NCT04883242
Isatuximab, Carfilzomib, Pomalidomide, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myelomatreatment2recruiting
NCT00912899
A Study of Noscapine HCl (CB3304 ) in Patients With Relapsed or Refractory Multiple Myelomatreatment1terminated
NCT00005799
Fludarabine Phosphate, Low-Dose Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies or Kidney CancertreatmentNot Availablecompleted
NCT00998049
Plerixafor in Treating Patients With Multiple Myeloma Previously Treated With Lenalidomide and Planning to Undergo Autologous Stem Cell Transplanttreatment2completed
NCT04119336
Nivolumab, Ixazomib, Cyclophosphamide, and Dexamethasone in Relapsed/Refractory Myelomatreatment2terminated
NCT00306813
Evaluation of Lenalidomide, Doxorubicin and Dexamethasone (RAD) in Patients With Relapsed or Refractory Multiple Myelomatreatment1 / 2completed
NCT01384513
A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignanciestreatment2completed
NCT05950113
CART-BCMA/CS1 in Treating Patients With Relapsed or Refractory Multiple Myelomatreatment1withdrawn
NCT02020941
Carfilzomib in Treating Patients With Multiple Myeloma in First Relapse or Refractory to First-Line Therapytreatment2terminated
NCT01078441
Bortezomib, Liposomal Doxorubicin Hydrochloride, Dexamethasone, and Cyclophosphamide in Treating Patients With Multiple Myeloma That Relapsed After Autologous Stem Cell Transplanttreatment2terminated
NCT04083534
First In Human (FIH) Study of REGN5459 in Adult Patients With Relapsed or Refractory Multiple Myeloma (MM)No drug interventionstreatment1 / 2active_not_recruiting
NCT03601624
Pomalidomide/Cyclophosphamide/Dexamethasone in Relapse Refractory Myeloma: Safety Profile in Mexicanstreatment2unknown_status
NCT04302324
A Phase II Study of Daratumumab, Clarithromycin, Pomalidomide And Dexamethasone (D-ClaPd) In Multiple Myeloma Patients Previously Exposed to Daratumumabtreatment2recruiting
NCT00310024
Vorinostat and Bortezomib in Treating Patients With Relapsed or Refractory Multiple Myelomatreatment1completed
NCT06385496
Testing MLN0128 (TAK-228) as Potentially Targeted Treatment in Cancers With mTOR Genetic Changes (MATCH - Subprotocol L)treatment2active_not_recruiting
NCT00078858
Mycophenolate Mofetil and Cyclosporine in Reducing Graft-Versus-Host Disease in Patients With Hematologic Malignancies or Metastatic Kidney Cancer Undergoing Donor Stem Cell Transplanttreatment1 / 2completed
NCT00014235
Fludarabine Phosphate and Total-Body Radiation Followed by Donor Peripheral Blood Stem Cell Transplant and Immunosuppression in Treating Patients With Hematologic MalignanciestreatmentNot Availablecompleted
NCT02103335
Combination Study of Pomalidomide, Marizomib, and Low-Dose Dexamethasone in Relapsed and Refractory Multiple Myelomatreatment1completed
NCT00243035
Tipifarnib and Bortezomib in Treating Patients With Relapsed Multiple Myelomatreatment1 / 2terminated
NCT05150522
B Cell Maturation Antigen Targeted CAR-T Cells in Treatment With Relapsed and Refractory Multiple MyelomaNo drug interventionstreatment1 / 2unknown_status
NCT03702725
Study of Ibrutinib in Combination With Revlimid/Dexamethasone in Relapsed/Refractory Multiple Myelomatreatment1active_not_recruiting
NCT06400225
Testing BVD-523FB (Ulixertinib) as Potentially Targeted Treatment in Cancers With Genetic Changes (MATCH - Subprotocol Z1L)treatment2active_not_recruiting
NCT06390826
Testing Sunitinib as Potentially Targeted Treatment in Cancers With cKIT Genetic Changes (MATCH - Subprotocol V)treatment2active_not_recruiting
NCT00003166
Bryostatin and Vincristine in B-Cell Malignanciestreatment1completed
NCT01529827
Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignanciestreatment2completed
NCT03770260
Ixazomib and Pevonedistat in Treating Patients With Multiple Myeloma That Has Come Back or Does Not Respond to Treatmenttreatment1completed
NCT01074060
Plerixafor and Filgrastim Following Cyclophosphamide for Stem Cell Mobilization in Patients With Multiple Myelomatreatment1completed
NCT03952091
TJ202, Lenalidomide and Dexamethasone vs. Lenalidomide and Dexamethasone in Subjects With Relapsed or Refractory Multiple Myelomatreatment3completed
NCT01199562
Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell TransplantNot AvailableNot Availablecompleted
NCT01118689
Dose Escalation Study of MLN0128 in Relapsed or Refractory Multiple Myeloma or Waldenstrom Macroglobulinemiatreatment1completed
NCT04439292
Testing Trametinib and Dabrafenib as a Potential Targeted Treatment in Cancers With BRAF Genetic Changes (MATCH-Subprotocol H)treatment2active_not_recruiting
NCT05020444
TriPRIL CAR T Cells in Multiple Myelomatreatment1recruiting
NCT00114101
Lenalidomide in Treating Patients With Multiple Myeloma Undergoing Autologous Stem Cell Transplanttreatment3active_not_recruiting
NCT00049504
Haploidentical Donor Bone Marrow Transplant in Treating Patients With High-Risk Hematologic Cancertreatment2completed
NCT00060372
Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancertreatment1completed
NCT00040846
Alemtuzumab, Fludarabine Phosphate, and Low-Dose Total Body Irradiation Before Donor Stem Cell Transplantation in Treating Patients With Hematological Malignanciestreatment2completed
NCT06203912
Donor Immune Cells (TGFbi NK Cells) and Isatuximab for the Treatment of Relapsed or Refractory Multiple Myelomatreatment1recruiting
NCT03201250
Cabozantinib as a Targeted Strategy to Reverse Carfilzomib Resistance in Refractory Multiple Myelomatreatment1 / 2terminated
NCT05431608
A Study of MCARH109 and MCARH125 in People With Multiple MyelomaNo drug interventionstreatment1recruiting
NCT06348108
Talquetamab in Combination With Iberdomide and Dexamethasone for Relapsed or Refractory Multiple Myelomatreatment1not_yet_recruiting
NCT04004338
Carfilzomib in Combination for the Treatment of RR MMNot AvailableNot Availableunknown_status
NCT06400264
Testing Nivolumab and BMS-986016 (Relatlimab) as Potentially Targeting Treatment in Cancers That Are LAG-3+ and Have Mismatch Repair Deficiency (MATCH - Subprotocol Z1M)treatment2withdrawn
NCT01083602
Efficacy of Panobinostat in Patients With Relapsed and Bortezomib-refractory Multiple Myelomatreatment2completed
NCT01954784
Lenalidomide After Donor Stem Cell Transplant and Bortezomib in Treating Patients With High Risk Multiple Myelomatreatment1terminated
NCT00918333
Panobinostat and Everolimus in Treating Patients With Recurrent Multiple Myeloma, Non-Hodgkin Lymphoma, or Hodgkin Lymphomatreatment1 / 2completed
NCT00003954
Melphalan and Stem Cell Transplant Before Total-Body Irradiation and Donor Stem Cell Transplant in Treating Patients With Stage I-III Multiple Myelomatreatment1 / 2completed
NCT06400251
Testing Ipatasertib as Potentially Targeted Treatment in Cancers With AKT Genetic Changes (MATCH - Subprotocol Z1K)treatment2active_not_recruiting
NCT00849251
Pegylated Liposomal Doxorubicin Hydrochloride, Bortezomib, Cyclophosphamide, and Dexamethasone in Treating Patients With Multiple Myelomatreatment1 / 2terminated
NCT04439253
Testing Crizotinib as a Potential Targeted Treatment in Cancers With ROS1 Genetic Changes (MATCH-Subprotocol G)treatment2active_not_recruiting
NCT01775553
Study of High Dose Carfilzomib in Multiple Myeloma Patients Who Have Progressed On Standard Dose Carfilzomibtreatment2completed
NCT04162353
BCMA-CD19 cCAR in Multiple Myeloma and Plasmacytoid LymphomaNo drug interventionstreatment1unknown_status
NCT01034553
Aurora A Kinase Inhibitor MLN8237 and Bortezomib in Treating Patients With Relapsed or Refractory Multiple Myelomatreatment1 / 2completed
NCT03389347
High Throughput Drug Sensitivity and Genomics Data in Developing Individualized Treatment in Patients With Relapsed or Refractory Multiple Myeloma or Plasma Cell LeukemiaNo drug interventionsotherNot Availablerecruiting
NCT02998047
A Phase I Study of Lintuzumab-Ac225 in Patients With Refractory Multiple Myelomatreatment1terminated
NCT05430945
A Study of BCMA-targeted CAR-T Cells Therapy for Refractory/Relapsed Multiple MyelomaNo drug interventionstreatment0recruiting
NCT01049945
Bendamustine Hydrochloride, Lenalidomide, and Dexamethasone in Treating Patients With Relapsed Multiple Myelomatreatment1 / 2completed
NCT00343798
A Pilot Study to Evaluate the Co-Infusion of Ex Vivo Expanded Cord Blood Cells With an Unmanipulated Cord Blood Unit in Patients Undergoing Cord Blood Transplant for Hematologic Malignanciestreatment1completed
NCT00124605
Arsenic Trioxide and Pamidronate in Treating Patients With Advanced Solid Tumors or Multiple Myelomatreatment1completed
NCT01155583
Low-Dose Azacitidine, Lenalidomide, and Low-Dose Dexamethasone in Relapsed or Refractory Multiple Myelomatreatment1 / 2completed
NCT00799461
Internet-Based Program With or Without Telephone-Based Problem-Solving Training in Helping Long-Term Survivors of Hematopoietic Stem Cell Transplant Cope With Late ComplicationsNo drug interventionssupportive_care3completed
NCT00089011
Tacrolimus and Mycophenolate Mofetil in Preventing Graft-Versus-Host Disease in Patients Who Have Undergone Total-Body Irradiation With or Without Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant for Hematologic Cancertreatment2completed
NCT00253578
Sorafenib in Treating Patients With Relapsed or Refractory Multiple Myelomatreatment2completed
NCT03158688
Study of Carfilzomib, Daratumumab and Dexamethasone for Patients With Relapsed and/or Refractory Multiple Myeloma.treatment3completed
NCT00856388
Fludarabine Phosphate, Melphalan, Total-Body Irradiation, Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer or Bone Marrow Failure DisorderstreatmentNot Availablecompleted
NCT05981209
Elotuzumab, CC-92480, and Dexamethasone for the Treatment of Relapsed or Refractory Myeloma After CD38- and BCMA-Targeted Therapiestreatment1recruiting
NCT02037256
Bortezomib and Filgrastim to Promote Stem Cell Mobilization in Patients With Non-Hodgkin Lymphoma or Multiple MyelomatreatmentNot Availablecompleted
NCT06171685
Horizon Adaptive Platform Trial Evaluating Therapies in RRMMtreatment2not_yet_recruiting
NCT03520985
Alternate Day Dosing of Pomalidomide in Patients With Refractory Multiple Myelomatreatment2terminated
NCT01588015
Vaccine Therapy in Preventing Cytomegalovirus Infection in Patients With Hematological Malignancies Undergoing Donor Stem Cell TransplantNo drug interventionssupportive_care1completed
NCT01564537
A Phase 3 Study Comparing Oral Ixazomib Plus Lenalidomide and Dexamethasone Versus Placebo Plus Lenalidomide and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myelomatreatment3completed
NCT03731832
Pomalidomide, Ixazomib, and Dexamethasone With or Without Intensification by Cyclophosphamide in Relapsed or Refractory Multiple Myelomascreening2active_not_recruiting
NCT01212952
Pomalidomide, Bortezomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myelomatreatment1 / 2completed
NCT04439175
Testing GDC-0032 (Taselisib) as a Potential Targeted Treatment in Cancers With PIK3CA Genetic Changes (MATCH-Subprotocol I)treatment2active_not_recruiting
NCT06138275
Elranatamab in R/R Multiple Myelomatreatment2recruiting
NCT01076270
Plerixafor and Filgrastim For Mobilization of Donor Peripheral Blood Stem Cells Before A Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic MalignanciestreatmentNot Availableterminated
NCT00118170
Sorafenib in Treating Patients With Metastatic or Unresectable Solid Tumors, Multiple Myeloma, or Non-Hodgkin's Lymphoma With or Without Impaired Liver or Kidney Functiontreatment1completed
NCT04764942
Selinexor, Pomalidomide, and Dexamethasone With or Without Carfilzomib for the Treatment of Patients With Relapsed Refractory Multiple Myeloma, The SCOPE Trialtreatment1 / 2recruiting
NCT01096342
Dinaciclib in Treating Patients With Relapsed or Refractory Multiple Myelomatreatment2completed
NCT01653106
Randomized Trial of Cryotherapy Duration Prior to High Dose Melphalan in Myeloma PatientsNo drug interventionstreatmentNot Availablecompleted
NCT04439149
Testing GSK2636771 as a Potential Targeted Treatment in Cancers With PTEN Genetic Changes (MATCH-Subprotocol N)treatment2active_not_recruiting
NCT04439136
Testing Afatinib as a Potential Targeted Treatment in Cancers With HER2 Genetic Changes (MATCH-Subprotocol B)treatment2active_not_recruiting
NCT06304636
Descartes-15 for Patients With Relapsed/Refractory Multiple MyelomaNo drug interventionstreatment1recruiting
NCT04439318
Testing Trametinib as a Potential Targeted Treatment in Cancers With NF1 Genetic Changes (MATCH-Subprotocol S1)treatment2active_not_recruiting
NCT04176718
Daratumumab, Carfilzomib, Pomalidomide, Dexamethasone In MMtreatment2recruiting
NCT01658319
Methoxyamine and Fludarabine Phosphate in Treating Patients With Relapsed or Refractory Hematologic Malignanciestreatment1completed
NCT05742217
A Study to Learn How Patients With Triple Class Refractory Multiple Myeloma (TCR-MM) Are Treated in Italian Centers for Blood Related DiseasesNo drug interventionsNot AvailableNot Availablerecruiting
NCT05641324
A Study of ANV419 Alone or in Combination With Approved Treatments in Patients With Multiple Myeloma (OMNIA-2)treatment1terminated
NCT02658396
GO-203-2C + Bortezomib For Relapsed Or Refractory MMtreatment1withdrawn
NCT00003196
Low-Dose Total Body Irradiation and Donor Peripheral Blood Stem Cell Transplant Followed by Donor Lymphocyte Infusion in Treating Patients With Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, or Multiple MyelomatreatmentNot Availablecompleted
NCT01110135
Bendamustine Hydrochloride, Etoposide, Dexamethasone, and Filgrastim For Peripheral Blood Stem Cell Mobilization in Treating Patients With Refractory or Recurrent Lymphoma or Multiple Myelomatreatment2completed
NCT01301963
Filgrastim With or Without Plerixafor in Treating Patients With Multiple Myeloma Previously Treated With Lenalidomidetreatment3terminated
NCT00182663
Thalidomide, Dexamethasone, and Clarithromycin in Treating Patients With Multiple Myeloma Previously Treated With Transplanttreatment2completed
NCT04355039
INCB053914 and Pomalidomide With Dexamethasone for Relapsed and/or Refractory Multiple Myelomatreatment1withdrawn
NCT03589222
SELIBORDARA: Selinexor, Bortezomib and Daratumumab in Multiple Myelomatreatment2unknown_status
NCT03031730
Testing the Addition of KRT-232 (AMG 232) to Usual Chemotherapy for Relapsed Multiple Myelomatreatment1terminated
NCT04439357
Testing Trametinib as a Potential Targeted Treatment in Cancers With GNAQ or GNA11 Genetic Changes (MATCH-Subprotocol S2)treatment2active_not_recruiting
NCT04439266
Testing Crizotinib as a Potential Targeted Treatment in Cancers With ALK Genetic Changes (MATCH-Subprotocol F)treatment2active_not_recruiting
NCT01273766
Deferasirox in Treating Iron Overload Caused By Blood Transfusions in Patients With Hematologic Malignanciessupportive_care2completed
NCT06352866
Siltuximab for Cytokine Release Syndrome Prophylaxis Prior to tx w/ Teclistamab in RRMMsupportive_care2not_yet_recruiting
NCT06390865
Testing MLN0128 (TAK-228) as Potentially Targeted Treatment in Cancers With TSC1 or TSC2 Genetic Changes (MATCH - Subprotocol M)treatment2active_not_recruiting
NCT02199665
Selinexor, Carfilzomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myelomatreatment1recruiting
NCT01812720
Carfilzomib and Dexamethasone in Treating Patients With Multiple Myeloma Who Previously Underwent a Stem Cell Transplanttreatment2withdrawn
NCT04802031
Rapid-infusion Isatuximab in Relapsed/Refractory Multiple Myelomatreatment2withdrawn
NCT04439331
Testing VS-6063 (Defactinib) as a Potential Targeted Treatment in Cancers With NF2 Genetic Changes (MATCH-Subprotocol U)treatment2active_not_recruiting
NCT04439227
Testing AZD1775 as a Potential Targeted Treatment in Cancers With BRCA Genetic Changes (MATCH-Subprotocol Z1I)treatment2active_not_recruiting
NCT00112827
Melphalan and Radiation Therapy Followed By Lenalidomide in Treating Patients Who Are Undergoing Autologous Stem Cell Transplant for Stage I, Stage II, or Stage III Multiple Myelomatreatment1 / 2completed
NCT04519476
Selinexor Treatment for Multiple Myeloma Patients Who Are Refractory to Lenalidomide-containing Therapy.treatment1recruiting
NCT01053494
Massage Therapy Given by Caregiver in Treating Quality of Life of Young Patients Undergoing Treatment for CancerNo drug interventionssupportive_careNot Availablecompleted
NCT05170789
Elotuzumab, Selinexor, and Dexamethasone for Relapsed Refractory Multiple Myelomatreatment2withdrawn
NCT03266692
Study of ACTR087 in Combination With SEA-BCMA in Subjects With Relapsed or Refractory Multiple Myelomatreatment1terminated
NCT06232044
Testing the Combination of Two Approved Drugs and One Experimental Drug in Patients With Relapsed or Refractory Multiple Myelomatreatment1 / 2not_yet_recruiting
NCT02101944
Wild-Type Reovirus in Combination With Carfilzomib and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myelomatreatment1completed
NCT04439344
Testing Binimetinib as a Potential Targeted Treatment in Cancers With NRAS Genetic Changes (MATCH-Subprotocol Z1A)treatment2active_not_recruiting
NCT00006244
Melphalan, Peripheral Stem Cell Transplantation, and Interleukin-2 Followed by Interferon Alfa in Treating Patients With Advanced Multiple Myelomatreatment2completed
NCT00536601
High-Dose Chemotherapy With or Without Total-Body Irradiation Followed by Autologous Stem Cell Transplant in Treating Patients With Hematologic Cancer or Solid TumorstreatmentNot Availablecompleted
NCT00719901
Obatoclax and Bortezomib in Treating Patients With Relapsed or Refractory Multiple Myelomatreatment1 / 2terminated
NCT05922501
Isatuximab, Bela Maf, Pom, and Dex in Relapsed/Refractory Multiple Myelomatreatment2not_yet_recruiting
NCT05847569
Alternate Doses and Dosing Schedules of Belantamab Mafodotin for Treatment of Triple-Class Refractory Multiple Myelomatreatment2recruiting
NCT04434469
A Study Evaluating The Safety And Pharmacokinetics Of Escalating Doses Of RO7297089 In Patients With Relapsed Or Refractory Multiple MyelomaNo drug interventionstreatment1completed
NCT04439110
Testing Ado-Trastuzumab Emtansine as a Potential Targeted Treatment in Cancers With HER2 Genetic Changes (MATCH-Subprotocol Q)treatment2active_not_recruiting
NCT01447914
Tivantinib in Treating Patients With Relapsed, or Relapsed and Refractory Multiple Myelomatreatment2completed
NCT01652014
Single or Double Donor Umbilical Cord Blood Transplant in Treating Patients With High-Risk Hematologic Malignanciestreatment2withdrawn
NCT04670055
A Study of Humanized BCMA-targeted CAR-T Cells Therapy for Refractory/Relapsed Multiple MyelomaNo drug interventionstreatment0not_yet_recruiting
NCT00112723
Flavopiridol in Treating Patients With Relapsed or Refractory Lymphoma or Multiple Myelomatreatment1 / 2terminated
NCT04439123
Testing AZD5363 as a Potential Targeted Treatment in Cancers With AKT Genetic Changes (MATCH-Subprotocol Y)treatment2active_not_recruiting
NCT05117008
Maintenance Belantamab Mafodotin (Blenrep®) After B-cell Maturation Antigen-Directed Chimeric Antigen Receptor T-cell Therapy in Patients With Relapsed and/or Refractory Multiple Myelomatreatment2terminated
NCT03860038
TJ202 Combined With Dexamethasone in Subjects With Relapsed or Refractory Multiple Myelomatreatment2active_not_recruiting
NCT06400238
Testing Copanlisib as Potentially Targeting Treatment in Cancers With PTEN Expression (MATCH - Subprotocol Z1H)treatment2active_not_recruiting
NCT00217438
Melphalan and Amifostine Followed By One or Two Autologous or Syngeneic Stem Cell Transplants and Maintenance Therapy in Treating Patients With Stage II-III Multiple Myelomatreatment3completed